Research Frontier: Cognitive Performance Genomics
New category in personal genomics research
Working with the brain: virtually all cognitive performance and mental health issues are a question of awareness of state or behavior
Brain Fingerprinting is a new computer-based technology to identify the perpetrator of a crime accurately and scientifically by measuring brain-wave responses to crime-relevant words or pictures presented on a computer screen. Brain Fingerprinting has proven 100% accurate in over 120 tests, including tests on FBI agents, tests for a US intelligence agency and for the US Navy, and tests on real-life situations including felony crimes. Brain fingerprinting is based on finding that the brain generates a unique brain wave pattern when a person encounters a familiar stimulus Use of functional magnetic resonance imaging in lie detection derives from studies suggesting that persons asked to lie show different patterns of brain activity than they do when being truthful. Issues related to the use of such evidence in courts are discussed. The author concludes that neither approach is currently supported by enough data regarding its accuracy in detecting deception to warrant use in court. In the field of criminology, a new lie detector has been developed in the United States of America. This is called “brain fingerprinting”. This invention is supposed to be the best lie detector available as on date and is said to detect even smooth criminals who pass the polygraph test (the conventional lie detector test) with ease. The new method employs brain waves, which are useful in detecting whether the person subjected to the test, remembers finer details of the crime. Even if the person willingly suppresses the necessary information, the brain wave is sure to trap him, according to the experts, who are very excited about the new kid on the block.
How Brain Activity Monitoring can Help Manage Asperger’s Syndromeandfaulkner
Using electroencephalography (a neuroimaging technique) to track mood, anxiety, stimulation level, cognitive functioning, concentration, and stress. Using feedback based on information provided by brain data (neurofeedback) to recommend therapies for Asperger's. Training and improving coping responses to states of overstimulation in Asperger's using neurofeedback-assisted mindfulness meditation. Sharing of self-collected brain data with medical professionals to improve Asperger's treatment.
Medical and pharmaceutical applications of mobile EEG (brain scanning)andfaulkner
Uses of inexpensive, personal, commercially-available, and portable EEG devices for medical research. Testing of new drugs, patient-specific drug selection, monitoring of patient progress, augmentation of treatments (via neurofeedback), prediction of 'attacks' in mental illnesses (e.g. panic disorder), and better diagnoses of neurological disorders.
Brain Fingerprinting is a new computer-based technology to identify the perpetrator of a crime accurately and scientifically by measuring brain-wave responses to crime-relevant words or pictures presented on a computer screen. Brain Fingerprinting has proven 100% accurate in over 120 tests, including tests on FBI agents, tests for a US intelligence agency and for the US Navy, and tests on real-life situations including felony crimes. Brain fingerprinting is based on finding that the brain generates a unique brain wave pattern when a person encounters a familiar stimulus Use of functional magnetic resonance imaging in lie detection derives from studies suggesting that persons asked to lie show different patterns of brain activity than they do when being truthful. Issues related to the use of such evidence in courts are discussed. The author concludes that neither approach is currently supported by enough data regarding its accuracy in detecting deception to warrant use in court. In the field of criminology, a new lie detector has been developed in the United States of America. This is called “brain fingerprinting”. This invention is supposed to be the best lie detector available as on date and is said to detect even smooth criminals who pass the polygraph test (the conventional lie detector test) with ease. The new method employs brain waves, which are useful in detecting whether the person subjected to the test, remembers finer details of the crime. Even if the person willingly suppresses the necessary information, the brain wave is sure to trap him, according to the experts, who are very excited about the new kid on the block.
How Brain Activity Monitoring can Help Manage Asperger’s Syndromeandfaulkner
Using electroencephalography (a neuroimaging technique) to track mood, anxiety, stimulation level, cognitive functioning, concentration, and stress. Using feedback based on information provided by brain data (neurofeedback) to recommend therapies for Asperger's. Training and improving coping responses to states of overstimulation in Asperger's using neurofeedback-assisted mindfulness meditation. Sharing of self-collected brain data with medical professionals to improve Asperger's treatment.
Medical and pharmaceutical applications of mobile EEG (brain scanning)andfaulkner
Uses of inexpensive, personal, commercially-available, and portable EEG devices for medical research. Testing of new drugs, patient-specific drug selection, monitoring of patient progress, augmentation of treatments (via neurofeedback), prediction of 'attacks' in mental illnesses (e.g. panic disorder), and better diagnoses of neurological disorders.
Realize preventive medicine through predictive risk profiling, determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventions
Health Futures: Participatory Medicine and Crowdsourced Research StudiesMelanie Swan
There are numerous participatory health initiatives underway ranging from light-touch to heavy engagement including social media, mobile health applications, personal health records, consumer genomics, health social networks, and crowdsourced health studies. Crowdsourced health studies are emerging as an important new investigatory tool in a multi-tier research ecosystem that includes quantified self-experimentation, participant-organized studies, and traditional researcher-led clinical trials. Accessing crowdsourced cohorts for health studies is a significant emerging opportunity that could have a positive impact on public health research, particularly as outcomes are shifting to the personalized, preventive medicine of the future.
Immersive Environments, Machine Learning, Neuroimaging, & Wearable Sensing Te...Stanford University
Walter Greenleaf's presentation to the Virtual Medicine 2019 Conference at Cedars-Sinai Medical Center
Immersive Environments, Machine Learning, Neuroimaging, And Wearable Sensing Technology - Treating Depression, Addictions, and Facilitating Behavior Change Using A Precision Medicine Model
Based on the methods used in the ENGAGE Study
Walter Greenleaf, PhD
Virtual Human Interaction Lab | Stanford University
Precision medicine models for treating depression, managing addictions and achieving sustained behavior change are largely outside of current clinical practice. Yet, changing self-regulatory behavior is fundamental to the self-management of complex lifestyle-related chronic conditions such as depression and substance use disorder - two top contributors to the global burden of disease and disability.
