Background: Many new brands of Hyaluronic acid (HA) fillers are being produced, and the longevity and safety are always major concern about HA fillers.
Objective: To evaluate the efficacy, tolerability, and safety of touch-up treatment of a HA filler, Elravie® deep line which is used for correcting nasolabial folds (NLFs).
Methods: The rheological property values of HA fillers were measured using a rheometer.A total of 50 subjects with visible NLFs were enrolled in this clinical study and were divided into test and control groups. All subjects were injected with same amount of HA in both NLFs and only the test group had touch-up treatment after 9 months of first injection. All participants were then reassessed for cosmetic changes using Wrinkle Severity Rating Scale (WSRS) and Global aesthetic improvement scale (GAIS).
This study compared the analgesic efficacy of preemptive oral ketorolac with submucous tramadol (Group A) versus oral ketorolac with submucous placebo (Group B) for impacted mandibular third molar surgery. 40 patients received each treatment in a double-blind, split-mouth study. Group A reported significantly lower pain intensity scores from 1-12 hours post-op and had a longer pain-free interval compared to Group B. Group A also required less postoperative analgesics in the first 24 hours. While Group A reported more headaches, nausea and local reactions, preemptive oral ketorolac with tramadol provided superior pain relief after third molar surgery compared to
EFFICACY OF TRANSDERMAL PATCHES IN THE MANAGEMENT OF POSTOPERATIVE PAIN: AN O...DrHeena tiwari
This study compared the efficacy of a single 100mg transdermal diclofenac patch to a single 75mg intramuscular diclofenac injection for managing postoperative pain in 30 patients who underwent maxillofacial surgery. Patients were randomly assigned to receive either the patch or injection. Pain levels were assessed at various timepoints using a visual analogue scale. The results found that the patch provided longer lasting analgesia (15 hours on average) compared to the injection (9 hours), and fewer patients in the patch group required rescue pain medication. No local complications occurred with the patch. The study concluded that a single diclofenac patch was more effective than intramuscular diclofenac for managing immediate postoperative pain
This study systematically reviewed clinical evidence on the use of small and large gel particle hyaluronic acid dermal fillers for soft tissue augmentation. The review found:
1) High-quality randomized controlled trials demonstrated the effectiveness and safety of these fillers for treating nasolabial folds.
2) Good evidence from some randomized trials showed these fillers were effective for lips, oral commissures, and glabella, though data was more limited.
3) Lower-level case reports and case series suggested effectiveness in other areas like the nose and cheeks, but required more research.
Impact of Drains on the Postoperative Sequel Following Third Molar Surgery: A...DrHeena tiwari
This document summarizes a study that assessed the impact of rubber drains on postoperative outcomes following third molar surgery. The study involved 60 patients who underwent bilateral third molar removal, with a drain placed on one side but not the other. Parameters like pain, swelling, trismus and infections were evaluated and compared between sides. The results found no significant differences between sides in any parameter, suggesting drains do not provide benefits. While some past studies found drains reduced sequelae, this study's findings did not support positive effects of drains on postoperative recovery from third molar surgery.
EFFICACY OF FIXED VERSUS REMOVAL RETAINER POST ORTHODONTIC TREATMENT: A COMP...DrHeena tiwari
This study compared the efficacy of fixed versus removable retainers for maintaining orthodontic treatment outcomes over 4 years. 48 participants from an original randomized controlled trial were evaluated. Those with fixed retainers had lower irregularity scores on average (0.85mm increase) compared to removable retainers (1.47mm increase). After adjusting for confounding factors, the difference in irregularity between groups was statistically significant, with removable retainers having 1.64mm more irregularity on average. No other significant differences were found between groups for other metrics like inter-canine width. Compliance with removable retainers decreased over time. Fixed retainers maintained their position better, though some required repair. In conclusion, fixed retainers appeared to
This study compared the analgesic efficacy of preemptive oral ketorolac with submucous tramadol (Group A) versus oral ketorolac with submucous placebo (Group B) for impacted mandibular third molar surgery. 40 patients received each treatment in a double-blind, split-mouth study. Group A reported significantly lower pain intensity scores from 1-12 hours post-op and had a longer pain-free interval compared to Group B. Group A also required less postoperative analgesics in the first 24 hours. While Group A reported more headaches, nausea and local reactions, preemptive oral ketorolac with tramadol provided superior pain relief after third molar surgery compared to
EFFICACY OF TRANSDERMAL PATCHES IN THE MANAGEMENT OF POSTOPERATIVE PAIN: AN O...DrHeena tiwari
This study compared the efficacy of a single 100mg transdermal diclofenac patch to a single 75mg intramuscular diclofenac injection for managing postoperative pain in 30 patients who underwent maxillofacial surgery. Patients were randomly assigned to receive either the patch or injection. Pain levels were assessed at various timepoints using a visual analogue scale. The results found that the patch provided longer lasting analgesia (15 hours on average) compared to the injection (9 hours), and fewer patients in the patch group required rescue pain medication. No local complications occurred with the patch. The study concluded that a single diclofenac patch was more effective than intramuscular diclofenac for managing immediate postoperative pain
This study systematically reviewed clinical evidence on the use of small and large gel particle hyaluronic acid dermal fillers for soft tissue augmentation. The review found:
1) High-quality randomized controlled trials demonstrated the effectiveness and safety of these fillers for treating nasolabial folds.
2) Good evidence from some randomized trials showed these fillers were effective for lips, oral commissures, and glabella, though data was more limited.
3) Lower-level case reports and case series suggested effectiveness in other areas like the nose and cheeks, but required more research.
Impact of Drains on the Postoperative Sequel Following Third Molar Surgery: A...DrHeena tiwari
This document summarizes a study that assessed the impact of rubber drains on postoperative outcomes following third molar surgery. The study involved 60 patients who underwent bilateral third molar removal, with a drain placed on one side but not the other. Parameters like pain, swelling, trismus and infections were evaluated and compared between sides. The results found no significant differences between sides in any parameter, suggesting drains do not provide benefits. While some past studies found drains reduced sequelae, this study's findings did not support positive effects of drains on postoperative recovery from third molar surgery.
EFFICACY OF FIXED VERSUS REMOVAL RETAINER POST ORTHODONTIC TREATMENT: A COMP...DrHeena tiwari
This study compared the efficacy of fixed versus removable retainers for maintaining orthodontic treatment outcomes over 4 years. 48 participants from an original randomized controlled trial were evaluated. Those with fixed retainers had lower irregularity scores on average (0.85mm increase) compared to removable retainers (1.47mm increase). After adjusting for confounding factors, the difference in irregularity between groups was statistically significant, with removable retainers having 1.64mm more irregularity on average. No other significant differences were found between groups for other metrics like inter-canine width. Compliance with removable retainers decreased over time. Fixed retainers maintained their position better, though some required repair. In conclusion, fixed retainers appeared to
Abstract—Scarring is a well recognized sequel of acne. Because of the prevalence of acne scarring and strong negative emotions it engendering affected patients, several approaches have been developed for its treatment with varying success rates. Glycolic acid 50% peels and Salicylic acid 30% Peels are classified as superficial peel and are consider safe in Indian patients. While chemical peels are widely being used in India for various indications. There is a paucity of published studies on the efficacy of chemical peel specifically for acne scars in Indian patients.
Purpose of this study was to evaluate and compare the effectively of these two agents in the treatment of acne scars. Eighty cooperative patients[≥18 years age]with predominantly moderately atrophic acne scarring were randomly divided into 2groups of 40each.Patients of group A received Glycolic acid peels and patients in group B, Salicylic acid was used at 3weeks interval for four sessions. Objective evaluations of treatment response. Subjective assessments of treatment response were also done separately by the researcher, an independent observer and the patients separately.
Both of agents led to significant reduction in the total acne scar score[p< 0.05]but no significant difference was noted between the two peels. Side effects were lesser with Salicylic acid peel.
