This document discusses managing Microsoft 365 deployments, specifically OneDrive sync, at a large research institute. It provides an overview of OneDrive sync functionality and licensing, how to configure known folder move to sync desktop, documents, and pictures folders to OneDrive, and considerations for deployment, troubleshooting, user adoption, and training. Recommendations are given for supporting OneDrive usage across web, mobile, and desktop and ensuring help desk staff and users understand how to use OneDrive features.