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Schmallenberg virus in
          Europe
Tarlinton, R., Daly, J., Dunham, S., Kydd, J.




                   School of Veterinary Medicine and Science
Schmallenberg why the
 fuss?
• Discovered in cattle with diarrhoea in Germany and the
  Netherlands in Autumn 2011
• Genetically very similar to a group of viruses (Akabane
  virus) known to cause birth defects in calves and lambs in
  Australia and Japan
• Mostly affect ruminants (sheep, goats and cattle in
  particular)
• Tests and monitoring therefore developed
• Over 6000 farms in Northern Europe reported deformed
  lambs or calves in spring/summer 2012
• http://www.youtube.com/watch?
  v=jtZ7kDTQWMM&feature=player_embedded#!




                            School of Veterinary Medicine and Science
How the viruses work
• Generally cause mild or no
  disease in adult animals
  (diarrhoea in cattle)
• If a pregnant animal is infected
  the virus replicates in the nerve
  cells of the foetus
• This (depending on when the
  animal is infected) leads to:
   – abortion
   – abnormalities of the bones
      and joints due to failure of
      normal muscle development
   – neurological deficits due to
      failure of brain development
                                        Photos courtesy of Amanda
                                        Straughton and Jennifer Price

                           School of Veterinary Medicine and Science
How does Akabane behave in
Australia and Japan?
 • It is spread by biting midges
 • In endemic areas most
   animals are infected
   pre-puberty and are immune
 • Only sporadic
   abortions/deformities are
   seen
 • If weather conditions change
   the range of the vector may
   extend resulting in large
   numbers of naive animals
   being infected
                                     Photo: culicoides.net
 • This leads to large-scale
   outbreaks of foetal
   deformities

                            School of Veterinary Medicine and Science
What we know now
• The virus has been found in
  Culicoides sp midges and this is
  probably how it is spreading in
  Europe
• Unfortunately these midges are
  found all over Europe
• Most cattle and sheep in the area
  where the virus was first identified
  have had it. It is assumed that
  they are immune and won’t have
  another affected calf or lamb
• It is spreading throughout the UK
  and other parts of northern
  Europe that didn’t have it last
  year at the moment                        Map courtesy of Flu
                                           trackers.com October
                                           2012


                                  School of Veterinary Medicine and Science
The UK as of Jan 2013
• The virus definitely circulated in the UK in summer/autumn
  2012
• 976 holdings across most of England and Wales have been
  exposed to the virus (AHVLA Dec 2012).
• Also first cases in Northern Island
• Vets who have been sending bulk milk samples from diary
  herds to BioBest laboratories to test for antibodies are
  reporting that almost all herds have been exposed
• Anecdotal reports of large numbers of ewes scanning
  empty
• Data from our own indoor herd would indicate that we have
  a lower percentage of animals exposed (25%) compared
  with the 70-100% reported in Belgium and the Netherlands



                         School of Veterinary Medicine and Science
The likely impact
• There are likely to be deformed lambs and calves
  born in spring/summer 2013
• Numbers will vary from farm to farm as the
  deformities will depend on what stage of
  pregnancy the animals were at when infected.
• Data our students collected last year demonstrate
  that losses may be as high as 30% on some
  severely affected holdings
• The virus will most likely circulate in further years
  (we have the midges)
• Merial have announced vaccine trials but it’s not
  likely to be available till next year at the earliest

                       School of Veterinary Medicine and Science

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Schmallenberg slide show

  • 1. Schmallenberg virus in Europe Tarlinton, R., Daly, J., Dunham, S., Kydd, J. School of Veterinary Medicine and Science
  • 2. Schmallenberg why the fuss? • Discovered in cattle with diarrhoea in Germany and the Netherlands in Autumn 2011 • Genetically very similar to a group of viruses (Akabane virus) known to cause birth defects in calves and lambs in Australia and Japan • Mostly affect ruminants (sheep, goats and cattle in particular) • Tests and monitoring therefore developed • Over 6000 farms in Northern Europe reported deformed lambs or calves in spring/summer 2012 • http://www.youtube.com/watch? v=jtZ7kDTQWMM&feature=player_embedded#! School of Veterinary Medicine and Science
  • 3. How the viruses work • Generally cause mild or no disease in adult animals (diarrhoea in cattle) • If a pregnant animal is infected the virus replicates in the nerve cells of the foetus • This (depending on when the animal is infected) leads to: – abortion – abnormalities of the bones and joints due to failure of normal muscle development – neurological deficits due to failure of brain development Photos courtesy of Amanda Straughton and Jennifer Price School of Veterinary Medicine and Science
  • 4. How does Akabane behave in Australia and Japan? • It is spread by biting midges • In endemic areas most animals are infected pre-puberty and are immune • Only sporadic abortions/deformities are seen • If weather conditions change the range of the vector may extend resulting in large numbers of naive animals being infected Photo: culicoides.net • This leads to large-scale outbreaks of foetal deformities School of Veterinary Medicine and Science
  • 5. What we know now • The virus has been found in Culicoides sp midges and this is probably how it is spreading in Europe • Unfortunately these midges are found all over Europe • Most cattle and sheep in the area where the virus was first identified have had it. It is assumed that they are immune and won’t have another affected calf or lamb • It is spreading throughout the UK and other parts of northern Europe that didn’t have it last year at the moment Map courtesy of Flu trackers.com October 2012 School of Veterinary Medicine and Science
  • 6. The UK as of Jan 2013 • The virus definitely circulated in the UK in summer/autumn 2012 • 976 holdings across most of England and Wales have been exposed to the virus (AHVLA Dec 2012). • Also first cases in Northern Island • Vets who have been sending bulk milk samples from diary herds to BioBest laboratories to test for antibodies are reporting that almost all herds have been exposed • Anecdotal reports of large numbers of ewes scanning empty • Data from our own indoor herd would indicate that we have a lower percentage of animals exposed (25%) compared with the 70-100% reported in Belgium and the Netherlands School of Veterinary Medicine and Science
  • 7. The likely impact • There are likely to be deformed lambs and calves born in spring/summer 2013 • Numbers will vary from farm to farm as the deformities will depend on what stage of pregnancy the animals were at when infected. • Data our students collected last year demonstrate that losses may be as high as 30% on some severely affected holdings • The virus will most likely circulate in further years (we have the midges) • Merial have announced vaccine trials but it’s not likely to be available till next year at the earliest School of Veterinary Medicine and Science