1) The paper discusses numerical versus quantitative variations in ingredients of Cyavanaprāśa, an Ayurvedic formulation containing Āmalaka (Indian gooseberry). Āmalaka is described in varying sizes depending on environmental factors.
2) The standard description of Cyavanaprāśa calls for 500 pieces of Āmalaka, but the weight of 500 pieces can vary greatly from 2.5-25.25 kg. This variation poses a challenge for developing standard operating procedures and standardized formulations.
3) Experimental studies were conducted to determine the weight of Āmalaka samples from different regions and its yield after processing. The results suggest the description of 500 pieces of Ā
A new RP -HPLC method development and validation for simultaneous estimation ...SriramNagarajan19
A simple, accurate, precise method was developed for the simultaneous estimation of the Aspirin and Omeprazole in Tablet dosage form. Chromatogram was run through Discovery 250 x 4.6 mm, 5m. Mobile phase containing Buffer and Acetonitrile in the ratio of 70:30 v/v was pumped through column at a flow rate of 1 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Aspirin and Omeprazole was 241 nm. Retention time of Aspirin and Omeprazole were found to be 2.454 min and 3.168 min %RSD of the Aspirin and Omeprazole were and found to be 1.1 and 0.8 respectively. Percentage recovery was obtained as 99.50% and 99.57%for Aspirin and Omeprazole. LOD, LOQ values were obtained from regression equations of Aspirin and Omeprazole were 0.26ppm, 0.80ppm and 0.06ppm, 0.17ppm respectively. Regression equation of Aspirin is y = 3524x + 3853, and of Omeprazole is y = 10438x+542.2.
This presentation describes the procedure of preparing ARKA LAVANA, a classical formulation mentioned in Rasatarangani. Its a simple medicine that can be prepared even at small level and can be prescribed for various GIT disorders.
A new RP -HPLC method development and validation for simultaneous estimation ...SriramNagarajan19
A simple, accurate, precise method was developed for the simultaneous estimation of the Aspirin and Omeprazole in Tablet dosage form. Chromatogram was run through Discovery 250 x 4.6 mm, 5m. Mobile phase containing Buffer and Acetonitrile in the ratio of 70:30 v/v was pumped through column at a flow rate of 1 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Aspirin and Omeprazole was 241 nm. Retention time of Aspirin and Omeprazole were found to be 2.454 min and 3.168 min %RSD of the Aspirin and Omeprazole were and found to be 1.1 and 0.8 respectively. Percentage recovery was obtained as 99.50% and 99.57%for Aspirin and Omeprazole. LOD, LOQ values were obtained from regression equations of Aspirin and Omeprazole were 0.26ppm, 0.80ppm and 0.06ppm, 0.17ppm respectively. Regression equation of Aspirin is y = 3524x + 3853, and of Omeprazole is y = 10438x+542.2.
This presentation describes the procedure of preparing ARKA LAVANA, a classical formulation mentioned in Rasatarangani. Its a simple medicine that can be prepared even at small level and can be prescribed for various GIT disorders.
Solid state fermentation of Lathyrus sativus and sugarcane bagasse by Pleurot...Innspub Net
Lathyrus sativus (Khesari plant) and sugarcane bagasse are considered as agro wastes. Khesari plants are generally grown in fields as weeds and they have to be removed prior to cultivation. Taking this view in mind, we have investigated the conversion of these lignocellulosic agro-waste as an enriched feed stock for cattle via by solid state fermentation using a cellulolytic fungus, Pleurotus sajor-caju.The strain required 8 weeks to complete the fermentation on both the untreated and treated (with alkali, lime and presoaked) substrates at 30°C. Higher amounts of reducing sugar and soluble protein were found in each of the lime treated substrates than untreated substrates. Results also indicated that presoaked substrate contain higher amounts of reducing sugar and soluble protein than unsoaked substrate. Among the substrates, mixed substrate (khesari plant + sugarcane bagasse) was found to accumulate higher amount of sugar, 22.15 mg/g and protein, 22.80 mg/g than those of khesari plant in the 5th week of fermentation. The treatments that augmented the level of sugar and protein were also found to enhance the cellobiase, carboxy methyl cellulase and avicelase activity of crude culture extracts. These results suggest that lime treatment and presoaking seem to increase the digestibility of the substrates by the fungal cellulolytic enzymes. During eight weeks of fermentation, relatively higher cellobiase activity was found as compared to that of carboxymethylcellulase and avicelase at 30 o C for the fungul strain. The results of the present study clearly indicate that fungal conversion with pretreatment transform these lignocellulosic agro-wastes to a nutritionally enriched animal feed. Get the full articles at: http://www.innspub.net/volume-4-number-5-may-2014-2/
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Assessment of antitussive activity of Cassia occidentalis Linn. root extractijperSS
ABSTRACT
The trend of using natural products has been increased and the active plant extracts are frequently screened for new drug discoveries. The present study deal with the screening of the methanolic extract of Cassia occidentalis roots and its antitussive activity in rats by sulphurdioxide induced cough reflex method. The plant Cassia occidentalis belongs to family Caesalpiniaceae, is a diffuse offensively odorous under shrub. The extract at a dose level of 200 and 400mg/kg showed significant antitussive activity which was comparable with that of Codeine phosphate.
