Introduction: Onychomycosis is a fungal infection, frequently caused by dermatophytes, that affects hand and foot nails. Infection rates in Western adult populations range from 2% to 14%, although up to 50% of people over 70 years of age may be affected. Prevalence of onychomycosis is also higher in immuno-compromised and patients with diseases that affect peripheral circulation, such as diabetes mellitus. The aim of the present study was to evaluate clinical efficacy of a nail acidifying
solution versus a nail lacquer containing 5% amorolfine for the local treatment of mild to moderate nail onychomycosis.
Patients and methods: 112 adults with confirmed onychomycosis (at least one great toenail) were randomized in this open, prospective, blinded trial. The acetic acid/ethyl lactate-based solution was brushed on twice-daily and the amorolfine lacquer applied and removed weekly for 168 days. Out of these 112 patients, a fully data analysis could be performed in 102 patients (53 acetic acid group and 49 amorolfine group, respectively). Clinical efficacy was evaluated at the following time points: day (D) D0 = baseline, D14, D28, D56, D112, and D168, respectively. All patients underwent microbiological testing at baseline and at the end of the
treatment. Primary objective of this trial was the change in the percentage of healthy nail surface at study end.
Results: The percentage of healthy surface between baseline and D168 increased with 11.4% (± 17.0%) in the acid-based treated patient group and 5.2% (± 12.6%) in the amorolfine group respectively. The observed difference in increase of percentage of healthy surface after application of the acidifying solution was statistically significant (95% CI: 0.4; 12.1, p = 0.037) in comparison to the amorolfine group. Both treatments resulted in significant (p < 0.05) improvement after 168 days (versus baseline) for nail dystrophy, discoloration, nail thickening, and healthy aspect but effects were more pronounced in the acetic acid group. Microbiological results and
improved quality of life further confirmed clinical efficacy. Both treatments were well tolerated and appreciated for their properties and efficacy.
Conclusion: The present trial confirmed clinical performance of daily acidification of the nail, as reflected by 1) the superior increase of percentage of healthy nail
surface when compared to amorolfine, 2) the overall improvement of other onychomycosis-related parameters, and 3) the convenience and absence of significant side
effects. These data indicate that acid/acid ester solutions can be a convenient, safe and equally effective alternative for the topical management of onychomycosis.
DOI:10.21276/ijlssr.2016.2.4.1
ABSTRACT- Introduction: Surgical Site Infections (SSI) still remains a significant problem following an operation
and the third most frequently reported nosocomial infections. SSI contributes significantly to increased health care costs in
terms of prolonged hospital stay and lost work days.
Objective: The current study was undertaken to identify incidence of SSI and the risk factors associated with it, and the
common organism isolated and its antibiotic sensitivity and resistance.
Material and Methods: A total number of 3211 patients admitted in general surgical wards for elective surgery in the
study period, out of which 1225 were clean and clean contaminated cases, fulfilling our study criteria. Totally 56 cases
had surgical site infections which had been taken up for this study. Wound discharges were sent for culture and sensitivity.
Results and Conclusions: The overall infection rate was 4.57%. The SSI rate was almost equal in clean surgeries and
clean contaminated ones. Superficial surgical site infections in the most commonest type and accounted for about 66.07%
of all the SSI’s and deep surgical site infection accounted for about 25% with 8.92% was organ space. The most
commonly isolated organism from surgical site infections was staphylococcus aureus followed by pseudomonas and then
E. coli. Drains, prosthesis usage and other risk factors of SSI have been identified. Most of the organisms which were
isolated were multidrug resistant. The high rate of resistance to many antibiotics underscored the need for a policy that
could promote a more rational use of antibiotics. Key-words- Surgical site infections, National Nosocomial Infections Surveillance (NNIS) risk index, Antibiotic
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Short-term improvement of clinical parameters and microbial diversity in peri...M ALTAMIMI
Indocyanine green-mediated photodynamic therapy is effective against chronic periodontitis. Here, we evaluated the efficiency of indocyanine green-based adjunctive antimicrobial photodynamic therapy in non- surgical treatment of chronic periodontitis patients
Running head JUBLIA1JUBLIA2JubliaChambe.docxwlynn1
Running head: JUBLIA 1
JUBLIA 2
Jublia
Chamberlain College of Nursing
NR-293, Pharmacology
Linda Le
Professor Ward
February 14, 2019
Jublia
This brochure has been designed to inform the people about the use of Efinaconazole for the treatment of onychomycosis. Onychomycosis is known as a fungal infection of the nail. This is targeted to educate the people on the treatment and use of Jublia as a toenail treatment. The brochure explains a small intro of necessary information regarding medicine like drug class, mechanism of action, and treat guide. The side effects and interactions are also explained. This is designed to provide awareness to layman regarding toenail infections.
References
Elewski, B. E., Rich, P., Pollak, R., Pariser, D. M., Watanabe, S., Senda, H., ... & Oli n, J. T. (2013).
Efinaconazole 10% solution in the treatment of toenail onychomycosis: two phase III
multicenter, randomized, double-blind studies. Journal of the American Academy of
Dermatology, 68(4), 600-608.
Tschen, E. H., Bucko, A. D., Oizumi, N., Kawabata, H., Olin, J. T., & Pillai, R. (2013).
Efinaconazole solution in the treatment of toenail onychomycosis: a phase 2, multicenter,
randomized, double-blind study. J Drugs Dermatol, 12(2), 186-92.
