This document discusses five common diseases that affect safflower: Alternaria blight, Sclerotinia head rot, root rot, gray mold, and rust. Alternaria blight causes dark lesions on stems and leaves and can rot seeds. Sclerotinia head rot causes heads to disintegrate, leaving sclerotia. Root rot causes wilting and bleaching as roots and stems rot. Gray mold causes soft rotting at wound sites. Rust causes powdery brown pustules on leaves, flowers and fruits. Management strategies include removing diseased plants, crop rotation, irrigation practices, fungicide application, and resistant varieties.