Key words: Cassia occidentalis Linn., methanolic root extract, antitussive activity, sulphurdioxide.
Separation of Water to Concentrate Aloe Vera Juice:IJERA Editor
Aloe Vera is a succulent plant and is found in different arid areas. Due to its healing effect and soothing
properties it is being used in herbal medicines for years and its importance has grown due to use in cosmetic
products. It contains more than thirty active ingredients, which are utilized in cosmetic and pharmaceutical
industry. It also contains 98% water. To remove water from those active ingredient Reverse osmosis is used in
order not to thermally damage the active ingredients present in the juice. A reverse osmosis is a separation
technique which utilizes difference in pressure to segregate water from plant without damaging the active
ingredients present in the plant. This research is dedicated to evaluate the parameter for separation of water from
aloe Vera so that aloe Vera can be obtained in a form which can be utilized for different purposes such as
cosmetics and medicine. Osmosis technique is preferred over other conventional technique for the separation
purpose because it is not operated at high temperature, which will not damage the aloe Vera juice quality. Next
step in this research is the preserving, drying and analysis of this juice so that this product can be utilized in
versatile way.
Comparison of some physiological parameters in leaves and stems of wild and c...researchplantsciences
The purpose of this study was to determine total pigment contents (chlorophyll a, chlorophyll b, and carotenoids), phenolic compounds and carbohydrate contents in leaves and stem of wild and cultivated almonds growing in the Adıyaman Province. Levels of chlorophyll a in leaves and stems of wild almond were found to be higher than cultivated almond. Chlorophyll b was determined to be at approximate levels for both almonds. While carotenoid levels in leaves of wild almond were higher than cultivated one, it was higher in stems of cultivated almond as well. Total phenolics in leaves and stems of wild almond were higher compared to cultivated almond. Total carbohydrate contents were higher in leaves and stems of cultivated almond in comparison with the wild almond.
Article Citation:
Aysel Sivaci
Comparison of some physiological parameters in leaves and stems of wild and cultivated almonds growing in Adiyaman Province/Turkey
Journal of Research in Plant Sciences (2013) 2(2): 222-226.
