Short bowel syndrome results from surgical resection, congenital defects, or loss of absorption in the small intestine that leads to malabsorption. It is characterized by an inability to maintain proper nutrient and fluid balance from diet alone due to less than 200 cm of remaining small intestine or extensive loss of absorptive surface area. Factors like the length and specific location of remaining intestine, loss of the ileocecal valve or colon, and existing malnutrition or disease can affect the course of short bowel syndrome. Diet modifications and intestinal adaptation aim to help patients manage the symptoms.