This document provides an introduction to ionizing radiation and the structure of matter. It defines elements, atoms, isotopes, and compounds. Atoms are made up of a nucleus containing protons and neutrons, and electrons orbiting the nucleus. The number of protons determines the element, while the number of neutrons determines the isotope. Unstable isotopes undergo radioactive decay, emitting radiation such as alpha, beta, gamma rays, or neutrons. Radiation can be ionizing or non-ionizing, with ionizing radiation capable of altering matter.
This document discusses the etiology of cancer. It classifies etiological factors into extrinsic (chemical, physical, biological) and intrinsic (genetic, hormonal, immune) factors. Extrinsic factors predominate in causing adult cancers while intrinsic factors are more common in pediatric cancers. Major extrinsic factors include chemicals, radiation, infections, and tobacco. Chemicals can directly or indirectly damage DNA. Radiation can directly or indirectly ionize DNA. Certain viruses and bacteria are associated with specific cancer types. The interaction between multiple genetic and environmental factors usually leads to cancer development.
Trauma Management in Primary Care Settingssnsharifa
1. The primary survey involves rapidly assessing and treating life-threatening injuries by evaluating the patient's airway, breathing, circulation, disability, and exposure (ABCDE). This includes establishing an open airway, assessing breathing and ventilation, treating hemorrhagic shock, and providing spinal immobilization and intravenous access when needed.
2. The secondary survey is a head-to-toe examination to identify any injuries that may have been missed during the primary survey. It includes detailed examination of specific body regions like the head, neck, chest, abdomen, and extremities.
3. Effective trauma management requires a coordinated team approach with assigned roles. The goals are to rapidly identify and treat life-threatening injuries,
Field of oncology has evolved since many decades! This presentation will demonstrate how oncology had evolved. Special focus is on current radiation oncology and surgical oncology practices along with principles of oncology.
The document discusses radiation exposure during pregnancy from diagnostic and interventional radiology procedures. While thousands of pregnant women are exposed to radiation annually, for most patients the exposure is medically justified and the radiation risk is minimal. Higher doses from procedures like CT scans or therapeutic radiology can harm the fetus, with risks being greatest during organ development in the first trimester. Procedures should only be performed if the medical benefit outweighs the radiation risk to the fetus.
The document discusses stage III non-small cell lung cancer (NSCLC), noting its heterogeneity in presentation, risk factors, and treatment approaches. Stage III NSCLC encompasses locally advanced tumors with varying degrees of lymph node involvement. Effective treatment requires a multidisciplinary team and individualized treatment plans based on tumor characteristics and patient health. While surgery can potentially cure some stage III NSCLC, many patients require pre-operative or post-operative chemotherapy and radiation therapy to improve outcomes.
This document discusses various carcinogenic agents and their mechanisms of action. It describes direct-acting carcinogens that damage DNA directly and indirect-acting carcinogens that require metabolic activation before becoming carcinogenic. It also discusses initiation and promotion in chemical carcinogenesis. Radiation carcinogenesis from ionizing radiation, ultraviolet light, and viral oncogenesis are also covered, noting specific cancer risks from different exposures.
This document discusses emergency response and preparedness in a radiation department. It defines a radiation emergency and classifies emergencies by whether they affect equipment, an individual patient, or many patients. Potential sources of error leading to emergencies in radiotherapy, nuclear medicine, brachytherapy, and diagnostic radiology are described. Regulations regarding reporting and investigating emergencies are summarized. Steps for handling common emergency situations like source stucks are outlined. The responsibilities of licensees and radiation safety officers in emergency planning and response are also covered.
This document discusses motion management techniques for lung cancer radiotherapy. It begins by explaining why motion management is important, as standard CT scans do not fully capture lung tumor motion. It then describes 4DCT and other methods for assessing tumor motion, as well as techniques like ITV, gating, tracking and breath-holding to control for motion. Specific examples of tracking systems like ExacTrac and Cyberknife are provided. Overall, the document provides an overview of the challenges of lung tumor motion and different strategies used to manage it in radiation treatment planning and delivery.
This document discusses the etiology of cancer. It classifies etiological factors into extrinsic (chemical, physical, biological) and intrinsic (genetic, hormonal, immune) factors. Extrinsic factors predominate in causing adult cancers while intrinsic factors are more common in pediatric cancers. Major extrinsic factors include chemicals, radiation, infections, and tobacco. Chemicals can directly or indirectly damage DNA. Radiation can directly or indirectly ionize DNA. Certain viruses and bacteria are associated with specific cancer types. The interaction between multiple genetic and environmental factors usually leads to cancer development.
Trauma Management in Primary Care Settingssnsharifa
1. The primary survey involves rapidly assessing and treating life-threatening injuries by evaluating the patient's airway, breathing, circulation, disability, and exposure (ABCDE). This includes establishing an open airway, assessing breathing and ventilation, treating hemorrhagic shock, and providing spinal immobilization and intravenous access when needed.
2. The secondary survey is a head-to-toe examination to identify any injuries that may have been missed during the primary survey. It includes detailed examination of specific body regions like the head, neck, chest, abdomen, and extremities.
3. Effective trauma management requires a coordinated team approach with assigned roles. The goals are to rapidly identify and treat life-threatening injuries,
Field of oncology has evolved since many decades! This presentation will demonstrate how oncology had evolved. Special focus is on current radiation oncology and surgical oncology practices along with principles of oncology.
The document discusses radiation exposure during pregnancy from diagnostic and interventional radiology procedures. While thousands of pregnant women are exposed to radiation annually, for most patients the exposure is medically justified and the radiation risk is minimal. Higher doses from procedures like CT scans or therapeutic radiology can harm the fetus, with risks being greatest during organ development in the first trimester. Procedures should only be performed if the medical benefit outweighs the radiation risk to the fetus.
The document discusses stage III non-small cell lung cancer (NSCLC), noting its heterogeneity in presentation, risk factors, and treatment approaches. Stage III NSCLC encompasses locally advanced tumors with varying degrees of lymph node involvement. Effective treatment requires a multidisciplinary team and individualized treatment plans based on tumor characteristics and patient health. While surgery can potentially cure some stage III NSCLC, many patients require pre-operative or post-operative chemotherapy and radiation therapy to improve outcomes.
