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SPINAL ANAESTHESIA
spinal anesthesia/anesthesiology/184-244 1
Objectives
• At the end of this lecture, the students should be able
to
- know the history of spinal anaesthesia
- define spinal anaesthesia
- know the anatomy related to spinal anaesthesia
- know the indications and contraindications of SAB
- perform the technique of SAB
- identify the complications
- solve the complications
- know the factors affecting to the spread of spinal
anaesthesia
- differentiate between spinal and epidural anaesthesia
spinal anesthesia/anesthesiology/184-244 2
Advantages of spinal anesthesia
1. Cost. The costs associated with SPA are
minimal.
2. Patient satisfaction. the majority of patients are
very happy with this technique.
3. Respiratory disease. SPA produces few
adverse effects on the respiratory system as
long as unduly high blocks are avoided.
4. Patent airway. As control of the airway is not
compromised, there is a reduced risk of airway
obstruction or the aspiration of gastric
contents.
3
spinal anesthesia/anesthesiology/184-244
5. Diabetic patients. There is little risk of unrecognised
hypoglycaemia in an awake patient.
6. Muscle relaxation. SPA provides excellent muscle relaxation
for lower abdominal and lower limb surgery.
7. Bleeding. Blood loss during operation is less than when the
same operation is done under general anaesthesia.
4
spinal anesthesia/anesthesiology/184-244
5
8. Splanchnic blood flow. Because of its effect on increasing
blood flow to the gut, spinal anaesthesia reduces the
incidence of anastomotic dehiscence.
9. Visceral tone. The bowel is contracted by SPA and
sphincters relaxed although peristalsis continues. Normal
gut function rapidly returns following surgery.
10. Coagulation. Post-operative deep vein thromboses and
pulmonary emboli are less common following spinal
anaesthesia.
spinal anesthesia/anesthesiology/184-244
Spinal Anaesthesia
• Spinal, or sub-arachnoid block is a form of regional anaesthesia
involving the injection of local anaesthetic into the sub-
arachnoid using a fine needle. This produces surgical
anaesthesia to a part of the body.
spinal anesthesia/anesthesiology/184-244 6
SPINAL ANAESTHESIA
• Subarachnoid block
• Intrathecal block
• Central neural block
• Definition
Injection of local anesthetic agents into the subarachnoid
space to produce transient motor, sensory & autonomic block.
spinal anesthesia/anesthesiology/184-244 7
History
• 1885- Corning USA (dog)
• 1898- August Bier
• 6 patients for lower extremity surgery
• Nausea, vomiting & headache!!
• Received spinal from colleague, Dr Hildebrandt
• Headache!!!
spinal anesthesia/anesthesiology/184-244 8
Anatomy 1
• 33 vertebrae; 7
cervical, 12
thoracic, 5 lumbar,
5 sacral (4
coccygeal
remnants).
• 3 curves
spinal anesthesia/anesthesiology/184-244 9
Anatomy 2
• 5 ligaments hold the
spinal column
together;
supraspinous,
interspinous,
ligamentum flavum.
Anterior & posterior
ligaments
spinal anesthesia/anesthesiology/184-244 10
Anatomy 3
• 3 membranes; pia, arachnoid & dura
• Dura outermost layer, to S2,
• Arachnoid also to S2 is middle. Subdural between.
• Sub arachnoid space contains spinal nerves and CSF
• Pia clings to surface of cord
spinal anesthesia/anesthesiology/184-244 11
spinal anesthesia/anesthesiology/184-244 12
Anatomy 4 – Anatomical layers
• Skin
• Subcutaneous fat
• Supraspinatus
• Interspinatus
• Ligamentum flavum
• Epidural space
• Dura
• Subdural space
• Arachnoid
• Sub-arachnoid space
spinal anesthesia/anesthesiology/184-244 13
Layers passing through the spinal needle during
spinal anesthesia
spinal anesthesia/anesthesiology/184-244 14
spinal anesthesia/anesthesiology/184-244 15
Anatomy 5
• Length of spinal cord varies with
age
• Adults;
• Majority @ L1
• 10% L3
• 13% T12
spinal anesthesia/anesthesiology/184-244 16
spinal anesthesia/anesthesiology/184-244 17
Paravertebral Block
• Injects local anaesthetic adjacent to thoracic vertebra where
spinal nerves emerge.
• Unilateral block, useful for hernia, mastectomy etc.
