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Salud y biodiversidad ,[object Object]
 
Atelopus sp. discovered near Tacarcuna Centrolene sp. Pristimantis sp. Photos: Marco Rada CI Nymphargus sp. Colostheus sp. Bolitoglossa taylori Pristimantis sp. Corchanella sp. Anomaloglossus
[object Object],Batrachotoxin A. Reitsma, Aquarium of the Pacific Phyllobates terribilis PNAS.2004;101(45):15857-15860 Choresine
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3 domain
[object Object],ENDANGERED Batrachotoxin A. Reitsma, Aquarium of the Pacific Phyllobates terribilis PNAS.2004;101(45):15857-15860 Choresine
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Molecular Biology of the Cell.  Garland Science , 2002 NATURE  |  VOL 409  |  22 FEBRUARY 2001
Molecular Biology of the Cell.  Garland Science , 2002 NATURE  |  VOL 409  |  22 FEBRUARY 2001
Molecular Biology of the Cell.  Garland Science , 2002 NATURE  |  VOL 409  |  22 FEBRUARY 2001
Molecular Biology of the Cell.  Garland Science , 2002 NATURE  |  VOL 409  |  22 FEBRUARY 2001
Reinert Library - Creighton University Oncogene  (2009) 28, 2051–2063
 
© National Institute for Medical Research
Stephen Dalton Ambystoma mexicanum
NATURE  |  Vol 460  |  2 July 2009
 
 
 
NDA 1998-2002 All new chemical entities approved by the  United States Food & Drug Administration 1981-2006 ( N  =  1184) J. Nat. Prod.  2007,  70,  461 - 477
Taxol Taxol
 
The last char cartoon La silla último El árbol último
Mitotic spindle
taxol
Star anise
Oseltamivir from anise
 
 
Nathan Muchhala Anoura fistulata 8.5cm
Nathan Muchhala Centropogon nigricans
WWF
 
 
 
 
Emerging Infections Phil. Trans. R. Soc. Lond. B (2001) 356, 983-989. N = 175
CDC
Dengue Fever Cases Americas Region
Nature Reviews Microbiology. 2004;2:789-801
 
 
Karl Ammann, karlammann.com
12 NOVEMBER 2004 VOL 306 SCIENCE
Nature, 2003;423:280–283. 1952 1958 1964 1980
 
 
1000 1800 1927 1960 1974 1999 2050 300 Million 1987
1000 1800 1927 1960 1974 1999 2050 1 Billion 1987
1000 1800 1927 1960 1974 1999 2050 2 Billion 1987
1000 1800 1927 1960 1974 1999 2050 3 Billion 1987
1987 1000 1800 1927 1960 1974 1999 2050 4 Billion 1987
1987 1987 1987 1000 1800 1927 1960 1974 1999 2050 5 Billion
1987 1000 1800 1927 1960 1974 1999 2050 6 Billion
1987 1000 1800 1927 1960 1974 1999 2050 9+ Billion
 
 
 
[object Object],Children’s Hospital Boston C ENTER FOR  H EALTH AND THE  G LOBAL  E NVIRONMENT H ARVARD  M EDICAL  S CHOOL http://chge.med.harvard.edu http://childrenshospital.org http://www.hsph.harvard.edu http://www.thomasfoundation.org.au/
 
 
Epipedobates tricolor Epibatidine
[object Object]
zetekitoxin AB Atelopus zeteki CRITICALLY ENDANGERED Panamanian golden frog

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Salud y Biodiversidad - Aaron Bernstein

Editor's Notes

  1. http://news.mongabay.com/2009/0203-colombia_frogs.html The amphibians were discovered during a recent Rapid Assessment Program (RAP) expedition in the Tacarcuna area of the Darien, near the border with Panama.
  2. Choresine beetle is source for batrachotoxins in genera pitohui and ifrita birds. Frogs Na channels immune to effects of batrachotoxin
  3. Choresine beetle is source for batrachotoxins in genera pitohui and ifrita birds. Frogs Na channels immune to effects of batrachotoxin
  4. homogenize nature; lose adaptations
  5. Oncogene (2009) 28, 2051–2063; doi:10.1038/onc.2009.68; published online 13 April 2009 Microarray coupled to quantitative RT–PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells Microarrays for Cancer Diagnosis and Classification
  6. Mouse embryo hippocampal neuron migration
  7. transformed Aztec god The U.S. Department of Defense has given a $6.25 million research grant in late 2009 to scientists studying the little creaturewith the aim of eventually helping the more than 1,000 soldiers who have come back from Iraq and Afghanistan with missing extremities. 400
  8. Martin Kragl we further demonstrate that positional identity is a cell-type-specific property of blastema cells, in which cartilage-derived blastema cells harbour positional identity but Schwann-derived cells do not. Our results show that the complex phenomenon of limb regeneration can be achieved without complete dedifferentiation to a pluripotent state, a conclusion with important implications for regenerative medicine.
  9. Lake Chalco 1847 Lake Xochimilco and Lake Chalco. The latter was drained because of flooding danger, and now the expansion of Mexico City is threatening the ecosystems of Lake Xochimilco
  10. Medicines come from species other than microbes Rosy periwinkle - vincristine & vinblastine Acyclovir - cryptotheca crypta (Caribbean sea sponge) Ziconotide - cone snails Roughly 50% of the most prescribed medicines in the United States are directly or indirectly derived from a natural source and, despite the significant contributions from rational drug design in recent years, a recent analysis demonstrates that the majority (116 out of 158) of new drugs licensed between 1998-2002 can be traced to natural product origins
  11. This woman in Maoxian county on the border of China and Nepal is hand-pollinating apple trees because the local bees have gone extinct, from an excessive use of pesticides. It takes 20-25 people to pollinate 100 apple trees, a job done with much greater efficiency by 2 bee hives. This photo, from the International Center for Integrated Mountain Development in Nepal.
  12. Anoura fistulata drinking honey-water from a glass tube.  This bat has the longest tongue, relative to body length, of any mammal ( Muchhala 2006a ).
  13. transition to ecosystem services - regulation of climate Forests - water quality -
  14. Particulates on a leaf honeylocust (NY)
  15. http://upload.wikimedia.org/wikipedia/commons/4/4e/Parque_Nacional_Natural_Chingaza_map_es.png
  16. Figure 7.6. A EDES AEGYPTI Mosquito . Ae. aegypti is the main vector in the world for yellow fever and for dengue fever, the latter caused by the world’s most prevalent mosquito-borne virus. Ae. aegypti is widely distributed, being found in tropical and semitropical areas on all continents. (Courtesy of the Centers for Disease Control and Prevention.)
  17. Dengue Fever Cases
  18. Murdered Gorilla Family. Because gorillas are often together as families, it is not diffi cult to slaughter them for bushmeat, all at the same time.
  19. Colour codes depict the number of fish caught per 100 hooks on pelagic longlines set by the Japanese fleet. Data are binned in a global 5° 5° grid.
  20. Bogotá in 1887 when the population was 120,000:
  21. Bogotá in 2007 when the population was 10,244,480:
  22. Bolivar province Ecuador
  23. Bogota Rail endangered
  24. It has been hypothesized that zetekitoxin production requires the presence of symbiotic bacteria, as various forms of bacteria are known to produce a related toxin (saxitoxin)