Nicotine addiction Nicotine increases several neurotransmitters like dopamine These neurotransmitters cause the euphoria & relaxation to brain Nicotine withdrawal Symptoms• Tension• Drowsiness• Lack of concentration• Irritability
Non –nicotine medication Varenicline Partial agonist Action at α4β2 nicotine receptor Blocks nicotine from binding to receptor Releases lower amounts of dopamine
Dose Treatment with Varenicline begins one week before the quit date. 0.5-1mg every day Adverse effects Nausea Head ache Difficulty to sleep Vomiting Constipation
Bupropion It is an α3β4 nicotinic antagonist Bupropion is a dopamine and norepinephrine reuptake inhibitor Dose Start 7-10 days prior to quit date Dose150-300mg every day Continue 7-12 weeks or longer17
Adverse effects hypertension Insomnia Dryness of mouth Seizures
CONCLUSION NRT is being provided to assist tobacco users to become tobacco free. NRT is not a treatment in itself, but is intended to complement the other assessments and treatments provided. Pharmacotherapy works and is relatively safe and more effective.