• Ultrasound
spinal anesthesia/anesthesiology/184-244 18
spinal anesthesia/anesthesiology/184-244 19
Local Anaesthetics
• Block Na Channels in nerve membrane, thus preventing
progression of Action Potential
• Site of Action – nerve roots and spinal cord
• 4 factors in uptake of local anaesthetic
• Concentration of LA in CSF
• Surface area of nerve tissue exposed to CSF
• Lipid content of nerve tissue
• Blood flow
spinal anesthesia/anesthesiology/184-244 20
Local Anaesthetics
• Spinal cord and nerves are mixed nerves
• LA blocks smaller, unmyelinated first , larger myelinated last
• May see variable clinical picture
spinal anesthesia/anesthesiology/184-244 21
Nerve sizes
• Aα Motor neurone
• Aδ Sensory, touch & pressure
• C Nocioceptors, temperature
• B preganglionic autononic
• C postganglionic autonomic
spinal anesthesia/anesthesiology/184-244 22
Local Anaesthetics
• Cocaine
• Lignocaine (lidocaine) (5% heavy lignocaine )
• Bupivacaine ( 0.5 % heavy bupivacaine )
• Prilocaine
• Tetracaine
spinal anesthesia/anesthesiology/184-244 23
Adjuncts
• Adrenaline
• Opiods
• Morphine, fentanyl, diamorphine
spinal anesthesia/anesthesiology/184-244 24
Physiological changes in spinal anaesthesia
• CNS
Order of blocking nerve fibres
(1) Autonomic preganglionic B fibre
(2) Temperature fibre (cold before warm)
(3) Pinprink fibre
(4) Fibre conveying pain greater than
pinprick
(5) Touch fibre
(6) Deep pressure fibre
(7) Somatic motor fibre
(8) Fibre conveying vibratory sense and
priopioceptive impulses
spinal anesthesia/anesthesiology/184-244 25
• CVS
- Vasodilatation of resistance & capacitance vessels
- Hypotension
- Bradycardia if block above T4
• Respiratory System
- Diaphragm remain uneffected
- Ascending block of intercostals muscle causes difficulty in
breathing
spinal anesthesia/anesthesiology/184-244 26
• Viscera
- Gut- small contracted gut with active peristalsis
- Bladder- atonic bladder
• Renal
- RBF& GFR remain uneffected except extreme
hypotension
• Neuroendocrine
- Block the complex neural & hormonal stress
response to surgery
spinal anesthesia/anesthesiology/184-244 27
Indications
• Lower limb surgery e.g. ORIF , amputation
• Lower abdominal surgery e.g. appendiectomy ,
hydrocele ,hernia
• Perianal region surgery e.g. pile, fistula , fissure
• Obstetric e.g. LSCS
• Gynecological surgery e.g: TAH ,VH , sterilization
• Urological surgery e.g. TURP ,TVP
spinal anesthesia/anesthesiology/184-244 28
Contraindications
• (A) Absolute contraindications
1.Patient refusal
2.Localized infection at the site of injection
3.Generalized infection or septicemia
4.Coagulopathy
5.Increased ICP
6.Severe hypovolemia or shock
7.Fixed cardiac output condition eg: severe
AS
8. Allergic to local anaesthetics
spinal anesthesia/anesthesiology/184-244 29
Contraindications
(B) Relative contraindications
1. Localized infection peripheral to the site of
injection
2. Backache
3. Patient taking platelet inhibitory drugs e.g.
aspirin
spinal anesthesia/anesthesiology/184-244 30
How to perform the spinal injection?
• Clean the patient’s back with antiseptic.
• Locate a suitable interspinous space.
• Raise an intradermal wheal of LA agent at
proposed puncture site.
31
spinal anesthesia/anesthesiology/184-244
How to perform the spinal injection? continue
32
 Insert the needle: the structures that will be passed skin ,
subcutaneous tissue, supraspinous ligament , interaspinous
ligament , lagementum flavum , epidural space, dura mater,
subdural space, arachnoid matter, and then subarachnoid
space.