This document discusses various carcinogenic agents and their mechanisms of action. It describes direct-acting carcinogens that damage DNA directly and indirect-acting carcinogens that require metabolic activation before becoming carcinogenic. It also discusses initiation and promotion in chemical carcinogenesis. Radiation carcinogenesis from ionizing radiation, ultraviolet light, and viral oncogenesis are also covered, noting specific cancer risks from different exposures.
This document discusses emergency response and preparedness in a radiation department. It defines a radiation emergency and classifies emergencies by whether they affect equipment, an individual patient, or many patients. Potential sources of error leading to emergencies in radiotherapy, nuclear medicine, brachytherapy, and diagnostic radiology are described. Regulations regarding reporting and investigating emergencies are summarized. Steps for handling common emergency situations like source stucks are outlined. The responsibilities of licensees and radiation safety officers in emergency planning and response are also covered.
This document discusses motion management techniques for lung cancer radiotherapy. It begins by explaining why motion management is important, as standard CT scans do not fully capture lung tumor motion. It then describes 4DCT and other methods for assessing tumor motion, as well as techniques like ITV, gating, tracking and breath-holding to control for motion. Specific examples of tracking systems like ExacTrac and Cyberknife are provided. Overall, the document provides an overview of the challenges of lung tumor motion and different strategies used to manage it in radiation treatment planning and delivery.
This document discusses different types of cancer treatments including immunotherapy, chemotherapy, and radiation therapy. Immunotherapy uses the body's immune system to fight cancer through methods like monoclonal antibodies, non-specific immunotherapies like interferons and interleukins, oncolytic virus therapy, T-cell therapy, and cancer vaccines. Chemotherapy uses anti-cancer drugs to cure, control, or palliate cancer by destroying cancer cells, either orally or intravenously. Radiation therapy uses high-energy particles or waves like x-rays to damage cancer cell DNA either directly or through free radicals, delivered externally or internally through brachytherapy.
This document discusses advanced non-small cell lung cancer and targeted therapies. It provides an overview of lung cancer epidemiology and risk factors like smoking. It also reviews molecular targets in NSCLC like EGFR, KRAS, and EML4-ALK and associated targeted therapies. The document outlines NSCLC diagnosis, staging, and management approaches including surgery, chemotherapy, and newer targeted therapies based on molecular profiling.
This document discusses the evolution of radiation therapy from its discovery in the late 19th century to modern techniques. It traces developments such as the discovery of x-rays and radioactivity, early radium and x-ray therapies, and the introduction of cobalt-60 and linear accelerators to improve targeting ability. Modern advances discussed include intensity-modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), proton beam therapy, and radiosurgery techniques like Gamma Knife and Cyberknife which allow extremely precise high dose radiation treatments.
Locally advanced and metastatic prostate cancer can be treated with surgery, radiation therapy, hormone therapy, chemotherapy, or a combination. For locally advanced disease, short-term and long-term hormone therapy combined with radiation therapy improves outcomes. Adjuvant radiation after prostatectomy improves survival for high-risk patients. Advanced disease is treated by depleting androgens through surgical or medical castration. Newer agents like abiraterone, enzalutamide, radium-223, cabazitaxel, and sipuleucel-T provide additional treatment options.
6th Training Course on Radiation Protection for Radiation Workers and RCOs of BAEC, Medical Facilities & Industries
Training Institute, AERE, Savar, BAEC
24 - 29 October 2021
This document summarizes adjuvant chemotherapy for resectable non-small cell lung cancer (NSCLC). It discusses that patients with stage I-IIIA NSCLC have a risk of recurrence even after surgery. Large clinical trials have found that platinum-based adjuvant chemotherapy can improve outcomes for completely resected NSCLC. Specifically, the IALT trial found that cisplatin-based chemotherapy improved 5-year survival from 40.4% to 44.5% compared to observation alone. The JBR.10 trial found that vinorelbine and cisplatin improved 5-year survival from 54% to 69% compared to observation. The CALGB 9633 trial initially found paclitaxel/carboplatin improved outcomes but
Polymerase chain reaction (PCR) is a laboratory technique for amplifying a specific DNA sequence. It involves repeated cycles of heating and cooling of the DNA sample to separate and copy the DNA strands. During each cycle, the DNA strands are separated by heating, primers anneal to the DNA by cooling, and the DNA polymerase enzyme synthesizes complementary DNA strands by extending the primers. This process results in exponential amplification of the target DNA sequence, generating millions of copies. PCR was invented by Kary Mullis in the 1980s and uses the thermostable Taq polymerase enzyme from bacteria. It has become essential to many areas of science including genetics, medicine and forensics.
Hormones play an important role in certain cancers like breast, prostate, and ovarian cancer. Hormones stimulate the growth of cancerous cells in hormone-dependent cancers. Risk factors for breast cancer include factors affecting hormone levels like early menarche, late menopause, hormone replacement therapy, and oral contraceptive use. Prostate cancer risk is influenced by ethnicity and androgen receptor genes. Hormonal therapies target hormone levels and receptors to slow cancer growth by using medications like anti-androgens and GnRH agonists.
Basic Radiation Physics - Mr. D.S. Patkulkar.pdfJayarajuBattula3
This document provides an overview of basic radiation physics for radiation safety officer (RSO) certification. It defines ionizing radiation and different types including alpha, beta, gamma, x-rays and neutron radiation. It describes the composition of atoms and isotopes. Unstable nuclei undergo radioactive decay through emission of particles or photons. Radiation has sufficient energy to ionize atoms. The document covers radiation quantities, units of measurement, radiation interactions with matter and shielding. Understanding basic radiation physics is essential for RSOs to safely control and use radioactive sources.
The document summarizes the history and key discoveries related to radioactivity and nuclear physics. It discusses how Becquerel discovered radioactivity in uranium in 1896, leading the Curies to isolate the elements polonium and radium. It then covers atomic structure, the different types of radioactive decay, units of radioactivity, decay processes, and nuclear reactions including fission and fusion.
Here is a semi-log plot of the data with an exponential trendline:
The equation of the trendline is:
y = 12456e-0.4693x
Taking the natural log of both sides:
ln(y) = ln(12456) - 0.4693x
The slope is -0.4693
Using the equation:
t1/2 = 0.693/λ
λ = 0.4693
t1/2 = 0.693/0.4693 = 1.5
Therefore, the half-life of the isotope is 1.5 intervals, or 1.5 x 30 s = 45 seconds.
