Merit Ehab Anwar Abdel-Hakeem is an Egyptian citizen seeking employment. He received a Bachelor's degree in 2016 from Cairo University's Faculty of Computers and Information with a grade point average of 2.61. He has experience in fundraising, robotics workshops, and project leadership. His technical skills include proficiency in C++, Java, C#, web development, and databases. He is fluent in English and has good communication and teamwork abilities.
Ahmed Hazem El-Zawawy is an IT professional with experience in software design, development, implementation, testing and requirements gathering. He has over 3 years of experience working with SharePoint 2010/2013 and PhoneGap for cross-platform mobile development. He has a bachelor's degree in Information Systems from Ain Shams University in Egypt. Some of his projects include developing portals for Riyadh Municipality and Qatar History using SharePoint 2013. He is fluent in English and Arabic.
JustKidding is an innovative retail franchise concept started in Dubai that offers a wide range of high-quality products for parents and children aged 0-5. It was created to address the lack of original products in the market and aims to be a one-stop destination for all parenting needs. JustKidding prides itself on its expert customer service and community involvement. It has experienced strong growth and success, winning several retail awards. The franchise is looking to expand internationally.
• What is a self image?
• How is your self image formed?
• How does your self image affect your performance, behaviour and relationships?
• How a Christian belief system impacts gay and lesbian sense of self?
• Ten evidences of a poor self image
• How does your sexual identity influence your sense of self worth?
• Cognitive dissonance - what is it and how does it affect your self image?
• How fragmentation and compartmentalisation of self occurs
• Internalised homophobia and its impact on self esteem
• How to move along the self esteem spectrum
• Ten ways to create a healthy self image
Osteoporoze ir sistēmiska kaulu slimība, ko raksturo samazināta kaulu masa un mikroarhitektonikas izmaiņas, kā rezultātā samazinās kaulu stiprums un palielinās lūzumu risks.
Merit Ehab Anwar Abdel-Hakeem is an Egyptian citizen seeking employment. He received a Bachelor's degree in 2016 from Cairo University's Faculty of Computers and Information with a grade point average of 2.61. He has experience in fundraising, robotics workshops, and project leadership. His technical skills include proficiency in C++, Java, C#, web development, and databases. He is fluent in English and has good communication and teamwork abilities.
Ahmed Hazem El-Zawawy is an IT professional with experience in software design, development, implementation, testing and requirements gathering. He has over 3 years of experience working with SharePoint 2010/2013 and PhoneGap for cross-platform mobile development. He has a bachelor's degree in Information Systems from Ain Shams University in Egypt. Some of his projects include developing portals for Riyadh Municipality and Qatar History using SharePoint 2013. He is fluent in English and Arabic.
JustKidding is an innovative retail franchise concept started in Dubai that offers a wide range of high-quality products for parents and children aged 0-5. It was created to address the lack of original products in the market and aims to be a one-stop destination for all parenting needs. JustKidding prides itself on its expert customer service and community involvement. It has experienced strong growth and success, winning several retail awards. The franchise is looking to expand internationally.
• What is a self image?
• How is your self image formed?
• How does your self image affect your performance, behaviour and relationships?
• How a Christian belief system impacts gay and lesbian sense of self?
• Ten evidences of a poor self image
• How does your sexual identity influence your sense of self worth?
• Cognitive dissonance - what is it and how does it affect your self image?
• How fragmentation and compartmentalisation of self occurs
• Internalised homophobia and its impact on self esteem
• How to move along the self esteem spectrum
• Ten ways to create a healthy self image
Osteoporoze ir sistēmiska kaulu slimība, ko raksturo samazināta kaulu masa un mikroarhitektonikas izmaiņas, kā rezultātā samazinās kaulu stiprums un palielinās lūzumu risks.
Šegrēna sindroms ir hroniska, lēni progresējoša autoimūna slimība, kam raksturīga limfocītu infiltrācija eksokrīnajos dziedzeros un kas rada mutes sausumu (kserostomiju) un acu sausumu (kseroftalmiju).
