This document summarizes basal cell carcinoma (BCC), the most common skin cancer. BCC is a locally invasive, malignant tumor that arises from basal epidermal cells and hair follicles. It typically appears as a small nodule or ulcer on sun-exposed areas of the head and neck in fair-skinned, older adults. While BCC rarely metastasizes, it can cause significant local tissue destruction if not treated. Treatment options include surgical excision, Mohs micrographic surgery, radiation therapy, or non-surgical procedures like laser vaporization.

1. PRESENTED BY:
JOHN R. SUNGOH
ROLL NO. 114
BDS 2nd YEAR

2. DEFINITION
It's a slow growing.
locally invasive.
Malignant tumor of epithelial cells.
 Arise from basal epidermis and hair follicles
Commonest malignant skin tumor
Also called "Rodent" Or"Tear " Cancer
Or Basal Cell Epithelioma

3. It was called a rodent ulcer
because this kind of cancer
sometimes looks like a tiny
rodent bite on the skin.

6. EPIDEMIOLOGY
1.Age:40-80 Years (95%).
2.Sex: Male : Female (3:1).
3.80% arise in head and neck.
4.90% in face.
5.Fair skinned > dark skinned people.

7. High Risk Factors
On exposure to:
a. * U. V light
b. Arsenic
c. Coal tar
d. X-rays
e. Infrared rays
f. Also genetic skin cancer syndromes

8. CLINICAL FEATURES
①Start as a small nodule.
②Ulcer formation with raised and rolled edge.
③Central part is covered with scab.
④Grosws very slowly.
⑤No lymph node
⑥Local destruction by infiltration.

10. ENLARGE VIEW:
Nodule,
Irregular in shape, with
raise and rolled edge.

11. SITE FOR BASAL CELL CARCINOMA
 In the middle 1/3 of face(90%)
 Medial canthus of the eye
 Lateral canthus of the eye.
 Nose
 Eyelid
 Cheek,
 Ear
 Scalp
 Neck
 Hand etc.

12. MORPHOLOGIC FEATURES
It's is:
A slow growing tumor.
With rare metastasis.
Local invasion .
Disfigurement.
Not spread to
other organ

14. PATHOGENESIS
No apparent precursor lesion
Hard to culture
Resist transplantation
Rare metastasis (17%)
But recurrent known after inadequate
treatment.
 mutation in TP53 gene.

15. HISTOPATHOLOGY
Irregular masses of basaloid cells.
Arrange in nests.
Shrinkage artifact
Cleft b/w B. CC nest and stroma
Cleft present due to shrinkage of
mucin in the stroma.

18. SUBTYPES OF B. CC
*(26 varieties of B. CC)
6 subtypes are:
1. NODULAR B. CC
2. PIGMENTED B. CC
3. CYSTIC B. CC
4. SUPERFICIAL B. CC(Arsenic)
5. MICRONUDULAR B. CC
6. MORPHOEIC B. CC

20. INVESTIGATIONS
 SKIN BIOPSY
 X-ray OF THE PART
 CT-SCAN

23. TREATMENT:
1. SURGICAL
• Excision
• MOHS MICRO
GRAPHY SURGERY
2.RADIOTHERAPY 3.NON-SURGICAL
• Electro Dissication
• Laser vaporization(in
multiple tumors)

24. THANK YOU