RentSilverSpring.xlsx
DATASize (Square feet) Rent ($)52411106161175666119083014104501210550122578014808151490107014956101680835181066016255901469675139574411508201140912122062814346451519840110580011308041250950144980011687871224960139175011456901093840135385015309651650106017406651235775155096015458271583655157553513106251195749120063411856411444860138574012755931050880165089513406921560
Starbucks.xlsx
DATATearViscosityPressurePlate Gap0.00350.00180.000.000.00350.00170.000.000.45319.00186.001.800.85380.00174.001.800.35350.00180.000.000.30300.00180.000.000.70400.00180.000.001.90350.00190.000.000.25350.00180.000.000.10319.00186.00-1.800.15380.00186.00-1.803.90350.00180.003.000.00380.00174.00-1.800.55350.00180.000.000.00350.00180.00-3.000.05319.00174.00-1.800.40319.00174.001.804.30380.00186.001.800.00350.00180.000.00
VinhoVerde.xlsx
DATAFixed AcidityVolatile AcidityCitric AcidResidual SugarChloridesFree Sulfur DioxideTotal Sulfur DioxideDensitypHSulphatesAlcoholQuality11.50.30.620.06712270.99813.110.9710.167.70.7150.012.10.06431430.993713.410.5711.8610.40.5750.612.60.076112413.160.69959.20.630.212.70.09729650.99883.280.589.657.90.350.463.60.07815370.99733.350.8612.888.90.7450.182.50.07715480.997393.20.479.767.60.510.242.40.0918380.9983.470.669.6610.80.50.462.50.0735271.00013.050.649.556.40.470.42.40.0718190.99633.560.7310.669.90.630.242.40.0776330.99743.090.579.456.90.68502.50.10522370.99663.460.5710.667.30.450.365.90.07412870.99783.330.8310.556.80.810.0520.076140.995623.510.6610.867.50.510.021.70.08413310.995383.360.5410.5610.40.340.583.70.1746160.9973.190.711.367.10.460.142.80.07615370.996243.360.4910.759.10.50.31.90.0658170.997743.320.7110.567.30.690.322.20.069351040.996323..
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
Desquamative gingivitis is described as an erythematous, desquamated or eroded gingival lesion. Various etiologic factors are present for the appearance of such lesions. Despite of considering etiology, treatment is oftenly provided by systemic or topical corticosteroids. Apart from steroid application, another optionable treatment is antioxidant therapy which provides rapid healing of the tissue. As antioxidants posses various advantageous properties, it can be considered as a first treatment option for desquamative gingivitis. The presented case report of desquamative gingivitis is successfully treated using systemic antioxidants in the form of commercially available „oxitard capsule‟.
DOI:10.21276/ijlssr.2016.2.4.1
ABSTRACT- Introduction: Surgical Site Infections (SSI) still remains a significant problem following an operation
and the third most frequently reported nosocomial infections. SSI contributes significantly to increased health care costs in
terms of prolonged hospital stay and lost work days.
Objective: The current study was undertaken to identify incidence of SSI and the risk factors associated with it, and the
common organism isolated and its antibiotic sensitivity and resistance.
Material and Methods: A total number of 3211 patients admitted in general surgical wards for elective surgery in the
study period, out of which 1225 were clean and clean contaminated cases, fulfilling our study criteria. Totally 56 cases
had surgical site infections which had been taken up for this study. Wound discharges were sent for culture and sensitivity.
Results and Conclusions: The overall infection rate was 4.57%. The SSI rate was almost equal in clean surgeries and
clean contaminated ones. Superficial surgical site infections in the most commonest type and accounted for about 66.07%
of all the SSI’s and deep surgical site infection accounted for about 25% with 8.92% was organ space. The most
commonly isolated organism from surgical site infections was staphylococcus aureus followed by pseudomonas and then
E. coli. Drains, prosthesis usage and other risk factors of SSI have been identified. Most of the organisms which were
isolated were multidrug resistant. The high rate of resistance to many antibiotics underscored the need for a policy that
could promote a more rational use of antibiotics. Key-words- Surgical site infections, National Nosocomial Infections Surveillance (NNIS) risk index, Antibiotic
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Short-term improvement of clinical parameters and microbial diversity in peri...M ALTAMIMI
Indocyanine green-mediated photodynamic therapy is effective against chronic periodontitis. Here, we evaluated the efficiency of indocyanine green-based adjunctive antimicrobial photodynamic therapy in non- surgical treatment of chronic periodontitis patients
Running head JUBLIA1JUBLIA2JubliaChambe.docxwlynn1
Running head: JUBLIA 1
JUBLIA 2
Jublia
Chamberlain College of Nursing
NR-293, Pharmacology
Linda Le
Professor Ward
February 14, 2019
Jublia
This brochure has been designed to inform the people about the use of Efinaconazole for the treatment of onychomycosis. Onychomycosis is known as a fungal infection of the nail. This is targeted to educate the people on the treatment and use of Jublia as a toenail treatment. The brochure explains a small intro of necessary information regarding medicine like drug class, mechanism of action, and treat guide. The side effects and interactions are also explained. This is designed to provide awareness to layman regarding toenail infections.
References
Elewski, B. E., Rich, P., Pollak, R., Pariser, D. M., Watanabe, S., Senda, H., ... & Oli n, J. T. (2013).
Efinaconazole 10% solution in the treatment of toenail onychomycosis: two phase III
multicenter, randomized, double-blind studies. Journal of the American Academy of
Dermatology, 68(4), 600-608.