 When CSF appears then slowly inject the local anesthetic.
spinal anesthesia/anesthesiology/184-244
Complications
• Hypotension & bradycardia
- Hypotension - SBP < 90 mmHg or
reduction of BP > 20 % of preoperative
value
- Bradycardia - HR < 60 beats per minute
- Treatment - maintain intravascular volume with NS or RL
- HR < 60 BPM – iv atropine
- HR > 60 BPM – iv ephedrine
- 5 degree head down tilt.
spinal anesthesia/anesthesiology/184-244 33
Complications
Dyspnea - reassurance of the patient
- adequate ventilation must be ensured
 Apnea - Immediate ventilatory support is
required
 Paresthesias - Direct trauma to the spinal
nerve or intraneural injection
spinal anesthesia/anesthesiology/184-244 34
Complications
Blood tap - d/t puncture of epidural veins
Tx - needle s/b withdrawn & reinserted
 Nausea & vomiting - d/t hypotension or
unopposed vagal
stimulation
Tx - restoration of BP
- administration of oxygen
- iv atropine
- antiemetic - care s/b taken
because it may cause hypotension
spinal anesthesia/anesthesiology/184-244 35
Complications
-Post dual puncture headache (PDPH)
- occipital headache
- worsened by patient sitting upright
- improved by lying down
- accompanied by tinitus, blurred vision,
diplopia
- onset is usually 24-48 hours postop
- d/t continuous leak of CSF through the
dura hole which reduce CSF pressure & produce
traction of meningeal vessel & nerve
spinal anesthesia/anesthesiology/184-244 36
Treatment of PDPH
- initial conservative treatment include bed rest
and iv fluids & analgesic
- caffeine (300 mg orally ) or caffeine benzoate
(500 mg in 500 ml of NS iv over 2 hours )
- epidural blood patch - placement of 10- 15 ml of
autologus blood into the epidural space if
headache is severe or persist > 24 hrs
- success rate 65%-- 95%
spinal anesthesia/anesthesiology/184-244 37
Complications
 Backache
- d/t flattening of the normal lumber lordosis
during muscle relaxation with resultant
stretching of joint capsule ligament &
muscle.
- treatment with analgesic & reassurance
 Infection - chemical and viral or bacterial
infection
spinal anesthesia/anesthesiology/184-244 38
Complications
• Neurological impairment
- m/b direct (e.g. needle trauma)
- toxic ( introduction of chemicals ,virus or bacteria)
- ischemic ( e.g. vascular compromise from compression
by an extra dual hematoma)
- transient radicular irritation (last 2-7 days)
spinal anesthesia/anesthesiology/184-244 39
Factors Affecting Spread of spinal anaesthesia
spinal anesthesia/anesthesiology/184-244 40
Factors affecting spread of spinal Block
 Local Anaesthetic
 Baricity
 Dose
 Volume
 Specific Gravity
 Patient
 Position
 Height
 Spinal column anatomy
 Decreased CSF volume (pregnancy)
spinal anesthesia/anesthesiology/184-244 41
Factors affecting spread of spinal Block 2
• Technique
• Site of injection
• Speed
• Bevel direction
• Variability in CSF volume makes accurate prediction of the
level of spinal blockade difficult, even if BMI considered.
spinal anesthesia/anesthesiology/184-244 42
Surface Anatomy
• T4 – Nipple level
• T6 – Xiphisternum
• T10 – Umbilicus
• L4-5 _ Illiac Crest (Tuffier’s Line)
spinal anesthesia/anesthesiology/184-244 43
Surface Anatomy
• Upper Abdominal T4 2.5-3mls
• Gynae/ Urology T6-10 2-2.5mls
• Vaginal delivery T10 1.5-2mls
• Hip, Knee Rep. T12-L1 1.5-2mls
• Foot/Ankle L2 1.5mls
• Perineal S2-5 1ml
spinal anesthesia/anesthesiology/184-244 44
Needle design
• Size and shape of needle determine size of hole and risk of
PDPH
spinal anesthesia/anesthesiology/184-244 45
spinal anesthesia/anesthesiology/184-244 46
Differences between Spinal and Epidural
Anesthesia
47
Spinal anaesthesia Extradural Anaesthesia
Level: below L1/L2, where the spinal cord
ends
Level: at any level of the vertebral column.
Injection: subarachnoid space i.e punture
of the dura mater
Injection: epidural space (between
Ligamentum flavum and dura mater) i.e
without punture of the dura mater
Identification of the subarachnoid space:
When CSF appears
Identification of the Peridural space:
Using the Loss of Resistance technique.