Naturally Occurring Radioactivity (NOR) in natural and anthropic environmentsSSA KPI
This document provides an overview of naturally occurring radioactivity (NOR) and naturally occurring radioactive materials (NORM) with a focus on their relevance to the oil and gas industry. It discusses the main radionuclides of interest, including radium-226, radium-228, uranium, radon-222, and lead-210. It also summarizes the origins of NORM in the oil and gas industry and the types of radiation emitted by NORM.
This document provides an overview of chemical bonding. It discusses valence electrons and how to determine the number for each element using the periodic table. It describes the different types of chemical bonds - ionic bonds formed by the transfer of electrons between atoms, and covalent bonds formed by the sharing of electron pairs. It also discusses concepts like electronegativity and how it relates to bond type and strength.
The document summarizes early atomic theory and the development of the modern atomic model. It discusses early thinkers like Democritus and Aristotle and their ideas. John Dalton proposed early atomic theory including that atoms are indivisible and unchangeable. J.J. Thomson's work led to the discovery of the electron. Rutherford determined atoms have a small, dense nucleus. Chadwick discovered the neutron in the nucleus. The modern atomic model includes protons, neutrons, and electrons. Radioactivity and nuclear reactions are discussed.
This document discusses types of radioactivity and nuclear decay. It describes alpha, beta, gamma radiation and positron emission. It explains that alpha particles consist of two protons and two neutrons, beta particles are high energy electrons, and gamma rays are high energy electromagnetic radiation without mass or charge. Nuclear decay occurs through radioactive processes like alpha, beta, gamma or positron emission. The rate of radioactive decay is measured by half-life, which is the time for half of a radioactive sample to decay. Radioisotope dating uses half-lives of elements like carbon-14, potassium-40 and uranium-238 to determine the age of materials.
The document discusses nuclear chemistry, including the structure of the nucleus, radioactive decay via alpha, beta, and gamma emissions, nuclear reactions like fission and fusion, and applications of nuclear processes like using fission to generate energy in nuclear reactors. Key concepts covered are the strong nuclear force, isotopes, radioactivity, decay modes, particle accelerators, and kinetics of radioactive decay. Nuclear reactions produce immense amounts of energy from tiny mass changes according to Einstein's equation E=mc2.
These notes covers chemistry chapter 2nd of class 11th which are strictly according to CBSE & state board syllabus.The contents covered are Model of atom, electronic configuration & many more..
Basic concept of radiation, radioactivity, radiation dosemahbubul hassan
This document provides information about a radiation protection training course taking place from October 24-28, 2021 in Dhaka, Bangladesh. It covers basic concepts in radiation, radioactivity, radiation dose units, types of radiation including alpha, beta, gamma, x-rays, and neutrons. It also discusses units of radioactivity, absorbed dose, dose equivalent, radiation weighting factors, and tissue weighting factors which are important concepts in radiation protection.
This document discusses atomic theory and electromagnetic radiation, including x-rays. It provides an overview of the atomic structure, including protons, neutrons, and electrons. It describes the electromagnetic spectrum and different types of ionizing radiation. X-rays are used in diagnostic imaging like radiography, fluoroscopy, mammography, and CT scans. Proper protection methods are needed to reduce radiation exposure for patients, staff, and the public.
This document discusses radioactivity and radiopharmaceuticals used in nuclear medicine for diagnosis and treatment. It defines isotopes, radioactive isotopes, and radioactivity. The major types of radioactive decay are described, including alpha particles, beta particles, gamma rays, and electron capture. The properties and effects of each type of radiation are summarized. The kinetics of radioactive decay are explained using decay constant and half-life. Radiation dosimetry is introduced as the calculation of radiation dose exposed to and absorbed by objects.
This document discusses different types of cancer treatments including immunotherapy, chemotherapy, and radiation therapy. Immunotherapy uses the body's immune system to fight cancer through methods like monoclonal antibodies, non-specific immunotherapies like interferons and interleukins, oncolytic virus therapy, T-cell therapy, and cancer vaccines. Chemotherapy uses anti-cancer drugs to cure, control, or palliate cancer by destroying cancer cells, either orally or intravenously. Radiation therapy uses high-energy particles or waves like x-rays to damage cancer cell DNA either directly or through free radicals, delivered externally or internally through brachytherapy.
This document discusses advanced non-small cell lung cancer and targeted therapies. It provides an overview of lung cancer epidemiology and risk factors like smoking. It also reviews molecular targets in NSCLC like EGFR, KRAS, and EML4-ALK and associated targeted therapies. The document outlines NSCLC diagnosis, staging, and management approaches including surgery, chemotherapy, and newer targeted therapies based on molecular profiling.
This document discusses the evolution of radiation therapy from its discovery in the late 19th century to modern techniques. It traces developments such as the discovery of x-rays and radioactivity, early radium and x-ray therapies, and the introduction of cobalt-60 and linear accelerators to improve targeting ability. Modern advances discussed include intensity-modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), proton beam therapy, and radiosurgery techniques like Gamma Knife and Cyberknife which allow extremely precise high dose radiation treatments.
Locally advanced and metastatic prostate cancer can be treated with surgery, radiation therapy, hormone therapy, chemotherapy, or a combination. For locally advanced disease, short-term and long-term hormone therapy combined with radiation therapy improves outcomes. Adjuvant radiation after prostatectomy improves survival for high-risk patients. Advanced disease is treated by depleting androgens through surgical or medical castration. Newer agents like abiraterone, enzalutamide, radium-223, cabazitaxel, and sipuleucel-T provide additional treatment options.