Full Text:
http://plantsciences.co.in/documents/PS0063.pdf
Moringa is a plantfood of high nutritional value, ecologically and economically beneficial and readily available in the countries hardest hit by the food crisis. http://miracletrees.org/ http://moringatrees.org/
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Solid state fermentation of Lathyrus sativus and sugarcane bagasse by Pleurot...Innspub Net
Lathyrus sativus (Khesari plant) and sugarcane bagasse are considered as agro wastes. Khesari plants are generally grown in fields as weeds and they have to be removed prior to cultivation. Taking this view in mind, we have investigated the conversion of these lignocellulosic agro-waste as an enriched feed stock for cattle via by solid state fermentation using a cellulolytic fungus, Pleurotus sajor-caju.The strain required 8 weeks to complete the fermentation on both the untreated and treated (with alkali, lime and presoaked) substrates at 30°C. Higher amounts of reducing sugar and soluble protein were found in each of the lime treated substrates than untreated substrates. Results also indicated that presoaked substrate contain higher amounts of reducing sugar and soluble protein than unsoaked substrate. Among the substrates, mixed substrate (khesari plant + sugarcane bagasse) was found to accumulate higher amount of sugar, 22.15 mg/g and protein, 22.80 mg/g than those of khesari plant in the 5th week of fermentation. The treatments that augmented the level of sugar and protein were also found to enhance the cellobiase, carboxy methyl cellulase and avicelase activity of crude culture extracts. These results suggest that lime treatment and presoaking seem to increase the digestibility of the substrates by the fungal cellulolytic enzymes. During eight weeks of fermentation, relatively higher cellobiase activity was found as compared to that of carboxymethylcellulase and avicelase at 30 o C for the fungul strain. The results of the present study clearly indicate that fungal conversion with pretreatment transform these lignocellulosic agro-wastes to a nutritionally enriched animal feed. Get the full articles at: http://www.innspub.net/volume-4-number-5-may-2014-2/
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Assessment of antitussive activity of Cassia occidentalis Linn. root extractijperSS
ABSTRACT
The trend of using natural products has been increased and the active plant extracts are frequently screened for new drug discoveries. The present study deal with the screening of the methanolic extract of Cassia occidentalis roots and its antitussive activity in rats by sulphurdioxide induced cough reflex method. The plant Cassia occidentalis belongs to family Caesalpiniaceae, is a diffuse offensively odorous under shrub. The extract at a dose level of 200 and 400mg/kg showed significant antitussive activity which was comparable with that of Codeine phosphate.
Key words: Cassia occidentalis Linn., methanolic root extract, antitussive activity, sulphurdioxide.
Separation of Water to Concentrate Aloe Vera Juice:IJERA Editor
Aloe Vera is a succulent plant and is found in different arid areas. Due to its healing effect and soothing
properties it is being used in herbal medicines for years and its importance has grown due to use in cosmetic
products. It contains more than thirty active ingredients, which are utilized in cosmetic and pharmaceutical
industry. It also contains 98% water. To remove water from those active ingredient Reverse osmosis is used in
order not to thermally damage the active ingredients present in the juice. A reverse osmosis is a separation
technique which utilizes difference in pressure to segregate water from plant without damaging the active
ingredients present in the plant. This research is dedicated to evaluate the parameter for separation of water from
aloe Vera so that aloe Vera can be obtained in a form which can be utilized for different purposes such as
cosmetics and medicine. Osmosis technique is preferred over other conventional technique for the separation
purpose because it is not operated at high temperature, which will not damage the aloe Vera juice quality. Next
step in this research is the preserving, drying and analysis of this juice so that this product can be utilized in
versatile way.
Comparison of some physiological parameters in leaves and stems of wild and c...researchplantsciences
The purpose of this study was to determine total pigment contents (chlorophyll a, chlorophyll b, and carotenoids), phenolic compounds and carbohydrate contents in leaves and stem of wild and cultivated almonds growing in the Adıyaman Province. Levels of chlorophyll a in leaves and stems of wild almond were found to be higher than cultivated almond. Chlorophyll b was determined to be at approximate levels for both almonds. While carotenoid levels in leaves of wild almond were higher than cultivated one, it was higher in stems of cultivated almond as well. Total phenolics in leaves and stems of wild almond were higher compared to cultivated almond. Total carbohydrate contents were higher in leaves and stems of cultivated almond in comparison with the wild almond.
Article Citation:
Aysel Sivaci
Comparison of some physiological parameters in leaves and stems of wild and cultivated almonds growing in Adiyaman Province/Turkey
Journal of Research in Plant Sciences (2013) 2(2): 222-226.
Full Text:
http://plantsciences.co.in/documents/PS0063.pdf
Moringa is a plantfood of high nutritional value, ecologically and economically beneficial and readily available in the countries hardest hit by the food crisis. http://miracletrees.org/ http://moringatrees.org/
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
SOP on Chyavanpraha
1. Indian Journal of Traditional Knowledge
Vol. 6(3), July 2007, pp. 426-428
Numerical v/s quantitative variations in ingredients of
Cyavanaprāśa — A limiting factor for SOP
Sujit Kumar Dalai*, Mohan S Dashora & Laxmikant Dwivedi
Department of Rasa Shastra & Bhaishajya Kalpana,
National Institute of Ayurveda, Madhav Vilas Palace, Amer Road, Jaipur, Rajasthan
E-mail: drsujitayu@yahoo.co.in
Received 20 May 2005; revised 22 February 2007
Numerical v/s quantitative variation in ingredients of various formulations of Indian Systems of Medicine is one of the
major limiting factors for development of SOP (Standard Operative Procedure) and standardization. The paper enumerates
& highlights SOP hiatus with special reference to formulation like Cyavanaprāśa having Āmalaka (Indian gooseberry;
Emblica officinalis Gaertn.) in 500 numbers in single lot.
