This document discusses cyberbullying and summarizes research findings. It begins with definitions of bullying and harassment, noting they can occur between people of unequal or equal power. Research finds 20-40% of youth experience online or text harassment. Most harassment occurs via rude comments. Victimization is linked to distress and other issues. The assumptions that cyberbullying is increasing, more distressing, or impacts everyone are not supported by data. The document provides advice for parents on discussing cyberbullying with kids and helping victims. It stresses empowering youth to handle issues themselves when possible.
Safe Community Partnership October 2013 Social Media & TechnologyScott Mills
Presented Oct 29, 2013 in Toronto, Ontario "Social Media And Technology: New Opportunities and Benefits, New Challenges" Faye Misha, Dean & Professor Factor-Inwentash Facutly of Social Work and Margaret & Wallace McCain Family Chair in Child & Family, University of Toronto
An updated look at the research and definitions around bullying and cyberbullying. Presented to the Youth Online Safety Working Group assembled by NCMEC, this talk unpacks both what current research can tell us about cyberbullying as well as where the gaps our understanding of this issue lie.
Safe Community Partnership October 2013 Social Media & TechnologyScott Mills
Presented Oct 29, 2013 in Toronto, Ontario "Social Media And Technology: New Opportunities and Benefits, New Challenges" Faye Misha, Dean & Professor Factor-Inwentash Facutly of Social Work and Margaret & Wallace McCain Family Chair in Child & Family, University of Toronto
An updated look at the research and definitions around bullying and cyberbullying. Presented to the Youth Online Safety Working Group assembled by NCMEC, this talk unpacks both what current research can tell us about cyberbullying as well as where the gaps our understanding of this issue lie.
Amanda Lenhart delivered this presentation to the Year of the Child summit at the National Association of Attorneys General Year of the Child Conference, Philadelphia, PA, this talk surveys the current research on cyberbullying and online harassment, pulling in Pew Internet data as well as the work of the Crimes Against Children Research Center at the University of New Hampshire, Internet Solutions for Kids and other academics and scholars researching this topic. 5/13/09
2011, Cyber Bullying, Digital Citizenship, and Learning: Network World by Ji...Jim "Brodie" Brazell
NETWORK WORLD: Cyber Bullying, Digital Citizenship, and Learning. South Carolina CTE Conference Featured Session with Jim Brazell of Ventureramp.com on August 30, 2011. Topics: Cyber Bullying, Digital Citizenship, Digital Rights, Digital Ethics, Digital Culture, Digital Communication, STEM, TEAMS, STEAM, Digital Art and Digital Criticism. Jim Brazell, http://www.ventureramp.com, jimbrazell@ventureramp.com.
Presented by senior researchers from the UTS Health Psychology Unit, this lecture unravels the facts about cyber bullying. It debunks media stereotypes of perpetrators and victims, lays bare its costs to individuals and communities and offers practical pathways for solutions and healing.
Social Media: To Fear or Not - What's the Facts? Presented @ Atlantis Rising Campus in Second Life for Bernajean Porter. See AtlantisSeekers.ning.com for more details and information to join us in more conversations.
Amanda Lenhart delivered this presentation to the Year of the Child summit at the National Association of Attorneys General Year of the Child Conference, Philadelphia, PA, this talk surveys the current research on cyberbullying and online harassment, pulling in Pew Internet data as well as the work of the Crimes Against Children Research Center at the University of New Hampshire, Internet Solutions for Kids and other academics and scholars researching this topic. 5/13/09
2011, Cyber Bullying, Digital Citizenship, and Learning: Network World by Ji...Jim "Brodie" Brazell
NETWORK WORLD: Cyber Bullying, Digital Citizenship, and Learning. South Carolina CTE Conference Featured Session with Jim Brazell of Ventureramp.com on August 30, 2011. Topics: Cyber Bullying, Digital Citizenship, Digital Rights, Digital Ethics, Digital Culture, Digital Communication, STEM, TEAMS, STEAM, Digital Art and Digital Criticism. Jim Brazell, http://www.ventureramp.com, jimbrazell@ventureramp.com.
Presented by senior researchers from the UTS Health Psychology Unit, this lecture unravels the facts about cyber bullying. It debunks media stereotypes of perpetrators and victims, lays bare its costs to individuals and communities and offers practical pathways for solutions and healing.