6th Training Course on Radiation Protection for Radiation Workers and RCOs of BAEC, Medical Facilities & Industries
Training Institute, AERE, Savar, BAEC
24 - 29 October 2021
This document summarizes adjuvant chemotherapy for resectable non-small cell lung cancer (NSCLC). It discusses that patients with stage I-IIIA NSCLC have a risk of recurrence even after surgery. Large clinical trials have found that platinum-based adjuvant chemotherapy can improve outcomes for completely resected NSCLC. Specifically, the IALT trial found that cisplatin-based chemotherapy improved 5-year survival from 40.4% to 44.5% compared to observation alone. The JBR.10 trial found that vinorelbine and cisplatin improved 5-year survival from 54% to 69% compared to observation. The CALGB 9633 trial initially found paclitaxel/carboplatin improved outcomes but
Polymerase chain reaction (PCR) is a laboratory technique for amplifying a specific DNA sequence. It involves repeated cycles of heating and cooling of the DNA sample to separate and copy the DNA strands. During each cycle, the DNA strands are separated by heating, primers anneal to the DNA by cooling, and the DNA polymerase enzyme synthesizes complementary DNA strands by extending the primers. This process results in exponential amplification of the target DNA sequence, generating millions of copies. PCR was invented by Kary Mullis in the 1980s and uses the thermostable Taq polymerase enzyme from bacteria. It has become essential to many areas of science including genetics, medicine and forensics.
Hormones play an important role in certain cancers like breast, prostate, and ovarian cancer. Hormones stimulate the growth of cancerous cells in hormone-dependent cancers. Risk factors for breast cancer include factors affecting hormone levels like early menarche, late menopause, hormone replacement therapy, and oral contraceptive use. Prostate cancer risk is influenced by ethnicity and androgen receptor genes. Hormonal therapies target hormone levels and receptors to slow cancer growth by using medications like anti-androgens and GnRH agonists.
Basic Radiation Physics - Mr. D.S. Patkulkar.pdfJayarajuBattula3
This document provides an overview of basic radiation physics for radiation safety officer (RSO) certification. It defines ionizing radiation and different types including alpha, beta, gamma, x-rays and neutron radiation. It describes the composition of atoms and isotopes. Unstable nuclei undergo radioactive decay through emission of particles or photons. Radiation has sufficient energy to ionize atoms. The document covers radiation quantities, units of measurement, radiation interactions with matter and shielding. Understanding basic radiation physics is essential for RSOs to safely control and use radioactive sources.
The document summarizes the history and key discoveries related to radioactivity and nuclear physics. It discusses how Becquerel discovered radioactivity in uranium in 1896, leading the Curies to isolate the elements polonium and radium. It then covers atomic structure, the different types of radioactive decay, units of radioactivity, decay processes, and nuclear reactions including fission and fusion.
Here is a semi-log plot of the data with an exponential trendline:
The equation of the trendline is:
y = 12456e-0.4693x
Taking the natural log of both sides:
ln(y) = ln(12456) - 0.4693x
The slope is -0.4693
Using the equation:
t1/2 = 0.693/λ
λ = 0.4693
t1/2 = 0.693/0.4693 = 1.5
Therefore, the half-life of the isotope is 1.5 intervals, or 1.5 x 30 s = 45 seconds.
Naturally Occurring Radioactivity (NOR) in natural and anthropic environmentsSSA KPI
This document provides an overview of naturally occurring radioactivity (NOR) and naturally occurring radioactive materials (NORM) with a focus on their relevance to the oil and gas industry. It discusses the main radionuclides of interest, including radium-226, radium-228, uranium, radon-222, and lead-210. It also summarizes the origins of NORM in the oil and gas industry and the types of radiation emitted by NORM.
This document provides an overview of chemical bonding. It discusses valence electrons and how to determine the number for each element using the periodic table. It describes the different types of chemical bonds - ionic bonds formed by the transfer of electrons between atoms, and covalent bonds formed by the sharing of electron pairs. It also discusses concepts like electronegativity and how it relates to bond type and strength.
The document summarizes early atomic theory and the development of the modern atomic model. It discusses early thinkers like Democritus and Aristotle and their ideas. John Dalton proposed early atomic theory including that atoms are indivisible and unchangeable. J.J. Thomson's work led to the discovery of the electron. Rutherford determined atoms have a small, dense nucleus. Chadwick discovered the neutron in the nucleus. The modern atomic model includes protons, neutrons, and electrons. Radioactivity and nuclear reactions are discussed.
This document discusses types of radioactivity and nuclear decay. It describes alpha, beta, gamma radiation and positron emission. It explains that alpha particles consist of two protons and two neutrons, beta particles are high energy electrons, and gamma rays are high energy electromagnetic radiation without mass or charge. Nuclear decay occurs through radioactive processes like alpha, beta, gamma or positron emission. The rate of radioactive decay is measured by half-life, which is the time for half of a radioactive sample to decay. Radioisotope dating uses half-lives of elements like carbon-14, potassium-40 and uranium-238 to determine the age of materials.
The document discusses nuclear chemistry, including the structure of the nucleus, radioactive decay via alpha, beta, and gamma emissions, nuclear reactions like fission and fusion, and applications of nuclear processes like using fission to generate energy in nuclear reactors. Key concepts covered are the strong nuclear force, isotopes, radioactivity, decay modes, particle accelerators, and kinetics of radioactive decay. Nuclear reactions produce immense amounts of energy from tiny mass changes according to Einstein's equation E=mc2.
These notes covers chemistry chapter 2nd of class 11th which are strictly according to CBSE & state board syllabus.The contents covered are Model of atom, electronic configuration & many more..
Basic concept of radiation, radioactivity, radiation dosemahbubul hassan
This document provides information about a radiation protection training course taking place from October 24-28, 2021 in Dhaka, Bangladesh. It covers basic concepts in radiation, radioactivity, radiation dose units, types of radiation including alpha, beta, gamma, x-rays, and neutrons. It also discusses units of radioactivity, absorbed dose, dose equivalent, radiation weighting factors, and tissue weighting factors which are important concepts in radiation protection.
This document discusses atomic theory and electromagnetic radiation, including x-rays. It provides an overview of the atomic structure, including protons, neutrons, and electrons. It describes the electromagnetic spectrum and different types of ionizing radiation. X-rays are used in diagnostic imaging like radiography, fluoroscopy, mammography, and CT scans. Proper protection methods are needed to reduce radiation exposure for patients, staff, and the public.
This document discusses radioactivity and radiopharmaceuticals used in nuclear medicine for diagnosis and treatment. It defines isotopes, radioactive isotopes, and radioactivity. The major types of radioactive decay are described, including alpha particles, beta particles, gamma rays, and electron capture. The properties and effects of each type of radiation are summarized. The kinetics of radioactive decay are explained using decay constant and half-life. Radiation dosimetry is introduced as the calculation of radiation dose exposed to and absorbed by objects.