Doses: 2.5- 3.5 ml bupivacaine 0.5%
heavy
Doses: 15- 20 ml bupivacaine 0.5%
Onset of action: rapid (2-5 min) Onset of action: slow (15-20 min)
Density of block: more dense Density of block: less dense
Hypotension: rapid Hypotension: slow
spinal anesthesia/anesthesiology/184-244

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SPINAL ANAESTHESIA Anaesthesiology .pptx

  • 2. Objectives • At the end of this lecture, the students should be able to - know the history of spinal anaesthesia - define spinal anaesthesia - know the anatomy related to spinal anaesthesia - know the indications and contraindications of SAB - perform the technique of SAB - identify the complications - solve the complications - know the factors affecting to the spread of spinal anaesthesia - differentiate between spinal and epidural anaesthesia spinal anesthesia/anesthesiology/184-244 2
  • 3. Advantages of spinal anesthesia 1. Cost. The costs associated with SPA are minimal. 2. Patient satisfaction. the majority of patients are very happy with this technique. 3. Respiratory disease. SPA produces few adverse effects on the respiratory system as long as unduly high blocks are avoided. 4. Patent airway. As control of the airway is not compromised, there is a reduced risk of airway obstruction or the aspiration of gastric contents. 3 spinal anesthesia/anesthesiology/184-244
  • 4. 5. Diabetic patients. There is little risk of unrecognised hypoglycaemia in an awake patient. 6. Muscle relaxation. SPA provides excellent muscle relaxation for lower abdominal and lower limb surgery. 7. Bleeding. Blood loss during operation is less than when the same operation is done under general anaesthesia. 4 spinal anesthesia/anesthesiology/184-244
  • 5. 5 8. Splanchnic blood flow. Because of its effect on increasing blood flow to the gut, spinal anaesthesia reduces the incidence of anastomotic dehiscence. 9. Visceral tone. The bowel is contracted by SPA and sphincters relaxed although peristalsis continues. Normal gut function rapidly returns following surgery. 10. Coagulation. Post-operative deep vein thromboses and pulmonary emboli are less common following spinal anaesthesia. spinal anesthesia/anesthesiology/184-244
  • 6. Spinal Anaesthesia • Spinal, or sub-arachnoid block is a form of regional anaesthesia involving the injection of local anaesthetic into the sub- arachnoid using a fine needle. This produces surgical anaesthesia to a part of the body. spinal anesthesia/anesthesiology/184-244 6
  • 7. SPINAL ANAESTHESIA • Subarachnoid block • Intrathecal block • Central neural block • Definition Injection of local anesthetic agents into the subarachnoid space to produce transient motor, sensory & autonomic block. spinal anesthesia/anesthesiology/184-244 7
  • 8. History • 1885- Corning USA (dog) • 1898- August Bier • 6 patients for lower extremity surgery • Nausea, vomiting & headache!! • Received spinal from colleague, Dr Hildebrandt • Headache!!! spinal anesthesia/anesthesiology/184-244 8
  • 9. Anatomy 1 • 33 vertebrae; 7 cervical, 12 thoracic, 5 lumbar, 5 sacral (4 coccygeal remnants). • 3 curves spinal anesthesia/anesthesiology/184-244 9
  • 10. Anatomy 2 • 5 ligaments hold the spinal column together; supraspinous, interspinous, ligamentum flavum. Anterior & posterior ligaments spinal anesthesia/anesthesiology/184-244 10
  • 11. Anatomy 3 • 3 membranes; pia, arachnoid & dura • Dura outermost layer, to S2, • Arachnoid also to S2 is middle. Subdural between. • Sub arachnoid space contains spinal nerves and CSF • Pia clings to surface of cord spinal anesthesia/anesthesiology/184-244 11
  • 13. Anatomy 4 – Anatomical layers • Skin • Subcutaneous fat • Supraspinatus • Interspinatus • Ligamentum flavum • Epidural space • Dura • Subdural space • Arachnoid • Sub-arachnoid space spinal anesthesia/anesthesiology/184-244 13
  • 14. Layers passing through the spinal needle during spinal anesthesia spinal anesthesia/anesthesiology/184-244 14
  • 16. Anatomy 5 • Length of spinal cord varies with age • Adults; • Majority @ L1 • 10% L3 • 13% T12 spinal anesthesia/anesthesiology/184-244 16
