The document discusses the pathophysiology of shock. It defines shock and describes the types and stages of shock. The types of shock include hypovolemic, septic, cardiogenic, neurogenic, and anaphylactic shock. The stages are initial compensated shock, progressive decompensated shock, and decompensated irreversible shock. The mechanisms of shock involve reduced circulating volume and tissue anoxia. Management involves treating the underlying cause, restoring perfusion and oxygen delivery, and supportive care.
Pathogenesis and Medicolegal aspect of shock Soreingam Ragui
shock is one of the main cause of death very common encountered in day to day practice,in this presentation we look at how it happen,what are the causes and how we diagnose it in brief and its forensic importance
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
this presentation includes all the parts of shock. its definition classisfication, types of shock, pathophysiology, and additiionaly also includes clinical emergencies such as anaphylactic shock and syncope. hope this helps everyone.
Dr satyaki Verma
Dept of perio
shock is a Life threatening clinical syndrome of cardio-vascular collapse characterized by Hypotension and Hypoperfusion. If uncompensated, these mechanisms may lead to impaired cellular metabolism and death.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
shock is the state of insufficient blood flow to the tissues of the body .it contains introduction, definition, stages of shock, types of shock, diagnostic evaluation, prognosis ,prevention, care for each stage.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
Pathogenesis and Medicolegal aspect of shock Soreingam Ragui
shock is one of the main cause of death very common encountered in day to day practice,in this presentation we look at how it happen,what are the causes and how we diagnose it in brief and its forensic importance
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
this presentation includes all the parts of shock. its definition classisfication, types of shock, pathophysiology, and additiionaly also includes clinical emergencies such as anaphylactic shock and syncope. hope this helps everyone.
Dr satyaki Verma
Dept of perio
shock is a Life threatening clinical syndrome of cardio-vascular collapse characterized by Hypotension and Hypoperfusion. If uncompensated, these mechanisms may lead to impaired cellular metabolism and death.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
shock is the state of insufficient blood flow to the tissues of the body .it contains introduction, definition, stages of shock, types of shock, diagnostic evaluation, prognosis ,prevention, care for each stage.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
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Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
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Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
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Ethnobotany in herbal drug evaluation,
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Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
3. DEFINITION:
Shock is defined as a clinical state of cardiovascular collapse characterised by
an acute reduction of effective circulating bood volume; and an inadequate
perfusion of cells and tissues.
The end result is hypotension and celllar hypoxia and, if uncompensated,
may lead to impaired cellular metabolism and death. Shock may be of twomain
types:
i)Primary (initial) shock
ii) Secondary (true) shock
4. I)PRIMARY (INITIAL)SHOCK:
Itis transient and usually a benign vasovagal attack resulting from sudden
reduction of venous return to the heart caused by neurogenic vasodilation and
consequent peripheral pooling of blood. Itcan result immediately following
trauma, severe pain or emotional over reaction such as due to fear,sorrow or
surprise.
Clinically the patient generally develops unconsciousness, weakness, sinking
sensation, pale & clammy limbs, weak and rapid pulse, low blood pressure. The
attack usually lasts for a few seconds/minutes.
5. II)SECONDARY (TRUE)SHOCK:
This is the form of shock which occurs due to haemodynamic
dearrangements with hypoperfusion of the cells. This type of shock is the true
shock which is commonly referred to as “shock”
.
6. TYPES OF SHOCK:
Shock is classified as follows:
1. Hypovolaemic shock
2. Septic shock
3. Cardiogenic shock
4. Neurogenic shock
5. Anaphylactic shock
7. 1.HYPOVOLAEMIC SHOCK:
Reduction in blood volume induces hypovolaemic shock. The causes of
hypovolaemia include following:
i) Severe haemorrhage (external or internal)
e.g. Intrauma, surgery
ii) Fluid loss
e.g. Insevere burns, crush injury to a limb, persistent vomitings and severe
diarrhoea causing dehydration.
8. 2.SEPTIC SHOCK:
Severe bacterial infections or septicaemia induce septic shock.The
predominant causes are as under:
i) Gram-negative septicaemia (endotoxic shock):
e.g. Infection with E.coli, proteus, klebsiella, pseudomonasand bacteriodes.
Endotoxins of Gram-negative bacilli have been implicated as the most important
mediator of septic shock.
ii) Gram-positive septicaemia (exotoxic shock):
Itis less common
e.g. Infection with streptococci, pneumococci.
9. 3.CARDIOGENIC SHOCK:
Acute circulatory failure with sudden fall in cardiac output from acute diseases of the heart
without actual reduction of blood volume (normovolaemia) results in cardiogenic shock. The
causes include the following:
i) Deficient emptying:
e.g. Myocardial infection, rupture of the heart, cardiac arrhythmia.
ii) Deficient filling:
e.g. Cardiac tamponade from haemopericardium.
iii) Obstruction to theoutflow:
e.g. Pulmonary embolism, ball valve thrombus.