Tschen, E. H., Bucko, A. D., Oizumi, N., Kawabata, H., Olin, J. T., & Pillai, R. (2013).
Efinaconazole solution in the treatment of toenail onychomycosis: a phase 2, multicenter,
randomized, double-blind study. J Drugs Dermatol, 12(2), 186-92.
RentSilverSpring.xlsx
DATASize (Square feet) Rent ($)52411106161175666119083014104501210550122578014808151490107014956101680835181066016255901469675139574411508201140912122062814346451519840110580011308041250950144980011687871224960139175011456901093840135385015309651650106017406651235775155096015458271583655157553513106251195749120063411856411444860138574012755931050880165089513406921560
Starbucks.xlsx
DATATearViscosityPressurePlate Gap0.00350.00180.000.000.00350.00170.000.000.45319.00186.001.800.85380.00174.001.800.35350.00180.000.000.30300.00180.000.000.70400.00180.000.001.90350.00190.000.000.25350.00180.000.000.10319.00186.00-1.800.15380.00186.00-1.803.90350.00180.003.000.00380.00174.00-1.800.55350.00180.000.000.00350.00180.00-3.000.05319.00174.00-1.800.40319.00174.001.804.30380.00186.001.800.00350.00180.000.00
VinhoVerde.xlsx
DATAFixed AcidityVolatile AcidityCitric AcidResidual SugarChloridesFree Sulfur DioxideTotal Sulfur DioxideDensitypHSulphatesAlcoholQuality11.50.30.620.06712270.99813.110.9710.167.70.7150.012.10.06431430.993713.410.5711.8610.40.5750.612.60.076112413.160.69959.20.630.212.70.09729650.99883.280.589.657.90.350.463.60.07815370.99733.350.8612.888.90.7450.182.50.07715480.997393.20.479.767.60.510.242.40.0918380.9983.470.669.6610.80.50.462.50.0735271.00013.050.649.556.40.470.42.40.0718190.99633.560.7310.669.90.630.242.40.0776330.99743.090.579.456.90.68502.50.10522370.99663.460.5710.667.30.450.365.90.07412870.99783.330.8310.556.80.810.0520.076140.995623.510.6610.867.50.510.021.70.08413310.995383.360.5410.5610.40.340.583.70.1746160.9973.190.711.367.10.460.142.80.07615370.996243.360.4910.759.10.50.31.90.0658170.997743.320.7110.567.30.690.322.20.069351040.996323..
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
Desquamative gingivitis is described as an erythematous, desquamated or eroded gingival lesion. Various etiologic factors are present for the appearance of such lesions. Despite of considering etiology, treatment is oftenly provided by systemic or topical corticosteroids. Apart from steroid application, another optionable treatment is antioxidant therapy which provides rapid healing of the tissue. As antioxidants posses various advantageous properties, it can be considered as a first treatment option for desquamative gingivitis. The presented case report of desquamative gingivitis is successfully treated using systemic antioxidants in the form of commercially available „oxitard capsule‟.
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
Desquamative gingivitis is described as an erythematous, desquamated or eroded gingival lesion. Various etiologic factors are present for the appearance of such lesions. Despite of considering etiology, treatment is oftenly provided by systemic or topical corticosteroids. Apart from steroid application, another optionable treatment is antioxidant therapy which provides rapid healing of the tissue. As antioxidants posses various advantageous properties, it can be considered as a first treatment option for desquamative gingivitis. The presented case report of desquamative gingivitis is successfully treated using systemic antioxidants in the form of commercially available „oxitard capsule‟.
“Desquamative Gingivitis Treated By An Antioxidant Therapy- A Case Report”inventionjournals
Desquamative gingivitis is described as an erythematous, desquamated or eroded gingival lesion. Various etiologic factors are present for the appearance of such lesions. Despite of considering etiology, treatment is oftenly provided by systemic or topical corticosteroids. Apart from steroid application, another optionable treatment is antioxidant therapy which provides rapid healing of the tissue. As antioxidants posses various advantageous properties, it can be considered as a first treatment option for desquamative gingivitis. The presented case report of desquamative gingivitis is successfully treated using systemic antioxidants in the form of commercially available „oxitard capsule‟
Content server (10)A randomized, controlled, double-blind prospective trial w...Missing Man
A randomized, controlled, double-blind prospective trial
with a Lipido-Colloid Technology-Nano-OligoSaccharide
Factor wound dressing in the local management of
venous leg ulcers
Effect of Skin Intervention Protocol on Incontinence-Associated Dermatitis am...iosrjce
IOSR Journal of Nursing and health Science is ambitious to disseminate information and experience in education, practice and investigation between medicine, nursing and all the sciences involved in health care. Nursing & Health Sciences focuses on the international exchange of knowledge in nursing and health sciences. The journal publishes peer-reviewed papers on original research, education and clinical practice.
By encouraging scholars from around the world to share their knowledge and expertise, the journal aims to provide the reader with a deeper understanding of the lived experience of nursing and health sciences and the opportunity to enrich their own area of practice. The journal publishes original papers, reviews, special and general articles, case management etc.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. dermatophyte infection via macroscopic and microscopic analysis.Yet, outcome
of these fungal cultures did not restrict subject inclusion since false negative
resultsregularlyoccurinclinicallyconfirmedcases[12].
Beside positive diagnosis, patients must have stopped any systemic and/or
topical antifungal treatment for at least 6 and 3 months, respectively, before
inclusion. Finally, female subjects of childbearing potential should use an
accepted contraceptive regimen at least 12 weeks prior to study start, during the
study,andatleast1 monthafterthestudyend.
