Pneumonia-medical information (symptoms , management , diagnosis)martinshaji
Pneumonia is an infection that inflames the air sacs in one or both lungs. The air sacs may fill with fluid or pus (purulent material), causing cough with phlegm or pus, fever, chills, and difficulty breathing. A variety of organisms, including bacteria, viruses and fungi, can cause pneumonia.
Pneumonia can range in seriousness from mild to life-threatening It is most serious for infants and young children, people older than age 65, and people with health problems or weakened immune systems.
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Pneumonia-medical information (symptoms , management , diagnosis)martinshaji
Pneumonia is an infection that inflames the air sacs in one or both lungs. The air sacs may fill with fluid or pus (purulent material), causing cough with phlegm or pus, fever, chills, and difficulty breathing. A variety of organisms, including bacteria, viruses and fungi, can cause pneumonia.
Pneumonia can range in seriousness from mild to life-threatening It is most serious for infants and young children, people older than age 65, and people with health problems or weakened immune systems.
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thank u
communicable diseases by radhika kulvi msc nursingRadhika kulvi
A communicable disease is one that is spread from one person to another through a variety of ways that include: contact with blood and bodily fluids; breathing in an airborne virus; or by being bitten by an insect.
Reporting of cases of communicable disease is important in the planning and evaluation of disease prevention and control programs, in the assurance of appropriate medical therapy, and in the detection of common-source outbreaks. California law mandates healthcare providers and laboratories to report over 80 diseases or conditions to their local health department. Some examples of the reportable communicable diseases include Hepatitis A, B & C, influenza, measles, and salmonella and other food borne illnesses.
How do these communicable diseases spread?
How these diseases spread depends on the specific disease or infectious agent. Some ways in which communicable diseases spread are by:
Physical contact with an infected person, such as through touch (staphylococcus), sexual intercourse (gonorrhea, HIV), fecal/oral transmission (hepatitis A), or droplets (influenza, TB)
Contact with a contaminated surface or object (Norwalk virus), food (salmonella, E. coli), blood (HIV, hepatitis B), or water (cholera);
Bites from insects or animals capable of transmitting the disease (mosquito: malaria and yellow fever; flea: plague); and
Travel through the air, such as tuberculosis or measles.
Tuberculosis, MTB or TB, which was formerly known as “Consumption”, “Phthisis
pulmonalis”, is an infectious bacterial disease that is caused by mycobacteria
mainly by “Mycobacterium tuberculosis”. Lungs are the main site of infection in
the tuberculosis, but other systems of the body are also infected. Tuberculosis
spread through air droplets from a person who has active disease through
respiratory system.
Diseases o respiratory system
In humans the respiratory tract is
the part of the anatomy that has to
do with the process of respiration.
The respiratory tract is divided into
3 segments:
Upper respiratory tract: nose and nasal passages, paranasal sinuses, and throat or pharynx
Respiratory airways: voice box or larynx, trachea, bronchi, and bronchioles
Lungs: respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli
i am the student of lahore college for women university. i have made this presentation is on vaccination. as you know vaccination is important for all. so its benefits, importance, advantages and disadvantages are mentioned in this. diseases which are cured by vaccination are also mentioned. types are also mention.
Pneumonia is an infectious disease in one or both lungs. Micro-organisms such as bacteria, fungi, and viruses can cause pneumonia. In adults, bacterial pneumonia is most common.
The disease is the malfunctioning of the body organs due to one reason or the other. In other words, it is a disorder of the body. The state of the body when any of its normal functions are disturbed or when the structures are altered is called disease. We understand that to remain healthy, we need to do much more than just keep away from disease. CONGENITAL DISEASE: This type of disease is present right from the birth. This is caused either due to genetic disorders or gene mutation or environmental factors. These diseases are passed on from one generation to next generation. Some examples of congenital diseases are Haemophilia, Sickle cell anaemia, Colour blindness, Thalassaemia etc.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
communicable diseases by radhika kulvi msc nursingRadhika kulvi
A communicable disease is one that is spread from one person to another through a variety of ways that include: contact with blood and bodily fluids; breathing in an airborne virus; or by being bitten by an insect.