Keywords: Āmalaka, Standard Operative Procedure, Cyavanaprāśa, Indian gooseberry, Indian Systems of Medicine
IPC Int. Cl.8: A61K36/00, A61P15/10, A61P25/00
Āmlā (Indian gooseberry) or Āmalaka (Emblica Āmlā has impact on the relative proportion of other
officinalis Gaertn.) belonging to family constituents but also changes in constituents such as
Euphorbiaceae is widely used as plant ingredient in ascorbic acid, etc. reflects in the product behaviour.
Indian Systems of Medicine. Emblica officinalis This alternation in the relative proportion of other
Gaertn. fruit is one of the chief constituents of constituents resulting change in efficacy, i.e. this
Cyavanaprāśa1. Āmalaka is also important constituent variation marks the potency of Kwātha dravyas or
of many other formulations such as Dhātri Rasāyana, Praksepa dravyas or to ratio of the other constituents
Brāhma Rasāyana, Āmalaka Avaleha, Dhātryarista, because they remain same as the formula by weight.
Agastya Haritaki Avaleha, Kusumādi Netravarti, etc. Thus, there is an urgent need that the weight of Āmlā
Special mention of Āmalaka has been made in and weight of its constituents need to be established
Rasāyana Pāda, i.e. AbhayĀmalaka Pāda; in Cikitsā and standardized. To evaluate these parameters, a
sthāna of Caraka Samhitā, reflecting its prime study was conducted and the results are presented
activity as Vayasthāpana (maintains youthness) herewith.
Dravya. Shusruta enlisted Āmalaka as best in Phala
varga (fruit group). The name Āmalaka was derived Methodology
by virtue of its taste on tongue; Āmla rasa-the sour Various sizes of Āmalaka were collected from the
taste. This is also known as Vayasthā, Tiyaphalā and market; experimental study was carried out with
Dhātri in Sanskrit texts. These nomenclatures denote reference to its pharmaceutical processes. The result
its nursing nature or foster mother behaviors. of the study was statistically analyzed and compared
Āmalaka in present day is available in different sizes with the reports, which were collected from other
depending on the eco-climatic conditions, regions2.
geography/grafting and genomic variations, etc.
In Indian Systems of Medicine, use of 500 number Results and discussion
of Āmlā in many of the formulations in single lot has According to Bhāvaprakāś Samhitā, Triphalā is a
been described. However, variation in size and composite product of Haritaki, Bibhitaka & Āmalaka,
quantity of available pulp is the biggest limiting but no mention has been made whether they are to be
factors for the SOP (Standard Operative Procedure) mixed equal in number or in weight. However,
and standardization. Weight of 500 fresh Āmlā varies Caraka Samhitā and Sārangadhara Samhitā describe
from 2.5-25.25 kg. Not only physical weight of each Triphalā as the composite product of Haritaki,
______________ Bibhitaka & Āmalaka in the ratio of 1:2:4,
*Corresponding author respectively3.
2. DALAI et al.: VARIATIONS IN CYAVANAPRĀŚA INGREDIENTS 427
Table 1 — Weight of various sizes of Āmalaka and its yield (sample: Jaipur market, Rajasthan)
Wt. of 500 (10×50) Boiled composite Dry composite Pulp Dry pulp
Āmalaka (gm) seed (%) seed (%) (%) (%)
25,250 4.031 1.964 79.603 10.792
20,500 5.365 2.439 79.268 10.975
15,600 3.846 2.403 70.512 11.858
4,950 4.040 2.020 76.767 10.101
2,660 15.338 7.556 69.548 13.345
Above 5 experimental reports is the mean of three values
The weight of a good quality (srestha) Haritaki is 2 sugar for its preparation. Even in foot note (in first
karsa equal to 24 gm. edition), three times of the weight of fresh Āmlā, i.e.