Exclusion criteria were: non-compliance with the protocol, enrolment in another
clinical trial during the test period, pregnant (or planning to) or nursing women,
known allergy to one of the ingredients of both products, patients suffering from
serious or progressive diseases (uncontrolled diabetes, peripheral circulatory
disease, HIV, psoriasis, lichen planus, immunosuppressive disorders), and
patientswithotherskindiseasesinthestudiedzone.
Informed consent, randomization,and baselinedata
Each subject received oral and written information concerning the studied
product, its nature, the duration and the conditions of the study. Written consent
was obtained before any study-specific procedures were performed in
accordancetotheHelsinkideclaration.
Following this informed consent, a patient screening number was assigned to
each patient. A randomisation list was provided prior to the start of the study. A
unique randomisation number attributed each included patient to one of the
treatment groups, with an equal probability (n=56 in each product arm). Baseline
demographic data were collected on gender, age, height, weight, blood pressure
parameters,andmedicationuse.
Blinding
Discernible differences in the product properties (e.g. different bottle, odour)
and in the administration process allowed patients to recognize both trial
products. Therefore, blinding and unbiased evaluation was guaranteed by
making digitalized macro-photographs of the toe nail, which were in turn
analysed by two blinded evaluators. The detailed procedure is described below
inchapter“Evaluationofclinicalefficacy”.
Study medication,dosage and administration
®
The acetic acid solution (Excilor ) was supplied in glass bottles (with brush
applicator) by Oystershell Laboratories (Ghent, Belgium). This product consists
of acetic acid (active ingredient), solvent (ethyl lactate), a penetration enhancer,
a film former, water, preservatives, acetylated lanolin alcohols, glycerol, and
biotin.
®
The amorolfine nail lacquer reference (Loceryl ; available in glass bottle) was
provided be the principal investigator. This medicated nail lacquer contains 5%
amorolfine (as amorolfine hydrochloride in ethanol, triacetin, butyl acetate,
ethylacetateandammoniummethacrylatepolymer).
The acetic acid solution was applied twice-daily with the brush, covering the
complete (cleaned) nail and the underside of the nail rim. If new growth
appeared,thenailwas trimmedusing anailclipper.
Amorolfine was applied once a week with a reusable spatula (supplied with the
product).Prior touse,thenailwas filedandcleanedwithisopropanolwipes.
Evaluationof clinicalefficacy
Patients were treated with the acetic acid solution or amorolfine lacquer,
respectively, for a period of 168 days. Onychomycosis evolution was evaluated
at distinct time points: day (D) 14, D28, D56, D112, and D168, and compared to
D0 (baseline). The primary objectives were to assess variation in the % of
healthy surface of the great toenail at the end of the study (D168) when compared
to baseline in both treatment groups. Diagnosis was performed using digital
image analysis. Briefly, at each time point, two macro-photographs (top and
front) were made of the great toenail, placed beside a piece of graph paper to
allow determination of the exact size of the nail during analysis (contour
tracing). Consequently, all pictures were digitalised and recorded on the
computer. Image analysis of the top picture was performed with Adobe
Photoshop software [13]. For each photograph, a blinded dermatologist traced
the healthy surface. Next, a second evaluator, also blinded, determined the
percentage of healthy surface and assigned the following scores: 0 = 100%
healthy surface, 1 = more than 66.6% healthy surface, 2 = 33.3-66% healthy
surface,and4 =lessthan33.3%healthysurface.
Secondaryobjectivesimpliedevaluationofthefollowingparameters:
a) Clinical efficacy against onychomycosis of the great toenail at D14, D28,
D56, andD112,
b) Microbiologicalefficacyoftheproduct(KOH stainingmethod),
c) Productsafety,
d) Impactonthequalityof life(QoL) of thesubjects,
e) Productefficacy, toleranceandacceptabilityby subject'sself-assessment.
At D14, D28, D56, D112, and D168, the following parameters have been scored
toassess onychomycosisevolution:
a) Onycholysis
b) Naildystrophy
c) Naildiscoloration
d) Nailthickening
The following scores were assigned: 0 = none, 1 = very slight, 2 = slight, 3 =
moderate,and4 =severe.
All patients evaluated the efficacy and acceptability of the treatment regime by
answering a questionnaire at each visit. In addition, at D0 (baseline), D56, D112
and D168, patients answered a validated questionnaire (NailQoL) to assess the
impactofonychomycosisontheirqualityoflife[14].
Safetyevaluation
At each visit the local tolerance (scored as “bad tolerance”, “moderate
tolerance”, “good tolerance”, and “very good tolerance”) and the global
tolerance (collection of all adverse events and subjective signs) were evaluated.
In addition, all patients were asked to report adverse events into a log book.
Study staff investigated all adverse events and determined the relationship to the
useofeachproduct.
Statisticalanalyses
Clinical efficacy was evaluated in the Intention-to-treat (ITT) population,
whereas safety and tolerability parameters were assessed in the “safety”
population. Briefly, continuous data were summarized by their mean, standard
deviation (SD), median, minimum and maximum. Categorical data have been
summarizedbyfrequenciesandpercentages.
Mean absolute changes in % healthy surface from baseline (D0) at D168
between both products were compared with an independent t-test after having
verified the assumptions of normality (QQ-plot) of the differences. Changes in
% healthy surface from baseline in function of treatmentduration were studied in
more detail using linear mixed-effects model with fixed effects for time and
treatment and random effect for subjects, after having verified normality and
homoscedasticityoftheresiduals(QQ-plotandresidualsversus fittedvalues).
