Do you know the acronym VUCA? Yes, it's a trendy managerial acronym. It exists for more than 50 years but the acronym resonates in a different way since the Covid-19 outbreak. Are you ready to thrive in this VUCA world?
this is a study on Conscliouness about a circuit that I create that involves attention, awarness asn levels of consciousness.
it is describe more precisely i the book: Brain inspired cognitive systems 2008 [electronic book] / Amir Hussain ... [et al.], editors.
Lecture 2 in the COMP 4010 class on AR/VR. This lecture provides an overview of various VR technologies. It was taught by Gun Lee on July 31st, 2018, at the University of South Australia.
Do you know the acronym VUCA? Yes, it's a trendy managerial acronym. It exists for more than 50 years but the acronym resonates in a different way since the Covid-19 outbreak. Are you ready to thrive in this VUCA world?
this is a study on Conscliouness about a circuit that I create that involves attention, awarness asn levels of consciousness.
it is describe more precisely i the book: Brain inspired cognitive systems 2008 [electronic book] / Amir Hussain ... [et al.], editors.
Lecture 2 in the COMP 4010 class on AR/VR. This lecture provides an overview of various VR technologies. It was taught by Gun Lee on July 31st, 2018, at the University of South Australia.
Subscription costs versus open access costs, & Dissolving journals' boundariesAlex Holcombe
draft of talk for Reclaiming the Knowledge Commons http://www.eventbrite.com.au/e/reclaiming-the-knowledge-commons-the-ethics-of-academic-publishing-and-the-futures-of-research-tickets-17560178968
Our Scholarship System is Broke. Can Open Access Fix It?Alex Holcombe
Auckland talk24october openaccessweek.
"Broke" in the sense of ain't got no money because giving too much to publishers. And "Broke" in the sense of broken, e.g. not publishing replication studies.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Subscription costs versus open access costs, & Dissolving journals' boundariesAlex Holcombe
draft of talk for Reclaiming the Knowledge Commons http://www.eventbrite.com.au/e/reclaiming-the-knowledge-commons-the-ethics-of-academic-publishing-and-the-futures-of-research-tickets-17560178968
Our Scholarship System is Broke. Can Open Access Fix It?Alex Holcombe
Auckland talk24october openaccessweek.
"Broke" in the sense of ain't got no money because giving too much to publishers. And "Broke" in the sense of broken, e.g. not publishing replication studies.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
2. Adapted from:
Tse, P. U., Intriligator, J., Rivest, J., & Cavanagh, P. (2004).Attention and the subjective expansion of time. Perception & Psychophysics, 66(7), 1171–1189.
4. Holcombe, Kanwisher, & Treisman (2001)
When many impressions follow in excessively rapid succession in
time, although we may be distinctly aware that they occupy some
duration, and are not simultaneous, we may be quite at a loss to tell
which comes first and which last
!
-William James (1890)
single-shot cycling
5. Subjective timeV
P
R
S
V
P
R
S
V
P
?
On a timeline, one event succeeds another.
!
But that succession order may not be available /
reportable.
6. Succession order not always available/
reportable, so there are seemingly seamless
transitions in experience but we can’t
report what they are transitioning between.
!
RESPONSE
Fine, but consciousness at any one time is
unified.
!
E.g. when we perceive an object, and
experience its color, and its motion, we
should experience it as having a particular
color and motion.
unified visual experience of
motion and color
7. RESPONSE
Fine, but consciousness at any one time is
unified.
!
E.g. when we perceive an object, and
experience its color, and its motion, we
should experience it as having a particular
color and motion.
unified visual experience of
motion and color
NO?
Any two qualities should be experienced as
simultaneous or not-simultaneous.
!
Simultaneity experience unknown?
http://www.psych.usyd.edu.au/staff/alexh/research/colorMotionSimple/
12. 500 250 125 63 32 16
duration of half cycle (ms)
1 2 4 8 16 32
alternation rate, hertz (cycles per second)
form-color separated
motion-color
motion-motion T
global form-color
higher order motion
word recognition
acceleration, direction change
jump pink
instantaneous position
selection from R S V P
& other arbitrary ♪ ♪
flicker perception
first-order motion perception
depth from binocular disparity
local elements ➞ global form
edges and texture boundaries
binding motion-motion non-T
color-orientation, common location
L eye: R eye:
1 target
object
tracking
2 targets
3 targets
Local
analysis
V1,V2
Non-local
analysis
V4, LOC
words
selection,
tracking
Visual
cognition
Massively
parallel
Very low
capacity
13. Movie1_threeFlickerPhaseLimits.mov
Above the
slow limit
Above the flicker,
motion, etc. limit
•Succession of experiences may
not yield experience of
succession
•Multiple timelines?, even for
features of the same object
(color and motion)
Holcombe, A.O. (2013).The temporal organisation of perception. In The Oxford Handbook of Perceptual Organisation. Wagemans, J., ed.
Holcombe, A.O. (2009). Seeing slow and seeing fast:Two limits on human perception. Trends in Cognitive Science, 13(5), 216-21.
Problems with timeline metaphor
Big brain, big visual system. Multiple timescales
https://vimeo.com/100287188
