Por: Isabela Cuartas M III Semestre de Medicina Universidad Pontificia Bolivariana

1. Isabela Cuartas Márquez
III Semestre
Facultad de Medicina
2018-2

2. Is the most prevalent
metabolic disease that
affecting about 10%
women of reproductive
age worldwide

3. Cytotoxic T-Iymphocyte
associated protein 4
Regulate T cell
homeostasis and
peripheral immune
tolerance, inhibiting
T cell activation.
The role of CTLA4 gene in
the PCOS are yet to be
known

4. Investigate the role of
CTLA4 gene in
polycystic ovary
syndrome in the
Chinese Han women
population

5. • 290 pacientes
con SOP
• Control: 312
mujeres
Chinos de etnia Han
Extrajo 5mL de
sangre anticoagulada
Aislar y almacenar
ADN
PCR-DGGE

6. Amplificación
enzimática de una
secuencia de ADN
Replicación de una hebra
sencilla por una DNA
polimerasa a partir de un primer
Fundamento
La secuencia que
se amplifico fue

7. Separación de cadenas de
ADN de doble cadena,
dependiendo de su punto
de desnaturalización
Fundamento
Se alcanza una determinada
T, donde la molecula se
desnaturaliza total o
parcialmente

9. LINEA 1 LINEA 2 LINEA 3

13. AUTHOR CONTRIBUTION YES OR NO
Krishna MB, et al.
Moreover, reduced capability
of Treg generation has been
found to lead to PCOS in
humans and exposed PCOS
mouse model.
Franks S
And an autoimmune etiology
is suggested to be the
pathogenesis of PCOS
Becker M, et al.
Tregs are being made to treat
type 2 diabetes associated
with obesity.

14. In this investigation it was possible to
demostrate that the CTLA4 gene is involved
in the metabolics systems that as a
consequence gives obesity. This is one of the
symptoms of PCOS.
Also in this investigation it was shown
that the CTLA4 gene is involved in
insulin resistence, and high level of this
can produced PCOS.