  • 18. Paravertebral Block • Injects local anaesthetic adjacent to thoracic vertebra where spinal nerves emerge. • Unilateral block, useful for hernia, mastectomy etc. • Ultrasound spinal anesthesia/anesthesiology/184-244 18
  • 20. Local Anaesthetics • Block Na Channels in nerve membrane, thus preventing progression of Action Potential • Site of Action – nerve roots and spinal cord • 4 factors in uptake of local anaesthetic • Concentration of LA in CSF • Surface area of nerve tissue exposed to CSF • Lipid content of nerve tissue • Blood flow spinal anesthesia/anesthesiology/184-244 20
  • 21. Local Anaesthetics • Spinal cord and nerves are mixed nerves • LA blocks smaller, unmyelinated first , larger myelinated last • May see variable clinical picture spinal anesthesia/anesthesiology/184-244 21
  • 22. Nerve sizes • Aα Motor neurone • Aδ Sensory, touch & pressure • C Nocioceptors, temperature • B preganglionic autononic • C postganglionic autonomic spinal anesthesia/anesthesiology/184-244 22
  • 23. Local Anaesthetics • Cocaine • Lignocaine (lidocaine) (5% heavy lignocaine ) • Bupivacaine ( 0.5 % heavy bupivacaine ) • Prilocaine • Tetracaine spinal anesthesia/anesthesiology/184-244 23
  • 24. Adjuncts • Adrenaline • Opiods • Morphine, fentanyl, diamorphine spinal anesthesia/anesthesiology/184-244 24
  • 25. Physiological changes in spinal anaesthesia • CNS Order of blocking nerve fibres (1) Autonomic preganglionic B fibre (2) Temperature fibre (cold before warm) (3) Pinprink fibre (4) Fibre conveying pain greater than pinprick (5) Touch fibre (6) Deep pressure fibre (7) Somatic motor fibre (8) Fibre conveying vibratory sense and priopioceptive impulses spinal anesthesia/anesthesiology/184-244 25
  • 26. • CVS - Vasodilatation of resistance & capacitance vessels - Hypotension - Bradycardia if block above T4 • Respiratory System - Diaphragm remain uneffected - Ascending block of intercostals muscle causes difficulty in breathing spinal anesthesia/anesthesiology/184-244 26
  • 27. • Viscera - Gut- small contracted gut with active peristalsis - Bladder- atonic bladder • Renal - RBF& GFR remain uneffected except extreme hypotension • Neuroendocrine - Block the complex neural & hormonal stress response to surgery spinal anesthesia/anesthesiology/184-244 27
  • 28. Indications • Lower limb surgery e.g. ORIF , amputation • Lower abdominal surgery e.g. appendiectomy , hydrocele ,hernia • Perianal region surgery e.g. pile, fistula , fissure • Obstetric e.g. LSCS • Gynecological surgery e.g: TAH ,VH , sterilization • Urological surgery e.g. TURP ,TVP spinal anesthesia/anesthesiology/184-244 28
  • 29. Contraindications • (A) Absolute contraindications 1.Patient refusal 2.Localized infection at the site of injection 3.Generalized infection or septicemia 4.Coagulopathy 5.Increased ICP 6.Severe hypovolemia or shock 7.Fixed cardiac output condition eg: severe AS 8. Allergic to local anaesthetics spinal anesthesia/anesthesiology/184-244 29
  • 30. Contraindications (B) Relative contraindications 1. Localized infection peripheral to the site of injection 2. Backache 3. Patient taking platelet inhibitory drugs e.g. aspirin spinal anesthesia/anesthesiology/184-244 30
  • 31. How to perform the spinal injection? • Clean the patient’s back with antiseptic. • Locate a suitable interspinous space. • Raise an intradermal wheal of LA agent at proposed puncture site. 31 spinal anesthesia/anesthesiology/184-244
  • 32. How to perform the spinal injection? continue 32  Insert the needle: the structures that will be passed skin , subcutaneous tissue, supraspinous ligament , interaspinous ligament , lagementum flavum , epidural space, dura mater, subdural space, arachnoid matter, and then subarachnoid space.  When CSF appears then slowly inject the local anesthetic. spinal anesthesia/anesthesiology/184-244
  • 33. Complications • Hypotension & bradycardia - Hypotension - SBP < 90 mmHg or reduction of BP > 20 % of preoperative value - Bradycardia - HR < 60 beats per minute - Treatment - maintain intravascular volume with NS or RL - HR < 60 BPM – iv atropine - HR > 60 BPM – iv ephedrine - 5 degree head down tilt. spinal anesthesia/anesthesiology/184-244 33
