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The document discusses the Efruzher cancer theory and the role of the T3 receptor in carcinogenesis. It states that cytokines and growth factors can stimulate both cell proliferation and differentiation depending on dosage levels. The T3 receptor is located in the nucleus and mitochondria. Cancer cells continuously receive high levels of ligand signaling for proliferation but have broken down mitochondrial energy generation and aerobic glycolysis. They also have unsuccessful transcription expression from normal DNA sequences.
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This document discusses the role of cytokines and growth factors in cell proliferation and differentiation, and how their levels impact these processes. It explains that the T3 receptor is located in the nucleus and mitochondria, and that energy generation is important for proliferation and differentiation. The document suggests that cancer cells continuously take high levels of ligand signaling, favoring proliferation over differentiation, and that their energy generation and DNA sequences are disrupted, making differentiation impossible.
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- Development follows cephalocaudal and proximodistal patterns from head to tail and center to periphery.
- Factors like heredity, environment, nutrition, and hormones influence growth and development.
- Physical growth involves changes in height, weight, head circumference, and chest size at different stages.
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- 1. “EFRUZHU CANCER (CARCİNOGENESİS) THEORY” T3 RECEPTOR AND İMPORTANCE OF CANCER . DETAİLED COMMENTS 22. = VOİCED 22. CYTOKİNES-GROWTH FACTORS MAKE PROLİFERATİVE AND DİFFERENCİATİVE EFFECT ONTO CELL DEPENDENT OF DOSAGE,HİGH DOSE PROLİFERATİVE,LOW/NORMAL DOSE MAKES DİFFERENCİATİON.T3 RECEPTOR LOCALİSED İN THE NUCLEUS AND MİTHOCHONDRİON.ENERGY VERY İMPORTANT CONDİTİON THAT PROLİFERATİON AND DİFFERENCİATİON.CANCER CELL CONTİNUOUSLY TAKES LİGAND SİGNALİNG HİGH LEVEL/DOSE SO DOMİNANTİVE BEHAVİOUR PROLİFERATİVE ACTİONS BUT ENERGY GENERATİON İN THE AEROBİC GLYCOLYSİS/MİTHOCHONDRİON HAS BROKEN DOWN OR LOW LEVEL NORMAL DNA SEQUENCE SHOULD NOT OPPENED(TRANSCRİPTİON EXPRESSİON UNSUCCESSFUL) TO PRODUCE OXİDATİVE PHOSPHORİLATİON POLİPEPTİDES,TRANSCİPTİON FACTOR,TRANSPORTER ETC.SO THAT