Mean absolute changes in global score from baseline (D0) at D168 between both
products were compared with an independent t-test after having verified the
assumptionsofnormality(QQ-plot)ofthedifferences.
To compare changes in nail dystrophy, discoloration, and nail thickening
between baseline and D168, five categories were reduced to two categories
(None to slight versus moderate to severe).The same was done for healthy aspect
of the nail (totally and quite healthy versus moderate to not healthy at all).The
McNemar test for paired data was used to test if there was a change in nail
dystrophy, discoloration,andnailthickeningbetweenbaselineandD168.
All descriptive and statistical analyses were performed in R version 3.3.1. (R
development core team, 2016). A p-value < 0.05 was considered as statistical
significant. No imputation of missing data is performed. The amount of missing
datais presentedinthetableswhereverappropriate.
Baselinedata
In total, 112 subjects were randomized into the study, with 56 persons in each
treatment group. Seven subjects (n=2 in the acetic acid group and n=5 in the
amorolfine group) did not complete the study (withdrawal of consent or lost to
follow-up), whereas clinical data of D168 from 3 subjects were not available.
For this reason, 10 subjects were excluded from the analysis, yielding a total of
102 subjects (n=53, acetic acid; n=49, amorolfine). For safety and tolerability
analysis, 108 subjects (n=54, acetic acid; n=54, amorolfine) were included into
the safety population.Asummary of demographic characteristics is presented in
table1.
Table 1: Demographic characteristics.
Original Research Paper
4 International Educational Applied Scientific Research Journal (IEASRJ)
Volume : 2 ¦ Issue : 5 ¦ May 2017 ¦ e-ISSN : 2456-5040
Test product Reference
Age
(average ± standard deviation (SD))
Minimum – median - maximum
46.5 ± 13.2yrs.
20 - 47 - 83
46.8 ± 12.8 yrs.
20 – 48.5 - 77
Sex
Male, n (%) 22 (39.3) 20 (35.7)
Female, n (%) 34 (60.7) 36 (64.3)
% Healthy surface
(average ± SD)
64.0 ± 13.3% 66.8 ± 9.8 %
NailQoL Score
(average ± SD)
57.7 ± 10.3 56.0 ± 12.9
KOH staining 100% 100%
Fungal culture 65% positive 68% positive
Genus of fungi
Trichophyton rubrum 75.0% 77.8%
3. Original Research Paper
5International Educational Applied Scientific Research Journal (IEASRJ)
Prior to product application (D0), no significant differences were found between
both treatment groups for average healthy surface (p=0.1353), secondary
clinical parameters (different p values; not shown), and average NailQoL score
(p=0.3920).
Direct detection of fungal infection with the KOH staining method was positive
for all subjects in both treatment groups. Consequent fungal culture was positive
for a majority of the subjects, with Trichophyton (T.) rubrum being the most
common pathogen (75 and 78% for the acetic acid solution and amorolfine
group, respectively). Other dermatophyte fungi were also detected, including T.
interdigitalae (both groups), and T. mentagrophytes (reference group only).
Infections with non dermatophytic pathogens (Aspergillus niger and Aspergillus
fusarium) wereverylimited(referencegroup only).
Results
Efficacyevaluation
Primaryefficacy:changeinpercentageof healthysurface
Efficacy of both treatments was compared in terms of percentage of healthy
surface.SummarystatisticsaredisplayedinTable2.
Volume : 2 ¦ Issue : 5 ¦ May 2017 ¦ e-ISSN : 2456-5040
Test product Reference
Trichophyton interdigitalae 19.4% 11.1%
Trichophyton mentagrophytes 0% 2.8%
Aspergillus niger 5.6% 5.6%
Aspergillus fusarium 0% 2.8%
Table 2: Efficacy of treatment with an acid solution versus 5 % amorolfine: summary statistics for the % of healthy surface (mean ± SD)
(number of subjects in brackets).
Treatment D0 D14 D28 D56 D112 D168
Acid solution 64.0 ± 13.3 (55) 67.6 ± 15.1 (50) 69.1 ± 14.5 (48) 70.5 ± 15.7 (53) 71.6 ± 15.2 (49) 74.8 ± 12.3 (54)
Amorolfine 66.8 ± 9.8 (55) 68.0 ± 12.7 (52) 71.7 ± 12.1 (47) 70.6 ± 13.0 (47) 67.8 ± 13.0 (46) 72.3 ± 12.9 (49-)
The percentage of healthy surface between baseline and D168 increased with
11.4% (SD=17.0) in the acetic acid group and 5.1% (SD=12.6) in the amorolfine
group, respectively.The observed difference in increase of percentage of healthy
surfacewas statisticallysignificant(95% CI:0.4;12.1, p = 0.037).
The percentage of healthy surface after 14, 28, 56, 112 and 168 days of treatment
was further compared between both treatment groups with a generalized linear
mixed-effects model. This model confirmed a significant increase in % of
healthy surface in function of treatment duration (p<0.001). Furthermore, this
improvement was significantly higher after 112 (7.3%, p = 0.006) and 168 days
(6.2%, p = 0.015) of treatment with the acetic acid solution versus the amorolfine
naillacquer.