To optimize treatments and address these burdens, methods to facilitate behavior change and self-regulation must be better understood in relation to their neurobiological underpinnings. Treatment strategies can then be developed that leverage the recent advances in immersive environments, machine learning, and wearable sensing technology and apply them to treat depression, manage addictions, and facilitate behavior change using a precision medicine model that is personalized to the individual.
This presentation will review the conceptual framework and protocol for a large multi-subject longitudinal study named Project ENGAGE. The ENGAGE study integrates neuroscience with behavioral science to better understand the self-regulation related mechanisms of behavior change for improving mood and weight outcomes among adults with comorbid depression and obesity. We collect assays of three self-regulation targets (emotion, cognition, and self-reflection) in multiple settings: neuroimaging and behavioral lab-based measures, virtual reality, and passive smartphone sampling.
By connecting human neuroscience and behavioral science in this manner within the ENGAGE study, we can develop a prototype for elucidating the underlying self-regulation mechanisms of behavior change outcomes and their application in optimizing intervention strategies for multiple chronic diseases.
https://www.ncbi.nlm.nih.gov/pubmed/29074231
Behav Res Ther. 2018 Feb;101:58-70. doi: 10.1016/j.brat.2017.09.012. Epub 2017 Oct 7.
The ENGAGE study: Integrating neuroimaging, virtual reality and smartphone sensing to understand self-regulation for managing depression and obesity in a precision medicine model.
Leanne M. Williams, Adam Pines, Andrea N. Goldstein-Piekarski, Lisa G. Rosas,
Monica Kullar, Matthew D. Sacchet, Olivier Gevaert, Jeremy Bailenson, Philip W.
Lavori, Paul Dagum, Brian Wandell, Carlos Correa, Walter Greenleaf, Trisha Suppes,
L. Michael Perry, Joshua M. Smyth, Megan A. Lewis, Elizabeth M. Venditti, Mark
Snowden, Janine M. Simmons, Jun Ma
Redesigning healthcare, biohacking our lives (IMEC ITF2014)Koen Kas
On our way to redesign healthcare, we will learn to combine different layers of our biological code (now in reading but soon in writing mode), data from visible and invisible sensors, and the connected Internet of Bodies/Things. These guardian angels will open up unseen opportunities for the way we deal with ourselves in health and disease. With DNA soon becoming the new software, combining biology, electronics, attractive design & smart communication will provide the tools to (bio)hack our lives.
Appropriate use of different (nano)technologies will convert us into health consumers, with our doctors as (virtual) coaches. This will move us away from current curative healthcare to precise, preventive and even augmented healthcare. But smart technologies and the data they generate, are just a tool. When not trusted by the established care provider, when not integrated and available in a personal data platform, healthcare will only be pseudo modernized. The real magic happens when these tools allow you to engage and change behaviour. But even in a rapidly automating world, we can’t automate such change. Or can we?
Presentation by Prof. Fernando Martin-Sanchez at the "Carlton Connect" Interdisciplinary conference in Melbourne, 2012.
http://www.carltonconnect.com.au/Conference/Conference.html
지난주말에 있었던 제 4회 대한신경집중치료학회 편집위원회 워크샵에서 발표했던 내용중에 발췌한 것입니다. 원래 제목은 "인공지능 관련 연구: 논문 작성과 심사에 관한 요령" 입니다. 최근에 deep learning in medical imaging으로 2편의 리뷰와 논문 1편, CADD 논문, 앙상블 논문 1편이 되면서 요청이 온것 같습니다.부족한 제가 하기 어려운 주제를 맡았는데, 혹시 도움이 되실 분이 있으면 도움을 되시라고 올려드립니다. 결론은 인공지능 연구라고 특별히 다르지는 않지만, 공학 연구와 의학연구가 다르고, 인공지능 특성을 잘 이해해야 한다 정도 될것 같습니다. (상당부분 저희병원 박성호 교수님의 radiology 논문 Methodology for Evaluation of Clinical Performance and Impact of Artificial Intelligence Technology for Medical Diagnosis and Prediction을 참고했습니다.)
A concept driving toward the needs of acquiring new visions at the same mission: Young adults healthcare... to prevent their involment in chronic diasabilities
Semantic Web for Health Care and Biomedical InformaticsAmit Sheth
Amit Sheth, "Semantic Web for Health Care and Biomedical Informatics," Keynote at NSF Biomed Web Workshop, Corbett, Oregon, December 4-5, 2007.
http://www.biomedweb.info/2007/
AI Health Agents: Longevity as a Service in the Web3 GenAI Quantum RevolutionMelanie Swan
Health Agents are a form of Math Agent as the concept of a personalized AI health advisor delivering “healthcare by app” instead of “sickcare by appointment.” Mobile devices
can check health 1000 times per minute as opposed to the standard one time per year doctor’s office visit, and model virtual patients in the digital twin app. As any AI agent, Health Agents “speak” natural language to humans and formal language to the computational infrastructure, possibly outputting the mathematics of personalized homeostatic health as part of their operation. Health Agents could facilitate the ability of physicians to oversee the health of thousands of individuals at a time. This could ease overstressed healthcare systems and contribute to physician well-being and the situation that (per the World Health Organization) more than half of the global population is still not covered by essential health services.