Reporting of cases of communicable disease is important in the planning and evaluation of disease prevention and control programs, in the assurance of appropriate medical therapy, and in the detection of common-source outbreaks. California law mandates healthcare providers and laboratories to report over 80 diseases or conditions to their local health department. Some examples of the reportable communicable diseases include Hepatitis A, B & C, influenza, measles, and salmonella and other food borne illnesses.
How do these communicable diseases spread?
How these diseases spread depends on the specific disease or infectious agent. Some ways in which communicable diseases spread are by:
Physical contact with an infected person, such as through touch (staphylococcus), sexual intercourse (gonorrhea, HIV), fecal/oral transmission (hepatitis A), or droplets (influenza, TB)
Contact with a contaminated surface or object (Norwalk virus), food (salmonella, E. coli), blood (HIV, hepatitis B), or water (cholera);
Bites from insects or animals capable of transmitting the disease (mosquito: malaria and yellow fever; flea: plague); and
Travel through the air, such as tuberculosis or measles.
Tuberculosis, MTB or TB, which was formerly known as “Consumption”, “Phthisis
pulmonalis”, is an infectious bacterial disease that is caused by mycobacteria
mainly by “Mycobacterium tuberculosis”. Lungs are the main site of infection in
the tuberculosis, but other systems of the body are also infected. Tuberculosis
spread through air droplets from a person who has active disease through
respiratory system.
Diseases o respiratory system
In humans the respiratory tract is
the part of the anatomy that has to
do with the process of respiration.
The respiratory tract is divided into
3 segments:
Upper respiratory tract: nose and nasal passages, paranasal sinuses, and throat or pharynx
Respiratory airways: voice box or larynx, trachea, bronchi, and bronchioles
Lungs: respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli
i am the student of lahore college for women university. i have made this presentation is on vaccination. as you know vaccination is important for all. so its benefits, importance, advantages and disadvantages are mentioned in this. diseases which are cured by vaccination are also mentioned. types are also mention.
Pneumonia is an infectious disease in one or both lungs. Micro-organisms such as bacteria, fungi, and viruses can cause pneumonia. In adults, bacterial pneumonia is most common.
The disease is the malfunctioning of the body organs due to one reason or the other. In other words, it is a disorder of the body. The state of the body when any of its normal functions are disturbed or when the structures are altered is called disease. We understand that to remain healthy, we need to do much more than just keep away from disease. CONGENITAL DISEASE: This type of disease is present right from the birth. This is caused either due to genetic disorders or gene mutation or environmental factors. These diseases are passed on from one generation to next generation. Some examples of congenital diseases are Haemophilia, Sickle cell anaemia, Colour blindness, Thalassaemia etc.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. 1. Asthma – is a condition when a person experiences difficulty in
breathing as a result of the narrowing and swelling of the bronchial
airways. This can be triggered by allergies brought by pollens, dust,
fumes, certain foods and medications, air pollutants and bacteria.
2. Common Cold – is among the most common respiratory disease.
This is a disease affecting the upper respiratory tract (nose and
throat). It is transmitted by virus infected airborne droplets or by
direct contact with infected secretions.
3. 3. Pneumonia – is the infection of the lungs caused by viruses and bacteria
wherein the alveoli in the lungs are inflamed and become filled with liquid
and pus making it difficult for the lungs to transfer oxygen to the blood. If not
treated immediately, this serious medical condition can lead to death.
4. Influenza – . is commonly called the flu. It is caused by the influenza
virus that attacks your throat, nose and lungs. It is a highly contagious
disease and can spread directly through air droplets when people with flu
sneeze, cough or talk and spread indirectly with objects contaminated with
virus.