Classification and Synthesis of Sulpha drugs, Anti Viral Drugs, Anti Fungal Agents, Anti Tubercular Agents, Anti leprotic Agents, Antiamoebic Agents, Anthelmintics, Anti Malarial Drugs, Anti cancer Drugs
Anticancer Drug, also called Anti-Neoplastic drug, that is effective in the treatment of malignant, or cancerous, disease. There are several major classes of anticancer drugs; these include Alkylating Agents, Anti-metabolites, Plant Alkaloids and Hormones.
This document discusses urine analysis including urine collection, 24 hour urine samples, specimen preservation, and urine examination. Key points include:
- Urine is formed in the kidneys and various samples can be collected including early morning, random, 24 hour, and catheterized samples.
- 24 hour urine samples are used to quantitatively estimate proteins, hormones, microalbumin, and metabolites.
- Preservatives like HCl, toluene, and boric acid can be used but may interfere with tests. Samples should be examined within 1-2 hours.
- Urine examination includes macroscopic tests of volume, color, odor, pH; microscopic tests; and chemical tests for proteins, sugars
El documento describe las características de la bacteria Escherichia coli, incluyendo su capacidad de patogenicidad, mecanismos de transmisión y factores de virulencia. E. coli es una bacteria comensal del intestino humano pero algunas cepas pueden ser patógenas. Las cepas más peligrosas son O157:H7 y EPEC, las cuales pueden causar diarrea e incluso síndrome urémico hemolítico. La bacteria puede transmitirse a través de alimentos y agua contaminados con heces y sus factores de virulencia
Este documento presenta el caso clínico de una paciente de 25 años con síndrome de Klippel-Trenaunay, caracterizado por malformaciones vasculares, hipertrofia de tejidos blandos y hueso en el miembro inferior derecho. Se describe la sintomatología de la paciente, los hallazgos del examen físico y las pruebas de imagenología realizadas. Finalmente, se discuten aspectos relacionados con la etiología, fisiopatología, diagnóstico y tratamiento de este raro síndrome genético
The right moisturiser can keep skin healthy throughout the yearNursing Crusade
The document discusses choosing the right moisturizer for different skin types and seasons. It recommends using a light, fast absorbing moisturizer like Vaseline Aloe Soothe during the summer months. For time spent outdoors, it suggests choosing a moisturizer with SPF of at least 20 to protect skin from the sun. As temperatures drop later in the year, it advises using a hydrating moisturizer like Vaseline Intensive Care that seals in moisture and is hypoallergenic.
The document discusses transport operations and ambulance driving. It covers standard competencies for EMS operations, transporting patients safely, defensive driving techniques, and safe driving practices like using turn signals and maintaining a cushion of safety around the ambulance. Key steps for ambulance staff include checking equipment, securing patients and supplies, and cleaning after transporting a patient. The goal is to safely transport patients while avoiding crashes.
This document provides information and strategies for sun safety at resorts and for outdoor employees. It discusses establishing a sun safety program that provides education materials to guests and training to employees. The program is based on a decade of successful sun safety programs for outdoor workers and recreators.
This document discusses the harms of marijuana abuse. It defines marijuana and how it is used. It then explains the short-term and long-term health effects of marijuana use. It notes that marijuana can negatively impact students, workers, and social life. The document advocates for treatment programs that focus on detoxification and support to reintegrate into society. It aims to dispel myths about marijuana and advocates for its characterization as a dangerous drug rather than a safe alternative to other substances.
How pizza shops, steakhouses harm environmentNursing Crusade
Pizza shops and steakhouses that use charcoal or wood burners produce significant emissions and damage the environment in major cities. A study of Sao Paulo, Brazil found emissions from wood burning pizza restaurants and charcoal-burning steakhouses posed an emerging environmental risk, despite Sao Paulo's green vehicle policies. The city is home to around 8,000 pizza parlors that produce close to a million pizzas per day using wood burning stoves, negating the positive effects of Sao Paulo's biofuel vehicle policies.