The computational infrastructure is becoming a vast interconnected fabric of formal methods, including per a major shift from 2d grids to 3d graphs in machine learning architectures
The implication is systems-level digital science at unprecedented scale for discovery in a diverse range of scientific disciplines
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Similar to Research Frontier: Cognitive Performance Genomics
Realize preventive medicine through predictive risk profiling, determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventions
Health Futures: Participatory Medicine and Crowdsourced Research StudiesMelanie Swan
There are numerous participatory health initiatives underway ranging from light-touch to heavy engagement including social media, mobile health applications, personal health records, consumer genomics, health social networks, and crowdsourced health studies. Crowdsourced health studies are emerging as an important new investigatory tool in a multi-tier research ecosystem that includes quantified self-experimentation, participant-organized studies, and traditional researcher-led clinical trials. Accessing crowdsourced cohorts for health studies is a significant emerging opportunity that could have a positive impact on public health research, particularly as outcomes are shifting to the personalized, preventive medicine of the future.
Immersive Environments, Machine Learning, Neuroimaging, & Wearable Sensing Te...Stanford University
Walter Greenleaf's presentation to the Virtual Medicine 2019 Conference at Cedars-Sinai Medical Center
Immersive Environments, Machine Learning, Neuroimaging, And Wearable Sensing Technology - Treating Depression, Addictions, and Facilitating Behavior Change Using A Precision Medicine Model
Based on the methods used in the ENGAGE Study
Walter Greenleaf, PhD
Virtual Human Interaction Lab | Stanford University
Precision medicine models for treating depression, managing addictions and achieving sustained behavior change are largely outside of current clinical practice. Yet, changing self-regulatory behavior is fundamental to the self-management of complex lifestyle-related chronic conditions such as depression and substance use disorder - two top contributors to the global burden of disease and disability.
To optimize treatments and address these burdens, methods to facilitate behavior change and self-regulation must be better understood in relation to their neurobiological underpinnings. Treatment strategies can then be developed that leverage the recent advances in immersive environments, machine learning, and wearable sensing technology and apply them to treat depression, manage addictions, and facilitate behavior change using a precision medicine model that is personalized to the individual.
This presentation will review the conceptual framework and protocol for a large multi-subject longitudinal study named Project ENGAGE. The ENGAGE study integrates neuroscience with behavioral science to better understand the self-regulation related mechanisms of behavior change for improving mood and weight outcomes among adults with comorbid depression and obesity. We collect assays of three self-regulation targets (emotion, cognition, and self-reflection) in multiple settings: neuroimaging and behavioral lab-based measures, virtual reality, and passive smartphone sampling.
By connecting human neuroscience and behavioral science in this manner within the ENGAGE study, we can develop a prototype for elucidating the underlying self-regulation mechanisms of behavior change outcomes and their application in optimizing intervention strategies for multiple chronic diseases.
https://www.ncbi.nlm.nih.gov/pubmed/29074231
Behav Res Ther. 2018 Feb;101:58-70. doi: 10.1016/j.brat.2017.09.012. Epub 2017 Oct 7.
The ENGAGE study: Integrating neuroimaging, virtual reality and smartphone sensing to understand self-regulation for managing depression and obesity in a precision medicine model.
Leanne M. Williams, Adam Pines, Andrea N. Goldstein-Piekarski, Lisa G. Rosas,
Monica Kullar, Matthew D. Sacchet, Olivier Gevaert, Jeremy Bailenson, Philip W.
Lavori, Paul Dagum, Brian Wandell, Carlos Correa, Walter Greenleaf, Trisha Suppes,
L. Michael Perry, Joshua M. Smyth, Megan A. Lewis, Elizabeth M. Venditti, Mark
Snowden, Janine M. Simmons, Jun Ma
Redesigning healthcare, biohacking our lives (IMEC ITF2014)Koen Kas
On our way to redesign healthcare, we will learn to combine different layers of our biological code (now in reading but soon in writing mode), data from visible and invisible sensors, and the connected Internet of Bodies/Things. These guardian angels will open up unseen opportunities for the way we deal with ourselves in health and disease. With DNA soon becoming the new software, combining biology, electronics, attractive design & smart communication will provide the tools to (bio)hack our lives.
Appropriate use of different (nano)technologies will convert us into health consumers, with our doctors as (virtual) coaches. This will move us away from current curative healthcare to precise, preventive and even augmented healthcare. But smart technologies and the data they generate, are just a tool. When not trusted by the established care provider, when not integrated and available in a personal data platform, healthcare will only be pseudo modernized. The real magic happens when these tools allow you to engage and change behaviour. But even in a rapidly automating world, we can’t automate such change. Or can we?
Presentation by Prof. Fernando Martin-Sanchez at the "Carlton Connect" Interdisciplinary conference in Melbourne, 2012.
http://www.carltonconnect.com.au/Conference/Conference.html
지난주말에 있었던 제 4회 대한신경집중치료학회 편집위원회 워크샵에서 발표했던 내용중에 발췌한 것입니다. 원래 제목은 "인공지능 관련 연구: 논문 작성과 심사에 관한 요령" 입니다. 최근에 deep learning in medical imaging으로 2편의 리뷰와 논문 1편, CADD 논문, 앙상블 논문 1편이 되면서 요청이 온것 같습니다.부족한 제가 하기 어려운 주제를 맡았는데, 혹시 도움이 되실 분이 있으면 도움을 되시라고 올려드립니다. 결론은 인공지능 연구라고 특별히 다르지는 않지만, 공학 연구와 의학연구가 다르고, 인공지능 특성을 잘 이해해야 한다 정도 될것 같습니다. (상당부분 저희병원 박성호 교수님의 radiology 논문 Methodology for Evaluation of Clinical Performance and Impact of Artificial Intelligence Technology for Medical Diagnosis and Prediction을 참고했습니다.)