Social Media: To Fear or Not - What's the Facts? Presented @ Atlantis Rising Campus in Second Life for Bernajean Porter. See AtlantisSeekers.ning.com for more details and information to join us in more conversations.
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DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
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Bullying and harassment in the context of emerging technologies
1. Get Schooled: Kids and Cyber Security Event
Department of State – Harry S. Truman Building
12:30 PM, May 3, 2011
Bullying and harassment in the
context of emerging technologies
Michele Ybarra MPH PhD
Center for Innovative Public Health Research
* Thank you for your interest in this
presentation. Please note that analyses included herein
are preliminary. More recent, finalized analyses may be
available by contacting CiPHR for further information.
2. Roadmap
Exactly what is cyberbullying?
How do I talk to my children about
it?
How can I help children who are
victims of cyberbullying?
3. Exactly what is cyberbullying and
Internet harassment?
There is wide variability in the definition of
harassment and bullying among researchers.
Generally, it refers to an act of intentional
aggression (e.g., “mean things”) towards
someone else via technology (i.e., Internet, cell
phone text messaging)
Bullying:
Is between (at least) two people with differential power
Occurs over time
Is repetitive
Harassment:
May be between two people of equal power
May happen once or many times
4. Context
Girl, 12: “These people from school were
calling me a prostitute and whore … and
saying I was raped. [It happened] because I‟m
an easy target. I didn‟t let it bother me until
about a month ago and [then] I started getting
physical with people.”
Boy, 15: “I was playing a first person shooter
game and unintentionally offended this person
who became very serious and began to
threaten me by saying if this was real life he
would physically harm me. [It happened
because he] was unable to accept this was just
a game.”
-Quotes from participants of the Youth Internet Safety Survey -2
(Finkelhor, Wolak, Mitchell, 2005)
5. Overlap between harassment and
bullying
Not involved
62%
Cyberbully-
only victim
1%
Internet
harassment-
only victim
24%
Cyberbully +
Internet
harassment
victim
13%
Average across Waves 2-3 of the Growing up with Media study (PI: Ybarra)
(Cyberbully questions were added in Wave 2)
6. Involvement
Depending on the measure
used, most studies report
between 20-40% of youth are
targeted by bullying or
harassment online and via text
messaging (see Tokunaga, 2010 for a review).
7. Overlap between victimization and
perpetration
Not involved
62%
Victim-only
18%
Perpetrator-
only
3%
Perpetrator-
victim
17%
Internet harassment
Average across Waves 1-3 of the Growing up with Media study (PI: Ybarra)
8. Cyberbully victimization by age
across time
Data from the Growing up with Media study, PI: Ybarra
(Cyberbully questions were added in Wave 2)
0%
10%
20%
30%
40%
50%
11 12 13 14 15 16 17
Wave 2 (34%)
Wave 3 (39%)
9. Internet harassment victimization
by age across time
Data from the Growing up with Media study, PI: Ybarra
0%
10%
20%
30%
40%
50%
10 11 12 13 14 15 16 17
Wave 1 (33%)
Wave 2 (34%)
Wave 3 (39%)
10. Text messaging harassment
victimization by age across time
Data from the Growing up with Media study, PI: Ybarra
(Text messaging-based harassment questions were added in Wave 2)
0%
10%
20%
30%
40%
50%
11 12 13 14 15 16 17
Wave 2 (14%)
Wave 3 (24%)
12. Distressing Internet harassment
victimization (age constant:12-15
y.o.)
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
50%
Rude / mean
comments
Rumors Threatening /
aggressive
comments
2006
2007
2008
Distress = very or extremely upset by the experience
Data from the Growing up with Media study, PI: Ybarra
13. Distressing text messaging
harassment victimization (age
constant:12-15 y.o.)