Module 1_Basics of biological effects of ionizing radiation.pptjinprix
The document provides an overview of biological effects of ionizing radiation. It discusses how radiation is absorbed and interacts with matter, producing ionizations through various processes like the photoelectric effect, Compton scattering, and pair production for photons. It also describes radiation quantities like absorbed dose and equivalent dose, which accounts for different biological damage potential of radiation types. DNA damage from ionizing radiation can occur directly or indirectly through free radicals produced by water radiolysis. The cell has repair pathways to respond to DNA damage through checkpoints in the cell cycle. Double-strand breaks are critical lesions that can be repaired by non-homologous end joining or homologous recombination mechanisms.
The document discusses key topics in nuclear physics including:
1) The structure and properties of the nucleus including its composition of protons and neutrons.
2) The discovery of the neutron by James Chadwick in 1932 which helped explain nuclear reactions.
3) The strong and weak nuclear forces that bind nucleons together in the nucleus.
4) Key nuclear properties such as atomic number, mass number, and isotopes which have the same number of protons but different neutrons.
5) Other concepts like mass defect, binding energy, and mass-energy equation which are important for understanding nuclear processes.
The document summarizes key topics in the chapter on nuclear physics, including:
1) The structure and properties of the nucleus, including its composition of protons and neutrons.
2) The discovery of the neutron by James Chadwick in 1932, which helped explain nuclear structure.
3) The strong and weak nuclear forces that bind nucleons together in the nucleus.
Marie Curie discovered radioactivity through her work on atoms and their structure. Nuclear reactions involve changes to the nucleus through loss of particles and rearrangement of protons and neutrons, releasing significant energy. There are three main types of radiation emitted in radioactive decay: alpha, beta, and gamma. Half-life refers to the time it takes for half of a radioactive sample to decay and is used in radioactive dating. Radiation is dangerous as it can ionize atoms and damage DNA, disrupting cells.
Marie Curie discovered radioactivity through her work on atoms and their structure. Nuclear reactions involve changes to the nucleus through loss of particles and rearrangement of protons and neutrons, releasing tremendous energy. There are three main types of radiation emitted in radioactive decay: alpha, beta, and gamma. Half-life refers to the time it takes for half of a radioactive sample to decay and is used in radioactive dating. Radiation is dangerous because it can ionize atoms and damage DNA, disrupting cells.
The document discusses nuclear chemistry concepts including mass defect, nuclear stability, and radioactivity. It explains that the mass of an atom is less than the sum of its parts due to the conversion of mass to nuclear binding energy during nucleus formation. This mass difference is called the mass defect. Examples of nuclear reactions like alpha, beta, and gamma emission are provided. Applications of nuclear chemistry such as nuclear power generation, radiocarbon dating, food irradiation, and nuclear medicine are also summarized.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Similar to Rp001 introduction to ionizing radiation (20)
Test bank advanced health assessment and differential diagnosis essentials fo...rightmanforbloodline
Test bank advanced health assessment and differential diagnosis essentials for clinical practice 1st edition myrick.
Test bank advanced health assessment and differential diagnosis essentials for clinical practice 1st edition myrick.
Test bank advanced health assessment and differential diagnosis essentials for clinical practice 1st edition myrick.
The story of Dr. Ranjit Jagtap's daughters is more than a tale of inherited responsibility; it's a narrative of passion, innovation, and unwavering commitment to a cause greater than oneself. In Poulami and Aditi Jagtap, we see the beautiful continuum of a father's dream and the limitless potential of compassion-driven healthcare.
Ensure the highest quality care for your patients with Cardiac Registry Support's cancer registry services. We support accreditation efforts and quality improvement initiatives, allowing you to benchmark performance and demonstrate adherence to best practices. Confidence starts with data. Partner with Cardiac Registry Support. For more details visit https://cardiacregistrysupport.com/cancer-registry-services/
English Drug and Alcohol Commissioners June 2024.pptxMatSouthwell1
Presentation made by Mat Southwell to the Harm Reduction Working Group of the English Drug and Alcohol Commissioners. Discuss stimulants, OAMT, NSP coverage and community-led approach to DCRs. Focussing on active drug user perspectives and interests
Research, Monitoring and Evaluation, in Public Healthaghedogodday
This is a presentation on the overview of the role of monitoring and evaluation in public health. It describes the various components and how a robust M&E system can possitively impact the results or effectiveness of a public health intervention.
Solution manual for managerial accounting 18th edition by ray garrison eric n...rightmanforbloodline
Solution manual for managerial accounting 18th edition by ray garrison eric noreen and peter brewer_compressed
Solution manual for managerial accounting 18th edition by ray garrison eric noreen and peter brewer_compressed
The facial nerve, also known as cranial nerve VII, is one of the 12 cranial nerves originating from the brain. It's a mixed nerve, meaning it contains both sensory and motor fibres, and it plays a crucial role in controlling various facial muscles, as well as conveying sensory information from the taste buds on the anterior two-thirds of the tongue.
NURSING MANAGEMENT OF PATIENT WITH EMPHYSEMA .PPTblessyjannu21
Prepared by Prof. BLESSY THOMAS, VICE PRINCIPAL, FNCON, SPN.
Emphysema is a disease condition of respiratory system.
Emphysema is an abnormal permanent enlargement of the air spaces distal to terminal bronchioles, accompanied by destruction of their walls and without obvious fibrosis.
Emphysema of lung is defined as hyper inflation of the lung ais spaces due to obstruction of non respiratory bronchioles as due to loss of elasticity of alveoli.
It is a type of chronic obstructive
pulmonary disease.
It is a progressive disease of lungs.
nursing management of patient with Empyema pptblessyjannu21
prepared by Prof. BLESSY THOMAS, SPN
Empyema is a disease of respiratory system It is defines as the accumulation of thick, purulent fluid within the pleural space, often with fibrin development.
Empyema is also called pyothorax or purulent pleuritis.
It’s a condition in which pus gathers in the area between the lungs and the inner surface of the chest wall. This area is known as the pleural space.
Pus is a fluid that’s filled with immune cells, dead cells, and bacteria.
Pus in the pleural space can’t be coughed out. Instead, it needs to be drained by a needle or surgery.
Empyema usually develops after pneumonia, which is an infection of the lung tissue. it is mainly caused due in infectious micro-organisms. It can be treated with medications and other measures.