Hence conclusion was drawn that both 50% Glycolic acid and 30% Salicylic acid peels are safe in Indian skin and equally effective in the treatment of mild to moderate acne scarring.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Module 4 Submodule 4. 2 Final June 2007Flavio Guzmán
The document discusses key considerations for clinicians in evaluating the results of drug clinical trials. It emphasizes the importance of critically assessing trial design, results, and whether the findings warrant changing clinical practice. Clinicians are advised to consider factors like trial methodology, potential biases, statistical/clinical significance, applicability to their patients, and safety. The document provides guidance on how to distinguish high-quality trials that produce useful results for patient care.
priyank-shah-skn-medical-college-and-general-hospital-indiaDr.Priyank shah
The document discusses drug induced contact dermatitis. It notes that contact dermatitis is a common skin reaction to drugs, especially topical medications like antiseptics, antibiotics, steroids, and NSAIDs. The study aimed to identify the most common culprit medications and clinical presentations in patients diagnosed with drug induced contact dermatitis. It found that antiseptics like povidone iodine and NSAIDs like diclofenac gel were most frequently responsible. Most cases were mild to moderately severe and preventable with modified treatment plans.
This document discusses non-surgical therapy for periodontal disease. It covers the objectives of plaque control and scaling and root planing, which is the gold standard of non-surgical periodontal therapy. It also discusses outcomes of non-surgical therapy such as reductions in pocket depth and clinical attachment levels, as well as changes to microflora and radiographic bone levels. Limitations of non-surgical therapy are outlined, as well as factors that influence treatment effectiveness like disease severity and the skill of the clinician. The role of adjunctive treatments like systemic antibiotics and full mouth disinfection are also summarized.
Kinesiology tape in comparison with oral diclofenac sodium in reducing swelli...Ziad Hazim Delemi
This study compared the effectiveness of Kinesiology tape and oral Diclofenac sodium (Voltarin) tablets in reducing swelling after surgical removal of lower wisdom teeth. Thirty patients were divided into two groups - one received Kinesiology tape applied for 7 days, the other received Voltarin tablets three times daily for 7 days. Facial swelling was measured on the first, third and seventh days post-operation. The results showed a statistically significant difference in swelling between the groups on the first, third and seventh days, with the Voltarin group experiencing greater swelling. The study concluded that Kinesiology tape was nearly as effective as Voltarin tablets in reducing post-operative swelling.
This document discusses a study examining the relationship between repair efficiency and response to PUVA therapy in vitiligo patients. The study assessed DNA damage and repair ability in 77 vitiligo patients and 30 healthy controls using comet assays and malonaldehyde levels. Patients showed significantly higher DNA damage and malonaldehyde levels than controls. When categorized as fast or slow responders based on treatment response time, slow responders exhibited significantly higher residual DNA damage after repair, suggesting variation in DNA repair efficiency correlates with PUVA treatment response. This is the first study to investigate how an individual's DNA repair ability may influence their response to PUVA therapy for vitiligo.
This document discusses different types of intradermal fillers used for minimally invasive treatment of facial aging. It categorizes fillers as biodegradable and non-permanent (such as collagen and hyaluronic acid), semi-permanent (such as poly methyl methacrylate and poly-L-lactic acid), and permanent (such as silicone). The document reviews various commercial products made from these materials and their effectiveness in treating facial aging by filling volume loss and smoothing lines and wrinkles. Skin testing is important for fillers from animal sources to check for allergic reactions.
Clinical and radiographic evaluation of one and two-visit eCharles Pereira
This randomized clinical trial compared the 1-year and 2-year clinical and radiographic outcomes of one-visit versus two-visit endodontic treatment of asymptomatic teeth with necrotic pulps and apical periodontitis. 101 teeth were randomly assigned to receive either one-visit treatment, which included intracanal dressing with iodine-potassium-iodide for 10 minutes, or standard two-visit treatment with calcium hydroxide dressing. At 1 and 2 years, there was no statistically significant difference in healing rates between the one-visit (65% and 75% healed) and two-visit (60% and 75% healed) groups. Teeth that tested negative on post-treatment microbiological samples
Systematic reviews of complementary therapies – an annotated bibliography. Pa...home
Complementary therapies are widespread but controversial. We aim to provide a
comprehensive collection and a summary of systematic reviews of clinical trials in three major
complementary therapies (acupuncture, herbal medicine, homeopathy). This article is dealing with
homeopathy. Potentially relevant reviews were searched through the register of the Cochrane
Complementary Medicine Field, the Cochrane Library, Medline, and bibliographies of articles and
books. To be included articles had to review prospective clinical trials of homeopathy; had to
describe review methods explicitly; had to be published; and had to focus on treatment effects.
Information on conditions, interventions, methods, results and conclusions was extracted using a
pretested form and summarized descriptively.
Mandibular Degree II Furcation Defects Treatment With Platelet-Rich Fibrin an...Dr Ripunjay Tripathi
journal club Mandibular Degree II Furcation Defects Treatment With Platelet-Rich Fibrin and 1% Alendronate Gel Combination: A Randomized Controlled Clinical Trial
Marginal and Internal Fit of Different Fixed Dental Prostheses: A Comparative...DrHeena tiwari
This study compared five methods for assessing the marginal and internal fit of fixed dental prostheses: the cross-sectional method, silicone replica technique, triple scan method, micro-computed tomography, and optical coherence tomography. Measurements of the marginal gap, axial gap, angle gap, and occlusal gap found statistically significant differences between the methods. The cross-sectional method and silicone replica technique showed the lowest mean values and were the most similar, while the triple scan method and optical coherence tomography also showed similarities. The study concluded that while fit values may fall within clinically acceptable ranges, differences between assessment methods should be considered.
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
This case report describes the successful treatment of desquamative gingivitis in a 52-year-old female patient using systemic antioxidant therapy. Desquamative gingivitis causes red, eroded patches on the gums. While topical steroids provided no improvement, taking an herbal antioxidant capsule containing extracts of various plants twice daily for two months resolved the lesions with no recurrence. Antioxidants can reduce oxidative damage and inflammation, providing an alternative to steroids for treating desquamative gingivitis.
journal club - scar revision with laser and narrowband intensed pulsed lightMalaM67
The document summarizes a study assessing the efficacy and safety of combined CO2-IPL and single light IPL in treating hypertrophic scars. 138 patients with hypertrophic scars were randomized to receive either 3 sessions of combined CO2-IPL or single light IPL treatment with a 3 month follow up. Results showed that the combined CO2-IPL treatment was more effective at improving scar characteristics according to POSAS scores. 100% of patients treated with CO2-IPL expressed satisfaction with outcomes compared to 84% for single light IPL. The study concludes that combined CO2-IPL therapy provides significant improvement in scar assessment and is a safe alternative for multi-photoelectric scar treatment.
Ewma 2014 ep399 results of a pilot, randomised, controlled clinical trial o...EWMA
This pilot study compared the efficacy of two antimicrobial foam dressings, Kendall AMDTM and Allevyn AgTM, in reducing the size of hard-to-heal chronic venous leg ulcers over 12 weeks. Results showed that 11 of 32 patients healed within 12 weeks, with 7 in the Kendall AMDTM group and 4 in the Allevyn AgTM group. Bacterial bioburden was reduced in 8 patients. While wound biochemistry and factors like pain, odor and exudate levels were measured, there were no significant differences observed between the treatment groups. The study provides preliminary evidence that Kendall AMDTM foam dressing can effectively manage hard-to-heal leg ulcers. Further research is needed to
A Randomized, Split-Face, Histomorphologic Study Comparing a Volumetric Calci...kpyu
Soft-tissue augmentation with dermal fillers is a popular, minimally invasive aesthetic procedure. In 2012, in the USA, most non-surgical augmentation treatments performed with a dermal filler used a product based on hyaluronic acid (HA), with the second most popular type being the calcium hydroxylapatite (CaHA)-based filler, Radiesse® (Merz Pharmaceuticals GmbH, Frankfurt, Germany), hereafter referred to as CaHA gel matrix.
Assessment of skin physiology change and safety after intradermal injections ...Felix J. Tapia
This randomized, double-blind, split-face study investigated the efficacy and safety of intradermal botulinum toxin (BTX) injections for reducing facial erythema in patients with rosacea. Twenty-four participants received intradermal injections of BTX in one cheek and a placebo in the other cheek. Outcomes including erythema, skin properties, and safety were assessed at regular intervals. The results showed that the BTX-treated side had significantly reduced erythema and improved skin elasticity and hydration compared to the placebo side. No significant safety issues were reported. The study demonstrates that intradermal BTX injections can effectively reduce facial erythema and rejuvenate skin in rosace
Abstract—Scarring is a well recognized sequel of acne. Because of the prevalence of acne scarring and strong negative emotions it engendering affected patients, several approaches have been developed for its treatment with varying success rates. Glycolic acid 50% peels and Salicylic acid 30% Peels are classified as superficial peel and are consider safe in Indian patients. While chemical peels are widely being used in India for various indications. There is a paucity of published studies on the efficacy of chemical peel specifically for acne scars in Indian patients.