Table 2 — Weight of various sizes of Āmalaka and its yield
uokfnxq.k ;qDrRoa rFkSok= f}d’kZrk A obtained (sample: Amaravati district, Maharastra state)
gjhrD;k% Qys;= };a rPNs’BeqP;rs AA Wt. of 500 Boiled composite Dry composite Dry pulp
(10×50) Āmalaka seed (%) seed (%) (%)
“Navādiguna yuktatwam tatheivātra dwikarsatā (gm)
Hritakyhā phaleyatra dwayam tachesthamucyate4” 2,700 14.184 7.407 12.592
2,450 16.734 7.755 12.500
Likewise, the weight of one good quality Bibhitaka 2,400 15.833 9.166 13.333
(karsa phala) is 12 gm. So, 2 Bibhitaka would be 24 2,150 18.372 10.232 13.953
gm. Hence, as per the principle of Triphalā, 4 1,735 21.733 11.54 20.196
Āmalaka must be 24 gm. This means use of equal Mean % = 17.371 9.22 14.514
weight of all the three constitutes, i.e. 24 gm is Table 3 — Weight of various sizes of Āmalaka (hybrid variety-
advocated while preparing Triphalā powder. On the cultivated) and its yield (sample: Azadpur Mandi, Delhi — A
above pretext, assuming 1 Āmalaka is equal to 6 gm, report of IMPCL)
500 Āmalaka would make 3 kg. Whether it is to be
Weight of 500 Boiled composite Pulp Dry pulp
taken in dry form or in fresh form is a subject of number of fresh seed (%) (%) (%)
consideration. According to the commentator Āmalaka (gm)
Ādhamalla (commentator of Sārangadhara Samhitā), 15,000 6.666 91.333 13.333
this is the dry value of the Āmalaka. The traditional 15,000 4 83.666 12.666
principle advocates, wet value should be two times or 13,500 5.555 83.333 11.111
double to that of dry value, i.e the weight of 500 fresh 15,000 5 56.666 7.333
Āmalaka should be taken as 6 kg (the dry value is 14,250 5.263 87.771 13.684
14,250 7.017 82.456 12.28
50% of wet value including the value of dry 10,250 4.87 17.073 9.756
composite seeds) 3. Dry composite seed varies from 2 13,250 6.037 84.905 11.32
to 12% (Tables 1-4). When the maximum percentage 15,000 4 65 8.333
(12%) is excluded, the rest (38%) is pure Āmalaka 11,750 8.51 85.1 14.042
17,500 7.142 85.714 12.857
powder, which does not go in consonance with the 12,500 8 96 14
result (13.894 %) of the report, which is the hiatus for 16,500 6.06 3.03 15.151
developing SOP for the formulations like 10,000 10 115 15
Cyavanaprāśa. 15,000 6.666 108.333 16.666
In case of Cyavanaprāśa, average weight of 500 20,000 5 82.5 12.5
18,000 5.555 81.944 13.055
number of Āmlā is taken into traditional consideration 18,500 5.405 85.135 13.513
to 6 kg fresh weight and if standard sugar (2.400 kg) 18,500 6.756 81.081 13.573
were to be added, would be inadequate for preparation 19,250 6.493 85.714 14.285
and would not be acceptable. At the same time, Mean % = 6.19975 85.518 12.722
Āyurvedic Formulary of India (AFI) mentions use of
2.5 kg for 500 number of fresh Āmalaka and 2.4 kg 7.5 kg of sugar was mentioned as a usual practice,
which was deleted in later edition.
3. 428 INDIAN J TRADITIONAL KNOWLEDGE, VOL 6, No. 3, JULY 2007
In Siddha Yoga Sangrh, where the formula is enumerated to show that the variation in weight of
derived from Sārangdhara Samhitā and partially 500 Āmalaka is the hiatus for developing SOPs of the
modified by use of 12.288 kg (1 drona) of sugar for product like Cyavanaprāśa (complex drug).
Table 4 — Weight of various small sizes Āmalaka (wild variety) Āmalaka is equal to 6 gm and so 500 Āmalaka
and its yield (sample: Kumau Mandal Vikas Nigam Ltd, equaling to 3 kg, the wet form of Āmalaka can be
Uttaranchal state — A report of IMPCL)
taken into consideration. In Kalpa sthāna, Caraka
Weight of 500 Boiled composite Pulp Dry pulp
while classifying three types of deśas (the growing
number fresh seed (%) (%) (%) area) Āmalaka has been enumerated with Jāngala
Āmalaka (gm) desiya (wild trees). This shows that Āmalaka
collected and used in those days was mainly obtained
3,850 10.389 77.922 16.883
3,500 8.571 81.428 18.571
from wild trees. Wild Āmlā fruit is comparatively
3,850 14.285 76.623 16.883 richer in vitamin C content than cultivated varieties.
