INTRODUCTION
A major limitation in improving patient care has been the shortage of staff nurses. In the control phase
staff patient ratio was 1:3 , 1:4 which affected the delivery of quality care nursing, affecting the patient
outcome in terms of infection and mortality rate.
It is hypothesized that sudden influx of inexperienced nurses may be detrimental for patient care in the
short term especially in absence of structured training & mentorship program in place.
AIMS AND OBJECTIVES
To assess the effect of new joinees as staff nurses on patient care in neurosurgery ICU using infection
rate and mortality rate as the surrogate markers for nursing care.
MATERIALS AND METHODS
In this retro-prospective study in neurosurgery ICU over 6 months( Oct 2010- Mar 2011), the infection
rates (using blood, tracheal & urine culture reports) were calculated for a group of patients.
RESULT
Hospital Mortality Rate and Gross Infection Rates in terms of tracheal, urine and blood cultures were
assessed . severity of head injury was also assessed as it can act as a ditermental factor affecting
Hospital mortality rate in control phase 18%, in training phase 16.4 % and final phase 15.3%
Gross infection rates: tracheal culture incidence in control phase 62.3%, traning phase 59.3%, final phase
22.3% . in terms of urine culture incidence control phase 48.9%, training phase 34.2%, final phase 12.6%
and for blood culture it was 24.9% in control phase, 14.5% in training phase and 4.2 in final phase.
CONCLUSION
•
There is significant decrease in mortality following introduction of 1:1 nursing in neurosurgery
ICU.
•
The severity of head injury was approximately in the same range of all the phases hence it has
no significant role to play in the reduction of mortality rate.
•
Blood infection rate (4.25), tracheal infection rate (22.3%) & urine infection rate (12.6%) in the
final phase were significantly lower (p<0.001) than the preceding two phases
Structured programs and mentorship plays a vital role in improving the nursing practices .
•
Hoi suc tim phoi mới nhất (năm 2015) theo hướng dẫn của Hiệp hội tim mạch Ho...Thoa doan
Hoi suc tim phoi mới nhất (năm 2015) theo hướng dẫn của Hiệp hội tim mạch Hoa Kì bao gồm: hồi sức cơ bản và nâng cao dành cho người không chuyên và nhân viên y tế
INTRODUCTION
A major limitation in improving patient care has been the shortage of staff nurses. In the control phase
staff patient ratio was 1:3 , 1:4 which affected the delivery of quality care nursing, affecting the patient
outcome in terms of infection and mortality rate.
It is hypothesized that sudden influx of inexperienced nurses may be detrimental for patient care in the
short term especially in absence of structured training & mentorship program in place.
AIMS AND OBJECTIVES
To assess the effect of new joinees as staff nurses on patient care in neurosurgery ICU using infection
rate and mortality rate as the surrogate markers for nursing care.
MATERIALS AND METHODS
In this retro-prospective study in neurosurgery ICU over 6 months( Oct 2010- Mar 2011), the infection
rates (using blood, tracheal & urine culture reports) were calculated for a group of patients.
RESULT
Hospital Mortality Rate and Gross Infection Rates in terms of tracheal, urine and blood cultures were
assessed . severity of head injury was also assessed as it can act as a ditermental factor affecting
Hospital mortality rate in control phase 18%, in training phase 16.4 % and final phase 15.3%
Gross infection rates: tracheal culture incidence in control phase 62.3%, traning phase 59.3%, final phase
22.3% . in terms of urine culture incidence control phase 48.9%, training phase 34.2%, final phase 12.6%
and for blood culture it was 24.9% in control phase, 14.5% in training phase and 4.2 in final phase.
CONCLUSION
•
There is significant decrease in mortality following introduction of 1:1 nursing in neurosurgery
ICU.
•
The severity of head injury was approximately in the same range of all the phases hence it has
no significant role to play in the reduction of mortality rate.
•
Blood infection rate (4.25), tracheal infection rate (22.3%) & urine infection rate (12.6%) in the
final phase were significantly lower (p<0.001) than the preceding two phases
Structured programs and mentorship plays a vital role in improving the nursing practices .