Purpose of this study was to evaluate and compare the effectively of these two agents in the treatment of acne scars. Eighty cooperative patients[≥18 years age]with predominantly moderately atrophic acne scarring were randomly divided into 2groups of 40each.Patients of group A received Glycolic acid peels and patients in group B, Salicylic acid was used at 3weeks interval for four sessions. Objective evaluations of treatment response. Subjective assessments of treatment response were also done separately by the researcher, an independent observer and the patients separately.
Both of agents led to significant reduction in the total acne scar score[p< 0.05]but no significant difference was noted between the two peels. Side effects were lesser with Salicylic acid peel.
Hence conclusion was drawn that both 50% Glycolic acid and 30% Salicylic acid peels are safe in Indian skin and equally effective in the treatment of mild to moderate acne scarring.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Module 4 Submodule 4. 2 Final June 2007Flavio Guzmán
The document discusses key considerations for clinicians in evaluating the results of drug clinical trials. It emphasizes the importance of critically assessing trial design, results, and whether the findings warrant changing clinical practice. Clinicians are advised to consider factors like trial methodology, potential biases, statistical/clinical significance, applicability to their patients, and safety. The document provides guidance on how to distinguish high-quality trials that produce useful results for patient care.
priyank-shah-skn-medical-college-and-general-hospital-indiaDr.Priyank shah
The document discusses drug induced contact dermatitis. It notes that contact dermatitis is a common skin reaction to drugs, especially topical medications like antiseptics, antibiotics, steroids, and NSAIDs. The study aimed to identify the most common culprit medications and clinical presentations in patients diagnosed with drug induced contact dermatitis. It found that antiseptics like povidone iodine and NSAIDs like diclofenac gel were most frequently responsible. Most cases were mild to moderately severe and preventable with modified treatment plans.
This document discusses non-surgical therapy for periodontal disease. It covers the objectives of plaque control and scaling and root planing, which is the gold standard of non-surgical periodontal therapy. It also discusses outcomes of non-surgical therapy such as reductions in pocket depth and clinical attachment levels, as well as changes to microflora and radiographic bone levels. Limitations of non-surgical therapy are outlined, as well as factors that influence treatment effectiveness like disease severity and the skill of the clinician. The role of adjunctive treatments like systemic antibiotics and full mouth disinfection are also summarized.
Kinesiology tape in comparison with oral diclofenac sodium in reducing swelli...Ziad Hazim Delemi
This study compared the effectiveness of Kinesiology tape and oral Diclofenac sodium (Voltarin) tablets in reducing swelling after surgical removal of lower wisdom teeth. Thirty patients were divided into two groups - one received Kinesiology tape applied for 7 days, the other received Voltarin tablets three times daily for 7 days. Facial swelling was measured on the first, third and seventh days post-operation. The results showed a statistically significant difference in swelling between the groups on the first, third and seventh days, with the Voltarin group experiencing greater swelling. The study concluded that Kinesiology tape was nearly as effective as Voltarin tablets in reducing post-operative swelling.
This document discusses a study examining the relationship between repair efficiency and response to PUVA therapy in vitiligo patients. The study assessed DNA damage and repair ability in 77 vitiligo patients and 30 healthy controls using comet assays and malonaldehyde levels. Patients showed significantly higher DNA damage and malonaldehyde levels than controls. When categorized as fast or slow responders based on treatment response time, slow responders exhibited significantly higher residual DNA damage after repair, suggesting variation in DNA repair efficiency correlates with PUVA treatment response. This is the first study to investigate how an individual's DNA repair ability may influence their response to PUVA therapy for vitiligo.
This document discusses different types of intradermal fillers used for minimally invasive treatment of facial aging. It categorizes fillers as biodegradable and non-permanent (such as collagen and hyaluronic acid), semi-permanent (such as poly methyl methacrylate and poly-L-lactic acid), and permanent (such as silicone). The document reviews various commercial products made from these materials and their effectiveness in treating facial aging by filling volume loss and smoothing lines and wrinkles. Skin testing is important for fillers from animal sources to check for allergic reactions.
Clinical and radiographic evaluation of one and two-visit eCharles Pereira
This randomized clinical trial compared the 1-year and 2-year clinical and radiographic outcomes of one-visit versus two-visit endodontic treatment of asymptomatic teeth with necrotic pulps and apical periodontitis. 101 teeth were randomly assigned to receive either one-visit treatment, which included intracanal dressing with iodine-potassium-iodide for 10 minutes, or standard two-visit treatment with calcium hydroxide dressing. At 1 and 2 years, there was no statistically significant difference in healing rates between the one-visit (65% and 75% healed) and two-visit (60% and 75% healed) groups. Teeth that tested negative on post-treatment microbiological samples
Systematic reviews of complementary therapies – an annotated bibliography. Pa...home
Complementary therapies are widespread but controversial. We aim to provide a
comprehensive collection and a summary of systematic reviews of clinical trials in three major
complementary therapies (acupuncture, herbal medicine, homeopathy). This article is dealing with
homeopathy. Potentially relevant reviews were searched through the register of the Cochrane
Complementary Medicine Field, the Cochrane Library, Medline, and bibliographies of articles and
books. To be included articles had to review prospective clinical trials of homeopathy; had to
describe review methods explicitly; had to be published; and had to focus on treatment effects.
Information on conditions, interventions, methods, results and conclusions was extracted using a
pretested form and summarized descriptively.
Mandibular Degree II Furcation Defects Treatment With Platelet-Rich Fibrin an...Dr Ripunjay Tripathi
journal club Mandibular Degree II Furcation Defects Treatment With Platelet-Rich Fibrin and 1% Alendronate Gel Combination: A Randomized Controlled Clinical Trial
Marginal and Internal Fit of Different Fixed Dental Prostheses: A Comparative...DrHeena tiwari
This study compared five methods for assessing the marginal and internal fit of fixed dental prostheses: the cross-sectional method, silicone replica technique, triple scan method, micro-computed tomography, and optical coherence tomography. Measurements of the marginal gap, axial gap, angle gap, and occlusal gap found statistically significant differences between the methods. The cross-sectional method and silicone replica technique showed the lowest mean values and were the most similar, while the triple scan method and optical coherence tomography also showed similarities. The study concluded that while fit values may fall within clinically acceptable ranges, differences between assessment methods should be considered.
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
This case report describes the successful treatment of desquamative gingivitis in a 52-year-old female patient using systemic antioxidant therapy. Desquamative gingivitis causes red, eroded patches on the gums. While topical steroids provided no improvement, taking an herbal antioxidant capsule containing extracts of various plants twice daily for two months resolved the lesions with no recurrence. Antioxidants can reduce oxidative damage and inflammation, providing an alternative to steroids for treating desquamative gingivitis.
journal club - scar revision with laser and narrowband intensed pulsed lightMalaM67
The document summarizes a study assessing the efficacy and safety of combined CO2-IPL and single light IPL in treating hypertrophic scars. 138 patients with hypertrophic scars were randomized to receive either 3 sessions of combined CO2-IPL or single light IPL treatment with a 3 month follow up. Results showed that the combined CO2-IPL treatment was more effective at improving scar characteristics according to POSAS scores. 100% of patients treated with CO2-IPL expressed satisfaction with outcomes compared to 84% for single light IPL. The study concludes that combined CO2-IPL therapy provides significant improvement in scar assessment and is a safe alternative for multi-photoelectric scar treatment.
Ewma 2014 ep399 results of a pilot, randomised, controlled clinical trial o...EWMA
This pilot study compared the efficacy of two antimicrobial foam dressings, Kendall AMDTM and Allevyn AgTM, in reducing the size of hard-to-heal chronic venous leg ulcers over 12 weeks. Results showed that 11 of 32 patients healed within 12 weeks, with 7 in the Kendall AMDTM group and 4 in the Allevyn AgTM group. Bacterial bioburden was reduced in 8 patients. While wound biochemistry and factors like pain, odor and exudate levels were measured, there were no significant differences observed between the treatment groups. The study provides preliminary evidence that Kendall AMDTM foam dressing can effectively manage hard-to-heal leg ulcers. Further research is needed to
A Randomized, Split-Face, Histomorphologic Study Comparing a Volumetric Calci...kpyu
Soft-tissue augmentation with dermal fillers is a popular, minimally invasive aesthetic procedure. In 2012, in the USA, most non-surgical augmentation treatments performed with a dermal filler used a product based on hyaluronic acid (HA), with the second most popular type being the calcium hydroxylapatite (CaHA)-based filler, Radiesse® (Merz Pharmaceuticals GmbH, Frankfurt, Germany), hereafter referred to as CaHA gel matrix.