Emotional and Behavioural Problems in Children - Counselling and Family Thera...PsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Test bank clinical nursing skills a concept based approach 4e pearson educati...rightmanforbloodline
Test bank clinical nursing skills a concept based approach 4e pearson education
Test bank clinical nursing skills a concept based approach 4e pearson education
Test bank clinical nursing skills a concept based approach 4e pearson education
At Malayali Kerala Spa Ajman, Full Service includes individualized care for every client. We specifically design each massage session for the individual needs of the client. Our therapists are always willing to adjust the treatments based on the client's instruction and feedback. This guarantees that every client receives the treatment they expect.
By offering a variety of massage services, our Ajman Spa Massage Center can tackle physical, mental, and emotional illnesses. In addition, efficient identification of specific health conditions and designing treatment plans accordingly can significantly enhance the quality of massaging.
At Malayali Kerala Spa Ajman, we firmly believe that everyone should have the option to experience top-quality massage services regularly. To achieve that goal we offer cheap massage services in Ajman.
If you are interested in experiencing transformative massage treatment at Malayali Kerala Spa Ajman, you can use our Ajman Massage Center WhatsApp Number to schedule your next massage session.
Contact @ +971 529818279
Visit @ https://malayalikeralaspaajman.com/
The crucial role of mathematics in ai development.pptx
Rp001 introduction to ionizing radiation
1. 11
An Introduction to IonizingAn Introduction to Ionizing
RadiationRadiation
H.L.Anil RanjithH.L.Anil Ranjith
Head-Div of Radiation ProtectionHead-Div of Radiation Protection
Atomic Energy AuthorityAtomic Energy Authority
2. 22
Composed of :Composed of :
Solid - Eg : gold, copper, common saltSolid - Eg : gold, copper, common salt
Liquid - Eg : water, milk, mercuryLiquid - Eg : water, milk, mercury
Gas - Eg : air, oxygenGas - Eg : air, oxygen
The Structure of MatterThe Structure of Matter
3. 33
ELEMENTELEMENT
AN ELEMENT IS A PURE SUBSTANCEAN ELEMENT IS A PURE SUBSTANCE
WHICH CAN NOT BE BROKEN IN TOWHICH CAN NOT BE BROKEN IN TO
OTHER SUBSTANCES BY ANY OTHEROTHER SUBSTANCES BY ANY OTHER
METHOD.METHOD.
ATOMATOM
SMALLEST PARTICLE OF AN ELEMENT THATSMALLEST PARTICLE OF AN ELEMENT THAT
HAS ALL THE CHEMICAL PROPERTIES OF THEHAS ALL THE CHEMICAL PROPERTIES OF THE
GIVEN ELEMENT.GIVEN ELEMENT.
4. 44
COMPOUNDCOMPOUND
A COMPOUND IS FORMED WHEN TWO OR MOREA COMPOUND IS FORMED WHEN TWO OR MORE
ELEMENTS COMBINE TOGETHER CHEMICALLYELEMENTS COMBINE TOGETHER CHEMICALLY
TO PROVIDE A MORE COMPLEX KIND OFTO PROVIDE A MORE COMPLEX KIND OF
MATTER.MATTER.
MOLECULEMOLECULE
SMALLEST PARTICLE OF ACOMPOUND THATSMALLEST PARTICLE OF ACOMPOUND THAT
CAN EXIST WITHOUT LOOSING CHEMICALCAN EXIST WITHOUT LOOSING CHEMICAL
PROPERTIES OF THE COMPOUND.PROPERTIES OF THE COMPOUND.
5. 55
THE STRUCTURE OF THE ATOMTHE STRUCTURE OF THE ATOM
BASICALLY CONSISTS OF TWO PARTSBASICALLY CONSISTS OF TWO PARTS::
NUCLEUS :NUCLEUS :
CENTRAL CORE WHERE ALMOST ALL THE MASS OF THECENTRAL CORE WHERE ALMOST ALL THE MASS OF THE
ATOM RESIDES.ATOM RESIDES.
CONSISTS OF: POSITIVELY CHARGED PROTONS ANDCONSISTS OF: POSITIVELY CHARGED PROTONS AND
ELECTRICALLY NEUTRAL NEUTRONS.ELECTRICALLY NEUTRAL NEUTRONS. (THESE TWO(THESE TWO
PARTICLES ARE COMMONLY CALLED “NUCLEONS”)PARTICLES ARE COMMONLY CALLED “NUCLEONS”)
ELECTRON :ELECTRON :
LIGHT WEIGHT NEGATIVELY CHARGED PARTICLESLIGHT WEIGHT NEGATIVELY CHARGED PARTICLES
ORBITING THE NUCLEUS, A GREAT DISTANCE AWAY.ORBITING THE NUCLEUS, A GREAT DISTANCE AWAY.
6. 66
Structure of the AtomStructure of the Atom
Protons 1
1p
(1.007276 amu)
Neutrons 1
0n
(1.008665 amu)Electrons
(0.0005486 amu)
7. 77
ATOMIC NUMBER(Z)ATOMIC NUMBER(Z)
NO OF PROTONS IN THENO OF PROTONS IN THE
NUCLEUSNUCLEUS
THE ATOMIC NUMBER DETERMINES THETHE ATOMIC NUMBER DETERMINES THE
CHEMICAL PROPERTIES OF THECHEMICAL PROPERTIES OF THE
ELEMENTELEMENT
9. 99
An atom of elementAn atom of element
having samehaving same
number of protonsnumber of protons
(z) and different(z) and different
number ofnumber of
neutrons (n) isneutrons (n) is
called an isotope ofcalled an isotope of
the element.the element.
Eg:Eg:
191191
Ir,Ir, 192192
Ir,Ir, 193193
IrIr
(Z=77)(Z=77)
5858
CoCo 5959
CoCo
6060
CoCo
(Z=27)(Z=27)
An IsotopeAn Isotope
10. 1010
An IsotopeAn Isotope
Hydrogen Deuterium Tritium
Hydrogen, deuterium, and tritium all have the same
atomic number Z: Their chemical properties are the
same, but their mass numbers are different.