Bill Gates says that genetically modified mosquitoes may be used to fight malaria within the next five years. Researchers are using a gene editing technique called a "gene drive" to alter mosquitoes so they are resistant to diseases like malaria and dengue. Gates believes this technology could dramatically reduce malaria deaths by suppressing mosquito populations. However, some scientists have concerns about the safety of releasing genetically modified mosquitoes into the wild and more regulation of gene drives may be needed.
India is facing a diabetes epidemic as the number of diabetics is projected to increase to over 100 million in the next 15 years. While India has made progress in reducing childhood stunting, the growing rate of overweight and obese individuals, especially those prone to diabetes, is a cause for concern. Public health policies need to be strengthened to combat both undernutrition and the rising threat of overnutrition and diabetes.
Flowers may be losing their scents and fragrances due to rising global temperatures associated with climate change. Scientists have found that higher ambient temperatures lead to a decrease in the production of floral scents. Flowers produce scents to attract pollinators like insects to ensure plant reproduction. However, increasing temperatures are interfering with the plant-pollinator relationship by reducing floral scents.
The document discusses the author's experience getting a haircut at various barbershops and salons over time. It describes visiting a neighborhood barber shop for cheap haircuts for years, but eventually ending the relationship due to poor hygiene. The author then tries several upmarket salons but is unsatisfied until finding one that meets most requirements and provides a good haircutting experience. The author learns about new hair products and their benefits from the barber.
Poverty changes dna of people, may make them drug addictsNursing Crusade
Living in poverty can cause changes to a person's DNA that increases the likelihood of depression, anxiety, and drug use. Researchers found that teenagers from low socioeconomic backgrounds showed changes to a gene linked to increased activity in the brain's fear and stress response center. This epigenetic change was also associated with lower levels of serotonin and can be passed to future generations. The study examined changes to the SLC6A4 gene in 132 adolescents over two years, finding that those from poorer backgrounds accumulated higher levels of a chemical tag on the gene, making their amygdala more sensitive to fearful stimuli.
Twenty mediterranean diet tricks to help you lose weight this summerNursing Crusade
The document discusses 20 ways to follow a Mediterranean diet to lose weight and improve health. Some of the key recommendations include using olive oil instead of other fats, eating tomatoes and garlic daily for their health benefits, choosing fish instead of red meat at least once a week, eating plenty of fruits and vegetables including options like peppers and avocados that are popular in Mediterranean diets, and enjoying red wine in moderation with meals for its antioxidants. The Mediterranean diet has been shown in studies to reduce the risk of heart disease, diabetes, cancer and other health issues while helping maintain a healthy weight.
South Koreans can now soothe hangovers with a new ice cream bar launched by a convenience store chain. Called "hang in there", it is the first ice cream marketed specifically for hangover relief. Drinking is a big part of business culture in South Korea, and the hangover remedy market is worth over $126 million annually. The ice cream contains oriental raisin tree fruit juice, a traditional Korean medicine for hangovers whose extract was found to reduce intoxication symptoms in rats.
The document discusses various topics related to emergency medical services (EMS) operations including transport operations, EMS roles and responsibilities, operating ground ambulances safely, assessing and treating patients, infectious disease protocols, ambulance design, checking and equipping ambulances, ambulance staffing, emergency response and transport, air medical transports, and helicopter medical evacuation operations. The overall document provides guidance and standard competencies for EMS professionals.
This document provides information about blood typing and characteristics. It discusses the discovery of blood types by Landsteiner in 1900 and the Rh factor in 1940. The document defines key terms like antigens, antibodies, agglutination. It describes the main blood types (A, B, AB, O) and Rh factors (+/-). It also summarizes blood composition, functions, transfusions and the genetics that determine blood type. Overall, the document presents foundational information about blood typing and characteristics.