Assessment of skin physiology change and safety after intradermal injections ...Felix J. Tapia
This randomized, double-blind, split-face study investigated the efficacy and safety of intradermal botulinum toxin (BTX) injections for reducing facial erythema in patients with rosacea. Twenty-four participants received intradermal injections of BTX in one cheek and a placebo in the other cheek. Outcomes including erythema, skin properties, and safety were assessed at regular intervals. The results showed that the BTX-treated side had significantly reduced erythema and improved skin elasticity and hydration compared to the placebo side. No significant safety issues were reported. The study demonstrates that intradermal BTX injections can effectively reduce facial erythema and rejuvenate skin in rosace
The document discusses factors related to stability and retention in class II division 1 malocclusions. It covers 3 main topics: 1) The relationship between stability and extraction patterns, finding that nonextraction and premolar extraction have similar long-term stability. 2) The relationship between treatment mechanics and stability, finding stability with functional appliances, Herbst, Twin Force Bite Corrector. 3) Surgical vs conventional treatment, finding functional appliances and surgery have similar stable results, though surgery has more vertical relapse. Relapse is multifactorial and can be reduced by ensuring proper occlusion, avoiding overcorrection of lower incisors, and continued retention as needed.
This study compared the effectiveness of hydroplasty versus intra-articular steroid injection for the treatment of idiopathic frozen shoulder. The study included 50 patients divided into two groups. The hydroplasty group showed significantly greater improvement in pain, shoulder function and range of motion compared to the steroid injection group at the 1 month and 3 month follow ups. Hydroplasty was found to be a more effective treatment for idiopathic frozen shoulder than intra-articular steroid injection alone.
Evidence regarding functional appliance treatment of class ii malocclusionMohanad Elsherif
The document summarizes current evidence from studies on different approaches to treating class II malocclusions, including:
1) Early treatment vs one-phase treatment during adolescence. High quality studies show early treatment does not provide advantages over one-phase adolescent treatment.
2) Treatment during adolescence with functional appliances or headgear vs untreated controls. Functional appliances are effective at reducing overjet but do not fully correct skeletal discrepancies.
3) Incremental vs maximum advancement with functional appliances. High quality studies found no advantages of one approach over the other.
This document discusses a panel of wound care experts that convened to review evidence and develop recommendations for the use of hypochlorous acid (HOCl) solutions to prevent and treat wound infections. The panel found that HOCl has promising antimicrobial properties without cytotoxicity based on in vitro studies. There is moderate evidence that HOCl is effective for resolving infection and improving healing in diabetic foot wounds. The panel recommended HOCl be used as an adjunct to standard wound care practices like debridement and that it be applied directly to the wound for 15 minutes after debridement. More clinical studies are still needed to evaluate HOCl's safety and efficacy for other wound types and application methods.
http://www.penetran.com | Penetran+Plus continues to grow in popularity because our users tell us and their neighbors that unlike other topical lotions Penetran+Plus can be used on everything from arthritis, tendinitis, bursitis and muscle aches and pains. We also get many reports on how Penetran+Plus reduces inflammation and pain from burns, bites, bruises, stings and abrasions.
Penetran+Plus is also pharmacist recommended among topical lotions for the temporary relief of aches and pains associated with arthritis.
Penetran+Plus works differently than other topical lotions and pain relievers which distract from the pain with hot or cold ingredients. Its primary active ingredients are quaternary ammonium compounds which have a neutralizing effect on pain signals. Penetran+Plus has the added effectiveness of MSM (Methyl Sulfonyl Methane), natural lemon oil and our own proprietary technology. Penetran+Plus' unique formula is patented, and the primary active ingredients are found in no other pain relief products.
Penetran+Plus relieves the muscle soreness after working out without greasiness or an overpowering odor. Instead, users enjoy a pleasant lemon scent. Penetran+Plus is a scientific victory that provides today’s most effective non-prescription topical pain relief and differs from all other topical analgesic products available. Why buy separate topical lotions to remove the itch associated with bed bug bites, relieve muscle soreness after working out, and provide arthritis relief, when one product, Penetran+Plus, has been found to satisfy all those needs?
Arthritis
Penetran+Plus is doctor and pharmacist recommended for the temporary relief of arthritic aches and pains associated with the natural aging process. Studies showed that a regular routine of applying Penetran+Plus four times daily will reduce the pain and symptoms of arthritis.
What are the common different types of arthritis?
There are many different types of arthritis, the two most common being Osteoarthritis and Rheumatoid. Osteoarthritis is the "wear and tear" arthritis definition. Rheumatoid Arthritis is an inflammatory type of arthritis that happens when the body's immune system does not work properly.
Did you know that there are more than 100 different types of arthritis? Common arthritic symptoms of inflammation, pain, and stiffness are usually caused by degenerative arthritis (osteoarthritis). Other different types of arthritis include rheumatoid arthritis and gout.
No matter which type of arthritis you have, you need an accurate diagnosis before your doctor can recommend a program for treatment. Pain management is important for ongoing pain control, especially if you suffer with long-term or chronic pain.
After getting a pain assessment, your doctor can prescribe pain medicine or other pain treatments to help you get pain relief. Sometimes psychotherapy is also useful in learning new coping skills to help with chronic arthritic pain.
jc scar and laser.pptx journal club scar treatmentMalaM67
This study assessed the efficacy and safety of combined CO2-IPL and single light IPL in treating hypertrophic scars. 138 patients with hypertrophic scars were randomized to receive either 3 sessions of combined CO2-IPL or single IPL treatment over 10-14 week intervals. Clinical assessment using the POSAS scale found that the combined CO2-IPL treatment resulted in significantly lower POSAS scores compared to single IPL, indicating greater improvement in scar characteristics. 100% of patients treated with CO2-IPL expressed satisfaction with results compared to 84% for single IPL. The combination of CO2-IPL was found to be a safe and effective alternative for treatment of hypertrophic sc
This study examined the effectiveness and efficiency of early treatment versus late treatment for Class II malocclusions. The researchers conducted a randomized controlled trial comparing early treatment using headgear or functional appliances to a control group receiving no early treatment. Results showed that while early treatment produced small changes to jaw growth, this initial advantage was not sustained. There were no differences found between the groups in final skeletal or dental measurements, need for extractions, treatment time, or quality of dental occlusion after treatment. Therefore, the study concluded that early treatment was generally no more effective than conventional late treatment for most cases of Class II malocclusion.
BE-STUDIES: BASICS, CONCEPTS AND CLINICAL APPLICATIONSSumant Saini
Bioequivalence studies are conducted to ensure clinical performance when a new product is intended as a substitute for an approved product. They are needed if there is a risk of bioinequivalence or pharmacotherapeutic failure. Important terms include equivalence, chemical equivalence, pharmaceutical equivalence, bioequivalence, and therapeutic equivalence. Study designs include completely randomized, randomized block, repeated measures, crossover, and carryover designs. Washout periods are used to avoid carryover effects in crossover studies.
Glaxo Smith Kline (HGS) Benlysta AutoinjectorJimmy Pang
This study assessed the relative bioavailability, safety, and usability of a single subcutaneous dose of belimumab 200 mg self-administered by healthy subjects using either an autoinjector or prefilled syringe. The pharmacokinetic profiles and exposure were similar between the two administration devices. The maximum concentration was slightly higher and area under the curve slightly lower with the autoinjector compared to the prefilled syringe, but differences were less than 7%. Adverse events were mostly mild and no serious adverse events occurred. Both devices were well tolerated and rated as usable by over 90% of subjects. These results support the use of either device for subcutaneous self-administration of belimumab.
