This document provides information on presacral tumors:
- Presacral tumors can arise from any germ cell layer and have varied etiologies including congenital and neurogenic tumors.
- Imaging such as MRI is important for evaluating the tumor extent and involvement of nearby structures. Biopsy may be needed prior to surgery.
- Complete surgical resection is often challenging due to the tumors' location near the sacrum and involvement of nearby nerves and vessels. A multidisciplinary team is typically involved in the surgical planning and approach.
- Posterior, anterior, and combined approaches can be used depending on the tumor location and extent. Nearby structures like the sacrum or rectum may need resection.
- Long
Abstract
Carotid body tumors are rare, slow-growing, hypervascular neuroendocrine tumors. Although these tumors are benign neoplasm, they also have a tendency to malignant transformation. Complete surgical excision is the gold standard therapeutic modality for the treatment of carotid body tumors. Early surgical removal is recommended to prevent the development of larger and more advanced tumors, which are associated with higher morbidity and mortality. In this report, we presented three cases of carotid body tumor which were successfully treated with complete surgical excision, and reviewed the current literature. Furthermore, it was emphasized the necessity of early surgical management regardless of patient age and tumor size.
Abstract
Carotid body tumors are rare, slow-growing, hypervascular neuroendocrine tumors. Although these tumors are benign neoplasm, they also have a tendency to malignant transformation. Complete surgical excision is the gold standard therapeutic modality for the treatment of carotid body tumors. Early surgical removal is recommended to prevent the development of larger and more advanced tumors, which are associated with higher morbidity and mortality. In this report, we presented three cases of carotid body tumor which were successfully treated with complete surgical excision, and reviewed the current literature. Furthermore, it was emphasized the necessity of early surgical management regardless of patient age and tumor size.
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1. Presacral Tumours
Presenter
Dr.Harshavardhana H P
SGE DNB Resident
GEM Hospital.
Centre for Colorectal Surgery,
GEM Hospital & Research
centre,
presents
PG Academic series
Moderator
Dr Rajapandiyan.S
Head of Colorectal unit
GEM hospital .
2. Introduction
Retrorectal
tumours
Heterogeneous
Can arise from any of the germ cell layers
Incidence of less than 1%
Two-thirds are congenital
More common in females than males
Malignancy is more common in men.
The most common malignant tumor is a sacrococcygeal
chordoma.
3. Anatomy
Anteriorly
• Posterior wall of the rectum and
mesorectum.
Posteriorly
• Anterior aspect of the sacrum.
Lateral borders
• lateral ligaments, the ureters, and iliac
vessels.
7. Content
• Loose connective tissue
• Middle sacral artery
• Superior hemorrhoidal vessels
• Branches of sympathetic and
parasympathetic nerves
8. Presacral tumors and
its challenges
The sacral nerve rootlets injury to leads to
• Defecatory
• Urological
• Sexual dysfunction.
unilateral sacrifice of all of the sacral nerve,
Atleast S1-3 roots present on either side:
no issue.
If bilateral S3 roots are damaged: fecal
incontinence.
may need a permanent colostomy
11. CLINICAL
PRESENTATION
• Vague and ill defined
• Discovered incidentally on routine pelvic or
rectal examination
• Pelvic or low back pain, constipation, a
palpable mass or obstructive type
symptoms.
• Classically, pain is aggravated by sitting and
ameliorated by standing or walking
• Urinary or fecal incontinence and sexual
dysfunction.
• Persistent perianal discharge.
17. Approch for biopsy
• Transrectal or transvaginal biopsy is contraindicated
• A transperineal or parasacral approach within the field of the resection is
recommended.
• Excision of the biopsy tract and site at the time of surgery advised.
18. ROLE OF PREOPERATIVE BIOPSY
• Simple cystic lesions, which are uniformly benign, biopsy C/I
• All solid or heterogeneous tumours, Consider biopsy prior to surgical
intervention.
(1) potential impact upon the operative approach,
(2) application of direct neoadjuvant therapy {Ewing sarcoma, osteogenic sarcoma,
and neurofibrosarcoma}
(3) better counsel the patient prior to Sx.
19. Dermoid and
Epidermoid
Cysts
• Failure of separation of cutaneous
ectoderm from neural ectoderm.
• more common in females
• a postanal dimple or sinus up to 30% of
present as a pelvic or perirectal abscess.
• may be misdiagnosed with fistula in ano
if a communication between an abscess
and a postanal dimple exists.
20. • Both exhibit keratinizing stratified squamous epithelium
• Epidermoid cysts bear no skin appendages
• Dermoid cysts have sweat glands, hair follicles, or sebaceous cysts.
21. Enterogenous
Cysts
• Duplication cysts of the rectum.
• Sequestration of the developing
hindgut lined by squamous
epithelium or columnar
epithelium.
• Multilocular cyst.
• well-defined muscular wall with a
myenteric plexus.
• Villi or crypts.
22. Tailgut Cysts
• Cystic hamartomas.
• Postanal gut cysts arise from remnants of
the embryonic primitive gut.