The document discusses legal and regulatory issues related to nursing practice. It covers topics such as sources of law, criminal and civil law, tort law including malpractice, intentional torts, strategies to prevent incidents, standards of care, selected laws including nurse practice acts, licensure, boards of nursing, advance directives, HIPAA, and privacy versus confidentiality. The overall document provides an overview of the legal and regulatory framework that governs nursing practice.
The document discusses the nurse-patient relationship and its various aspects. It describes the different phases of the relationship from the pre-interaction phase to engagement, active intervention, and termination. It also outlines the roles, requisites, and characteristics of a good relationship between nurses and patients. Barriers like role stress and autonomy struggles that can impact effective professional relationships are examined as well. The importance of relationships between nurses and families and other healthcare professionals is also highlighted.
Šegrēna sindroms ir hroniska, lēni progresējoša autoimūna slimība, kam raksturīga limfocītu infiltrācija eksokrīnajos dziedzeros un kas rada mutes sausumu (kserostomiju) un acu sausumu (kseroftalmiju).
Classification and Synthesis of Sulpha drugs, Anti Viral Drugs, Anti Fungal Agents, Anti Tubercular Agents, Anti leprotic Agents, Antiamoebic Agents, Anthelmintics, Anti Malarial Drugs, Anti cancer Drugs
Anticancer Drug, also called Anti-Neoplastic drug, that is effective in the treatment of malignant, or cancerous, disease. There are several major classes of anticancer drugs; these include Alkylating Agents, Anti-metabolites, Plant Alkaloids and Hormones.
This document discusses urine analysis including urine collection, 24 hour urine samples, specimen preservation, and urine examination. Key points include:
- Urine is formed in the kidneys and various samples can be collected including early morning, random, 24 hour, and catheterized samples.
- 24 hour urine samples are used to quantitatively estimate proteins, hormones, microalbumin, and metabolites.
- Preservatives like HCl, toluene, and boric acid can be used but may interfere with tests. Samples should be examined within 1-2 hours.
- Urine examination includes macroscopic tests of volume, color, odor, pH; microscopic tests; and chemical tests for proteins, sugars
El documento describe las características de la bacteria Escherichia coli, incluyendo su capacidad de patogenicidad, mecanismos de transmisión y factores de virulencia. E. coli es una bacteria comensal del intestino humano pero algunas cepas pueden ser patógenas. Las cepas más peligrosas son O157:H7 y EPEC, las cuales pueden causar diarrea e incluso síndrome urémico hemolítico. La bacteria puede transmitirse a través de alimentos y agua contaminados con heces y sus factores de virulencia
Este documento presenta el caso clínico de una paciente de 25 años con síndrome de Klippel-Trenaunay, caracterizado por malformaciones vasculares, hipertrofia de tejidos blandos y hueso en el miembro inferior derecho. Se describe la sintomatología de la paciente, los hallazgos del examen físico y las pruebas de imagenología realizadas. Finalmente, se discuten aspectos relacionados con la etiología, fisiopatología, diagnóstico y tratamiento de este raro síndrome genético
The right moisturiser can keep skin healthy throughout the yearNursing Crusade
The document discusses choosing the right moisturizer for different skin types and seasons. It recommends using a light, fast absorbing moisturizer like Vaseline Aloe Soothe during the summer months. For time spent outdoors, it suggests choosing a moisturizer with SPF of at least 20 to protect skin from the sun. As temperatures drop later in the year, it advises using a hydrating moisturizer like Vaseline Intensive Care that seals in moisture and is hypoallergenic.
The document discusses transport operations and ambulance driving. It covers standard competencies for EMS operations, transporting patients safely, defensive driving techniques, and safe driving practices like using turn signals and maintaining a cushion of safety around the ambulance. Key steps for ambulance staff include checking equipment, securing patients and supplies, and cleaning after transporting a patient. The goal is to safely transport patients while avoiding crashes.