Secondaryefficacycriteria
Onychomycosisevolution
The proportion of subjects with an improvement or success increased from 8.9%
after 14 days ((53.6% (D28), 76.8% (D56), 87.3% (D112)) to 92.6% after 168
days of treatment with the acetic acid solution. Improvement or success was also
observed with reference but this was less pronounced and remained more or less
the same between days 56 (62.3%) and 168 (56.9%). After 112 and 168 days of
treatment, significantly (p=0.035 and p<0.001, respectively) more subjects from
the test product group showed improvement or success in comparison to the
referencegroup.
Onycholysis
No important changes in onycholysis were observed over treatment time and
betweenbothsubstances.
Dystrophy
At baseline, moderate to severe nail dystrophy was observed in 50% of the
subjects (acetic acidgroup: 51.8% (29/56) and in the amorolfinegroup: 48.2%
(27/56). Generally, nail dystrophy improved over treatment time, but the
improvement was more pronounced in the acetic acid group. After 168 days of
treatment, moderate to severe nail dystrophy was observed for 9.3% (5/54) of the
subjects in the acetic acid group in comparison to 29.4% (15/51) in the
amorolfine group. Of note, both substances resulted in a significant
improvement of nail dystrophy (McNemar p < 0.001 and p = 0.034, respectively)
betweenbaselineandD168.
Discoloration
At baseline, moderate to severe discoloration was observed in 92.0% of the
subjects (acetic acidgroup: 94.6% (53/56) and in the amorolfine group: 89.3%
(50/56). Generally, nail discoloration improved over treatment time, but the
improvement was more pronounced in the acetic acid group. After 168 days of
treatment, moderate to severe discoloration was observed for 9.3% (5/53) of the
subjects in the acetic acid group in comparison to 43.1% (22/51) for the
amorolfine group. Both substances resulted in a significant improvement of
discoloration (McNemar, p < 0.001 and p < 0.001, respectively) between
baselineandD168.
Nailthickening
At baseline, moderate to severe nail thickening was observed in 87.5% of the
subjects (acetic acid group: 82.1% (46/56) and in the amorolfinegroup: 92.9%
(52/56). Generally, nail thickening improved over treatment time, however the
improvement was more pronounced in the acetic acid group. After 168 days of
treatment, moderate to severe nail thickening was observed for 13.0% (7/54) of
the subjects in the acetic acid group in comparison to 35.3% (18/51) for the
amorolfine group. Both substancesresulted in a significant improvement of nail
dystrophy (McNemar p < 0.001 and p < 0.001, respectively) between baseline
andD168.
Healthyaspectof nail
At baseline, quite to totally healthy was observed in 15.2% of the subjects (acetic
acid group: 14.3% (8/56) and amorolfine group: 16.1% (9/56). Generally, the
healthy aspect of the nail improved over treatment time, but this improvement
was more pronounced in the acetic acid product group. After 168 days of
treatment, quite to totally healthy was observed for 64.8% (35/54) of the subjects
in the acetic acid group in comparison to 37.2% (19/51) for the amorolfine
group. Both substancesresulted in a significant improvement of nail dystrophy
(McNemarp <0.001andp= 0.010, respectively)betweenbaselineandD168.
Secondaryefficacycriterion:microbiologicalevaluation
After 168 days, only 37% in the acetic acid group and 38% of the subjects in the
amorolfine group remained KOH positive. Results of fungal culture
demonstrated a decrease of 51% (66% to 15%; acetic acid group) and 56% (68%
to 12%; amorolfine group), respectively, at day 168. These differences were not
statisticallysignificant.
Secondaryefficacycriterion:evaluationof subjects' QualityofLife
Efficacy of both products on the quality of life (QoL) of the subjects was
evaluated with the validated NailQoLquestionnaire [15] at the start of the study,
and 56, 112 and 168 days after start of the treatment, respectively. Summary
statisticsareprovidedintable3.
Table 3: Summary statistics for the evaluation of subject's quality of life
(NailQoL global score) by treatment and in function of time
(number of subjects in brackets).
A NailQoL global score of 0 corresponds to a quality of life never altered by
onychomycosis, whereas a score of 100 corresponds to a quality of life that is
always affected by onychomycosis. Both treatments resulted in a reduction of
the NailQoL global score in function of duration of the therapy, indicating an
improvement of subject's quality of life. After 168 days of treatment with the
acetic acid solution, mean NailQoLscore decreased with 38.9 units compared to
baseline. For subjects treated with amorolfine, mean NailQoL score decreased
with 29.7 units. This improvement in subject's quality of life after 168 days was
significantly higher for subjects treated with the acetic acid solution, showing an
improvement of on average 9.2 units (95% CI: 3.1 to 15.2, p=0.003) when
comparedtoamorolfine.
Safetyevaluation
Local tolerance of the treatment was assessed by the investigator via clinical
evaluation and subject interrogatory at each visit during the trial. Overall, both
treatments were very well tolerated with a score = 3 during each visit, with the
exception of one subject from the reference group who received a score of 2
(good tolerance)duringonevisit(D14).
