Spanish National Rare Diseases Biobank (BioNER) was created in 2013 to establish a framework for systematically collecting biological samples and clinical data from rare disease patients, families, and controls. BioNER aims to promote research and support diagnosis and treatment development. It operates under open access policies to widely share data and enable collaboration. BioNER follows ethical standards for informed consent and protecting donor privacy. It connects to Spain's rare disease patient registry to link biosamples with phenotypic data. BioNER's sample catalogue makes de-identified biosamples searchable and available to researchers.