•
Hoi suc tim phoi mới nhất (năm 2015) theo hướng dẫn của Hiệp hội tim mạch Ho...Thoa doan
Hoi suc tim phoi mới nhất (năm 2015) theo hướng dẫn của Hiệp hội tim mạch Hoa Kì bao gồm: hồi sức cơ bản và nâng cao dành cho người không chuyên và nhân viên y tế
Ranse J. (2023). Research priorities in mass gatherings; invited speaker for the 5th International Conference for Mass Gathering Medicine: Legacy for Global Health Security, Riyadh, Kingdom of Saudi Arabia, 31st October
Clinical governance aspects of mass gatheringsJamie Ranse
Ranse J. (2023). Clinical governance aspects of mass gatherings; invited speaker for the 5th International Conference for Mass Gathering Medicine: Legacy for Global Health Security, Riyadh, Kingdom of Saudi Arabia, 30th October
The impact of Chemical, Biological, Radiological, Nuclear and Explosive event...Jamie Ranse
Ranse J. (2021). The impact of Chemical, Biological, Radiological, Nuclear and Explosive events on Emergency Departments: An integrative review; invited speaker for Qatar Health 2021, Doha, Qatar, 22nd January. [online]
Recommencing mass gathering events in the context of COVID-19: Lessons from A...Jamie Ranse
Ranse J. (2021). Recommencing mass gathering events in the context of COVID-19: Lessons from Australia; invited speaker for Qatar Health 2021, Doha, Qatar, 22nd January. [online]
Novel respiratory viruses in the context of mass gathering events: A systemat...Jamie Ranse
Ranse J. (2021). Novel respiratory viruses in the context of mass gathering events: A systematic review to inform event planning from a health perspective; invited speaker for Qatar Health 2021, Doha, Qatar, 21st January [online]
Ranse J. (2020). Australian bush fire experience; online presentation [via Zoom] at the Georgetown University, Emergency Management Program, Miami, Florida, United States of America, USA, 21st April.
Ranse J. (2019). The 2018 Commonwealth Games Experience; invited speaker for 4th International Conference for Mass Gathering Medicine, Jeddah, Saudi Arabia, 16th December.
Impact of mass gatherings on ambulance services and emergency departmentsJamie Ranse
Ranse J. (2020). Impact of mass gatherings on ambulance services and emergency departments; invited speaker for Qatar Health 2020, Doha, Qatar, 17th January
Australian civilian hospital nurses’ lived experience of the out-of-hospital ...Jamie Ranse
Ranse J, (2019). Australian civilian hospital nurses’ lived experience of the out-of-hospital environment following a disaster: Psychosocial aspects. Paper presented at the WADEM Congress on Disaster and Emergency Medicine, Brisbane, 7th May.
End-of-life care in postgraduate critical care nurse curricula: An evaluation...Jamie Ranse
Ranse K, Delaney L, Ranse J, Coyer F, Yates P. (2018). End-of-life care in postgraduate critical care nurse curricula: An evaluation of current content informing practice. Poster presented at the ANZICS/ACCCN Intensive Care Annual Scientific Meeting, Adelaide, 11th - 13th October.
Phenomenology: Moving from philosophical underpinnings to a practical way of ...Jamie Ranse
Ranse J. (2018). Phenomenology: Moving from philosophical underpinnings to a practical way of doing; presentation at the University of Newcastle, School of Nursing and Midwifery, Research Week, Newcastle, NSW, 10th August.
Mass gatherings: Impacts on emergency departmentsJamie Ranse
Ranse J. (2018). Mass gatherings: Impacts on emergency departments; presentation to nurses and doctors of the Royal Adelaide Hospital, Emergency Department, Adelaide, SA, 16th May
Australian civilian hospital nurses’ lived experience of an out-of-hospital e...Jamie Ranse
Ranse, J. (2017). Australian civilian hospital nurses’ lived experience of an out-of-hospital environment following a disaster. Doctorate of Philosophy. Flinders University, South Australia.
Caring during catastrophe: How nurses can make a differenceJamie Ranse
Ranse J. (2017). Caring during catastrophe: How nurses can make a difference; invited speaker for Disaster Nursing - Not If, But When… Melbourne, Vic, 27th July.