This document provides information and strategies for sun safety at resorts and for outdoor employees. It discusses establishing a sun safety program that provides education materials to guests and training to employees. The program is based on a decade of successful sun safety programs for outdoor workers and recreators.
This document discusses the harms of marijuana abuse. It defines marijuana and how it is used. It then explains the short-term and long-term health effects of marijuana use. It notes that marijuana can negatively impact students, workers, and social life. The document advocates for treatment programs that focus on detoxification and support to reintegrate into society. It aims to dispel myths about marijuana and advocates for its characterization as a dangerous drug rather than a safe alternative to other substances.
How pizza shops, steakhouses harm environmentNursing Crusade
Pizza shops and steakhouses that use charcoal or wood burners produce significant emissions and damage the environment in major cities. A study of Sao Paulo, Brazil found emissions from wood burning pizza restaurants and charcoal-burning steakhouses posed an emerging environmental risk, despite Sao Paulo's green vehicle policies. The city is home to around 8,000 pizza parlors that produce close to a million pizzas per day using wood burning stoves, negating the positive effects of Sao Paulo's biofuel vehicle policies.
Bill Gates says that genetically modified mosquitoes may be used to fight malaria within the next five years. Researchers are using a gene editing technique called a "gene drive" to alter mosquitoes so they are resistant to diseases like malaria and dengue. Gates believes this technology could dramatically reduce malaria deaths by suppressing mosquito populations. However, some scientists have concerns about the safety of releasing genetically modified mosquitoes into the wild and more regulation of gene drives may be needed.
India is facing a diabetes epidemic as the number of diabetics is projected to increase to over 100 million in the next 15 years. While India has made progress in reducing childhood stunting, the growing rate of overweight and obese individuals, especially those prone to diabetes, is a cause for concern. Public health policies need to be strengthened to combat both undernutrition and the rising threat of overnutrition and diabetes.
Flowers may be losing their scents and fragrances due to rising global temperatures associated with climate change. Scientists have found that higher ambient temperatures lead to a decrease in the production of floral scents. Flowers produce scents to attract pollinators like insects to ensure plant reproduction. However, increasing temperatures are interfering with the plant-pollinator relationship by reducing floral scents.
The document discusses the author's experience getting a haircut at various barbershops and salons over time. It describes visiting a neighborhood barber shop for cheap haircuts for years, but eventually ending the relationship due to poor hygiene. The author then tries several upmarket salons but is unsatisfied until finding one that meets most requirements and provides a good haircutting experience. The author learns about new hair products and their benefits from the barber.
Poverty changes dna of people, may make them drug addictsNursing Crusade
Living in poverty can cause changes to a person's DNA that increases the likelihood of depression, anxiety, and drug use. Researchers found that teenagers from low socioeconomic backgrounds showed changes to a gene linked to increased activity in the brain's fear and stress response center. This epigenetic change was also associated with lower levels of serotonin and can be passed to future generations. The study examined changes to the SLC6A4 gene in 132 adolescents over two years, finding that those from poorer backgrounds accumulated higher levels of a chemical tag on the gene, making their amygdala more sensitive to fearful stimuli.
Twenty mediterranean diet tricks to help you lose weight this summerNursing Crusade
The document discusses 20 ways to follow a Mediterranean diet to lose weight and improve health. Some of the key recommendations include using olive oil instead of other fats, eating tomatoes and garlic daily for their health benefits, choosing fish instead of red meat at least once a week, eating plenty of fruits and vegetables including options like peppers and avocados that are popular in Mediterranean diets, and enjoying red wine in moderation with meals for its antioxidants. The Mediterranean diet has been shown in studies to reduce the risk of heart disease, diabetes, cancer and other health issues while helping maintain a healthy weight.
