4. BASAL CELL PAPILLOMA
SOFT WARTY LESIONS,PIGMENTED AND HYPERKERATOTIC IN
BASAL LAYER
PAPILLARY WART
BENIGN SKIN TUMOURS HPV
FRECKLE
NORMAL NUMBER OF MELANOCYTES WITH INCREASE
PRODUCTION
5. LENTIGO
โข SHARPLY CIRCOMSCRIBED PIGMENTED MACULES
โข MAY AT TIMES ASSOCIATED WITH PEUTZ JEGHERS
SYNDROME
MOLES/NAEVUS
โข MOLES/NAEVUS ARE LAYERED OR AGGREGATES OF
MELONICYTES IN EPIDERMIS
21. GIANT CONGINATAL PIGMENTED NAEVUS
GCPNSPRECURSORS FOR MM
MORE LIKELY WITH AXIAL LESIONS
RETROPERITONEAL OR INTRACRANIAL LESIONS
MULTIDICSIPILANARY MANAGEMENT
PERINATAL CURETTAGE,DERMAABRASION,LASER RESURFACING,
SURGICAL EXCISION WITH SKIN GRAFTS
DYSPLASTIC NAEVUS
IRREGULAR PROLIFERATIONS ATYPICAL MELANOCYTES
AT BASAL LAYER OF EPIDERMIS
25. ACTINIC SOLAR
KREATOSIS
20% S CC
CUTANEOUS HORN 10โ% SCC
KERATOACHANTHOM
A
SCC
BOWENS DISEASE 3-11% SCC
EXTRA MAMMARY
PAGETS
GIANT CONGENITAL
PIMEMENTD NAEVUS
25% SCC
3-5% MM
26. BASAL CELL CARCINOMA
EPIDEMIOLOGY
โข SLOW GROWING LOCALLY INVASIVE MALIGNANT TUMOUR
โข PLURIPOTENT EPITHELIAL CELLS
โข UVR IS STRONGEST PREDISPOSING FACTOR
โข OTHERS MAY BEARSENICAL COMPOUNDS,COAL TAR,AROMATIC HYDROCARBONS
โข 90%LESION ON FACE ABOVE ALINE FROM THE LOBE OF THE EAR TO THE CORNER OF
MOUTH
โข WHITE SKIN 40-80 YRS M>F
PATHOGENESIS
โข SLOW GROWING PROPOTIANTE TO DOSE OF CARCINOGEN
โข RARLY METASTISE
โข HARD TO CULTURE
MACROSCOPIC APPEARANCE
โข NODULAR
โข NODULOCYSTIC
โข CYSTIC
MICROSCOPIOC APPEAREANCE
โข OVOID CELLS IN NEST WITH SINGLE OUTER PALISADING LAYER
31. SQUAMOUS CELL CARCINOMA
EPIDEMIOLOGY
MALIGNANT TUMOUR OF KERATINISING CELLS OF EPIDERMIS OR ITS APPENDAGES
SECOND MOST COMMON TUMOUR
WHITE SKIN ELDERLY MEN WITH CUMULATIVE SUN EXPOSURE
ALSO ASSOCIATED CHRONIC INFLAMMATION(SINUS TRACTS , PREEXISTING SCARS
,OSTEOMYLETIS,BURNS,IMMUNOSUPPRESION,MARJOLINS )2% METASTASIS
20% RECURRENCE
MACROSCOPIC
โข EVERTED EDGES WITH INFLAMMED SKIN
โข SMOOTH NODULAR,VERROCOUS
โข PAPILLOMATOUS
โข ULCERATING
MICROSCOPIC
โข IRREGULAR MASSES OF SQUAMOUS EPITHELIUM
โข CELLULAR MORPHOLOGY,BRODERS GRADE ,DEPTH OF INVASIONPERINEURAL OR
VASCULAR INVASION
34. MANAGEMENT
โข DEFINTE TREATMENT SURGICAL
LOUPE EXCISION(4MM CLEARANCE
MARGIN IF <2 AND 1CM MARGIN >2CM
LESIONS )
โข IN TRANSIT METSTASIS
โข LYMPHATIC METSTASIS
35. MALIGNANT MALENOMA
โข EPIDEMIOLOGY
โข MM IS CANCER MELNOCYTES
โข MM ACCOUNTS FOR 5% OF SKIN
MALIGNANCY
โข INCREASES UVR EXPOSURE
โข 3%OF ALL MALIGNANCYS
โข 75% OF ALL DEATHS
โข 7%OCCULT METASTASIS
36. RISK FACTORS:
โข XERODERMAPIGMENTOSUM
โข PAST MEDICAL OR FAMILY HISTORY
โข HIGH NUMBER OF NAEVI
โข TENDENCY TO FRECKLE
โข GCPN
โข DYSPLASTIC NAEVUS
โข IMMUNOCOMPROMISED
MACROSCOPIC APPEANRANCE
โข SUPERFICIAL SPREADING MELANOMA75%
โข NODULAR MELANOMA 15%
โข LENTIGO MALIGNA MELANOMA5-10%
โข ACRAL LENTIGIOUS MELANOMA2-8%
FEATURES IN NAEVI SUGGESTING MM
โข CHANGE IN SIZE ,SHAPE COLOUR ,ITCHING,SATELLITE
LESIONS
โข BLOOD SUPPLY