A concept driving toward the needs of acquiring new visions at the same mission: Young adults healthcare... to prevent their involment in chronic diasabilities
Semantic Web for Health Care and Biomedical InformaticsAmit Sheth
Amit Sheth, "Semantic Web for Health Care and Biomedical Informatics," Keynote at NSF Biomed Web Workshop, Corbett, Oregon, December 4-5, 2007.
http://www.biomedweb.info/2007/
AI Health Agents: Longevity as a Service in the Web3 GenAI Quantum RevolutionMelanie Swan
Health Agents are a form of Math Agent as the concept of a personalized AI health advisor delivering “healthcare by app” instead of “sickcare by appointment.” Mobile devices
can check health 1000 times per minute as opposed to the standard one time per year doctor’s office visit, and model virtual patients in the digital twin app. As any AI agent, Health Agents “speak” natural language to humans and formal language to the computational infrastructure, possibly outputting the mathematics of personalized homeostatic health as part of their operation. Health Agents could facilitate the ability of physicians to oversee the health of thousands of individuals at a time. This could ease overstressed healthcare systems and contribute to physician well-being and the situation that (per the World Health Organization) more than half of the global population is still not covered by essential health services.
The computational infrastructure is becoming a vast interconnected fabric of formal methods, including per a major shift from 2d grids to 3d graphs in machine learning architectures
The implication is systems-level digital science at unprecedented scale for discovery in a diverse range of scientific disciplines
We know that we are in an AI take-off, what is new is that we are in a math take-off. A math take-off is using math as a formal language, beyond the human-facing math-as-math use case, for AI to interface with the computational infrastructure. The message of generative AI and LLMs (large language models like GPT) is not that they speak natural language to humans, but that they speak formal languages (programmatic code, mathematics, physics) to the computational infrastructure, implying the ability to create a much larger problem-solving apparatus for humanity-benefitting applications in biology, energy, and space science, however not without risk.
This work introduces “quantum intelligence” as a concept of intelligence for operating in the quantum realm may help in a potential AI-Quantum Computing convergence (~2030e), and towards the realization of SRAI for well-being (economics, health, energy, space). “Scale-free intelligence” is formulated as a generic capacity for learning.
AI did not spring onto the scene with chatGPT, but is in an ongoing multi-year adoption. A transition may be underway from an information society to a knowledge society (one tempered and specifically using knowledge to improve the human condition). AI is a dual-use technology with both significant risk and upleveling possibilities.
SRAI for well-being is a social objective, and also a technological objective. SRAI is part of AI development and within the technological trajectory of harnessing all scales of physical reality ranging from quantum materials to space exploration.
Conceptually, thinking in quantum and relativistic terms expands the physical worldview, and likewise the social worldview of entities inhabiting the larger world. Practically, SRAI may be realized in phases: short-term regulation and registries, medium-term agents learning to implement human values with internal reward functions, and long-term responsible human-AI entities acting in partnership in a future of SRAI for well-being.
The Human-AI Odyssey: Homerian Aspirations towards Non-labor IdentityMelanie Swan
The visionary progression in The Odyssey from shipbuilding to seafaring to advanced civilization informs contemporary tension in the human-AI relation forcing a broader articulation of human-identity beyond labor-identity. Edith Hall analyzes why one of the earliest known literatures, The Odyssey, remains a central cultural trope with numerous references in the storytelling vernacular of all eras, ranging from 1860s British theater to a highly-watched 1990 episode of The Simpsons. The argument is that The Odyssey provides a constant aspirational reference for human identity – who we think we are and where we are going on the epic journey of life, especially at the current crossroad in our relationship with technology.
The contemporary moment finds humanity, and the humanities, experiencing an identity crisis in the relationship with technology. Information science is having an ever more pervasive role in academia, and the machine economy continues to offload vast classes of tasks to labor-saving technology giving rise to two questions. First, at the level of labor-identity, humans wonder who they are as they have long defined their sense of self through their professional participation in the economy. Second, at the level of human-identity, with AI now performing cognitive labor in addition to physical labor, humans wonder if there is anything that remains uniquely human.
The effect of The Odyssey is to provide world-expanding imaginaries to change the way we see ourselves as subjects; in this way, Homer is an early modernist in reconfiguring our self-concept.
This work applies a philosophy (of literature)-aided information science method to discuss how Homer’s Odyssey persists as a literary imaginary to help us think through potential futures of human-AI flourishing as rapid automation continues to impact humanity. The intensity of the human-AI relation is likely to increase, which invites thought leadership to steward the transition to a potential AI abundance economy with fulfilling human-technology collaboration.
The shipbuilding-seafaring-advanced civilization progression in The Odyssey identifies that the human-AI relation is not one of the labor-identity-crisis of “robots stealing our jobs,” but rather one of the more difficult challenge of envisioning who we can be in the new larger world of human-AI partnership addressing a larger set of planetary-scale problems. Towards this new configuration of human-AI relation, the longer-term may hold radically different notions of identity, as we become physical-virtual hybrids, augmented post-disease entities in the health-faring, space-civilizing, energy-marshalling post-scarcity cultures of the future.
AdS Biology and Quantum Information ScienceMelanie Swan
Quantum Information Science is a fast-growing discipline advancing many areas of science such as cryptography, chemistry, finance, space science, and biology. In particular AdS/Biology, an interpretation of the AdS/CFT correspondence in biological systems, is showing promise in new biophysical mathematical models of topology (Chern-Simons (solvable QFT), knotting, and compaction). For example, one model of neurodegenerative disease takes a topological view of protein buildup (AB plaques and tau tangles in Alzheimer’s disease, alpha-synuclein in Parkinson’s disease, TDP-43 in ALS). AdS/Neuroscience methods are implicated in integrating multiscalar systems with different bulk-boundary space-time regimes (e.g. oncology tumors, fMRI + EEG imaging), entanglement (correlation) renormalization across scales (MERA, random tensor networks, melonic diagrams), entropy (possible system states), entanglement entropy (interrelated fluctuations and correlations across system tiers), and non-ergodicity (implied efficiency mechanisms since biology does not cycle through all possible configurations per temperature (thermotaxis), chemotaxis, and energy cues); Maxwell’s demon of biology (partition functions), conservation across system scales (biophysical gauge symmetry (system-wide conserved quantity)), and the presence of codes (DNA, codons, neural codes). A multiscalar AdS/CFT correspondence is mobilized in 4-tier ecosystem models (light-plankton-krill-whale and ion-synapse-neuron-network (AdS/Brain)).
