Life Sciences Library




   Searching Resources in Evidence-
           Based Medicine
                               Robin Featherstone, MLIS
                               Liaison Librarian (Medicine)
                               robin.featherstone@mcgill.ca
Winter 2012
Objectives

By the end of this lecture, you will be able to:

1. Describe the Evidence-Based Medicine (EBM)
   process
2. Formulate clinical questions using PICO
3. Locate best available medical evidence


                                                   2
Evidence-Based Medicine: The Process
                                                  Formulating
          Evaluating                              the clinical
          the Process                             question



                        Your patient for whom
                        you are uncertain about
                        therapy, diagnosis, or          Searching
  Incorporating         prognosis                       the
  evidence into                                         Evidence
  decision-
  making


                             Appraising
                             the Evidence
                                                                    LINK

                                                                       3
Patient Scenario
     Formulate a Clinical Question


Patient, Population, or Problem
Intervention
Comparison
Outcomes
Patient Scenario
              Clinical Scenario
You have been asked to review the practice guidelines
for treating warts. You are confident that cryotherapy
is the most effective treatment but a colleague
suggested some alternatives to investigate, including
duct tape.
Could duct tape be used for eliminating warts? Does
the literature provide evidence to support this
treatment?
Patient Scenario
          Clinical Question



                PICO

In patients with common warts, is duct tape as
effective as cryotherapy in eliminating warts?
What is the Evidence?

  Systematic Reviews
                   Case-control studies
 Randomized control trials
Cohort studies         Case reports
        Editorials
                       Animal research


 All types of articles found in MEDLINE
Question                         Best Evidence

           Cost-effectiveness               •Economic analyses

           Diagnosis                        •Diagnostic validation studies
                                            •Prospective studies / blind comparison to a gold standard
           Etiology                         •Randomized controlled trials
                                            •Case-control or cohort studies
                                            •Case series
           Prevention                       •Randomized controlled trials
                                            •Cohort studies, case control studies
                                            •Systematic reviews / meta-analyses

           Prognosis                        •Inception cohort studies
                                            •Case control studies
                                            •Case series
           Quality of life                  •Qualitative studies
           Therapy                          •Randomized controlled trials
                                            •Systematic reviews / meta-analyses
1   Heneghan, Carl, and Douglas Badenoch. Evidence-Based Medicine Toolkit. 2nd ed. Malden, Mass.: BMJ Books/Blackwell Pub., 2006.
2   Glover, Jan, and Lei Wang. Find it Fast: The Clinical Question : www.med.yale.edu/library/education/guides/screencasts/finditfast/finditfast_2/
Levels of Evidence
                               for Therapy Question

 Level of Evidence Type of Study

          1a             Systematic reviews of randomized controlled trials
                         (RCTs)
          1b             Individual RCTs with narrow confidence interval
          2a             Systematic reviews of cohort studies
          2b             Individual cohort studies and low-quality RCTs
          3a             Systematic reviews of case-control studies
          3b             Case-control studies
           4             Case series and poor quality cohort and case-control
                         studies
           5             Expert opinion

Levels of evidence (2001). Centre for Evidence Based Medicine. Retrieved 26 Aug 2008 from
            http://www.cebm.net/index.aspx?o=1025                                           9
Information Sources
              for Therapy Question
                            Synopsis
                               of
                            synthesis


          Summaries

                      Filtered




         1b        1a            1b          1a


    2b        2a                        2b        2a
                   Unfiltered

                       3b         3b
4             5                                   4    5
Criteria for Selecting an Information
                     Source
1.   Soundness of evidence-based approach
2.   Comprehensiveness and specificity
3.   Ease of use
4.   Availability
Information Sources
   for Therapy Question




          Filtered
Information Sources
   for Therapy Question




          Filtered
Information Sources
   for Therapy Question




          Filtered
Information Sources
   for Therapy Question




          Filtered
Information Sources
   for Therapy Question




          Filtered
Information Sources
   for Therapy Question




          Filtered




         Unfiltered
Information Sources
   for Therapy Question




         Unfiltered
Course Website


http://www.mcgill.ca/library/library-
findinfo/courses/guides/ebm_intro/




                                        19
http://m.library.mcgill.ca/healthsciguide/
Summary Quiz
1. UpToDate is a _______ resource. And Medline is
   a ________ resource.
2. The 5 stages in the EBM process are _______.
3. The best evidence to answer a therapy question
   is _______.
4. To find systematic reviews of RCTs use _______.
5. To evaluate a clinical topic page, look for
   _______.
                                            LINK
Life Sciences Library




