Road traffic injuries result in approximately 1.35 million deaths annually and cause significant economic losses, particularly in low-income countries where traffic deaths are disproportionately high. Key risk factors include speeding, alcohol and drug use, non-use of safety devices, distracted driving, and inadequate road infrastructure, with young males under 25 being the most affected demographic. Effective multi-sectoral actions, including improved road safety policies and infrastructure design, are essential for reducing fatalities and injuries from road traffic crashes.