• lesions are often multicystic and
multilocular.
• Lining is a combination of squamous,
glandular columnar, or transitional.
• No evidence of a well-defined muscular
wall with myenteric plexus.
23. • Calcification are uncommon.
• CT imaging reveals a well defined, homogeneous mass, with
preservation of adjacent fat planes.
• Risk of malignancy 2 to 13%
24. TERATOMA AND
TERATOCARCINOMA
• Presacral teratoma is the most common
teratoma in infancy.
• A female predominance.
• Contain cells from all three germ layers.
• Tumor with recognizable hair, bone or
teeth, are more likely to be benign.
• Benign lesions are usually cystic.
• Malignant lesions are having solid or
heterogenous component.
25. • 90% of SCT externally visible in
infants.
• Teratomas in adults are most
commonly intrapelvic.
• Type I is predominantly external.
• Type Il is external tumor with
intrapelvic extension.
• Type III is predominantly intrapelvic
with external extension.
• Type IV is a presacral tumor
27. Neurogenic
tumours
• Represent about 10% of all retrorectal
tumors.
• Schwannomas were the most common
benign tumor.
• Malignant peripheral nerve sheath
tumors, the most common malignant
lesions.
• The most common presenting symptom
is pain (most commonly sciatalgia).
28. • Preoperative biopsy in neurogenic tumour.
1.Pathology is unclear on imaging
2. >5 cm benign tumor on imaging
3. Neurogenic tumour with clinical features moderate or severe neurologic deficit.
Indication of sx in benign neurogenic tumours
1. >5 cm benign tumor on imaging.
2. <5cm but symptomatic tumor.
3. <5cm, asymptomatic tumor but rapidly growing.
(10% growth in last 1 year on serial MRI).
29. SACROCOCCYGEAL
CHORDOMAS
• Most frequently encountered malignant
tumor of the retrorectal space
• Originate from the primitive notochord
tissue either from the nucleus pulposi or
from abnormal rests.
• anywhere along the spinal column
• M/C at the sphenoocipital and the
retrorectal regions.
30. • male predominance.
• Usually after 30 year age.
• long-standing history of vague pain.
• aggravated by sitting and ameliorated by standing or walking.
• Most important predictor of survival was a wide negative margin.
31. Osseous
lesions
• 10% of all retrorectal tumors
• Most osseous lesions of the
presacral space are metastatic.
• Pain remains the most common
presenting feature.
• most aggressive of all the
retrorectal tumors.
• locally destructive
• Pronounced metastatic potential.
32. Currarino
syndrome
Triad of
• Presacral mass
• Anorectal malformations
• Sacral anomalies
Most frequent component of the presacral
mass is
Meningocele
Teratomas (20% to 40%).
HLXB9 gene mutation located on
chromosome 7q36.
36. Tumors located below S3-
The Posterior Approach
• Prone jackknife position.
• Incision over the lower sacrum and
coccyx.
• Coccygectomy or Distal Sacrectomy
only if malignancy invading it.
• Plane of dissection- between the retro
rectal fat and the tumor
(Pseudocapsule).
37. Combined Anterior- Posterior Approach.
• Indication- tumor above the level of S3.
Anterior Phase
• Supine position, transabdominally.
• Modified Dorsal Lithotomy position- if rectal resection is planned.
• “Sloppy lateral position- two team approach.
• Plane of dissection- Anteriorly between its capsule and mesorectum.
Posteriorly between the lesion and rectum.
• Small, Beningn tumours – Circumferential dissection and remove.
• Bulky tumors/Invasion – enblock resection of rectum with anastomosis and
diverting ileostomy.
38. • If bilateral S3 roots or S2 involved- End Sigmoid colostomy.
• If Major Sacrectomy is planned – Ligation of middle sacral artery and inter iliac artery and
its branches.
• Preserve anterior division of internal iliac artery – as it gives of inferior gluteal artery and
prevents potential perennial and gluteal necrosis.
• If extended sacral resection- Rectal abdominis flap.
39. Posterior phase
• Abdominal incision is closed and ostomy created before prone position.
• Midline incision over sacrum and coccyx.
• Anococcygeal ligament transected and levators retracted bilaterally.
• Dissection of gluteus maximus muscle on both sides.
• Transection of sacrospinous and sacrotuberous ligaments.
• Division of Piriformis to expose the sciatic nerves.
• Osteotomy – at S3 level or higher. Preseve atleast one S 3 nerve root.
• The neural sac may need to be ligated.
40. Minimal Invasive
Approaches for
Presacral Tumors
• Highly selected beningn tumours
• Lengyel et al described laparoscopic
approach for advanced malignant lesion.
I. Laparoscopic abdominal phase -
Modified Lloyd davis position.
II. Transsacral phase – prone jackknife
position.
41. Follow up
Beningn tumors
• Annual visit – DRE, Baseline CT (repeated at 5years interval if normal)
Malignant tumours
• Annual Abdominopelvic MRI.
• Annual Chest CT scan
• Annual DRE
• Endoscopic examination.
First 5 years