Humanity’s constant project is expanding the range of attainable geography. Melville’s romance of the sea gives way to Kerouac’s romance of the road, and now the romance of space. In expanding into new geographies, markets (commerce) is the driving impulse, entailing a legal and judiciary system to order the new larger continuous marketplace, which brings a bigger overall scope of world under our control, and hence a new idea of who we are as subjects in this bigger domain.
Space Humanism is a concept of humanism based on the principles of inclusion, progress, and equity posited as a condition of possibility for a potential large-scale human movement into space. A philosophy of literature approach is used to contextualize Space Humanism, first through Melville-Foucault to articulate the mind-frame of extra-planetary geographies as one of human expansion, and second through posthuman philosophy extending from Shakespeare’s Renaissance humanism to contemporary enhancement-based theories of subjectivation.
Historical imaginaries outline subjectivation moments that have changed the whole notion who we are as humanity. Four examples are: the concept of the “new world” in Hegel’s philosophy, von Humboldt’s infographic maps, Baudelaire as the Painter of Modern Life, and Keats’s seeing the world in a new way upon reading an updated translation of Homer.
The reach to beyond-Earth geographies is a two-cultures project involving both arts and science. Technical competence is necessary to realize the aspirational, explorational, and survivalist aims of humanity pushing beyond planetary limits. Space was once a fantastic dream that is becoming quotidian with fourteen U.S. spaceports, six completed Blue Origin space tourist missions, and SpaceX having over 155 successful rocket launches including human space flights to and from the International Space Station. The notion of Space Human articulated through Shakespeare, Moby-Dick, and neuroenhancement informs the project of our reach to awaiting beyond-Earth geographies.
Quantum Information Science and Quantum Neuroscience.pptMelanie Swan
Mathematical advance in quantum information science is proceeding quickly and applies to many fields, particularly the complexities of neuroscience (here focusing on image-readable physical behaviors such as neural signaling, as opposed to higher-order operations of cognition, memory, and attention). Quantum mathematical models are extensible to neuroscience problem classes treating dynamical time series, diffusion, and renormalization in multiscalar systems. Approaches first reconstruct wavefunctions observed in EEG and fMRI scans. Second, single-neuron models (Hodgkin-Huxley, integrate-and-fire, theta neurons) and collective neuron models (neural field theories, Kuramoto oscillators) are employed to model empirical data. Third, genome physics is used to study time series sequence prediction in DNA, RNA, and proteins based on 3d+ complex geometry involving fields, curvature, knotting, and information compaction. Finally, quantum neuroscience physics is applied in AdS/Brain modeling, Chern-Simons biology (topological invariance), neuronal gauge theories, network neuroscience, and the chaotic dynamics of bifurcation and bistability (to explain epileptic and resting states). The potential benefit of this work is an improved understanding of disease and pathology resolution in humans.
Quantum information science enables a new tier of scientific problem-solving as exemplified in early-adopter fields, foundational tools in quantum cryptography, quantum machine learning, and quantum chemistry (molecular quantum mechanics), and advanced applications in quantum space science, quantum finance, and quantum biology
Grammatology and Performativity: A Critical Theory of Silence: Silence is a crucial device for subversion, opposition, and socio-political commentary, the theoretical underpinnings of which are just starting to be understood. This work illuminates another position in the growing field of critical silence studies, theorizing silence as an asset whose ontological value has been lost in a world of literal and figurative noise. Part 1 philosophizes silence as a continuation of Derrida’s grammatology project. Such a grammatology of silence valorizes silent thinking over noisy speaking, and identifies the deconstructive binary pairing not as silence-speaking, but rather as silence-noise. Noise has a simultaneous physical-virtual existence as Shannon entropy calculates signal-to-noise ratios in modern communications networks. Part 2 employs the philosophy of noise to assess what is conceptually necessary to overcome noise in a critical theory of silence. Malaspina draws from Simondon to argue that noise is a form of individuation, essentially a living thing with unstoppable growth potential, not defined by a binary on-off switch but as a matter of gradation. Hence different theory resources are required to oppose it. Part 3 then develops a critical theory of silence to oppose noise in both its physical and virtual instantiations, with the two arms of a deeply human positive performativity (Szendy, Bennett) and a beyond-computational posthumanism (Puar). The result is a novel critical theory of silence as positive performativity that destabilizes noise and recoups the ontological status of silence as not merely an empty post-modern reification but a meaningful actuality.
Philosophy-aided Physics at the Boundary of Quantum-Classical Reality The philosophical themes of truth-knowledge and appearance-reality are used to interrogate the contemporary situation of the quantum-classical boundary, and more broadly the quantum-classical-relativistic stratification of physical scale boundaries. The contemporary moment finds us at breakneck pace in the industrial information revolution, digitizing remaining matter-based industries into a seamless exchange between physical-digital reality. Digitized news is giving way to digitized money and perhaps in the farther future, digitized mindfiles (such as personalized connectome files for precision medicine, autologous (own-DNA) stem cell therapies, and CRISPR for Alzheimer’s disease prevention). Our technologies are allowing us control over vast new domains, the relativistic with GPS and space-faring, and the quantum with quantum computing, harnessing the properties of superposition, entanglement, and interference. Philosophy provides critical thinking tools that can help us understand and master these rapid shifts in science and technology to avoid an Adornian instrumental reality (subsuming humanity under societal structures) and to maintain a Heideggerian backgrounded and enabling relation with technology (versus technology enframing us into mindless standing reserve).