3,750 16 66.666 16 The wild variety was later designated as Ksudra
3,750 13.333 69.333 14.666 Dhātri (in Rāja Nighantu). Looking into the ratio of
3,850 12.987 77.922 16.883 sugar, AFI recommended 2.5 kg for the weight of 500
3,500 14.285 78.571 14.285
3,250 16.923 61.538 12.307 number of fresh Āmalaka in Cyavanaprāśa. Hence,
3,800 11.842 69.736 13.157 the weight of 500 number of fresh Āmalaka to be
4,000 13.75 78.75 13.75 taken as 2.5 kg in Cyavanaprāśa, needs to be
4,000 15.625 78.125 12.5 pharmacognostically as well as biologically examined
4,000 12.5 87.5 12.5
3,750 20 93.333 16.883
so that same quality of the drug is maintained
3,750 16 73.333 14.666 globally.
3,500 14.285 64.285 15
Mean % = 14.051 75.671 14.995 References
1 Ayurvedic Formulary of India, Part – I (ISMH, Govt. of
Mean report Yield of dry pulp i.e. India), 2003, 37.
Āmalaka in powder form (%) 2 Dalai Sujit Kumar & Dwivedi Laxmikant, Study of Free
1. - Report of Table - 1 (Exp No- 5) - 13.345 % Radical Scavenging Activity of Chyavanaprasha wsr to
Amalaki & Pippali, PG Thesis (Department of Rasa Shastra
- Report of Table - 2 - 14.514 %
& Bhaisajya Kalpana, National Institute of Ayurveda,
- Report of Table - 4 - 14.995 %
Jaipur), 2004, 119.
These reports are inconsonance with 3 Shastri Parsuram, Sarangadhara Samhita with the
wild variety commentary of Adhamalla’s Dipika and Kasiram’s
2. - Report of Table - 3 (hybrid variety) - 12.722 % Gudhartha Dipika, (Chaukhamba Orientalia Varanasi), 2002,
Total Mean value - 13.894 % 3, 179.
4 Mishra Brahma Shankar, Bhavaprakasha Samhita
500 number of fresh Āmlā (6 kg fresh weight) Haritakyadi varga, Vol I, (Chaukhamba Sanskrit Santha,
Varanasi), 1988, 6.
showing the double the quantity of sugar (more than 5 5 Acharya Yadavji Trikamji, Sidha Yoga Samgraha
times the standard, i.e. 2.400 kg)5. Boiling of 500 (Baidyanath Ayurved Bhavan Ltd, Nagpur), 2000, 78.
numbers of Āmlā with decoction results in pH change 6 Sharma Priyavrat, Cakradatta (Cikitsa Samgraha) of
due to variation in quantity and consequently acid Cakrapanidatta with Ratna Prabha, commentary by
soluble content would only be released accordingly. Mahamahopadhyaya Niscalakara, (Swami Jayaramdas
Ramprakasha Trust, Jaipur), 1993.
Changed pH can lead to hydrolysis/cleavage of 7 Sengupta Balaichandra, Caraka Samhita with Ayurveda
various bioactive molecules. Such as sugars, amino Dipika, commentary of Srimat Cakrapanidatta
acids, carbohydrates, alkaloids, proteins and phenols, (Chaukhambha Orientalia, Varanasi), 1991.
etc. which in turn may lead to change in elongative 8 Acarya Jadavaji TrikamaJi & Nandkishor, Susruta Samhita
(Sutrasthana) with Bhanumati, commentary by
phase of molecular synthesis. The variation in weight Cakrapanidatta (Shri Swami Laxmiram Trust, Jaipur), 1939.
of 500 Āmalaka would also lead to change in 9 Ram Prasad, Rajaballabha Nighantu, (Khemraj Srikrishna
consistency, efficacy, quality, colour and texture of Das, Sri Venkatswar Steam Mudranalaya, Bombay), 1911.
the product. All these are the gullies, which are