Dr. Shikhman outlines the ultimate natural treatment for Sjogren's Syndrome using dietary supplements.

1. SJOGREN’S SYNDROME
the ultimate
integrative approach
Alexander R Shikhman MD PhD FACR
Gluten Free Remedies

3. SJOGREN’S SYNDROME

4. SJOGREN’S SYNDROME
key pathologic mechanisms
• Reactivation of dormant viral infections, such as EBV and CMV
• TH1/TH2 imbalance with TH1 predominance
• Increased proliferation of Th17 cells
• Production of anti-SSA/Ro and anti-SSB/La autoantibodies
• Increased production muscarinic M3 receptor antibodies and
correspondent suppression of water channel protein aquaporin-5
• Decreased methylation of epithelial cells in exocrine gland

5. SJOGREN’S SYNDROME
goals of therapy
• Improve dryness
• Normalize autoimmune responses
• Prevent malignancies

6. THE ULTIMATE RECIPE
• Improve dryness
SalivaStim
Black Currant Seed Oil
Krill oil
• Normalize autoimmune responses
Artemisinin
Cordyceps Sinensis
N-Acetylcysteine
I3C/DIM
Black Currant Seed Oil
Krill Oil
• Normalize defective methylation
of epithelial cells
TMG Plus
• Prevent malignancies
Artemisinin
I3C/DIM
SalivaStim

7. ARTEMISININ
• Inhibition of EBV and CMV
• Inhibition of TH1 responses
• Inhibition of Th17 responses
• Inhibition of B cell proliferation and autoantibody formation

8. SalivaStim
• Increase of water channel aquaporin-5 protein expression
• Increase of tear and saliva production

9. N-ACETYLCYSTEINE
• Optimization of TH1/2 and Th17 responses
• Antioxidant activity

10. I3C/DIM
• Optimization of Th1/2 response
• Protection of salivary and lacrimal glands from the
immunostimulatory effects of estrogens
• Anti-viral activity
• Protection of epithelial cells lining salivary and lacrimal glands

11. BLACK CURRANT SEED
OIL/KRILL OIL
• Normalization of TH1/TH2 responses
• Inhibition of inflammation

12. CORDYCEPS SINENSIS
• Optimization of TH1/TH2 responses
• Synergistic effect with Artemisinin

13. THE DOSAGE REGIMEN
• SalivaStim 1000mg in the AM &
500 – 1000mg at 3-4:00pm
• Black Currant Seed Oil 2000mg a day
• Krill Oil 2000mg a day
• Artemisinin 100 mg up to 600mg a day
• Cordyceps Sinensis 750 – 1500mg in the AM &
at 3 – 4:30pm
• N-Acetylcysteine up to 2400mg a day
• I3C/DIM up to 1600mg a day
• TMG Plus 600-1200mg in the AM

14. ADJUNCT THERAPY
Improvement of intestinal health
• Digestive enzymes
• Triphala
• Probiotics
• Prebiotics
• Leaky Gut Day,Night, Probiotics
Candida/yeast overgrowth
control
• Candidacillin
• Black Walnut Hulls
• Berberine