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Nicotin replacement therapy


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prevent withdrawal symptoms of TOBACO

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Nicotin replacement therapy

  1. 1. Introduction smoking Smoke contents - 4000 chemicals - 400 toxic - 43 known cancer causing
  2. 2. Contents of cigarette smokeAcetone CyanideAluminum DDT/DieldrinAmmonia EthenolArsenic FormaldehydeBenzene Hydrogen cyanideButane LeadCadmium MethanolCarbon monoxide NicotineCarbon dioxide TarChloroform Vinyl Chloride
  3. 3. Nicotine addiction Nicotine increases several neurotransmitters like dopamine These neurotransmitters cause the euphoria & relaxation to brain Nicotine withdrawal Symptoms• Tension• Drowsiness• Lack of concentration• Irritability
  4. 4. Types of NRT Nicotine Medications - Nicotine patches - Nicotine gum - Nicotine lozenge - Nicotine oral inhalers - Nicotine nasal spray
  5. 5. Non-Nicotine Medications By nicotine agonists  By nicotine antagonists - acetyl choline - Bupropion - choline - mecamylamine - - 18-methoxy epibatidine coronaridie - lobeline - varenicline
  6. 6. Nicotine medication Nicotine patchesUse:-Apply to clean skin area (upper trunk/ arms)-24 or 16 hour dosingDosing:14-21mg/patchLength of Treatment:-Up to 12 weeks
  7. 7. side effects  Drowsiness, hallucination  Skin irritation  Allergic reaction
  8. 8. Nicotine gum Use: Chew and park Slow, buccal absorption Dosing: 2-4mg/dayLength of Treatment 8-10 weeks
  9. 9. Side effects High amount nicotine produce irritation Prolonged usage may cause ediction
  10. 10. Nicotine Lozenge These are nicotine sublingual tablets Nicotine is absorbed through lining of mouth
  11. 11. Nicotine Nasal spray/inhaler This are aerosols contain nicotine They are absorbed through lining of the nose and through lungs They show quick onset of action
  12. 12. Side effectNose and throat irritation
  13. 13. Non –nicotine medication Varenicline Partial agonist Action at α4β2 nicotine receptor Blocks nicotine from binding to receptor Releases lower amounts of dopamine
  14. 14. Dose Treatment with Varenicline begins one week before the quit date. 0.5-1mg every day Adverse effects Nausea Head ache Difficulty to sleep Vomiting Constipation
  15. 15. Bupropion  It is an α3β4 nicotinic antagonist  Bupropion is a dopamine and norepinephrine reuptake inhibitor Dose  Start 7-10 days prior to quit date  Dose150-300mg every day  Continue 7-12 weeks or longer17
  16. 16. Adverse effects hypertension Insomnia Dryness of mouth Seizures
  17. 17. CONCLUSION NRT is being provided to assist tobacco users to become tobacco free. NRT is not a treatment in itself, but is intended to complement the other assessments and treatments provided. Pharmacotherapy works and is relatively safe and more effective.
  18. 18. Thank you