Discussion
Fungal infections are reported to cause 23% of foot diseases and 50% of nail
conditions in people seen by dermatologists, but are less common in the general
population, affecting 3% to 5% of people [16]. The prevalence varies among
populations, which may be due to differences in screening techniques. In one
large European project (13,695 people with a range of foot conditions), 35% had
a fungal infection diagnosed by microscopy/culture [17]. One prospective study
in Spain (1000 adults aged >20 years) reported a prevalence of fungal toenail
infection as 2.7% (infection defined as clinically abnormal nails with positive
microscopy and culture) [18]. In Denmark, one study (5755 adults aged >18
Treatment D0 D56 D112 D168
Acid
solution
57.7 ± 10.3
(56)
29.8 ± 15.5 (56) 24.0 ± 14.1
(55)
18.7 ± 16.3
(54)
Amorolfine 56.0 ± 12.9
(56)
32.3 ± 15.8 (53) 26.9 ± 16.4
(51)
26.4 ± 15.0
(51)
4. Original Research Paper
6 International Educational Applied Scientific Research Journal (IEASRJ)
years) reported the prevalence of fungal toenail infection as 4.0% (determined
by positive fungal cultures) [19]. The incidence of mycotic nail infections may
have increased over the past few years, perhaps because of increasing use of
systemic antibiotics, immunosuppressive treatment, more advanced surgical
techniques,andtheincreasingincidenceofHIVinfection[20].
During recent years, different topical products have been put on the market for
the treatment of onychomycosis. They are used either alone or in combination
with systemic treatments, resulting in higher cure rates. For topical treatment,
both medicated nail solutions and medical devices with a physical mode of
action are commercially available. In the present study, the acetic acid-based nail
solution, which inhibits fungal growth by acidification of the nail environment,
was compared to a nail lacquer containing 5% amorolfine [21, 22].Amorolfine is
amorpholineantifungaldrug whichdisruptsthefungalcellmembrane[10].
All subjects were diagnosed with either superficial onychomycosis or light to
moderate disto-lateral onychomycosis (no affection of matrix; involvement <2/3
of the tablet) on at least one great toenail. Fungal infection was further confirmed
usingtheKOH stainingmethod[11].
Both women and men were included, with a higher proportion of women.
Average age was 46.5 ± 13.2 years and 46.8 ± 12.8 years in the acetic acid and
amorolfine group, respectively. At baseline (D0), both treatment arms were
homogeneousfor allstudiedparameters.
At the end of the study (D168), 7 subjects (n=2, test product; n=5, reference) did
not complete the study (withdrawal of consent or lost to follow-up), whereas
clinical data of D168 from 3 subjects were not available. For this reason, these
subjects were excluded from the data analyses, resulting in a final number of 102
patients. Safety and tolerability analysis was performed in the safety population,
consistingof108 subjects(n=54forbothgroups).
The primary objective of this study implied evaluation of the effect of both
treatments on the evolution in % of healthy surface between baseline and D168.
For the acetic acid product, an increase of 11.4% was observed, whereas
treatment with amorolfine resulted in an increase of 5.1%. The difference in
increase was significantly different (95% CI: 0.4; 12.1, p = 0.037). Clinical
performance of the acetic acid solution was further confirmed by the number of
patients showing onychomycosis improvement or success (completely cured) at
the end of the study: 92.6% (acetic acid)versus 56.9% (amorolfine). Again, the
differencebetweenbothtreatmentarmswas significant(p< 0.001).
Evaluation of other onychomycosis-related parameters demonstrated that the
effect of the acetic acid solution (when compared to amorolfine) was more
pronounced for nail dystrophy, discoloration, nail thickening, and healthy aspect
of the nail. For all parameters, a significant improvement when compared to
baseline,was shown forbothtreatments.
Clinical efficacy was further reflected by the improvement in patient's quality of
life, as evaluated using a validated questionnaire (NailQoL) [14]. This was
observed in both treatment arms but at study end, the effect in the acetic acid
groupwas significantlymorepronounced.
Finally, bothtreatmentswerewelltolerated,herebyconfirmingproductsafety.
The mode of action of the acid solution, which contains acetic acid and the acidic
ester ethyl lactate, relies on acidification of the nail. Following application, acid
penetration and consequent pH decrease of the nail environment will inhibit
acid-sensitive keratolytic enzymes, which are essential for dermatophyte nail
penetration [9, 23, 24, 25]. In turn, fungal growth inhibition allows the infected
parttogrow outinvivo, withoutfurtherfungalspreading.
Susceptibility of dermatophytes towards acids has been demonstrated in
independent experiments and literature reports. Results of a “minimum
inhibitory concentration” assay confirmed fungal growth inhibition following
exposure to different organic acids, including acetic acid [8]. Furthermore, in a
validated bovine hoof assay, both acetic acid solution and the amorolfine product
were able to penetrate the nail and to inhibit Trichophyton mentagrophytes
growth [9]. These in vitro data are further confirmed by the results of the present
clinicaltrial.
In conclusion, the tested acetic acid solution is an efficient and safe treatment for
mild to moderate cases of onychomycosis.At study end, the % of healthy surface
®
of the nail was significantly more increased when compared to Loceryl .
Clinical performance of the test product was further confirmed by: 1) the
significantly higher number of patients with onychomycosis improvement or
success (92.6% test product vs. 56.9%; reference), 2) the more pronounced
positive evolution of onychomycosis-related parameters in function of time, 3)
the positive impact on quality of life of the patients, and 4) confirmed safety. The
present clinical data confirm that the tested medical device is a safe and an
adequate alternative for medicated nail lacquers for the treatment of superficial
onychomycosisorlighttomoderatedisto-lateralonychomycosis.