4. 5. Bronchitis - is the inflammation or swelling of bronchial
tube lining. Person with bronchitis may experience breathing
difficulty because of the mucus or phlegm forms in the airways
obstructing the flow of oxygen into the lungs.
6. Tuberculosis (TB) – is a bacterial infection of the lungs caused by
mycobacterium tuberculosis, which is an airborne disease that can spread
from person to person through respiratory droplets via coughing and
sneezing. This may cause death if not treated early and properly.
5. Diseases of the blood vessels and the heart are known as cardiovascular
diseases. There are ways to prevent circulatory diseases by living a healthy
lifestyle.
Atherosclerosis – is a condition that develops when a substance called plaque builds
up in the walls of the arteries making it harder for blood to flow through. If a blood clot forms, it can block
the blood flow that can cause heart attack or stroke. The risk factors for these diseases are smoking,
eating food high in fats, excessive alcohol intake, diabetes and increased stress.
Stroke – occurs when it damages the brain when a blood vessel gets blocked or
usually leaked from a blood clot. Some risk factors for stroke include smoking, high blood pressure,
excessive alcohol intake and diabetes.
6. Hypertension – is the another name for high blood pressure. It can lead to severe health complications.
Is also known as the silent killer due to the fact that people with hypertension usually has no symptoms.
The causes of this disease include obesity, diabetes, lack of fruits and vegetables in the diet and high salt
intake.
Heart attack – occurs when the blood flow to the part of the heart is blocked by blood clot, the
heart muscle supplied by the artery begins to die. The causes for the heart attack are atherosclerosis,
diabetes, high blood pressure and gender (more common in males).
Prevention on both respiratory and circulatory
disease is always better than their treatment.
7. The following are some ways to prevent
respiratory and circulatory diseases:
1.Good nutrition, good sleep and rest enhances your immune
system that helps the body to resist infections. And avoid eating
high cholesterol and fatty foods.
2. Do not smoke. Cigarettes contain harmful substances that can
be fatal to your body.
8. 3. Exercise regularly. It improves the health of your lungs and
heart.
4. Observe strict personal hygiene. Always keep your body
clean because it will reduce the risk of catching any diseases.
5. Avoid crowds. Avoid direct contact with person suffering
from respiratory diseases. To avoid contamination it is very
important to take all the necessary precautions.
9. Identify the respiratory/circulatory disease by each statement.
Choose the correct answer from list:
A. Hypertension F. Covid-19
B. Atherosclerosis G. Heart attack
C. Common Cold H. Pneumonia
D. Bronchitis I. Influenza
E. Tuberculosis J. Asthma
10. _________1. It is the inflammation or swelling of bronchial tube lining.
_________2. It is caused by a virus that attacks your throat, nose and lungs. It is a
highly contagious disease and can spread directly through air
droplets and spread indirectly with objects contaminated with virus.
_________3. It is a condition when a person experiences difficulty in breathing as a
result of the narrowing and swelling of the bronchial airways.
_________4.It occurs when the blood flow to the part of the heart is blocked by
blood clot, the heart muscle supplied by the artery begins to die.
_________5. It is a condition that develops when a substance called plaque builds
up in the walls of the arteries making it harder for blood to flow through.
_________6.It is a bacterial infection that can spread from person to person
through respiratory droplets via coughing and sneezing.
_________7.It is the another name for high blood pressure. The causes of this
disease includes obesity, diabetes, lack of fruits and vegetables in the
diet and high salt intake.
_________8. It is part of a family of viruses called corona viruses that infect both
people and animals. It can affect nose, sinuses, throat and lungs.
_________9.It is among the most common respiratory disease. This is a disease
affecting the upper respiratory tract (nose and throat).
.
_________10.It is the infection of the lungs caused by viruses and bacteria wherein
the alveoli in the lungs are inflamed and become filled with liquid
and pus making it difficult for the lungs to transfer oxygen to the
blood.