The document describes a role-playing game to simulate the process of fertilization. Players are assigned roles representing sperm, cervical mucus, the zona pellucida surrounding the egg, and the egg itself. The sperm race from the penis to penetrate the zona pellucida surrounding the egg while encountering obstacles modeled after processes in the female reproductive system. The first sperm to reach the egg triggers the cortical reaction blocking other sperm.

1. Welcome to CERVIX! (pop. 200-500 Million)

2. Now entering UTERUS

3. BEWARE OF ANGRY COMPETITIVE SEMEN

4. ZONA PELLUCIDA

5. Sperm deposited near cervix Mucus = capacitation of sperm Sperm is drawn to egg by chemoxtaxis Sperm travel to uterus Uterine contractions propel sperm towards fallopian tubes Sperm try to bind to zona pellucida The first sperm to penetrate egg’s surface causes egg to create boundary against other sperm = Cortical reaction Penis’ spin sperm around 2x , remove blindfolds Capacitation: Mucus (8 people) Removes hand bindings, Put “Capacitated sign on forehead” Egg! Zona Pellucida: Can form a wall right in front of the egg, but cannot move to prevent sperm from grabbing the egg. Once one sperm grabs the egg, Yell “CORTICAL REACTION!” Obstacles! (Filler Sperm)

6. Sperm 1: Race from the Penis to the Zona Pellucida, Grab the egg to win! (Good luck, with your legs being tied and all) Sperm 2: Race from the Penis to the Zona Pellucida, Grab the egg to win! Sperm 3: Race from the Penis to the Zona Pellucida, Grab the egg to win! Sperm 4: Race from the Penis to the Zona Pellucida, Grab the egg to win! Penis 1:Once whistle is blown, Spin sperm 1 around once and direct towards egg Penis 2:Once whistle is blown, Spin sperm 2 around once and direct towards egg Penis 3:Once whistle is blown, Spin sperm 3 around once and direct towards egg Penis 4:Once whistle is blown, Spin sperm 4 around once, but do not direct towards egg Mucus 1: Once Sperm 1 crosses the line, remove his/ her blindfold Mucus 2: Once Sperm 2 crosses the line, remove his/ her blindfold Mucus 3: Once Sperm 3 crosses the line, redirect him/her towards the egg, but don’t remove blindfold Mucus 4: Once Sperm 4 crosses the line, remove his/ her blindfold Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. | Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Egg: Stand behind the Zona Pellucida. You can’t move, but you can reach your arm towards a sperm to be tagged Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. Zona Pellucida: With the other ZPs, form a wall in front of the egg and don’t move! Once a sperm grabs the egg, you holler “CORTICAL REACTION” and can move to block the other sperm. “ Filler Sperm from the last guy”: Plant yourself along your line. You cannot move, but when sperm comes towards you, you and the other FSFTLGs can holler anything at the sperm that you think might convince them NOT to get the egg” “ Filler Sperm from the last guy”: Plant yourself along your line. You cannot move, but when sperm comes towards you, you and the other FSFTLGs can holler anything at the sperm that you think might convince them NOT to get the egg” “ Filler Sperm from the last guy”: Plant yourself along your line. You cannot move, but when sperm comes towards you, you and the other FSFTLGs can holler anything at the sperm that you think might convince them NOT to get the egg” “ Filler Sperm from the last guy”: Plant yourself along your line. You cannot move, but when sperm comes towards you, you and the other FSFTLGs can holler anything at the sperm that you think might convince them NOT to get the egg”

7. PENIS 1 PENIS 2 PENIS 3 PENIS 4 SPERM 1 SPERM 2 SPERM 3 SPERM 4 EGG MUCUS 1 MUCUS 2 MUCUS 3 MUCUS 4 TEAM FILLER SPERM TEAM FILLER SPERM TEAM FILLER SPERM TEAM FILLER SPERM TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA TEAM ZONA PELLUCIDA