This document discusses using social media for clinical trials. It notes that 97% of Americans and 58% of the world use social media, providing a large reach for sharing health information. People frequently seek health information and support online, with 70% of caregivers looking for information and 52% participating in health-related online activities. The document advocates an approach to social intelligence that uses publicly available online conversations to quantitatively answer questions and solve challenges, while avoiding bias through diversity and using patient language rather than industry terms. It provides examples of data sources and segmentation approaches that could be used to predict trends, monitor adverse events, and help with recruitment and participation for clinical trials.