11. 1111
Nuclear StabilityNuclear Stability
Impairs by presence of too many or tooImpairs by presence of too many or too
few neutrons in the nucleusfew neutrons in the nucleus
12. 1212
Too many or too few neutronsToo many or too few neutrons in the nucleusin the nucleus
causecause UNSTABILITYUNSTABILITY of the atomof the atom
Unstable atom seeks to become stable by breakingUnstable atom seeks to become stable by breaking
and emits energy asand emits energy as RADIATION.RADIATION. The process isThe process is
calledcalled RADIOACTIVITYRADIOACTIVITY and the Atom is said to beand the Atom is said to be
RadioactiveRadioactive
Isotopes of
elements which
are radioactive
are called
RADIONUCLIDERADIONUCLIDE
SS
14. 1414
RadioactivityRadioactivity
The process of rearrangements of nuclei byThe process of rearrangements of nuclei by
changing the relative no. of neutrons andchanging the relative no. of neutrons and
protons in the nuclei of unstable atomsprotons in the nuclei of unstable atoms
The rearrangements will cause release ofThe rearrangements will cause release of
energy in the form of particles orenergy in the form of particles or
electromagnetic radiation (commonly calledelectromagnetic radiation (commonly called
radiation)radiation)
16. 1616
Radiation DecayRadiation Decay
Half-life is the time itHalf-life is the time it
takes for half of the nucleitakes for half of the nuclei
in a substance to undergoin a substance to undergo
radio-active decayradio-active decay
Isotopes found in natureIsotopes found in nature
typically have long half-typically have long half-
lives; medical isotopeslives; medical isotopes
typically have short half-typically have short half-
liveslives
Typically the shorter theTypically the shorter the
half-live the morehalf-live the more
radioactive the materialradioactive the material
17. 1717
Radioactive Decay (RadioactiveRadioactive Decay (Radioactive
DisintegrationDisintegration
Time taken to decay half of the atoms in a sample at
certain time.
Half-life (THalf-life (T1/21/2))
21. 2121
Ionizing RadiationIonizing Radiation
When radiation has enough energy to alter
the matter that it collides with or passes
through it is referred to as ionizing
radiation
Since humans are made up of matter,
ionizing radiation can affect us adversely
22. 2222
Ionizing Radiation (cont’d)Ionizing Radiation (cont’d)
There are 2 types of ionizing radiation:There are 2 types of ionizing radiation:
electromagnetic waveselectromagnetic waves
sub-atomic particlessub-atomic particles
Typically, particles are parts of atomsTypically, particles are parts of atoms
alpha (helium nucleus)alpha (helium nucleus)
beta (electron)beta (electron)
positron (positive anti-electron)positron (positive anti-electron)
neutron (component of nucleus)neutron (component of nucleus)
23. 2323
““Radioactive” versusRadioactive” versus
“Radiation”“Radiation”
The terms “radioactive” and “radiation” areThe terms “radioactive” and “radiation” are
often confusedoften confused
By keeping the following relationship inBy keeping the following relationship in
mind, these two terms can bemind, these two terms can be
distinguished:distinguished:
Radioactive atoms emit radiationRadioactive atoms emit radiation
Radioactive atoms emit radiationRadioactive atoms emit radiation
24. 2424
RadiationRadiation is particles or waves ofis particles or waves of
energy emitted from unstable atomsenergy emitted from unstable atoms
Radioactive ContaminationRadioactive Contamination isis
radioactive material usually in anyradioactive material usually in any
location you do not want itlocation you do not want it
Radiation vs. RadioactiveRadiation vs. Radioactive
ContaminationContamination
25. 2525
RF µwave infrared visible uv x-rayγ-ray cosmic
low energylow energy high energyhigh energy
ionizing radiationionizing radiationnon-ionizingnon-ionizing
Electromagnetic SpectrumElectromagnetic Spectrum
27. 2727
ALPHA PARTICLEALPHA PARTICLE
EMISION OF TWO PROTONS AND TWO NEUTRONSEMISION OF TWO PROTONS AND TWO NEUTRONS
FROM THE NUCLEUSFROM THE NUCLEUS
238238
9292UU-------------->>234234
9090Th +Th +44
22He (Alpha)He (Alpha)
30. 3030
MECHANISUM OF BETAMECHANISUM OF BETA
EMISSIONEMISSION
ELECTRON EMISSIONELECTRON EMISSION
00
11
nn 11
11
P + -P + -11
00
e + ve + v
POSITRON EMISSIONPOSITRON EMISSION
31. 3131
Phosphorous –32 beta spectrum
0.5 1.0 1.50
E = 0.70 MeV
Beta particle energy,MeV
Emax = 1.71 MeV
R
E
L
A
T
I
V
E
N
U
M
B
E
R
32. 3232
ELECTRON EMISSIONELECTRON EMISSION
AN EXAMPLEAN EXAMPLE
3232
1515PP 3232
1616S +S + 00
-1-1 e + 1.71 MeVe + 1.71 MeV
POSITRON EMISSIONPOSITRON EMISSION
AN EXAMPLEAN EXAMPLE
2222
1111NaNa 2222
1010Ne +Ne + 00
11e + ve + v
33. 3333
ORBITAL ELECTRON CAPTUREORBITAL ELECTRON CAPTURE
INSTEAD OF CONVERTING A PROTON TO AINSTEAD OF CONVERTING A PROTON TO A
NEUTRON AND A POSITRON,IN SOMENEUTRON AND A POSITRON,IN SOME
RADIOACTIVE TRANSFORMATION ONE OFRADIOACTIVE TRANSFORMATION ONE OF
THE EXTRA- NUCLEAR ELECTRON ISTHE EXTRA- NUCLEAR ELECTRON IS
CAPTURED BY THE NUCLEUS, AND UNITSCAPTURED BY THE NUCLEUS, AND UNITS
WITH AN INTRA-NUCLEAR PROTRON TOWITH AN INTRA-NUCLEAR PROTRON TO
FORM A NEUTRON ACCORDING TO THEFORM A NEUTRON ACCORDING TO THE
FOLLOWING EQUATIONFOLLOWING EQUATION
00
-1-1 e +e + 11
11 HH 11
00 n +vn +v
38. 3838
NEUTRON RADIATIONNEUTRON RADIATION
CAN MAKE THE MATERIAL THROUGHCAN MAKE THE MATERIAL THROUGH
WHICH THEY PASS RADIOACTIVE BY BEINGWHICH THEY PASS RADIOACTIVE BY BEING
ABSORBED BY NUCLEI ( THIS PROCESS ISABSORBED BY NUCLEI ( THIS PROCESS IS
CALLED NEUTRON ACTIVATION)CALLED NEUTRON ACTIVATION)
HAS NO CHARGEHAS NO CHARGE
CAN CAUSE SIGNIFICANT CELL DAMAGE BYCAN CAUSE SIGNIFICANT CELL DAMAGE BY
INDIRECT IONISATION AND OTHERINDIRECT IONISATION AND OTHER
PROCESSESPROCESSES
CAN CAUSE FISSION IN HEAVY ISOTOPESCAN CAUSE FISSION IN HEAVY ISOTOPES
SUCH ASSUCH AS 235235
U ORU OR 239239
PuPu
When atoms throw off energy in an attempt to re-balance themselves that process is called decay. Half-life is the time it takes for half of the nuclei in a substance to undergo radioactive decay.