Australian civilian hospital nurses' lived experience of the out-of-hospital ...Jamie Ranse
Ranse J, Arbon P, Cusack L, Shaban R. (2017) Australian civilian hospital nurses' lived experience of the out-of-hospital environment following a disaster: A lived-space perspective; paper presented at the 17th WADEM Congress on Disaster and Emergency Medicine. Toronto, Canada 25th April.
Ranse J. (2017). Trends in mass gathering health; presentation and guest panel member to volunteer members of the St John Ambulance, South Australia, Adelaide, SA, 16th March.
Impact of mass gatherings on emergency departmentsJamie Ranse
Ranse J, Hutton A, Crilly J, Johnston A. (2017). Impact of mass gatherings on emergency departments: A free workshop for emergency doctors, nurses and paramedics, Adelaide, SA, 16th March.
Health service impact from mass-gatherings: A systematic literature reviewJamie Ranse
Ranse J, Hutton A, Keene T, Lenson S, Luther M, Bost N, Johnston A, Crilly J, Cannon M, Jones N, Hayes C, Burke B. (2016) Health service impact from mass-gatherings: A systematic literature review; paper presented at the 14th International Conference for Emergency Nurses. Alice Springs, Australia. 20th October.
The impact of mass gatherings on ambulance services and hospitalsJamie Ranse
Ranse J. (2016). The impact of mass gatherings on ambulance services and hospitals; webinar presentation to members of the Mass Gathering Section of the World Association for Disaster and Emergency Medicine, 14th October.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Ranse J. (2023). Research priorities in mass gatherings; invited speaker for the 5th International Conference for Mass Gathering Medicine: Legacy for Global Health Security, Riyadh, Kingdom of Saudi Arabia, 31st October
Clinical governance aspects of mass gatheringsJamie Ranse
Ranse J. (2023). Clinical governance aspects of mass gatherings; invited speaker for the 5th International Conference for Mass Gathering Medicine: Legacy for Global Health Security, Riyadh, Kingdom of Saudi Arabia, 30th October
The impact of Chemical, Biological, Radiological, Nuclear and Explosive event...Jamie Ranse
Ranse J. (2021). The impact of Chemical, Biological, Radiological, Nuclear and Explosive events on Emergency Departments: An integrative review; invited speaker for Qatar Health 2021, Doha, Qatar, 22nd January. [online]
Recommencing mass gathering events in the context of COVID-19: Lessons from A...Jamie Ranse
Ranse J. (2021). Recommencing mass gathering events in the context of COVID-19: Lessons from Australia; invited speaker for Qatar Health 2021, Doha, Qatar, 22nd January. [online]
Novel respiratory viruses in the context of mass gathering events: A systemat...Jamie Ranse
Ranse J. (2021). Novel respiratory viruses in the context of mass gathering events: A systematic review to inform event planning from a health perspective; invited speaker for Qatar Health 2021, Doha, Qatar, 21st January [online]
Ranse J. (2020). Australian bush fire experience; online presentation [via Zoom] at the Georgetown University, Emergency Management Program, Miami, Florida, United States of America, USA, 21st April.
Ranse J. (2019). The 2018 Commonwealth Games Experience; invited speaker for 4th International Conference for Mass Gathering Medicine, Jeddah, Saudi Arabia, 16th December.
Impact of mass gatherings on ambulance services and emergency departmentsJamie Ranse
Ranse J. (2020). Impact of mass gatherings on ambulance services and emergency departments; invited speaker for Qatar Health 2020, Doha, Qatar, 17th January
Australian civilian hospital nurses’ lived experience of the out-of-hospital ...Jamie Ranse
Ranse J, (2019). Australian civilian hospital nurses’ lived experience of the out-of-hospital environment following a disaster: Psychosocial aspects. Paper presented at the WADEM Congress on Disaster and Emergency Medicine, Brisbane, 7th May.