This study assessed the relative bioavailability, safety, and usability of a single subcutaneous dose of belimumab 200 mg self-administered by healthy subjects using either an autoinjector or prefilled syringe. The pharmacokinetic profiles and exposure were similar between the two administration devices. The maximum concentration was slightly higher and area under the curve slightly lower with the autoinjector compared to the prefilled syringe, but differences were less than 7%. Adverse events were mostly mild and no serious adverse events occurred. Both devices were well tolerated and rated as usable by over 90% of subjects. These results support the use of either device for subcutaneous self-administration of belimumab.
Introduction: Onychomycosis is a fungal infection, frequently caused by dermatophytes, that affects hand and foot nails. Infection rates in Western adult populations range from 2% to 14%, although up to 50% of people over 70 years of age may be affected. Prevalence of onychomycosis is also higher in immuno-compromised and patients with diseases that affect peripheral circulation, such as diabetes mellitus. The aim of the present study was to evaluate clinical efficacy of a nail acidifying
solution versus a nail lacquer containing 5% amorolfine for the local treatment of mild to moderate nail onychomycosis.
Patients and methods: 112 adults with confirmed onychomycosis (at least one great toenail) were randomized in this open, prospective, blinded trial. The acetic acid/ethyl lactate-based solution was brushed on twice-daily and the amorolfine lacquer applied and removed weekly for 168 days. Out of these 112 patients, a fully data analysis could be performed in 102 patients (53 acetic acid group and 49 amorolfine group, respectively). Clinical efficacy was evaluated at the following time points: day (D) D0 = baseline, D14, D28, D56, D112, and D168, respectively. All patients underwent microbiological testing at baseline and at the end of the
treatment. Primary objective of this trial was the change in the percentage of healthy nail surface at study end.
Results: The percentage of healthy surface between baseline and D168 increased with 11.4% (± 17.0%) in the acid-based treated patient group and 5.2% (± 12.6%) in the amorolfine group respectively. The observed difference in increase of percentage of healthy surface after application of the acidifying solution was statistically significant (95% CI: 0.4; 12.1, p = 0.037) in comparison to the amorolfine group. Both treatments resulted in significant (p < 0.05) improvement after 168 days (versus baseline) for nail dystrophy, discoloration, nail thickening, and healthy aspect but effects were more pronounced in the acetic acid group. Microbiological results and
improved quality of life further confirmed clinical efficacy. Both treatments were well tolerated and appreciated for their properties and efficacy.
Conclusion: The present trial confirmed clinical performance of daily acidification of the nail, as reflected by 1) the superior increase of percentage of healthy nail
surface when compared to amorolfine, 2) the overall improvement of other onychomycosis-related parameters, and 3) the convenience and absence of significant side
effects. These data indicate that acid/acid ester solutions can be a convenient, safe and equally effective alternative for the topical management of onychomycosis.
1) This study aims to compare outcomes of K-wire insertion for fracture reduction with and without antibiotic coverage, focusing on infection rates, healing times, and complications.
2) A prospective cohort study of at least 60 patients requiring K-wire insertion for fracture reduction will be conducted over 3 years. Patients will receive antibiotics or no antibiotics, and outcomes will be compared.
3) Standardized assessments will be used to collect data on demographics, medical history, fracture characteristics, antibiotic regimens, infection rates, healing progress, and functional outcomes. Data will be analyzed to determine if antibiotics provide benefits.
Aloe Vera vs. SSD in the Treatment of Burns-Clinical StudyJohn Fisher
This study compared the efficacy of Aloe Vera gel to 1% silver sulfadiazine cream for treating partial thickness burns. 50 patients with burns covering less than 25% of their total body surface area were randomly assigned to have their wounds dressed with either Aloe Vera gel or silver sulfadiazine cream. Patients treated with Aloe Vera gel showed significantly faster wound healing, with epithelialization beginning by the 5th day and complete healing within 40 days on average, compared to longer healing times for those treated with silver sulfadiazine. Aloe Vera gel also provided faster pain relief. The authors concluded that Aloe Vera gel demonstrated advantages over silver sulfadiazine for burn wound dressing by promoting earlier wound healing and pain relief
臨床研究文獻 Human clinical studies with mora devices Dr. Michael GalleWei Chung Chang
The document summarizes several human clinical studies that evaluated the effectiveness of MORA bioresonance therapy. It discusses studies on allergies, rheumatic conditions, gastrointestinal issues, liver disease, asthma, and more. The majority of studies showed positive results from bioresonance therapy, such as reduced allergy symptoms, decreased pain and inflammation, and improved lab values. However, a few studies had contradictory or non-significant results. No serious side effects were reported from any of the bioresonance therapy treatments.
The document discusses the effectiveness of surgical versus non-surgical treatment for acute Achilles tendon ruptures. It reviews 4 studies that compared outcomes of the different treatment approaches. The studies found that surgical treatment significantly reduced the risk of re-rupture compared to non-surgical treatment. However, surgical treatment also carried higher risks of complications like infection. Non-surgical treatment had fewer complications but a higher re-rupture rate. Overall, the document concludes that surgical treatment may be better for reducing re-ruptures, while non-surgical treatment could be preferable for older, less active patients due to complication risks.
Similar to Scientific Journal of Clinical Research in Dermatology (20)
A 5-year old boy, with an established diagnosis of a topic
dermatitis, previously treated by topical corticosteroids and emollient cream with a good improvement, developed widespread papules on his legs, hands and forearm that appeared 5 months ago.
Methods: Retrospectively, the file records of the patients who underwent sleeve gastrectomy were examined. Demographic features, Body Mass Index (BMI), the mouth opening, Mallampati score, thyromental distance, sternomental distance, neck circumference measurements and videolaryngoscopic examination results were recorded Results: In a total of 140 consecutive patients (58 male, 82 female) were included in the study. The mean age of the study participants was 35.40 ± 9.78 and the mean BMI of the patients was 44.33 ± 7.52 kg/m2
. The mean mouth opening of the patients was 4.82 ± 0.54 cm
and the mean neck circumference was 43.52 ± 4.66 cm. The mean thyromental distance was 8.02 ± 1.00 cm and the mean sternomental distance was16.58 ± 1.53 cm. Difficult intubation was determined in 8 (5.7%) patients. In logistic regression analysis, age (p : 0.446), gender (p : 0.371), BMI (p : 0.947), snoring (p : 0.567), sleep apnea (p : 0.218), mouth opening (p : 0.687), thyromental distance (p :0.557), sternomental (p : 0.596) and neck circumference (p : 0.838) were not the independent predictors of difficult intubation. However, Mallampati score (p : 0.001) and preoperative direct laryngoscopy findings (p : 0.037) performed in outpatient clinic were the significant
predictors of difficult intubation. Interestingly, all patients with grade 4 laryngoscopy findings had difficult intubation.
Introduction: Laparoscopic surgery has been performed in Mexico since 1989, but no reports about training tendencies exist. We conducted a national survey in 2015, and here we report the results concerning training characteristics during the surgical residence of the respondents. Materials and Methods: A prospective study was conducted through a survey questioning demographic data, laparoscopic training during pre and post surgical residency and other of areas of laparoscopic practice. The sample was calculated and survey piloted before
application. Special interest in this report was placed on type and quality of training received. Data are reported in percentages.
Heterotopic Ossification (HO) is defined as pathological bone formation at locations where bone normally does not exist. The
presence of HO has been found to be a rare complication after stroke in several studies, whereas there are only sporadic references relating HO to Cerebral Palsy (CP) and few for CP and stroke. No effective treatment for HO has yet been found, whereas the cellular and molecular mechanisms have not been completely understood. Therefore, increased awareness among physicians is required, as a challenge for early diagnosis and treatment. A case of a male patient with CP, who developed HO on the paretichip joint following an ischemic stroke is presented.
Objectives: To assess the practice of food hygiene and safety, and its associated factors among street food vendors in urban areas of Shashemane, West Arsi Zone, Oromia Ethiopia, 2019.
Methods: Cross-sectional study design was applied from December 28, 2019 to January 27, 2020. Data was collected from 120 food handlers, which were selected by purposive sampling techniques. Information was gathered from interview and field observation by conducting food safety survey and using questionnaires via face to face interview. The collected data was entered using Epi Data 3.1 and finally, it was analyzed using SPSS VERSION 20.
A Division I football player experienced acute posterior leg pain while playing. An ultrasound examination revealed an unusual injury - a complete rupture of the plantaris tendon mid-substance. This type of isolated plantaris tendon injury has rarely been reported. Ultrasound was useful for diagnosis and guided rehabilitation by monitoring healing over time. The athlete was able to return to full competition within 3 weeks through a progressive rehabilitation program focused on restoring range of motion and strength. This case suggests isolated plantaris tendon injuries may allow for faster return to play than other potential causes of posterior leg pain.
