TSU-68 is a novel kinase inhibitor developed for cell signaling and oncology research. It has significant antitumor activity against many types of tumors by inducing apoptosis in vascular and tumor cells, perturbing tumor vasculature and inhibiting angiogenesis. TSU-68 inhibits the tyrosine kinase phosphorylation of VEGF, PDGF and bFGF receptors to block angiogenesis. Studies show it inhibits tumor proliferation and metastasis in colon cancer models by blocking tumor angiogenesis, but does not affect ovarian cancer cell proliferation directly. TSU-68 binds to VEGF and PDGF receptors to inhibit their phosphorylation rather than acting directly on the growth factors.

1. Product Information Novel Kinase Inhibitors
for cell signaling & oncology research
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Technical Data:
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Formula: C18H18N2O3 OH
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Solubility: DMSO N
Purity: 99%
H
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Storage: at -20℃ 2 years N
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CAS No.: 252916-29-3 Synonyms: SU6668 techbio@selleckchem.com
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Biological Activity
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TSU-68 has significant antitumor activity against many types of tumor xenograft explants in
athymic mice. TSU-68 inhibits angiogenesis through several mechanisms, including the induction
of apoptosis in vascular endothelial cells and tumor cells, resulting in perturbing existing tumor
vascular function and also inhibiting newly synthesis angiogenesis for the tumor growth.[1] TSU-68,
a molecular-targeting drug, has the effect on blocking the tyrosine kinase phosphorylation of the
receptors not only for VEGF but also for PDGF and bFGF, and inhibiting angiogenesis. Studies
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using in vivo experimental models of cancers such as colon cancer have reported that TSU-68
has the effect on inhibiting tumor proliferation and metastasis through the inhibition of tumor
angiogenesis. In vitro TSU-68 does not influence the proliferation of ovarian cancer cells.[2] The
administration of TSU-68 does not influence the concentration of VEGF or PDGF in the ascetic
fluid of mice with peritoneal dissemination of ovarian cancer. TSU-68 does not act directly on Return Policy
VEGF or PDGF, but binds to their receptors, thereby inhibiting their phosphorylation. [2] Please inspect packages immediately upon
receipt and notify customer service within
References 3 days of delivery of any damage or
discrepancies.Our team will take quick and
[1] Ueda Y et al. Cancer Chemother Pharmacol. 2010 Jul 30 appropriate action to correct any problem.
[2] Machida S et al. Int J Cancer. 2005 Mar 20; 114 (2): 224-9
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