End-of-life care in postgraduate critical care nurse curricula: An evaluation...Jamie Ranse
Ranse K, Delaney L, Ranse J, Coyer F, Yates P. (2018). End-of-life care in postgraduate critical care nurse curricula: An evaluation of current content informing practice. Poster presented at the ANZICS/ACCCN Intensive Care Annual Scientific Meeting, Adelaide, 11th - 13th October.
Phenomenology: Moving from philosophical underpinnings to a practical way of ...Jamie Ranse
Ranse J. (2018). Phenomenology: Moving from philosophical underpinnings to a practical way of doing; presentation at the University of Newcastle, School of Nursing and Midwifery, Research Week, Newcastle, NSW, 10th August.
Mass gatherings: Impacts on emergency departmentsJamie Ranse
Ranse J. (2018). Mass gatherings: Impacts on emergency departments; presentation to nurses and doctors of the Royal Adelaide Hospital, Emergency Department, Adelaide, SA, 16th May
Australian civilian hospital nurses’ lived experience of an out-of-hospital e...Jamie Ranse
Ranse, J. (2017). Australian civilian hospital nurses’ lived experience of an out-of-hospital environment following a disaster. Doctorate of Philosophy. Flinders University, South Australia.
Caring during catastrophe: How nurses can make a differenceJamie Ranse
Ranse J. (2017). Caring during catastrophe: How nurses can make a difference; invited speaker for Disaster Nursing - Not If, But When… Melbourne, Vic, 27th July.
Australian civilian hospital nurses' lived experience of the out-of-hospital ...Jamie Ranse
Ranse J, Arbon P, Cusack L, Shaban R. (2017) Australian civilian hospital nurses' lived experience of the out-of-hospital environment following a disaster: A lived-space perspective; paper presented at the 17th WADEM Congress on Disaster and Emergency Medicine. Toronto, Canada 25th April.
Ranse J. (2017). Trends in mass gathering health; presentation and guest panel member to volunteer members of the St John Ambulance, South Australia, Adelaide, SA, 16th March.
Impact of mass gatherings on emergency departmentsJamie Ranse
Ranse J, Hutton A, Crilly J, Johnston A. (2017). Impact of mass gatherings on emergency departments: A free workshop for emergency doctors, nurses and paramedics, Adelaide, SA, 16th March.
Health service impact from mass-gatherings: A systematic literature reviewJamie Ranse
Ranse J, Hutton A, Keene T, Lenson S, Luther M, Bost N, Johnston A, Crilly J, Cannon M, Jones N, Hayes C, Burke B. (2016) Health service impact from mass-gatherings: A systematic literature review; paper presented at the 14th International Conference for Emergency Nurses. Alice Springs, Australia. 20th October.
The impact of mass gatherings on ambulance services and hospitalsJamie Ranse
Ranse J. (2016). The impact of mass gatherings on ambulance services and hospitals; webinar presentation to members of the Mass Gathering Section of the World Association for Disaster and Emergency Medicine, 14th October.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. ROLE OF CRITICAL CARE NURSES IN
DISASTERS
Jamie Ranse www.jamieranse.com
Assistant Professor twitter.com/jamieranse
University of Canberra youtube.com/jamieranse
linkedin.com/in/jamieranse
http://lifelineenergy.org/blog/wp-content/uploads/2011/03/jap-11.jpg
11. surge capacity?
180
160
140
Presentation Frequency
120 Total Influenza Presentations
Mean Influenza Presentations
Mean Total Presentations
100
Mean Total Presentations - Excluding Influenza
80
60
40
20
0
Sun
Tue
Thu
Tue
Thu
Sun
Mon
Thu
Sun
Tue
Thu
Sun
Tue
Thu
Fri
Fri
Fri
Fri
Sat
Mon
Sat
Sat
Mon
Sat
Mon
Fri
Wed
Wed
Wed
Wed
Wed
Day
16. ROLE OF CRITICAL CARE NURSES IN
DISASTERS
Jamie Ranse www.jamieranse.com
Assistant Professor twitter.com/jamieranse
University of Canberra youtube.com/jamieranse
linkedin.com/in/jamieranse
http://lifelineenergy.org/blog/wp-content/uploads/2011/03/jap-11.jpg