Conflictsof interest
Funder of the study was Oystershell Laboratories, who is also the manufacturer
of the test product and employer of the co-authors Frank Eertmans and Bart
Rossel. The sponsor was involved in the study planning as well as in the decision
to publish, but was not involved in data collection, data analysis and data
interpretation. Oystershell Laboratories engaged the CRO Dermscan
(Laboratoires Dermscan, Villeurbanne, France) to independently design and
perform the study. Co-author Professor Néjib Doss was the principle
investigator of the study and responsible for patient investigation / recruitment
and data collection. Statistical analyses were performed by an independent,
external consultant, Els Adriaens (Adriaens Consulting, Bellegem, Belgium).
Pedro-AntonioRegidoris MedicalDirectorWesternEurope&GermanyExeltis
References
1. Chabasse D, Pihet M. Mycological diagnosis of Onychomycosis. J Mycol Med 2014;
24:269-278.
2. Elewski BE. Onychomycosis: Pathogenesis, Diagnosis and Management. Clin
MicrobiolRev1998;11:415-429.
3. Ghannoum M, Isham N. Fungal Nail Infections (Onychomycosis): A Never-Ending
Story?PLoSPathog2014;10:e1004105.
4. Baran R, Hay RJ. New clinical classification for onychomycoses. J Mycol Med 2014;
24:247-260.
5. Shirwaikar AA, Thomas T, Shirwaikar A, Lobo R, Prabhu KS. Treatment of
Onychomycosis:An Update.IndJPharm Sci2008;70:710-714.
6. Bunyaratavej S, Pattanaprichakul P, Leeyaphan C, Chayangsu O, Bunyaratavej S,
Kulthanan K. Onychomycosis: A study or self-recognition by patients and quality of
life.IndianJ DermatolVenerolLeprol2015;81:270-274.
7. Elewski BE, Tosti A. Risk Factors and Comorbidities for Onychomycosis. J Clin
AesthetDermatol2015.8:38-42.
8. Del Rosso JQ. The Role of Topical Antifungal Therapy for Onychomycosis and the
EmergenceofNewerAgents.JClinAesthetDermatol2014.7:10-18.
9. Sleven R, Lanckacker E, Delputte P, Maes L, Cos P. Evaluation of topical antifungal
productsinaninvitroonychomycosismodel.Mycoses2016;59:327-330.
10. Kunert J. Physiology of keratinophilic fungi. in: Biology of dermatophytes and other
keratinophilic fungi. In: Kushwaha, RKS, Guarro (eds.) Revista Iberoamericana de
Micología,Bilbao,2000:77-85.
11. PolakA. Preclinical data and mode of action of amorolfine. Dermatology 1992; 184: 3-
7.
12. Lim CS, Lim SL. Practical tip: Chicago Sky Blue (CSB) stain can be added to the
routine potassium hydroxide (KOH) wet-mount to provide a color contrast and
facilitatethediagnosisofdermatomycoses.DermatolOnlineJ2011;17:11.
13. Gupta AK, Jain HC, Lynde CW, Watteel GN, Summerbell RC. Prevalence and
epidemiology of unsuspected onychomycosis in patients visiting dermatologists'
offices in Ontario, Canada - a multicenter survey of 2001 patients. Int J Dermatol 1997.
36:783-787.
14. Kaliyadan F, Manoj J, Venkitakrishnan S, Dharmaratnam AD. Basic digital
photographyindermatology. IndianJDermatolVenerolLeprol2008;74:532-536.
15. Warshaw EM, Foster JK, Cham PM, Grill JP, Chen SC. NailQoL: a quality-of-life
instrumentforonychomycosis.IntJDermatol2007;46:1279-1286.
16. Evans EGV. The rationale for combination therapy. Br J Dermatol 2001;145(suppl
60):9–13.
17. Roseeuw D. Achilles foot screening project: preliminary results of patients
screened by dermatologists. J Eur Acad Dermatol Venereol 1999;12(suppl 1):
S6–S9
18. Del Palacio A, Cuetara MS, Garau M, et al. Onychomycosis: a prospective survey
of prevalence and etiology in Madrid. Int J Dermatol 2006; 45:874–876
19. Svejgaard EL, Nilsson J. Onychomycosis in Denmark: prevalence of fungal nail
infection in general practice. Mycoses 2004; 47:131–135
20. Trepanier EF, Amsden GW. Current issues in onychomycosis. Ann Pharmacother
1998; 32: 204–214
21. Iorizzo M, Harmane I, DervenieceA, Mikazans I. Ciclopirox 8% HPCH Nail Lacquer
in the Treatment of Mild-to-Moderate Onychomycosis:ARandomized, Double-Blind
Amorolfine Controlled Study Using a Blinded Evaluator. Skin Appendage Disord
2016;1:134-140.
22. Auvinen T, Tiihonen R, Soini M, Wangel M, Sipponen A, Jokinen JJ. Efficacy of a
topical resin lacquer, amorolfine and oral terbinafine for treating toenail
onychomycosis: a prospective, randomized, controlled, investigator-blinded, parallel-
groupclinicaltrial.BrJ Dermatol2015;173:940-948.
23. Guo J, Brosnan B, Furey A, Arendt E, Murphy P, Coffey A. Antifungal activity of
Lactobacillus against Microsporum canis, Microsporum gypseum and
Epidermophytonfloccosum.BioengBugs2012.3:102-111.
24. Lastauskiene E, ZinkevicieneA, Girkontaite I, KaunietisA, KvedarieneV. Formic acid
and acetic acid induce a programmed cell death in pathogenic Candida species. Curr
Microbiol2014;69:303–10.
25. Lind H, Jonsson H, Schnurer J. Antifungal effect of dairy propionibacteria -
contributionoforganicacids.IntJ Food Microbiol2005;98:157–65.
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