  • 34. Complications Dyspnea - reassurance of the patient - adequate ventilation must be ensured  Apnea - Immediate ventilatory support is required  Paresthesias - Direct trauma to the spinal nerve or intraneural injection spinal anesthesia/anesthesiology/184-244 34
  • 35. Complications Blood tap - d/t puncture of epidural veins Tx - needle s/b withdrawn & reinserted  Nausea & vomiting - d/t hypotension or unopposed vagal stimulation Tx - restoration of BP - administration of oxygen - iv atropine - antiemetic - care s/b taken because it may cause hypotension spinal anesthesia/anesthesiology/184-244 35
  • 36. Complications -Post dual puncture headache (PDPH) - occipital headache - worsened by patient sitting upright - improved by lying down - accompanied by tinitus, blurred vision, diplopia - onset is usually 24-48 hours postop - d/t continuous leak of CSF through the dura hole which reduce CSF pressure & produce traction of meningeal vessel & nerve spinal anesthesia/anesthesiology/184-244 36
  • 37. Treatment of PDPH - initial conservative treatment include bed rest and iv fluids & analgesic - caffeine (300 mg orally ) or caffeine benzoate (500 mg in 500 ml of NS iv over 2 hours ) - epidural blood patch - placement of 10- 15 ml of autologus blood into the epidural space if headache is severe or persist > 24 hrs - success rate 65%-- 95% spinal anesthesia/anesthesiology/184-244 37
  • 38. Complications  Backache - d/t flattening of the normal lumber lordosis during muscle relaxation with resultant stretching of joint capsule ligament & muscle. - treatment with analgesic & reassurance  Infection - chemical and viral or bacterial infection spinal anesthesia/anesthesiology/184-244 38
  • 39. Complications • Neurological impairment - m/b direct (e.g. needle trauma) - toxic ( introduction of chemicals ,virus or bacteria) - ischemic ( e.g. vascular compromise from compression by an extra dual hematoma) - transient radicular irritation (last 2-7 days) spinal anesthesia/anesthesiology/184-244 39
  • 40. Factors Affecting Spread of spinal anaesthesia spinal anesthesia/anesthesiology/184-244 40
  • 41. Factors affecting spread of spinal Block  Local Anaesthetic  Baricity  Dose  Volume  Specific Gravity  Patient  Position  Height  Spinal column anatomy  Decreased CSF volume (pregnancy) spinal anesthesia/anesthesiology/184-244 41
  • 42. Factors affecting spread of spinal Block 2 • Technique • Site of injection • Speed • Bevel direction • Variability in CSF volume makes accurate prediction of the level of spinal blockade difficult, even if BMI considered. spinal anesthesia/anesthesiology/184-244 42
  • 43. Surface Anatomy • T4 – Nipple level • T6 – Xiphisternum • T10 – Umbilicus • L4-5 _ Illiac Crest (Tuffier’s Line) spinal anesthesia/anesthesiology/184-244 43
  • 44. Surface Anatomy • Upper Abdominal T4 2.5-3mls • Gynae/ Urology T6-10 2-2.5mls • Vaginal delivery T10 1.5-2mls • Hip, Knee Rep. T12-L1 1.5-2mls • Foot/Ankle L2 1.5mls • Perineal S2-5 1ml spinal anesthesia/anesthesiology/184-244 44
  • 45. Needle design • Size and shape of needle determine size of hole and risk of PDPH spinal anesthesia/anesthesiology/184-244 45
  • 47. Differences between Spinal and Epidural Anesthesia 47 Spinal anaesthesia Extradural Anaesthesia Level: below L1/L2, where the spinal cord ends Level: at any level of the vertebral column. Injection: subarachnoid space i.e punture of the dura mater Injection: epidural space (between Ligamentum flavum and dura mater) i.e without punture of the dura mater Identification of the subarachnoid space: When CSF appears Identification of the Peridural space: Using the Loss of Resistance technique. Doses: 2.5- 3.5 ml bupivacaine 0.5% heavy Doses: 15- 20 ml bupivacaine 0.5% Onset of action: rapid (2-5 min) Onset of action: slow (15-20 min) Density of block: more dense Density of block: less dense Hypotension: rapid Hypotension: slow spinal anesthesia/anesthesiology/184-244