Rickets is a deficiency disease in infants characterized by changes in the skeleton. It is caused by a lack of vitamin D, which leads to hypocalcemia and hypophosphatemia. Clinical symptoms include deformities of the head such as frontal bossing and widened sutures, chest abnormalities like rib swelling and spinal curvature, and bone deformities in the arms, legs, and pelvis such as bowed limbs and knock-knees. Symptoms generally present before age 2 and can sometimes persist throughout life.