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COMMUNITY ACQUIRED
PNEUMONIA
DR TAYYABA KHALID
CONTENT
• Introduction
• Pathophysiology
• Risk factors
• Causes
• Clinical features
• Investigations
• Management
• Complications
• Prevention
INTRODUCTION
Pneumonia
Inflammation of the Pulmonary parenchyma in which the alveoli are filled with fluid.
This may cause a decrease in the amount of oxygen that blood can absorb from air
breathed into the lung.
1. Community acquired peumonia (CAP)
2. Hospital acquired peumonia (HAP)
3. Health care associated pneumonia (HCP)
4. Ventilator associated pneumonia (VAP)
Community acquired pneumonia (CAP) is acute infection of pulmonary
parenchyma that develops in outpatient setting or with 48 hours of hospital admission.
PATHOPHYSIOLOGY
1. Infection to the lung by bacteria or viruses
2. Inflammatory response initiated
3. Alveolar edema + Exudate formation
4. Alveoli And respiratory bronchioles Fills with serous exudate ,
Blood cells , fibrin , bacteria
5. Consolidation of lung tissue
STAGES OF PNEUMONIAE
• Stage of congestion
• Stage of red hepatization
• Stage lf grey hepatization
• Stage of resolution
RISK FACTORS
• Cigarette smoking
• Upper respiratory infection
• Old age
• Alcohol
• Recent influenza infection
• Preexisting lung disease
• Glucocorticoid therapy
• Indoor air pollution
• Altered mental status
• HIV
COMMON AGENTS
BACTERIA
• Streptococcus pneumoniae
• Haemophilus influenzae
• Staphylococcus aureus
• Mycoplasma pneumoniae
• Legionella pneumophila
• Chlamydia pneumoniae
VIRUSES
• Influenza, parainfluenza
• Adenovirus
• Measles
• Cytomegalovirus
• Coronavirus
• Varicella
MODE OF TRANSMISSION
Ways you can get pneumonia include:
• Inhaling the infection (Droplet infection)
• Through the mouth or eyes
• Food particles and irritants from the intestinal tract can also cause aspiration pneumonia and
can occur when a person accidentally inhales these substances.
• Fungal pneumonia typically develops when people inhale microscopic particles of fungus from
the environment.
CLINICAL FEATURES
Typical CAP
Symptoms
• Acute onset of fever with rigors and chills
• Productive cough with mucopurulent sputum
• Pleuritic chest pain
• Dyspnea
Signs
• Tachycardia , tachypnea
• Dullness on percussion
• Inspiratory crackels , bronchial breath sounds,
increased vocal resounce
Atypical CAP
Symptoms
• Insidious onset , fever ( chills are
uncommon)
• Dry cough
• Headache, sore throat, fatigue, myalgia
Signs
• Pulse temperature dissociation
• Wheezing , ronchi , crackles
• Diffuse reticulonodular infiltrates on CXR
SEVERITY SCORING CRITERIA
• CURB-65 score
• Pneumonia severity index (PSI)
CLINICAL DIAGNOSIS
• History ( signs and symptoms suggesting pneumonia)
• Clinical Examination ( Ascultation of chest)
• Chest Xray
INVESTIGATIONS
Chest Xray
• Lobar pneumonia ( patchy opacification evolves into
homogeneous consolidation , Air bronchogram)
• Bronchopneumonia ( typical patchy and segmental
shadowing)
• Complications ( para-pneumonic effusion)
LOBAR PNEUMONIA. INTERSTITIAL PNEUMONIA
INVESTIGATIONS
• CBC
• Urea and electrolytes
• Gram staining and culture of sputum
• ESR/CRP
• Serum procalcitonin level
• ABGs(if severe)
• Viral PCR
• LFTs
• Blood culture
• Oropharyngeal swab
• Urine antigen assay for legionella
• Pleural Tap
• Bronchoscopy
MANAGEMENT
• Oxygen therapy ( Oxygen should be administered to all patients with tachypnoea, hypoxaemia,
hypotension or Acidosis .The aim of maintaining the PaO2 at or above 60mmHg or the SaO2 at
or above 92%.High concentrations (35% or more), preferably humidified, should be used in all
patients who do not have hypercapnia associated with COPD. )
• Fluid balance (These should be considered in patients with severe illness, older patients and
those who are vomiting. Otherwise, an adequate oral intake of fluid should be encouraged.
Inotropic support may be required in patients with shock)
• Antibiotic treatment
• Antipyretics
• Treatment of pleural pain ( paracetamol, Codeine, NSAIDS)
• Physiotherapy ( May help expectoration in those who suppress cough because of pleural pain.)
COMPLICATIONS
• Para-pneumonic effusion
• Empyema
• Lobar collapse( due to retention of sputum)
• Deep vein thrombosis and pulmonary embolism
• Pneumothorax (staphylococcus aureus)
• Lung abcess
• ARDS, Multiorgan failure
• Ectopic abcess formation
PREVENTION
• Avoid smoking
• Improve housing conditions
• Immunization ( influenza and
pneumococcal vaccine)
• Frequent hand washing
• Wearing surgical masks
• Practice good hygiene
Q: A person with Legionella pneumophila can be best treated with:
A | Vancomycin.
B | linezolid.
C | Erythromycin.
D | ceftazidime.
Q: All of the following can be used to diagnose atypical CAP EXCEPT?
A | ESR and CRP
B | Xray
C | Gram stain.