               Questions

                               Robin Featherstone, MLIS
                               Liaison Librarian (Medicine)
                               robin.featherstone@mcgill.ca
Winter 2012

Searching EBM Resources

  • 1.
    Life Sciences Library Searching Resources in Evidence- Based Medicine Robin Featherstone, MLIS Liaison Librarian (Medicine) robin.featherstone@mcgill.ca Winter 2012
  • 2.
    Objectives By the endof this lecture, you will be able to: 1. Describe the Evidence-Based Medicine (EBM) process 2. Formulate clinical questions using PICO 3. Locate best available medical evidence 2
  • 3.
    Evidence-Based Medicine: TheProcess Formulating Evaluating the clinical the Process question Your patient for whom you are uncertain about therapy, diagnosis, or Searching Incorporating prognosis the evidence into Evidence decision- making Appraising the Evidence LINK 3
  • 4.
    Patient Scenario Formulate a Clinical Question Patient, Population, or Problem Intervention Comparison Outcomes
  • 5.
    Patient Scenario Clinical Scenario You have been asked to review the practice guidelines for treating warts. You are confident that cryotherapy is the most effective treatment but a colleague suggested some alternatives to investigate, including duct tape. Could duct tape be used for eliminating warts? Does the literature provide evidence to support this treatment?
  • 6.
    Patient Scenario Clinical Question PICO In patients with common warts, is duct tape as effective as cryotherapy in eliminating warts?
  • 7.
    What is theEvidence? Systematic Reviews Case-control studies Randomized control trials Cohort studies Case reports Editorials Animal research All types of articles found in MEDLINE
  • 8.
    Question Best Evidence Cost-effectiveness •Economic analyses Diagnosis •Diagnostic validation studies •Prospective studies / blind comparison to a gold standard Etiology •Randomized controlled trials •Case-control or cohort studies •Case series Prevention •Randomized controlled trials •Cohort studies, case control studies •Systematic reviews / meta-analyses Prognosis •Inception cohort studies •Case control studies •Case series Quality of life •Qualitative studies Therapy •Randomized controlled trials •Systematic reviews / meta-analyses 1 Heneghan, Carl, and Douglas Badenoch. Evidence-Based Medicine Toolkit. 2nd ed. Malden, Mass.: BMJ Books/Blackwell Pub., 2006. 2 Glover, Jan, and Lei Wang. Find it Fast: The Clinical Question : www.med.yale.edu/library/education/guides/screencasts/finditfast/finditfast_2/
  • 9.
    Levels of Evidence for Therapy Question Level of Evidence Type of Study 1a Systematic reviews of randomized controlled trials (RCTs) 1b Individual RCTs with narrow confidence interval 2a Systematic reviews of cohort studies 2b Individual cohort studies and low-quality RCTs 3a Systematic reviews of case-control studies 3b Case-control studies 4 Case series and poor quality cohort and case-control studies 5 Expert opinion Levels of evidence (2001). Centre for Evidence Based Medicine. Retrieved 26 Aug 2008 from http://www.cebm.net/index.aspx?o=1025 9
  • 10.
    Information Sources for Therapy Question Synopsis of synthesis Summaries Filtered 1b 1a 1b 1a 2b 2a 2b 2a Unfiltered 3b 3b 4 5 4 5
  • 11.
    Criteria for Selectingan Information Source 1. Soundness of evidence-based approach 2. Comprehensiveness and specificity 3. Ease of use 4. Availability
  • 12.
    Information Sources for Therapy Question Filtered
  • 13.
    Information Sources for Therapy Question Filtered
  • 14.
    Information Sources for Therapy Question Filtered
  • 15.
    Information Sources for Therapy Question Filtered
  • 16.
    Information Sources for Therapy Question Filtered
  • 17.
    Information Sources for Therapy Question Filtered Unfiltered
  • 18.
    Information Sources for Therapy Question Unfiltered
  • 19.
  • 20.
  • 21.
    Summary Quiz 1. UpToDateis a _______ resource. And Medline is a ________ resource. 2. The 5 stages in the EBM process are _______. 3. The best evidence to answer a therapy question is _______. 4. To find systematic reviews of RCTs use _______. 5. To evaluate a clinical topic page, look for _______. LINK
  • 22.
    Life Sciences Library Questions Robin Featherstone, MLIS Liaison Librarian (Medicine) robin.featherstone@mcgill.ca Winter 2012

Editor's Notes

  • #20 Remind them about the room that they are in.
  • #21 Show them the page, what it offers for each resource.