This document discusses various methods for smoking cessation, including nicotine replacement therapies and medications. It describes nicotine gum, patches, lozenges, nasal spray, the prescription drugs Zyban and Chantix, and nicotine inhalers. All methods aim to deliver nicotine to reduce withdrawal symptoms but avoid the harmful chemicals in cigarettes. Common side effects include nausea, headaches, and skin irritation. The document emphasizes that quitting smoking improves health and that individuals can choose to live tobacco-free.
The video for this presentation is available on our Youtube channel:
https://youtube.com/allceuseducation A continuing education course for this presentation can be found at https://www.allceus.com/member/cart/index/index?c=
Unlimited Counseling CEUs for $59 https://www.allceus.com/
Specialty Certificate tracks starting at $89 https://www.allceus.com/certificate-tracks/
Live Webinars $5/hour https://www.allceus.com/live-interactive-webinars/
Patreon: https://www.patreon.com/CounselorToolbox
Pinterest: drsnipes
Youtube.com: https://www.youtube.com/user/allceuseducation
Explore the current pharmacologic interventions for alcohol and opiate dependence.
The video for this presentation is available on our Youtube channel:
https://youtube.com/allceuseducation A continuing education course for this presentation can be found at https://www.allceus.com/member/cart/index/index?c=
Unlimited Counseling CEUs for $59 https://www.allceus.com/
Specialty Certificate tracks starting at $89 https://www.allceus.com/certificate-tracks/
Live Webinars $5/hour https://www.allceus.com/live-interactive-webinars/
Patreon: https://www.patreon.com/CounselorToolbox
Pinterest: drsnipes
Youtube.com: https://www.youtube.com/user/allceuseducation
Explore the current pharmacologic interventions for alcohol and opiate dependence.
The presentation by Dr.M.S.Chandragupta, Chief Dental Surgeon, Dr. Gupta's Dental Specialities Centre, deals with Tobacco Cessation Methodologies.
Tobacco is the number one killer in the world and kills around 9 lakh people annually in India alone. The victims succumb to tobacco in the most productive years of their life. To curb this issue the World Health Organization has brought out a public health legal treaty called ‘Frame Work Convention on Tobacco Control (FCTC)’ which more than 176 countries have signed and ratified the same. India has signed in the year 2005 and initiated measures to bring down the demand and supply of tobacco in India as mandated by the FCTC. India has the second highest number of tobacco users in the world, at an alarming number of 274 million users (GATS Report, 2010) and it is high time we act together to make India Tobacco Free for a healthier and wealthier tomorrow
Nicotine Replacement Therapy (NRT) can help with the withdrawal symptoms in patients who find it difficult to quit tobacco. It is available in the form of - gums, patches, sprays, inhalers or lozenges.
5 A’s of smoking cessation guidelines, Nicotine replacement therapy (NRT), Bupropion, Varenicline, Tips to quit smoking and Complementary Health Approaches for Smoking Cessation are discussed in this presentation.
Lifestyle and health : Drug effects , cause and how to stop!SerenaLuu
We have heard much of nicotine, especially when we speak about the effects of tobacco to human health. Quit the essence is to relieve the addiction of nicotine acting on the user. However just a few people clearly understand what is nicotine, what is its harm and does it totally harm ? So today this presentation will help you to know!
Nicotex (Generic Nicotine Polacrilex Chewing Gum) is used for smoking cessation therapy. It reduces withdrawal symptoms including Nicotine craving associated with quitting smoking/chewed tobacco.
The chewing gums should be used whenever there is an urge to smoke.
Continue use of Nicotex for up to three months to break the habit of smoking, then gradually reduce the gum use.
Introduction TO VOMITING,Pathophysiology of vomiting,Emetics,Anti emetics,classification,pharmacology,Drug treatment in selected circumstances FOR EMETICS were included.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The presentation by Dr.M.S.Chandragupta, Chief Dental Surgeon, Dr. Gupta's Dental Specialities Centre, deals with Tobacco Cessation Methodologies.
Tobacco is the number one killer in the world and kills around 9 lakh people annually in India alone. The victims succumb to tobacco in the most productive years of their life. To curb this issue the World Health Organization has brought out a public health legal treaty called ‘Frame Work Convention on Tobacco Control (FCTC)’ which more than 176 countries have signed and ratified the same. India has signed in the year 2005 and initiated measures to bring down the demand and supply of tobacco in India as mandated by the FCTC. India has the second highest number of tobacco users in the world, at an alarming number of 274 million users (GATS Report, 2010) and it is high time we act together to make India Tobacco Free for a healthier and wealthier tomorrow
Nicotine Replacement Therapy (NRT) can help with the withdrawal symptoms in patients who find it difficult to quit tobacco. It is available in the form of - gums, patches, sprays, inhalers or lozenges.
5 A’s of smoking cessation guidelines, Nicotine replacement therapy (NRT), Bupropion, Varenicline, Tips to quit smoking and Complementary Health Approaches for Smoking Cessation are discussed in this presentation.
Lifestyle and health : Drug effects , cause and how to stop!SerenaLuu
We have heard much of nicotine, especially when we speak about the effects of tobacco to human health. Quit the essence is to relieve the addiction of nicotine acting on the user. However just a few people clearly understand what is nicotine, what is its harm and does it totally harm ? So today this presentation will help you to know!
Nicotex (Generic Nicotine Polacrilex Chewing Gum) is used for smoking cessation therapy. It reduces withdrawal symptoms including Nicotine craving associated with quitting smoking/chewed tobacco.
The chewing gums should be used whenever there is an urge to smoke.
Continue use of Nicotex for up to three months to break the habit of smoking, then gradually reduce the gum use.