10. 4. NEUROGENIC SHOCK:
Itis caused by spinal cord injury, usually as a result of a traumatic accident or
injury. Italso arises due to damage to the central nervous system,which impairs
cardiac function by reducing heart rate and loosening the blood vessel tone,
resulting in severe hypotension.
11. 5.ANAPHYLACTIC SHOCK:
Itis a type of severe hypersensitivity or allergic reaction. Itscauses include
allergy to insect stings, medicines or foods (nuts,berries, sea foods) etc. Itis
caused by a severe reaction to an allergen, leading to the release of histaminethat
causes widespread vasodilation and hypotension.
12. MECHANISM/PATHOPHYSIOLOGY OF SHOCK:
There are two basic features in the mechanism of shock:
1.Reduced effective circulating volume.
2.Reduced supply of oxygen to the cells and tissues with resultant anoxia (tissue
anoxia).
1.Reduced effective circulating volume:
Itmay result by either of the following mechanisms:
i) Byactual loss of blood volume as occurs in hypovolaemic shock.
ii) Bydecreased cardiac output without actual loss of blood (normovolaemia) as
occurs in cardiogenic and septic shock.
13. CONTD...
2. Tissue anoxia:
Following reduction in the effective circulating blood volume, there is
decreased venous return to the heart resulting in decreased cardiac output.This
consequently causes reduced supply of oxygen to the organs and tissues and
hence tissue anoxia and shock ensues.
14. SEQUENTIAL EVENTS IN THE MECHANISM OF
SHOCK:
1. Decreased effective circulating blood volume
2. Decreased venous return to the heart
3. Decreased cardiac output
4. Decreased blood flow
5. Decreased supply of oxygen
6. Anoxia
7. Shock
15. STAGESOF SHOCK:
Deterioration of the circulation in shock is a progressive phenomenon and
can be divided into 3stages:
1. Non-progressive (initial, compensated, reversible)shock
2. Progressive decompensated shock
3. Decompensated (irreversible) shock
16. 1.NON-PROGRESSIVE (INITIAL, COMPENSATED,
REVERSIBLE) SHOCK:
Inthe early stage of shock, an attempt is made to maintain adequate cerebral
and coronary blood supply by redistribution of blood so that the vital organs (brain &
heart) are adequately perfused and oxygenated. This is achieved by activation of
various neurohumoral mechanisms causing “wide spread vasoconstriction” and by
“fluid conservation by the kidney”. Ifthe condition that caused the shock are
adequately treated, the compensatory mechanism may be able to bring about
recovery & re-establish the normal circulation; this is called compensated or reversible
shock. These compensatory mechanisms are:
i) Wide spread vasoconstriction
ii) Fluid conservation by the kidney
iii) Vascular autoregulation
17. I)WIDE SPREADVASOCONSTRICTION:
Inresponse to reduced blood flow (hypotension) and tissue anoxia, the
neural and humoral factors (e.g. Baroreceptors, chemoreceptors, catecholamines,
renin & VEM/vasoexcitor material from hypoxic kidney) are activated. All these
bring about vasoconstriction, particularly in the vessels of the skin and abdominal
viscera. Wide spread vasoconstriction is a protective mechanism as it causes
increased peripheral resistance, increased heart rate (tachycardia) and increased
BP.Clinically cutaneous vasoconstriction is responsible for cool and pale skin in
initial stage of shock.
18. II)FLUID CONSERVATION BY THE KIDNEY:
Inorder to compensate the actual loss of blood volume in hypovolaemic
shock, the following factors may assist in restoring the blood volume and improve
venous return to the heart:
• Release of aldosterone from hypoxic kidney.
• Release of ADH due to decreased effective circulating bloodvolume.
• Reduced GFR due to arteriolar constriction.
• Shifting of tissue fluids into the plasma due to lowered capillaryhydrostatic
pressure (hypotension).
20. 2.PROGRESSIVE DECOMPENSATED SHOCK:
This is a stage when the patient suffers from other stress or risk factors (e.g.
Pre-existing cardiovascular and lung disease) besides persistence of the shock so
that there is a progressive deterioration. The effects of progressive
decompensated shock due to tissue hypoperfusion are asfollows:
a) Pulmonary hypoperfusion with resultant tachypnoea and adult respiratory
distress syndrome.
b) Tissue anoxia causing anaerobic glycolysis results in metabolic lactic acidosis.