Type 1 Diabetes (T1D), is a severe disease, representing 5-10% of all reported cases of diabetes worldwide. Fulminant Type 1 Diabetes Mellitus (FT1D) is a subtype of type 1 diabetes mellitus that is largely characterized by the abrupt onset of Diabetic Ketoacidosis (DKA) and severe hyperglycemia without insulin defi ciency. Viral infections have been hypothesized to play a major role in the pathogenesis of Fulminant Type 1 Diabetes Mellitus (FT1D) through the complete and rapid destruction of pancreatic beta cells. Coxsackie viral infection has been detected in islets of 50% of the pancreatic tissue recovered from recent-onset Type 1 Diabetes (T1D) patients. In this report we have highlighted a case where the patient developed a Group B Coxsackie virus infection culminating in the development of Fulminant Type 1 Diabetes Mellitus (FT1D).
Methods: Cercariae are released by infected water snails. To determine the occurrence of cercariae-emitting snails in SchleswigHolstein, 155 public bathing places were visited and searched for fresh water snails. Family and genus of the collected snails were determined and the snails were examined for the shedding of cercariae, using a standard method and a newly developed method.
Objective: To generate preliminary information about of enteroviruses and Enterovirus 71 (EV71) in patients with aseptic meningitis in Khartoum State, Sudan.
Method: Cerebrospinal fluid specimens were collected from 89 aseptic meningitis patients from different Khartoum Hospitals
(Mohammed Alamin Hamid Hospital, Soba Teaching Hospital, Omdurman Military Hospital, Alban Gadeed Teaching Hospital and Police Hospital) within February to May 2015. Among these 89 patients, 43 (48%) were males and 46 (52%) were females. The patient’s age ranged between 1 day and 30 years old. The collected specimens were assayed to detect enteroviruses and EV71 RNA using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) technique
Femoral hernias, comprise 2% to 4% of all hernias in the inguinal region, and occur most commonly in women. Th ey present typically with a mass below the level of the inguinal ligament. The sac may contain preperitoneal fat, omentum, small bowel, or other structures and have a high rate of incarceration and strangulation due to the small size of the hernia neck orifice, requiring emergency surgery. We present the case of a 54-year-old female patient with intestinal occlusion due to incarcerated femoral hernia, repaired by laparoscopic approach, that gave the patient the opportunity to attend her daughter’s wedding the same day.
Small Supernumerary Marker Chromosome (sSMC) is a rare genetic condition marked by the presence of an extra chromosome to the 46 human chromosomes. This case report describes a 4 year old child with SSMC on the 46th chromosome. The child presented with delayed speech and language development, seizures and mild developmental delay. Speech and Language evaluation was carried out and management options are discussed.
A catheter is a thin tube made from medical grade materials that serve a broad range of functions, but mainly catheters are medical devices that can be inserted in the body to treat disease or perform surgical procedures. Catheters have been inserted into body cavities, ducts, or vessels to allow for drainage, administration of therapeutic fluids or gases, operational access for surgery. Catheters help perform tasks in various systems such as cardiovascular, urological, gastrointestinal, neurovascular, and ophthalmic systems. A dataset of 12 patients with varying “weights” and “heights” was recorded along with the lengths of their catheter tubes. This data set was found from two revered statistical textbooks on linear regression and the Department of Scientific Computing at Florida State University. This data set was not able to be linked to any particular clinical or experimental research studies, but the data set can be used to help catheter manufacturers and medical professionals better decide on what particular catheter lengths to use for patients knowing only their height & weight. These research insights could be helpful to healthcare professionals that have patients with incomplete or no healthcare records
to decide what catheter length to use. The main investigative inquiry that needed to be answered was how does patient weight & height influence catheter length together and separately? We conducted linear regression and other statistical analysis procedures in R program & Microsoft Excel and discovered that this data exhibited a quality called multi collinearity. With multi collinearity, all predictors (2 or more
independent variables) are not significant in an all encompassing linear aggression, but the predictors might be significant in their own individual linear regressions. Individual linear regression analyses were conducted for both patient height & weight to see how much they both contribute to varying catheter length. Patient weight was found to be more impatful than patient height in relationship to catheter length, even though height and weight are a classical example of multi collinearity predictors.
Bovine mastitis has a negative impact through economic losses in the dairy sector across the globe. A cross sectional study was carried out from September 2015 to July 2016 to determine the prevalence of bovine mastitis, associated risk factors and isolation of major causative bacteria in lactating dairy cows in selected districts of central highland of Ethiopia. A total of 304 lactating cows selected randomly from five districts were screened by California Mastitis Test (CMT) for subclinical mastitis. Based on CMT result and clinical examination, over all prevalence of mastitis at cow level was 70.62% (214/304).
Two hundred fourteen milk samples collected from CMT positive cows were cultured for isolation of major causative bacteria. From 214 milk samples,187 were culture positive and the most prevalent isolates were Staphylococcus aureus 42.25% (79/187) followed by Streptococcus agalactiae 14.43%
(27/187). Other bacterial isolates were included Coagulase Negative Staphylococcus species 12.83% (24/187), Streptococcus dysgalactiae 5.88% (11/187), Escherichia coli 13.38% (25/187) and Entrococcus feacalis 11.23% (21/187) were also isolated. Moreover, age, parity number, visible teat abnormalities,husbandry practice, barn fl oor status and milking hygiene were considered as risk factors for the occurrence of bovine mastitis and they were found significantly associated with the occurrence of mastitis (p < 0.05). The findings of this study warrants the need for strategic approach including dairy extension that focus on enhancing dairy farmers’ awareness and practice of hygienic milking, regular screening for subclinical mastitis, dry cow therapy and culling of chronically infected cows.
A 36-year-old female developed right upper quadrant pain and nausea after taking the herbal supplement kratom for two weeks to manage back pain. Laboratory tests showed elevated liver enzymes. A liver biopsy ruled out other causes and determined she had drug-induced liver injury from kratom use. Her symptoms and liver enzymes gradually returned to normal over six weeks after stopping kratom. The case report discusses kratom's potential for hepatotoxicity and advises clinicians to consider its effects on patient health.
The assessment, diagnosis and treatment of critically ill patients is extremely challenging. Patients often deteriorate whilst being
reviewed and their rapidly changing pathophysiology barrages healthcare professionals with new data. Furthermore, comprehensive assessments must be postponed until the patient has been stabilised. So, important data and interventions are often missed in the heat of the moment. In emergency situations, suboptimal management decisions may cause signifi cant morbidity and mortality. Fortunately, standardisation and careful design of documentation (i.e. proformas and checklists) can enhance patient safety. So, I have developed a series of checklist proformas to guide the assessment of critically ill patients. These proformas also promote the systematic recording and presentation of information to facilitate the retrieval of the precise data required for the management for critically ill patients. The proformas have been modifi ed extensively over the last twenty years based on my personal experience and extensive consultation with colleagues in several world-renowned centres of excellence. The proformas were originally developed for use in the intensive therapy unit
or high dependency unit. However, they have been adapted for use by outreach teams reviewing patients admitted outside of critical care areas. The use of these tools can direct eff orts to provide appropriate organ support and provides a framework for diagnostic reasoning.
This review article discusses microvascular and macrovascular disease in systemic hypertension. It summarizes that:
1) Cardiac imaging plays a crucial role in risk stratifying hypertensive patients and identifying management strategies by properly diagnosing microvascular and coronary artery disease.
2) The nitric oxide synthase (eNOS) G298 gene allele may be a marker for microvascular angina in hypertensive patients, as studies have found it to be more prevalent in hypertensive patients with chest pain and reversible myocardial defects but normal coronary arteries.
3) Both structural changes like capillary rarefaction and functional changes like endothelial dysfunction can cause microvascular dysfunction and angina in hypertensive individuals in the absence of
This study characterized dengue infections in Pakistan by analyzing hematological and serological markers in 154 suspected dengue cases and 146 control patients with other febrile illnesses. NS1 antigen was detected in 55% of dengue cases, IgM antibodies in 30%, and both in 15%. Control groups primarily had malaria (71%) and enteric fever (20%). Hematological markers (platelet count, hematocrit, WBC) measured before and after treatment showed significant differences for platelet count and hematocrit but not WBC count between the groups. Analysis of clinical symptoms and serological/hematological markers helps diagnose dengue, assess prognosis, and inform prevention efforts to reduce morbidity, mortality and spread of the disease.