The philosophical theme underlying the investigation of the scales of planets, persons, and particles is the relationship between truth and knowledge (or appearance and reality). The truth-knowledge problem is whether knowledge of the truth, true knowledge, the reality under the appearance, is even possible. Three salient moments in the history of the truth-knowledge problem are examined here. These are the German idealism of Kant and Hegel, the deconstructive postmodernism of Foucault and Derrida, and the unclear leanings of the current moment. The German idealism lens incorporates the self-knowing subject as agent into the truth and knowledge problem. The postmodernist view breaks with the subject and emphasizes the hidden opposites in the formulations, the constant reinterpretation of meaning, and porous boundaries. The contemporary moment wonders whether truth-knowledge boundaries still hold, in a Benjaminian view of non-identity between truth and knowledge, and truth increasingly being seen as a Foucauldian biopolitical manufactured quantity. Contemporaneity has a bimodal distribution of the subject: the hyperself (the constantly digitally represented selfie self) and the alienated post-subject subject.
These moments in the truth and knowledge debate inflect into the scale considerations of relativity, classicality, and quantum mechanics. Whereas general relativity and quantum mechanics are domains of universality, totality, and multiplicity, everyday classical reality is squeezed in as a belt between the two multiplicities as the concretion of drawing a triangle or tossing a ball. Recasting truth and k
Comprehensive philosophical programs arise within a historical context (for Hegel and Derrida in the democracy-shaping moments of the French Revolution (1789) and the student-worker protests (1968) in which French politics serve as a global harbinger of contemporary themes). In the Derrida-Hegel relationship, there is more rapprochement concerning core notions of difference, history, and meaning-assignation than may have been realized. In particular, Hegel’s philosophy, despite being assumed to be a totalizing system, in fact indicates precisely some of the same kinds of revised metaphysics-of-presence formulations that Derrida exhorts, namely those that are flexible, expansive, and include non-identity and identity.
A crucial Derrida-Hegel interchange is that of différance and difference. Derrida develops the notion directly from Hegel (“Différance,” “The Pit and the Pyramid”), but only draws from the Encyclopedia, not Hegel’s masterwork, the Phenomenology of Spirit. For Derrida, the “A” in différance is inspired by the form of the pyramid in the capitalized letter and in Hegel’s comparing the sign “to the Egyptian Pyramid” (“Différance,” p. 3). Derrida invokes the symbolism of the pyramid, antiquity, and Egyptian hieroglyphics as an early semiotic system. However, when considering Hegel’s central definition of difference in the dialectical progression of thesis-antithesis-synthesis in the Phenomenology of Spirit (§§159-163), the articulations of différance and difference are remarkably aligned.
Parallel formulations are also seen in history as a series of reinterpretable events, and indexical wrappers as a mechanism for meaning assignation. The thinkers examine the universal and the particular by exploring regulative mechanisms such as law (natural and social). In Glas, Derrida highlights not the singular-universal relation, but the law of singularity and the law of universality relation as being relevant to Hegel’s Antigone interpretation (Glas, p. 142a), a theme continued in “Before the Law.” Finally (time permitting), there is a question whether the most valid critiques of Hegel (Nietzsche’s unreason and Benjamin’s non-synthesis), as alternatives to Hegelian dialectics, are visible in Derrida’s thought.
The upshot is that the two thinkers produce similar formulations, derived from different trajectories of philosophical work; a situation which points to the potential universality of fundamental solution classes to open-ended philosophical problems, including the future of democracy.
Quantum Moreness: Kantian Time and the Performative Economics of Multiplicity
There is no domain with greater moreness than that of the quantum. A philosophy-aided physics approach (postmodernism and Continental philosophy) examines the contemporary situation of quantum moreness (more time and space dimensions than are available classically). Quantum moreness is configured by quantum reality being probabilistic; a multiplicity of outcomes all co-existing in superposition until collapsed in measurement. The quantum mindset uses quantum moreness to solve problems by thinking in terms of the greater scalability afforded in time and space with the quantum properties of superposition, entanglement, and interference. Quantum studies fields proliferate in arts and sciences, raising the Levi-Straussian raw-cooked dilemma of how “traditional humanities” are to be named alongside “digital humanities” and “quantum humanities.” Kant facilitates the conceptualization of quantum moreness by insisting on the dual nature of time as transcendentally ideal and empirically real. Kant’s moreness is allness, the absolute totality and multiplicity of time at the ideal level. Each faculty (sensibility, understanding, reason) has its own species of the a priori synthetic unity of ideal time that precedes and conditions the operation of the faculty. Each faculty also has a concretized formulation of empirically-real time as the time series, which is the basis for the faculties to interoperate to perform the conception of any empirical object. Kant’s achievement of time interoperability has potential extensibility to other areas of temporal incompatibility such as the scales of general relativity, Newtonian mechanics (human-scale), and quantum mechanics. The quantum moreness mindset with which Kant connects the ideal-real is visible in the domain of economics, itself too an ideal-real construction. The quantum moreness of money configures the postmodern abstraction of global cryptocurrencies and smart contract pledges, the implicative hope of which is a post-debt capital world that restores the human esprit in the face of an increasingly intense technologized reality.
Blockchain Crypto Jamming: Subverting the Instrumental Economy
The ultimate subversion is money, refusing the pecuniary resources of the state. This project applies a philosophical and critical theory lens to examine the use of nomenclature in one of the most radical longitudinal transformations in contemporary times, the shift away from state-run monetary resources towards cryptocurrencies and smart contracts in citizen-determined decentralized financial networks.