Introduction TO VOMITING,Pathophysiology of vomiting,Emetics,Anti emetics,classification,pharmacology,Drug treatment in selected circumstances FOR EMETICS were included.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Smoking cessation project
1. SMOKING CESSATION
Ashley Olsen
Stacy Coon
Nichole Carter
Angela Morgan
2. HEALTH EFFECTS
Harms every organ in the body
Causes many diseases/cancer
gum disease, cardiovascular disease, emphysema,
bronchitis
stomach, lung, esophagus, oral cancer
4. ORAL CAVITY
Bad breath
Inflammation of salivary glands
Plaque and tarter
Loss of bone within jaw
Leukoplakia
Delayed healing process following dental procedures
Alveolar osteitis (dry socket)
7. NICOTINE GUM CONT.
HOW IT WORKS:
Chewing the gum releases nicotine which is absorbed
into the bloodstream from the lining of the mouth
Chew slowly and only chew when more nicotine is
needed
Comes in different doses
8. NICOTINE GUM CONT.
SIDE EFFECTS:
Mouth ulcers
Dizziness
Nausea
Allergic reactions (swelling of the gums,
itching)
9. NICOTINE GUM CONT.
Advantages:
Convenient
Discrete
Fast acting
Many flavors
10. NICOTINE GUM CONT.
Disadvantages:
Do not drink or eat 15 min. before or while chewing
TMJ
Inconvenient for those with dental prosthesis
12. NICOTINE PATCH CONT.
HOW IT WORKS:
Releasing a controlled dose
of nicotine throughout the
day through the skin
Comes in different doses: 7mg, 14mg, 21mg
14. NICOTINE PATCH CONT.
Advantages:
Greatly reduces the urge
Easy to use
Effective substitute for those who do not prefer oral
methods
Can combine with short acting NRT’s
17. LOZENGE CONT.
HOW IT WORKS:
Dissolves slowly in your mouth or under your tongue
Takes 30 min. to dissolve
Small doses of nicotine at a time
Dosage: 2mg, 4mg
19. LOZENGES CONT.
Advantages:
Easy to use
Variety of flavors
Delivers 25% higher nicotine dosage than the
nicotine gum
20. LOZENGES CONT.
Disadvantages:
No drinking/eating 15 min. before or during use
Should not be chewed or swallowed
Nausea
Appealing to children and teens
22. NASAL SPRAY CONT.
HOW IT WORKS:
The spray is pumped into each nostril and
absorbed via the nasal membranes
Recommended dosage; one spray in each
nostril 1-3x/hr.
24. Advantages:
Fastest delivery of nicotine currently available
Easy to use
Disadvantages:
Prescription required
Must be used frequently to obtain adequate nicotine
levels
25. MEDICATION
Two FDA approved drugs:
Varenicline Tartrate(Chantix)
Bupropion(Zyban), first non-nicotine medicine shown to be
effective
In 2009 the FDA issued a black box warning for both because of
their detriment to mental health
26. MEDICATION
Zyban:
Blocks uptake of the neurotransmitters dopamine and
norepinephrine
Dopamine controls signals of pleasure and pain, motor
skills, and emotional responses
Norepinephrine helps relay messages to the brain and
help it respond to stimuli it receives
Categorized as an antidepressant
27. ZYBAN CONT.
Zyban:
Taken orally
Extended/sustained release tablets
Extended tablets; 1x/day
Sustained tablets; 2x/wk
Should be taken with food and same time each day
28. ZYBAN CONT.
SIDE EFFECTS:
Xerostomia, Drowsiness, Headache, Weight loss
Uncontrollable shaking of body parts
Severe side effects include:
Seizures, Chest pain, Irregular heart beat
Suicidal thoughts, Hallucination
29. ZYBAN CONT.
Advantages:
Non addictive, Pill form
Disadvantages:
Prescription required
Contraindicated w/ certain medical
conditions(seizures) and medications
May take up to 4 wks. to feel full effect
Strict time regiment
30. MEDICATION
Chantix:
When a person smokes, the nicotine attaches to
receptors that go to your brain and stimulate the
release of Dopamine, which causes the feeling of
pleasure people get from tobacco.
Chantix blocks this receptor so dopamine can't be
released, and therefore, people don't receive that
pleasure feeling when they smoke.
31. CHANTIX CONT.
Chantix:
Taken orally in tablet form
1-2 times per day
Dosage slowly increased over time, then maintained
over a three month period
32. CHANTIX CONT.
Side Effects:
Nausea, Constipation
Unusual dreams/nightmares
Weakness or numbness in
extremities
Swelling of extremities and face (lips, gums, eyes, etc.)
Suicidal thoughts and depression
33. CHANTIX CONT.
Advantages:
Easy to use; Pill form
No known drug interactions
44% success rate
Disadvantages:
Nausea is common
Prescription is required
35. NICOTINE INHALER
HOW IT WORKS;
Transmucousal delivery, then enters bloodstream
Uses a nicotine cartridge
Delivers a small pump of nicotine vapor
Gives sensation of smoking w/o inhaling harmful toxins
that are found within cigarette smoke
8-10 puffs off of inhaler is equivalent to one cigarette
37. NICOTINE INHALER
Advantages:
Flexible dosing
You control nicotine intake
Can be used in conjunction with other NRT
Mimics the hand to mouth behavior
38. NICOTINE INHALER
Disadvantages:
Prescription is required
Needs to be used multiple times per day
May cause mouth/throat irritation
39. THE CHOICE IS YOURS!
One thousand Americans stop smoking every day - by dying.
“You don't get to choose how you're going to die. Or when.
You can only decide how you're going to live. Now.”