Researchers from Utrecht recently published yet another paper on the use of Magnetic Resonance Imaging (MRI)demonstrating an additional failed attempt to understand the importance of qualitative versus quantitative imaging, and anatomic versus physiologic imaging. Th e implications of this failure here cannot be overstated.
Introduction: Stroke is an even more dramatic major public health problem in young people. Goal of the study: Contribute to the knowledge of strokes in young people. Methodology: This was a retrospective study carried out over a period of 02 years (January 2017 to December 2018) including the files of patients aged 18 to 49 years hospitalized for any suspected case of stroke in the Neurology department of the University Hospital
Center of the Sino-Central African Friendship (CHUSCA) of Bangui.
Background: This report describes a unique case of a patient that developed psychotic symptoms believed to be secondary
to a tentorial meningioma with associated hydrocephalus. These psychotic symptoms subsequently abated with placement of a
ventriculoperitoneal shunt. Case description: 60-year-old female was admitted to an inpatient psychiatric facility on a psychiatric involuntary commitment petition due to progressive paranoia, homicidal ideation and psychosis. The work up showed a calcified six cm tentorial meningioma with associated hydrocephalus. The patient initially rejected treatment but later became amenable to placement of Ventriculoperitoneal Shunt
(VPS).
More from SciRes Literature LLC. | Open Access Journals (20)
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
2. Cite this Article: Park KY, Jeong SY, Suh JH, Choi SY,Choi
E,AREATA A et al. The Efficacy and Safety of Touch-up
Treatment with Hyaluronic Acid Filler for the Correction of
Nasolabial Folds. Sci J Clin Res Dermatol. 2015;1(1): 003-008.
SCIRES Literature - Volume 1 Issue 1 - www.scireslit.com Page - 005
Scientific Journal of Clinical Research in Dermatology
KEYWORDS: hyaluronic acid, nasolabial folds
INTRODUCTION
Hyaluronic acid (HA) filler is becoming most popular choice as
a temporary filler for facial augmentation. It is a safe, non-surgical
procedure that conveniently softens facial lines and furrows. HA is a
normal component of human skin, where it provides a low degree of
immunogenicity, therefore it has the added benefit of not requiring
skin testing before use [1].
Different commercial HA fillers are similar, but their physical
characteristics and clinical outcomes can differ. Favorable physical
properties of administered HA include ease of administration,
resistance to deformation after application, acceptable persistence,
biocompatibility, and reversibility with hyaluronidase [2,3], HA
implantation is not permanent. Like natural HA, manufactured HA
once injected into the skin will gradually break down and be absorbed
by the body. In most cases, the augmentation usually lasts anywhere
between 3-9 months. To maintain the initial results, repeat treatments
or touch-up treatments will be necessary, but comparative research on
the efficacy and safety of touch-up treatment is limited [4].
In this study, we compared the efficacy and safety of touch-up
treatment with newly developed HA filler (Elrevie®
, Huons, Korea)
for correcting nasolabial folds.
MATERIALS AND METHODS
Subjects
This randomized, controlled study was conducted at single center
in Seoul, South Korea. We included 50 healthy Korean subjects over
the age of 20 with visibly moderate to severe NLFs of 3 to 4 points on
the Wrinkle Severity Rating Scale (WSRS)[5]. All subjects voluntarily
participated in the study and were able to freely terminate their
participation at any time. Written informed consent was obtained
from all participants after a full explanation of the risks and benefits
of the procedure, and the study protocol conformed to the guidelines
of the Declaration of Helsinki and Korea Good Clinical Practice. The
study was approved by Chung Ang University Institutional Ethics
Committee.
Materials
The Elravie®
deep line used in the study is a transparent, colorless,
viscoelastic gel containing HA at a concentration of 23 mg/mL. It was
administered via sterile, 1.0-mL, pre-filled syringes with 28-gauge
needles.
Rheology measurement
The rheological property of HA fillers can be described by a
complex modulus G*, which is defined as the sum of storage modulus
G’ and loss modulus G’’, also known as elastic and viscous modulus,
respectively. The storage modulus G’ is often used to characterize the
rigidity of a gel, and a stiffer material has a higher G’ and a softer
material has a lower G’. The G’ and G’’ values were measured using a
rheometer (Kinexus, Malvern, UK) for determining δ=G’’/G’. All the
measurements were performed using a 20-mm steel plate oscillating
at a frequency between 0.1 Hz and 10 Hz. The presented values were
obtained at the frequency of 1 Hz and were compared.
Treatment
The faces of all subjects were digitally photographed at rest upon
every visit. Subjects were randomized using a computer-generated
code to determine who would receive touch-up treatment 9 months
after first injection. Evaluating investigators were blinded, but subjects
and treating investigators were not, as implied by study design. The
same amount of 1.0 mL for each NLF was injected for each subject.
Efficacy Measures
The primary efficacy measure was point improvement in baseline
WSRS scores as determined by the blinded evaluating investigators.
Secondary efficacy measures included changes in Global Aesthetic
Improvement Scale (GAIS) scores measured through subject self-
assessment and also by the treating investigators. Pretreatment
photographs of each subject taken at the screening visit were reviewed
during each visit to aid severity assessments as a control.
ABSTRACT
Background: Many new brands of Hyaluronic acid (HA) fillers are being produced, and the longevity and safety are always major
concern about HA fillers.
Objective: To evaluate the efficacy, tolerability, and safety of touch-up treatment of a HA filler, Elravie®
deep line which is used for
correcting nasolabial folds (NLFs).
Methods: The rheological property values of HA fillers were measured using a rheometer.A total of 50 subjects with visible NLFs were
enrolled in this clinical study and were divided into test and control groups. All subjects were injected with same amount of HA in both
NLFs and only the test group had touch-up treatment after 9 months of first injection. All participants were then reassessed for cosmetic
changes using Wrinkle Severity Rating Scale (WSRS) and Global aesthetic improvement scale (GAIS).
Results: By month 9, the mean improvement in the WSRS of test group compared to control was not statistically significant. But on
month 12, 15 and 18, the mean WSRS of test group compared to control were remarkably improved. GAIS of test group showed also
significant high score since month 12, compared to control. The touch-up treatments of filler were well-tolerated and adverse reactions
were mild and transient in most cases.
Conclusion:The touch-up of HA filler, which is performed before injected filler was not fully disappeared, is safe, effective and more
satisfactory treatment for correcting NLFs.
3. Cite this Article: Park KY, Jeong SY, Suh JH, Choi SY,Choi
E,AREATA A et al. The Efficacy and Safety of Touch-up
Treatment with Hyaluronic Acid Filler for the Correction of
Nasolabial Folds. Sci J Clin Res Dermatol. 2015;1(1): 003-008.
SCIRES Literature - Volume 1 Issue 1 - www.scireslit.com Page - 006
Scientific Journal of Clinical Research in Dermatology
Safety Measures
All abnormal reactions during this clinical test were documented.
Statistical Analysis
Inter-treatment differences were verified using Wilcoxon’s signed
rank test with a 5% significance level. A safety analysis of local
injection site reactions and systemic adverse events was performed
for both treatment groups using McNemar’s test.
RESULTS
The rheological property of HA fillers was described in Table
1. A total of 50 subjects were randomized and treated with Elravie®
deep line; 40 subjects completed this study with 18-months follow-
up period. The baseline WSRS were 3.16±0.37 in experimental
groups and 3.08±0.28 in control groups, respectively. Average
values of WSRS differences between the experimental and control
groups were evaluated by independent assessors on the 18 months
after first injection and found to be 1.75±0.55 and 2.85±0.49 in
the experimental and control groups, respectively. And this was
statistically significant. The average value on the 9 months after
first injection (just before touch-up) was 2.50±0.67 and 2.33±0.56
for experimental and control groups, respectively, and there was no
statistical significance. The statistical significant difference between
two groups was appearing since 12 months after first injection (Figure
1). Similarly, baseline GAIS rated by treating investigators and study
subjects was not significantly different for the two groups, and then
statistical significance was beginning to appear from 12 months after
first injection (Figure 2,3). This demonstrates that all study subjects
judged the severity of NLFs to be generally improved up to 9 months
after the first injections of Elravie®
, and the control groups was more
improved 12 months after first injection. Representative photographs
of the NLFs of a subject with touch-up taken before and after NLF
correction are shown in Figure 4.