21. 3.DECOMPENSATED (IRREVERSIBLE) SHOCK:
When the shock is so severe that inspite of compensatory mechanisms and despite therapy
and control of etiologic agent which caused the shock, no recovery takes place, it iscalled
decompensated or irreversible shock. It’seffects due to widespread cell injury include the
following:
a) Progressive fall in the blood pressure due to deterioration in cardiac output attributedto
release of myocardial depressant factor (MDF).
b) Severe metabolic acidosis due to anaerobic glycolysis.
c) Respiratory distress due to pulmonary oedema, tachypnoea and adult respiratory distress
syndrome (ARDS).
d) Ischemic cell death of brain, heart and kidneys due to reduced blood supply tothese
organs.
22. CONTD...
Clinically, at this stage the patient has features of coma, worsened heart function and progressive
renal failure due to acute tubular necrosis.
A number of hypothesis or factors have been described in irreversibility of shock, with tissue
anoxia occupying the central role. These are as under:
• Persistence of widespread vasoconstriction.
• Vasodilation and increased vascular permeability.
• Myocardial ischemia and cerebral ischemia.
• Vasodepressor material (VDM) and tumour necrosis factor (TNF).
• Intestinal factor & bacterial factor.
• Hypercoagulability of blood.
23. MANAGEMENT OF SHOCK:
General principles of shock management:
1. The overall goal of shock management is to improve oxygen
delivery/utilisation inorder to prevent cellular and organinjury.
2. Effective therapy requires treatment of underlying etiology.
3. Restoration of adequate perfusion, monitoring and comprehensivesupportive
care.
4. Interventions to restore perfusion center on achieving an adequateblood,
increasing cardiac output and optimising oxygen content of theblood.
5. Oxygen demand should also be reduced.
24. MANAGEMENT OF HYPOVOLAEMIC SHOCK:
• Maximise oxygen delivery-completed by ensuring adequacy of ventilation,
increasing oxygen saturation of the blood and restoring blood flow.
• Control further blood loss.
• Fluid resuscitation.
• Also, the patient’s disposition should be rapidly and appropriately determined. It
may require multiple blood transfusions in severe cases. Innormal cases, it is treated
with fluids (saline).
• Drugs like antisecretory agents have vasoconstrictive properties and can reduce
blood flow to portal systems. E.g. Stomatostatin (zencil).
25. MANAGEMENT OF SEPTICSHOCK:
The most important aspects of medical therapy for patients with septic
shock/sepsis include:
• Adequate oxygen delivery.
• Crystalloid fluid administration-normal saline (0.9%NaCl), lactated ringer
,
plasmylate.
• Broad spectrum antibiotics-cefotaxim, clindamycin, ceftriaxone, ciprofloxacin,
metronidazole, cefepime, levofloxacin, vancomycin.
• Alpha and beta adrenergic agonists-nor epinephrine, dopamine, dobutamine,
epinephrine, vasopressin, phenylephrine.
• Corticosteroids like hydrocortisone, dexamethasone.
26. MANAGEMENT OF CARDIOGENICSHOCK:
Management of cardiogenic shock includes supportive measures:
• Oxygen therapy, judicious use of fluids with careful monitoring of central venous
pressure or pulmonary wedge pressure.
• Other monitoring should include continuous ECG, 12lead ECG, urine output, urea
and electrolytes & blood gases.
• Patient should be preferably managed in coronary care unit.
• Drugs like morphine 5-10mg i.v
.hepls to relieve pain and anxiety associated with
myocardial infarction. Inotropic support, vasodilators and mechanical support may
be needed.
27. MANAGEMENT OF NEUROGENICSHOCK:
Management of neurogenic shock involves:
• Restoring sympathetic tone: it would be either through the stabilisation of a spinal cord injury
or in the instance of spinal anaesthesia by positioning the patient appropriately.
• Immobilization: if the patient has a suspected case of spinal cord injury, a traction may be
needed to stabilize the spine to bring it to properalignment.
• IVfluids: administration of i.v
.fluids is done to stabilize the patient’s bloodpressure.
• Inotropic agents such as dopamine may be infused for fluid resuscitation.
• Atropine is given intravenously to manage severe bradycardia.
• Administration of low molecular weight heparin as prescribed may prevent thrombus
formation.
28. MANAGEMENT OF ANAPHYLACTIC SHOCK:
During an anaphylactic attack, cardiopulmonary resuscitation (CPR) may br
needed if breathing or heart beat is stopped. Medications given to anaphylactic
shock includes:
• Epinephrine (adrenaline) to reduce body’s allergic response.
• Oxygen, which helps in breathing.
• Intravenous (i.v
.)antihistamines and cortisone to reduce inflammation of air
passages and improve breathing.
• A beta agonist (e.g. Albuterol) to relieve breathingsymptoms.