Data from Waves 2 and 3 of the Growing up with Media study, PI: Ybarra
86%
80%
10%
16%
4% 4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Wave 2 Wave 3
14. Bullying victimization rates by
environment
0%
5%
10%
15%
20%
25%
Every day /
almost every
day
Once or twice a
week
Once or twice a
month
Less often
School
Internet
Text messaging
Data from the Growing up with Media study, PI: Ybarra
15. Distress related to bullying
victimization rates by environment
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
Very/extremely upset by most memorable experience
School
Internet
Text messaging
Data from the Growing up with Media study, PI: Ybarra
16. Cyberbully perpetration by age
across time
Data from the Growing up with Media study, PI: Ybarra
0%
10%
20%
30%
40%
50%
10 11 12 13 14 15 16 17
Wave 1 (21%)
Wave 2 (19%)
Wave 3 (23%)
17. Text messaging harassment
perpetration by age across time
Data from the Growing up with Media study, PI: Ybarra
(Text messaging-based harassment questions were added in Wave 2)
0%
10%
20%
30%
40%
50%
11 12 13 14 15 16 17
Wave 2 (10%)
Wave 3 (16%)
19. Concurrent psychosocial problems
for victims
Interpersonal victimization / bullying offline
(Ybarra, Mitchell, Espelage, 2007;
Ybarra, Mitchell, Wolak, Finkelhor, 2006; Ybarra, 2004)
Alcohol use (Ybarra, Mitchell, Espelage, 2007)
Social problems (Ybarra, Mitchell, Wolak, Finkelhor, 2006)
Depressive symptomatology and suicidal
ideation (Ybarra, 2004; Mitchell, Finkelhor, Wolak, 2000; The
Berkman Center for Internet & Society, 2008; Hinduja & Patchin, in
press)
School behavior problems – including weapon
carrying (Ybarra, Diener-West, Leaf, 2007)
Poor caregiver-child relationships (Ybarra, Diener-
West, Leaf, 2007)
20. Assumptions about cyberbullying and
harassment
Everyone‟s doing it
It‟s increasing over time
It‟s getting nastier / kids are more
affected
Everyone‟s a hapless victim
21. None of these assumptions are
supported by the data
“Everyone‟s doing it”:
◦ 38% (about 2 in 5) are involved in harassment
◦ That means that 62% (3 in 5) are NOT involved in any way
It‟s increasing over time
◦ Neither perpetration nor victimization rates appear to be
increasing from 2006-2008
It‟s getting nastier / kids are more affected
◦ There is no indication that young people are more likely to be
upset by harassment now (in 2008) then they were 2 years ago
(2006). If anything, there‟s some indication that youth are *less*
likely to be upset now.
Everyone‟s a hapless victim
◦ 17% of all youth are BOTH victims and perpetrators of
harassment
◦ The odds of victimization increase about 8 fold if you are a
perpetrator and vice versa
22. How do I talk to my children about
cyberbullying?
Make it an ongoing conversation.
Ask your children what they do and
who they hang out with online in the
same way you talk to them about
what they do and who they hang
out with offline.
23. How do I talk to my children about
cyberbullying?
Share your expectations for
„cyber etiquette‟ and why it is
important to you.
If you have a specific
concern, address it directly.
◦ Practice with a friend first what you want
to say.
◦ Listen more than you talk
24. How do I talk to my children about
cyberbullying?
Make the discussion (and any
restrictions) developmentally
appropriate; and behaviorally
appropriate.
Older youth and those who
demonstrate responsibility should be
given greater freedom than younger
youth and those acting irresponsibly.
25. How do I help a child who is being
bullied or harassed online?
Put them in control: Ask how you can
help them
Recognize that many children –
especially older adolescents – may be
able and wanting to handle this on their
own. If so, support and empower them in
their endeavor.
Stay calm; recognize that your feelings
might somewhat be related to your
anxiety about the technology itself as well
as your child‟s situation
26. How do I help a child who is being
bullied or harassed online?
Resist the temptation to restrict the victim
from the technology; this is a punishment
Be open to the possibility that the child is
a perpetrator as well as a victim; listen
If appropriate, help the child reach out to
mental health professionals for more
intensive support
27. Final musings
The majority of youth are not being
harassed or bullied online
The majority who youth who are harassed
or bullied online are not seriously upset
by it.
An important minority are bullied or
harassed, and are seriously affected by it.
We need to do a better job of
identifying these youth and getting
them into services (e.g., therapy).
Similarly, data from the Youth Internet Safety Surveys 1 and 2 (Finkelhor, Mitchell, Wolak) suggest that about one in three victims of harassment are very or extremely upset by the experience
As an aside, bullying is most common at school
As an aside, internet is the least distressing type of bullying
We need to resist the temptation to fear-monger and perpetuate the myth that the majority of youth are cyberbullied and horribly affected by itAnd at the same time, recognize that this is a difficult experience for a small minority of youth who probably need professional support