A Cryptoeconomic Theory of Social Change is presented in which linguistic progression serves as a tracking mechanism. The steps to lasting change have their own vocabulary (Brandom). First, there is the social critique, the complaint about what is wrong, the negative side (Adorno and Horkheimer highlight instrumental reason and the empty culture industry). Second, there is the antidote, an alternative that can overcome the complaint, the positive side. Third, the solution becomes the new reality, and as a consequence, the whole of reality is now seen in this context, adopting its vocabulary (“fiat health” system for example, referring to the antiquated method). The social movement graduates from language game (Wittgenstein) to form of life (Jaeggi).
Blockchains are Occupy with teeth, notable in the level of personal responsibility-taking by individuals to steward their own financial resources. The crypto citizen is not merely trading CryptoKitties and Bored Ape Yacht Club tokens, but getting blocktime loans through DeFi liquidity pools instead of fiat banks, earning labor income in crypto, and shifting all economic activity to blockchain networks. The artworld signals mainstream acceptance with Christie’s non-fungible token digital artwork auctioned from Beeple for $61 million. At the global level, coin communities constitute a new form of Kardashev-level (planetary-scale) democracy. Blockchains emerge as a robust smart network automation technology for super-class projects ranging from space-faring to quantum computing and thought-tokening. The further stakes of this work are having a language-based theory of social change with broad applicability to social transformation.
This work argues that the emerging understanding of time in quantum information science can be articulated as a philosophical theory of change. Change and time are interrelated, and one can be used to interrogate the other, namely, a theory of change can be derived from a theory of time. What is new in quantum science is time being regarded as just another property to be engineered. At the quantum scale, time is reversible in certain ways, which is quite different from the everyday experience of time whose unidirectional arrow does not allow a dropped egg to reassemble. At the quantum scale of atoms, though, a particle retains the history of its trajectory, which may be retraced before collapsed in measurement.
Quantum scientists evolve systems backward and forward in time, controlling phase transitions with Floquet engineering. Quantum systems are entangled in time and space, with temporal correlations exhibiting greater multiplicity than spatial correlations. The chaotic time regimes of ballistic spread followed by saturation are implemented in quantum walks for faster search and heightened cryptosecurity. In quantum neuroscience, seizure may be explained by chaotic dynamics and normal resting state by Floquet-like periodic cycles. Time is revealed to have the same kinds of repeating structures as space (described by entanglement, symmetry, and topology), differently instantiated and controlled.
The quantum understanding of time can be propelled into a macroscale-theory of change through its connotation of a more flexible, malleable, probabilistic interface with reality. Change becomes less rigid. Probability is the lever of change, but notoriously difficult for humans to grasp, as we think better in storylines than statistics. The idea of manipulating quantum system properties in which time, space, dynamics (change), are all just parameters, is an empowering frame for the acceptance of change. The quantum mindset affords greater facility with probability-driven events (change).
Blockchains in Space: Non-Euclidean Spacetime and Tokenized Thinking - Two requirements for the large-scale beyond-terrestrial expansion of human intelligence into the universe are the ability to operate in diverse spatiotemporal regimes and to instantiate thinking in various formats. Newtonian mechanics describe everyday reality, but Einsteinian physics is needed for GPS and the orbital technologies of telescopes and spacecraft. Space agencies already integrate the Earth-day and the slightly-longer Martian-sol. A more substantial move into space requires facility with non-Euclidean spacetimes. One challenge is that general relativity and quantum mechanics are non-interoperable. However, the theories can be formulated together when considering black holes and quantum computing since geometric theories and gauge theories are both field-based. Quantum blockchains instantiate blockchain logic in quantum computational environments. Blockchains have their own temporal regime (blocktime: the number of blocks for an event to occur), and hence quantum blocktime is a non-classical functionality for operating in diverse spatiotemporal regimes. Thinking is a rule-based activity that is unrestricted by medium. Central to thinking is concepts, which are referenced by words. Word-types include universals, particulars, and indexicals which can be encoded into a formal system as thought-tokens, and registered to blockchains. Blockchains are contemplated as an automation technology for asteroid mining and space settlement construction, and thought-tokening adds an intelligence layer. Time and tokenized thinking come together in the idea of smart networks in space. In blockchain quantum smart networks, spatiotemporal regimes and thought-tokens are simply different value types (asset classes) coordinated with blockchain logic, towards the aim of extending human capabilities into the farther reaches of space.
Cryptography, entanglement, and quantum blocktime: Quantum computing offers a more scalable energy-efficient platform than classical computing and supercomputing, and corresponds more naturally to the three-dimensional structure of atomic reality. Blockchains are a decentralized digital economic system made possible by the 24-7 global nature of the internet.
Quantum Neuroscience: CRISPR for Alzheimer’s, Connectomes & Quantum BCIsMelanie Swan
This talk provides an introduction to quantum computing and how it may be deployed to study the human brain and its diseases of pathology and aging. Refined to its present state over centuries, the brain is one of the most complex systems known, with 86 billion neurons and 242 trillion synapses connected in intricate patterns and rewired by synaptic plasticity. Research continues to illuminate the mysteries of the brain. Quantum computing provides a more capacious architecture with greater scalability and energy efficiency than current methods of classical computing and supercomputing, and more naturally corresponds to the three-dimensional structure of atomic reality. The vision for quantum neuroscience is to model the nature of the brain exactly as it is, in three-dimensional atomically-accurate representations. Neuroscience (particularly genetic disease modeling, connectomics, and synaptomics) could be the “killer application” of quantum computing. Implementations in other industries are also important, including in quantum finance, quantum cryptography using Shor’s factoring algorithm (“the Y2K of Crypto”), Grover’s search, quantum chemistry, eigensolvers, quantum machine learning, and continuous-time quantum walks. Quantum computing is a high-profile worldwide scientific endeavor with platforms currently available via cloud services (IBM Q 27-qubit, IonQ 32-qubit, Rigetti 19Q Acorn) and is in the process of being applied in various industries including computational neuroscience.
