The document outlines an integrative approach to treating Sjögren’s syndrome, focusing on the key pathological mechanisms and the associated goals of therapy, such as improving dryness and normalizing autoimmune responses. It provides a list of remedies and supplements, including salivastim, black currant seed oil, and artemisinin, along with recommended dosages for each. Additionally, it addresses adjunct therapies aimed at improving intestinal health and controlling candida/yeast overgrowth.

1. SJOGREN’S SYNDROME
the ultimate
integrative approach
Alexander R Shikhman MD PhD FACR
Gluten Free Remedies

3. SJOGREN’S SYNDROME

4. SJOGREN’S SYNDROME
key pathologic mechanisms
• Reactivation of dormant viral infections, such as EBV and CMV
• TH1/TH2 imbalance with TH1 predominance
• Increased proliferation of Th17 cells
• Production of anti-SSA/Ro and anti-SSB/La autoantibodies
• Increased production muscarinic M3 receptor antibodies and
correspondent suppression of water channel protein aquaporin-5
• Decreased methylation of epithelial cells in exocrine gland

5. SJOGREN’S SYNDROME
goals of therapy
• Improve dryness
• Normalize autoimmune responses
• Prevent malignancies

6. THE ULTIMATE RECIPE
• Improve dryness
SalivaStim
Black Currant Seed Oil
Krill oil
• Normalize autoimmune responses
Artemisinin
Cordyceps Sinensis
N-Acetylcysteine
I3C/DIM
Black Currant Seed Oil
Krill Oil
• Normalize defective methylation
of epithelial cells
TMG Plus
• Prevent malignancies
Artemisinin
I3C/DIM
SalivaStim

7. ARTEMISININ
• Inhibition of EBV and CMV
• Inhibition of TH1 responses
• Inhibition of Th17 responses
• Inhibition of B cell proliferation and autoantibody formation

8. SalivaStim
• Increase of water channel aquaporin-5 protein expression
• Increase of tear and saliva production

9. N-ACETYLCYSTEINE
• Optimization of TH1/2 and Th17 responses
• Antioxidant activity

10. I3C/DIM
• Optimization of Th1/2 response
• Protection of salivary and lacrimal glands from the
immunostimulatory effects of estrogens
• Anti-viral activity
• Protection of epithelial cells lining salivary and lacrimal glands

11. BLACK CURRANT SEED
OIL/KRILL OIL
• Normalization of TH1/TH2 responses
• Inhibition of inflammation

12. CORDYCEPS SINENSIS
• Optimization of TH1/TH2 responses
• Synergistic effect with Artemisinin

13. THE DOSAGE REGIMEN
• SalivaStim 1000mg in the AM &
500 – 1000mg at 3-4:00pm
• Black Currant Seed Oil 2000mg a day
• Krill Oil 2000mg a day
• Artemisinin 100 mg up to 600mg a day
• Cordyceps Sinensis 750 – 1500mg in the AM &
at 3 – 4:30pm
• N-Acetylcysteine up to 2400mg a day
• I3C/DIM up to 1600mg a day
• TMG Plus 600-1200mg in the AM

14. ADJUNCT THERAPY
Improvement of intestinal health
• Digestive enzymes
• Triphala
• Probiotics
• Prebiotics
• Leaky Gut Day,Night, Probiotics
Candida/yeast overgrowth
control
• Candidacillin
• Black Walnut Hulls
• Berberine