Decay is a random process. Background radiation fluctuates up and down all day long. Important to take background readings of the entire port.
Radionuclides found in nature typically have long half-lives; medical radionuclides typically have short half-lives.
Uranium (natural) – long half-life of 4.5 billion years
Medical nuclides – short half-lives – Carbon 11 has a half-life of 20 minutes - that’s why for some medical radionuclides it literally has to be made down the hall from the person receiving it, otherwise the material would be rendered useless.
6X half-life for a substance to be decayed down to 1%
If you were to inadvertantly wander through the tunnel of the VACIS or an x-ray machine while it was scanning, you would be irradiated. However, once the source of x-rays is turned off - you would no longer be irradiated.
However, if you were to get a radioactive substance (powder, liquid, etc.) “on” you - you would be contaminated. In other words, that source of contamination “goes with you” no matter where you (and can contaminate others as well) until you are decontaminated.
Alpha ( ) particles are helium nuclei (4He).
They consist of 2 protons + 2 neutrons, forming a very stable atom.
-particles are quite heavy particles (atomic mass = 4), i.e. 4 times the mass of the hydrogen nucleus. The electrical charge is + 2. Usually -particles are emitted from heavy atoms, with high energy of several MeV (Mega = million electronvolt).
If -particles penetrate matter they cause heavy ionization, loose their energy fast and are stopped by few centimeters of air or millimeters of solid material (e.g. one sheet of paper). In biological tissue they create a lot of damage by killing many cells in a small volume.
Beta () radiation consists of electrons emitted from the nucleus.
Normally electrons are negatively charged. If they are positively charged they are called “positrons”.
The mass of the electron is much (~1/8000th) smaller than that of alphas, therefore ionization is much weaker, penetration through matter much deeper.
Betas penetrate meters of air and centimeters of solid material. They are stopped by some cm of plastic (e.g. plexiglass), or few mm of glass (goggles).
Note: Never handle any Beta sources without eye protection - goggles!!
Gamma () radiation is a kind of electromagnetic radiation, similar to light or radiowaves, only with much higher energy. It has no mass and no charge.
Gamma “particles” are called “photons”.
Ionization of matter by -radiation is very weak, penetration through matter very deep and dependent on the energy. The higher the energy, the deeper the penetration through matter. For low energetic -radiation (up to ~ 0.5 MeV) high-Z materials (lead) provide better shielding. For higher energies only the product of density and thickness counts.
High energy -radiation can penetrate kilometers of air, meters of water or concrete. Typical shielding materials are several 10 cm of lead or up to 1 m of concrete. -radiation completely penetrates the body, causing a deep dose.
X-rays have physically the same nature as gamma rays, i.e. they are electromagnetic radiation. However, while -rays are emitted from the nucleus of the atom, X-rays are generated in the shell, by electrons moving from a higher to a lower energy level (“characteristic X-rays”). X-rays can also emerge when charged particles are slowed down, called “Bremsstrahlung”
Neutron radiation exists in nature only as part of cosmic radiation impinging on the earth from outer space. Neutrons are mostly produced in nuclear reactors and accelerators. Only a few man-made “Trans-uranium” elements (e.g. Pu, Americium, Californium) undergo “spontaneous fission” and emit neutrons.
Neutrons have no charge and mass 1 (same as protons). They give up their energy by bouncing on other nuclei, like billiard balls. If a neutron hits a proton, all the energy from the neutron may be transferred to the proton, which will then transfer it to the surrounding matter (“indirect ionization”).
Hydrogen (consisting of protons), e.g. in form of water or plastics, is therefore the most efficient shielding material for neutrons.
Shielding alpha and beta particles
Due to the fact that alpha and beta particles deposit so much energy over such a short distance they are very easy to shield. Alpha particles require little or no shielding as they travel only a very short distance in air.
For beta-emitting radioisotopes, low atomic number material such as plastic is recommended. Plastic will adequately shield the betas and keep bremsstrahlung production to a minimum. The thickness of the shield will depend on the range of the beta in the chosen material. A 3/8" plexiglass shield is recommended when working with P-32.
Due to their weak penetration -radiation is not dangerous in view of external exposure, - particles are stopped in the outmost layer of the skin. However, if -emitting radionuclides are incorporated in the body, e.g. inhaled in the lung, they can be very dangerous and destroy the inner organs.
Shielding of -radiation is very easy, a plastic wrapper or piece of paper is sufficient to completely stop all -particles. They will not penetrate clothing or goggles.
Note: always carefully avoid incorporation of - emitting radionuclides !!
Beta radiation penetrates the skin up to a few cm of tissue. It can heavily damage (burn) the skin and is particularly dangerous for the eye.
Note: never touch beta sources with your fingers, always use tweezers or tongs and wear goggles to protect your eyes !!
The intensity of -radiation decreases with the square of the distance from the source (“1/R2 law”). So if you retreat from the source from 10 cm to 1 m the intensity and your exposure will decrease by a factor of 100 !
NOTE: never take a gamma source in your fingers, use at least tongs or tweezers of some length ! The first few centimeters make a lot of difference !
Neutrons penetrate through the body like gammas, leading to a deep dose.
It takes several meters of concrete or metals to stop neutrons, but only some 10 cm of water, paraffin or plastic (hydrogen).
Best shielding for fast neutrons is first to slow them down in a moderator containing hydrogen, e.g. water of paraffine, then to absorb them by some particular elements, such as boron or cadmium.