Adverse events (AEs) were actively elicited from all subjects in this
study by asking about any redness, swelling, bruising, bleeding, and
pain following filler treatments. Both treatments were well-tolerated
and in most cases, AEs were mild and transient. Local reactions
mostly disappeared within two weeks without any treatment, and
there were no reports of serious local reactions or local reactions that
required treatment (Table 2). The safety of touch-up group was not
different from that of control groups.
DISCUSSION
Injecting fillers to correct wrinkles has become a standard
therapeutic method in modern cosmetic practice. Due to the
Figure 1: The change of Wrinkle Severity Rating Scale (WSRS) at baseline, 1, 3, 6, 9, 12, 15 and 18 month after the treatment with hyaluronic acid filler for the
correction of nasolabial Folds. Statistical analysis showed significant difference since 12 months after first injection. *p<0.05.
Figure 2: The change of Global Aesthetic Improvement Scale (GAIS), which is scored by subject, at baseline, 1, 3, 6, 9, 12, 15 and 18 month after the treatment
with hyaluronic acid filler for the correction of nasolabial Folds. Statistical analysis showed significant difference since 12 months after first injection.*p<0.05.
4. Cite this Article: Park KY, Jeong SY, Suh JH, Choi SY,Choi
E,AREATA A et al. The Efficacy and Safety of Touch-up
Treatment with Hyaluronic Acid Filler for the Correction of
Nasolabial Folds. Sci J Clin Res Dermatol. 2015;1(1): 003-008.
SCIRES Literature - Volume 1 Issue 1 - www.scireslit.com Page - 007
Scientific Journal of Clinical Research in Dermatology
Table 1.The rheological property of HA filler(Elravie deep line®
) G'
G'(Pa)
(1Hz)
G''(Pa) (1Hz)
G*(Pa)
(1Hz)
ŋ*(Pa s)
(1Hz)
δ(°)
(1Hz)
ŋ(Pa s)
(450s)
tanδ
Elasticity
%
Elravie Deep Line®
265.1 33.89 267.2 42.63 7.29 1008.0 0.128 88.665
Table 2.Incidence of adverse events
Treatment Adverse case (%) 95% Confidence interval Adverse event (%) Total
Touch up 5 20.00% (4.3%, 35.7%) 6 24.00% 25
Control 5 20.00% (4.3%, 35.7%) 6 24.00% 25
Total 10 20.00% (8.9%, 31.1%) 12 24.00% 50
Figure 3: The change of Global Aesthetic Improvement Scale (GAIS), which is scored by physician, at baseline, 1, 3, 6, 9, 12, 15 and 18 month after the treatment
with hyaluronic acid filler for the correction left nasolabial Folds. Statistical analysis showed significant difference since 12 months after first injection.*p<0.05.
Figure 4: Representative photographs of the NLFs of a subject with touch-up taken before (a) and after (b) NLF correction.
increasing demand for filler injection, the market for dermal fillers
has grown dramatically over the last several years. HA is currently
the first-choice filler material for facial contouring via intradermal
injection because HA fillers have several advantages over other fillers.
Numerous studies have demonstrated that HA dermal fillers have
better persistence than older collagen-containing products[6,7]. The
favorable physical properties of HA include ease of administration,
resistance to deformation after application, acceptable persistence,
biocompatibility, and reversibility with hyaluronidase. HA can
attract water to keep skin firm and moisturized. In addition, HA is
a normal component of human skin and provides a low degree of
immunogenicity [1-3,9].
As the filler market expands, many medical and pharmaceutical
companies have begun manufacturing their own HA fillers. Elravie®
belongs to the family of monophasic HA fillers. The Korean Food
and Drug Administration approved Elravie®
for correcting NLFs,
and there is study of cosmetic results and safety profiles of Elravie®
in the published literature[8]. The amount of time each patient gets
from the fillers before needing a touch-up treatment varies by person;
placement of product and frequency/timing of ongoing touch-ups.
All these factors play a role in how long each filler lasts-from a few
months to a few years. As with other advanced dermal fillers, many
patients require less product and longer treatment intervals over time.
In practice, patients and medical practitioners have reported needing
less product and longer intervals between touch up treatments over
time, if patients are diligent in returning for touch ups before the
product has completely dissipated. Added longevity can be achieved
from a touch-up while some filler is still present in the face, as this
usually causes a response of additional collagen production from the
skin. Whereas HA fillers usually last average 6-9 months, Elravie®
with high quality cross-linking technology has been lasted over a year.
5. Cite this Article: Park KY, Jeong SY, Suh JH, Choi SY,Choi
E,AREATA A et al. The Efficacy and Safety of Touch-up
Treatment with Hyaluronic Acid Filler for the Correction of
Nasolabial Folds. Sci J Clin Res Dermatol. 2015;1(1): 003-008.
SCIRES Literature - Volume 1 Issue 1 - www.scireslit.com Page - 008
Scientific Journal of Clinical Research in Dermatology
So we decided a touch-up time to 9 month after first injection.
In this study, the mean improvement in the WSRS of test group
compared to control was not statistically significant by month 9. But
on month 12, 15 and 18, the mean WSRS of touch-up group compared
to control was remarkably improved. GAIS of touch-up group showed
also significant high score since month 12, compared to control.
The fillers were well-tolerated and adverse reactions were mild and
transient in most cases. There were no significant differences in local
reactions to touch-up and control group. In this study, the touch-up
injection of HA filler proved to be generally safe.
A careful review of filler material characteristics is needed to select
fillers that enhance performance and safety. In addition, we could
maximize cosmetic result and patient satisfaction through touch-up
treatment of HA filler.
ACKNOWLEDGEMENTS
All persons who have made substantial contribution, but who are
not eligible as authors are named in acknowledgment.
REFERENCES
1. Bentkover SH. The biology of facial fillers. See comment in PubMed
Commons below Facial Plast Surg. 2009; 25: 73-85.
2. Kablik J, Monheit GD, Yu L, Chang G, Gershkovich J. Comparative physical
properties of hyaluronic acid dermal fillers. See comment in PubMed
Commons below Dermatol Surg. 2009; 35 Suppl 1: 302-312.
3. Brandt FS, Cazzaniga A. Hyaluronic acid gel fillers in the management of
facial aging. See comment in PubMed Commons below Clin Interv Aging.
2008; 3: 153-159.
4. Beasley KL, Weiss MA, Weiss RA. Hyaluronic acid fillers: a comprehensive
review. See comment in PubMed Commons below Facial Plast Surg. 2009;
25: 86-94.
5. Narins RS, Brandt F, Leyden J, Lorenc ZP, Rubin M, Smith S. A randomized,
double-blind, multicenter comparison of the efficacy and tolerability of
Restylane versus Zyplast for the correction of nasolabial folds.DermatolSurg
2003;29:588-595.
6. Lindqvist C, Tveten S, Bondevik BE, Fagrell D. A randomized, evaluator-
blind, multicenter comparison of the efficacy and tolerability of Perlane
versus Zyplast in the correction of nasolabial folds. See comment in PubMed
Commons below Plast Reconstr Surg. 2005; 115: 282-289.
7. Baumann LS, Shamban AT, Lupo MP, Monheit GD, Thomas JA, Murphy
DK, Walker PS. Comparison of smooth-gel hyaluronic acid dermal fillers with
cross-linked bovine collagen: a multicenter, double-masked, randomized,
within-subject study. DermatolSurg 2007;33Suppl 2:S128-135.
8. Rhee do Y, Won CH, Chang SE, Noh TK, Kim MS, Kim BJ, Park GH. Efficacy
and safety of a new monophasic hyaluronic acid filler in the correction of
nasolabial folds: a randomized, evaluator-blinded, split-face study. See
comment in PubMed Commons below J Dermatolog Treat. 2014; 25: 448-
452.
9. Kim H, Park KY, Choi SY, Koh HJ, Park SY, Park WS, Bae IH1. The efficacy,
longevity, and safety of combined radiofrequency treatment and hyaluronic
Acid filler for skin rejuvenation. See comment in PubMed Commons below
Ann Dermatol. 2014; 26: 447-456.