South Koreans can now soothe hangovers with a new ice cream bar launched by a convenience store chain. Called "hang in there", it is the first ice cream marketed specifically for hangover relief. Drinking is a big part of business culture in South Korea, and the hangover remedy market is worth over $126 million annually. The ice cream contains oriental raisin tree fruit juice, a traditional Korean medicine for hangovers whose extract was found to reduce intoxication symptoms in rats.
The document discusses various topics related to emergency medical services (EMS) operations including transport operations, EMS roles and responsibilities, operating ground ambulances safely, assessing and treating patients, infectious disease protocols, ambulance design, checking and equipping ambulances, ambulance staffing, emergency response and transport, air medical transports, and helicopter medical evacuation operations. The overall document provides guidance and standard competencies for EMS professionals.
This document provides information about blood typing and characteristics. It discusses the discovery of blood types by Landsteiner in 1900 and the Rh factor in 1940. The document defines key terms like antigens, antibodies, agglutination. It describes the main blood types (A, B, AB, O) and Rh factors (+/-). It also summarizes blood composition, functions, transfusions and the genetics that determine blood type. Overall, the document presents foundational information about blood typing and characteristics.
The document discusses legal and regulatory issues related to nursing practice. It covers topics such as sources of law, criminal and civil law, tort law including malpractice, intentional torts, strategies to prevent incidents, standards of care, selected laws including nurse practice acts, licensure, boards of nursing, advance directives, HIPAA, and privacy versus confidentiality. The overall document provides an overview of the legal and regulatory framework that governs nursing practice.
The document discusses the nurse-patient relationship and its various aspects. It describes the different phases of the relationship from the pre-interaction phase to engagement, active intervention, and termination. It also outlines the roles, requisites, and characteristics of a good relationship between nurses and patients. Barriers like role stress and autonomy struggles that can impact effective professional relationships are examined as well. The importance of relationships between nurses and families and other healthcare professionals is also highlighted.
A survey by GOQii on fitness in India showed that the most common health goals are to get active and fit, reduce stress, manage weight, and improve sleep quality. The survey found that Delhiites prefer outdoor cardio exercises while Bengaluru residents favor yoga. It also showed that Mumbaikars take the most daily steps on average and residents of Pune sleep the most hours per night.
The document discusses communicating respectfully with elderly patients. It provides examples of unacceptable caregiver responses that fail to meet patients' needs and respect their dignity. It emphasizes the importance of ethical principles like maintaining patients' autonomy and respecting their physical and psychological well-being. The objectives are to help students reflect on how to avoid mistreatment and establish warm relations through minor acts of empathy. Responding to requests can satisfy needs and build trust if caregivers break from routines to think creatively and personalized care.
No creches yet, poor fret over children's safetyNursing Crusade
The document discusses the lack of creche facilities in slums, which is causing worry for low-income families. A pilot project aimed to set up 30 creches by December, but it has been delayed. The delay is due to issues recruiting additional staff needed to run the creches. Advocates express concern over the delay and need for dedicated funding and monitoring of creche programs.
Researchers found that regular chocolate consumption was associated with better performance on cognitive tests. A study of over 900 people aged 23-98 found that those who ate chocolate more frequently did better on tests of visual-spatial memory, organization, working memory, abstract reasoning and mental status. Regular chocolate consumption was linked to better cognitive function, except for working memory, even after accounting for cardiovascular and lifestyle factors.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
One health condition that is becoming more common day by day is diabetes.
According to research conducted by the National Family Health Survey of India, diabetic cases show a projection which might increase to 10.4% by 2030.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
1. Sperm tech to help infertile
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Scientists are developing new low-cost, sperm-sorting devices that can
select the best sperm cells for assisted reproductive technologies such
as IVF. The most commonly used method involves centrifugation that
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used. But this method tends to increase chemical levels, causing DNA
damage. Waseem Asghar from Florida Atlantic University is working on
a device consisting of one inlet for the injection of a semen sample and
two plastic chambers divided by porous membrane. Healthy sperm
swim through the membrane leaving behind less functional ones in the
bottom chamber.
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