D | All the above apply
REFERENCE
• Davidson's Principles and Practice of Medicine - 24th Edition
• Harrison’s Principal of Internal Medicine 20th Edition
• www.radiopaedia.org
REVIEW OF COMMUNITY ACQUIRED PNEUMONIA..

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REVIEW OF COMMUNITY ACQUIRED PNEUMONIA..

  • 2. CONTENT • Introduction • Pathophysiology • Risk factors • Causes • Clinical features • Investigations • Management • Complications • Prevention
  • 3. INTRODUCTION Pneumonia Inflammation of the Pulmonary parenchyma in which the alveoli are filled with fluid. This may cause a decrease in the amount of oxygen that blood can absorb from air breathed into the lung. 1. Community acquired peumonia (CAP) 2. Hospital acquired peumonia (HAP) 3. Health care associated pneumonia (HCP) 4. Ventilator associated pneumonia (VAP) Community acquired pneumonia (CAP) is acute infection of pulmonary parenchyma that develops in outpatient setting or with 48 hours of hospital admission.
  • 4. PATHOPHYSIOLOGY 1. Infection to the lung by bacteria or viruses 2. Inflammatory response initiated 3. Alveolar edema + Exudate formation 4. Alveoli And respiratory bronchioles Fills with serous exudate , Blood cells , fibrin , bacteria 5. Consolidation of lung tissue STAGES OF PNEUMONIAE • Stage of congestion • Stage of red hepatization • Stage lf grey hepatization • Stage of resolution
  • 5. RISK FACTORS • Cigarette smoking • Upper respiratory infection • Old age • Alcohol • Recent influenza infection • Preexisting lung disease • Glucocorticoid therapy • Indoor air pollution • Altered mental status • HIV
  • 6. COMMON AGENTS BACTERIA • Streptococcus pneumoniae • Haemophilus influenzae • Staphylococcus aureus • Mycoplasma pneumoniae • Legionella pneumophila • Chlamydia pneumoniae VIRUSES • Influenza, parainfluenza • Adenovirus • Measles • Cytomegalovirus • Coronavirus • Varicella
  • 7. MODE OF TRANSMISSION Ways you can get pneumonia include: • Inhaling the infection (Droplet infection) • Through the mouth or eyes • Food particles and irritants from the intestinal tract can also cause aspiration pneumonia and can occur when a person accidentally inhales these substances. • Fungal pneumonia typically develops when people inhale microscopic particles of fungus from the environment.
  • 8. CLINICAL FEATURES Typical CAP Symptoms • Acute onset of fever with rigors and chills • Productive cough with mucopurulent sputum • Pleuritic chest pain • Dyspnea Signs • Tachycardia , tachypnea • Dullness on percussion • Inspiratory crackels , bronchial breath sounds, increased vocal resounce Atypical CAP Symptoms • Insidious onset , fever ( chills are uncommon) • Dry cough • Headache, sore throat, fatigue, myalgia Signs • Pulse temperature dissociation • Wheezing , ronchi , crackles • Diffuse reticulonodular infiltrates on CXR
  • 9. SEVERITY SCORING CRITERIA • CURB-65 score • Pneumonia severity index (PSI)
  • 10. CLINICAL DIAGNOSIS • History ( signs and symptoms suggesting pneumonia) • Clinical Examination ( Ascultation of chest) • Chest Xray
  • 11. INVESTIGATIONS Chest Xray • Lobar pneumonia ( patchy opacification evolves into homogeneous consolidation , Air bronchogram) • Bronchopneumonia ( typical patchy and segmental shadowing) • Complications ( para-pneumonic effusion)
  • 13. INVESTIGATIONS • CBC • Urea and electrolytes • Gram staining and culture of sputum • ESR/CRP • Serum procalcitonin level • ABGs(if severe) • Viral PCR • LFTs • Blood culture • Oropharyngeal swab • Urine antigen assay for legionella • Pleural Tap • Bronchoscopy
  • 14. MANAGEMENT • Oxygen therapy ( Oxygen should be administered to all patients with tachypnoea, hypoxaemia, hypotension or Acidosis .The aim of maintaining the PaO2 at or above 60mmHg or the SaO2 at or above 92%.High concentrations (35% or more), preferably humidified, should be used in all patients who do not have hypercapnia associated with COPD. ) • Fluid balance (These should be considered in patients with severe illness, older patients and those who are vomiting. Otherwise, an adequate oral intake of fluid should be encouraged. Inotropic support may be required in patients with shock) • Antibiotic treatment • Antipyretics • Treatment of pleural pain ( paracetamol, Codeine, NSAIDS) • Physiotherapy ( May help expectoration in those who suppress cough because of pleural pain.)
  • 15.
  • 16. COMPLICATIONS • Para-pneumonic effusion • Empyema • Lobar collapse( due to retention of sputum) • Deep vein thrombosis and pulmonary embolism • Pneumothorax (staphylococcus aureus) • Lung abcess • ARDS, Multiorgan failure • Ectopic abcess formation
  • 17. PREVENTION • Avoid smoking • Improve housing conditions • Immunization ( influenza and pneumococcal vaccine) • Frequent hand washing • Wearing surgical masks • Practice good hygiene
  • 18. Q: A person with Legionella pneumophila can be best treated with: A | Vancomycin. B | linezolid. C | Erythromycin. D | ceftazidime.
  • 19. Q: All of the following can be used to diagnose atypical CAP EXCEPT? A | ESR and CRP B | Xray C | Gram stain. D | All the above apply
  • 20. REFERENCE • Davidson's Principles and Practice of Medicine - 24th Edition • Harrison’s Principal of Internal Medicine 20th Edition • www.radiopaedia.org