This document discusses complexity science and its implications for decision making in healthcare systems. It contrasts linear, Newtonian thinking with an appreciation of complexity, uncertainty, and positive deviance. Tools are needed to address non-linear situations, such as minimum specifications, wicked questions, and generative relationships. Positive deviance identifies uncommon but successful practices within a community. Variation is unpredictable, and black swan events represent surprises that linear thinking cannot anticipate. A variety of references are provided to further explore these complexity-related concepts.