Art Theory: Two Cultures Synthesis of Art and ScienceMelanie Swan
Thesis: Aesthetic resources contribute broadly to the human endeavor of progress, self-understanding, and science, beyond the immediate experience of art. Aesthetic Resources are frameworks, concepts, and modes of expression in art, literature, and philosophy that capture the imagination and the intellect through the senses. The role of art is to inspire the future: the romance of the sea, the open road, space.
The arts are a hallmark of civilization, but can their benefit be crystallized as aesthetic resources that can be mobilized to new situations? How can aesthetic resources help in moments of crisis?
A worldwide social identity crisis has been provoked by pandemic recovery, politics, equity, and environmental sustainability. Philosophical and aesthetic resources can help. Understanding art as a reflection of who we are as individuals and groups, this talk explores conceptualizations of art, with examples, in different periodizations from the 1800s to the present. A marquis definition as to what constitutes an artwork is Adorno’s, for whom the work must promulgate its own natural law and engage in novel materials manipulation. For many theorists, art is the pressing of our self-concept into concrete materiality (whether pyramids, sculpture, or painting). What do contemporary periodizations of art mean to our current and forward-looking self-concept? Recent eras include the neo-avant-gardes of 1945, the conceptual art of the 1960s, and post-conceptual art starting in the 1970s, produced generatively with found materials, the digital domain, and audience interactivity. What is the now-current idea of art? Is today’s Baudelairian flâneur and Balzacian modern hero incarnated in the quantum aesthetic imaginary and the digital cryptocitizen? Far from an “end of art” thesis sometimes attributed to Hegel, aesthetic practices are more relevant than ever. Individually and societally, we are reinventing creative energy and productive imagination in venues from science, technology, health, and biology to the arts.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
Today, after several years of existence, an extremely active community and an ultra-dynamic ecosystem, Kubernetes has established itself as the de facto standard in container orchestration. Thanks to a wide range of managed services, it has never been so easy to set up a ready-to-use Kubernetes cluster.
However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
UiPath Test Automation using UiPath Test Suite series, part 4
Research Frontier: Cognitive Performance Genomics
1. Research Frontier:
Cognitive Performance Genomics
Quantified Creativity and the Attendant Issues of
Objective Metrics: The Re-Lexiconing of Emotion
and Neural Data Privacy Rights
Melanie Swan
Founder
DIYgenomics
AAAI 2013 Spring Symposium +1-650-681-9482
Data Driven Wellness @DIYgenomics
March 26, 2013, Stanford University www.DIYgenomics.org
m@melanieswan.com
Slides: http://slideshare.net/LaBlogga
2. Conceptual Frame
• Contemporary state of the world and key enablers
– Era of big health data and data driven wellness as a
big data challenge
– Integrated data streams for preventive medicine:
• “Genetics loads the gun and environment pulls the trigger”
– Francis Collins, Director NIH 2010
– Quantifying subjective experience with objective
metrics
• Research Frontier: Cognitive Performance
Genomics
1. New category in personal genomics research
2. Working with the brain: virtually all cognitive
performance and mental health issues are a
question of awareness of state or behavior
2
3. Sensor Mania! Wearable Electronics
Smart Gadgetry Creates Continuous Personal
Information Climate
Smartphone, Fitbit, Smartwatch (Pebble), Electronic T-shirt (Carre)
Smartring (ElectricFoxy), Electronic tattoos (mc10), $1 blood API
(Sano Intelligence), Continuous Monitors (Medtronic)
Source: Swan, M. Sensor Mania! The Internet of Things, Objective Metrics, and the Quantified Self 2.0. J Sens
Actuator Netw 2012. 3
4. Electrochemical
BioSensor Aesthetics
“Hi-Tech Tattoos: When Artists and
Engineers Work Together”
• Wearable explosive detection devices
in temporary transfer tattoos
• Electrochemical sensors applied
directly to skin or sewn into clothing
• Detect vapors (external)
– Chemical constituents of explosives
– Environmental toxins
Electronic
• Detect vital signs (internal)
http://www.jacobsschool.ucsd.edu/pulse/winter2013/page3.shtml#tattoos 4
5. Augmenting the Brain
24/7 Consumer EEG, Eye-tracking, Emotion-Mapping, Augmented Reality Glasses
Consumer EEG Rigs Augmented Reality Glasses
1.0
2.0
Source: Swan, M. Sensor Mania! The Internet of Things, Objective Metrics, and the Quantified Self 2.0. J Sens
Actuator Netw 2012. 5
6. Building Exosenses
Extending our senses in new ways to perceive data as sensation
Magnetic Sense: Finger and Arm Magnets
Eric Boyd – Heart Spark Nancy Dougherty – Serendipitous Joy
http://sensebridge.net/projects/heart-spark/ Smile-triggered EMG muscle sensor
The North Paw- A Haptic Compass Anklet with an LED headband display
http://www.youtube.com/watch?v=D4shfNufqSg 6
7. Big Health Data Streams
‘Omics’ Data Streams Traditional Data Streams Quantified Self
Data Streams
Genome:
SNP mutations Personal and Family
Structural variation Health History Self-reported data:
Epigenetics health, exercise, food,
mood journals, etc.
Microbiome
Prescription History
Transcriptome Mobile App Data
Lab Tests: History and
Metabolome Current
Quantified Self Device
Proteome Demographic Data Data
Diseasome
Standardized Biosensor Data
Instrument Response Objective Metrics
Environmentome
Swan, M. Health 2050: The Realization of Personalized Medicine through Legend: Consumer-available
Crowdsourcing, the Quantified Self, and the Participatory Biocitizen. J Pers
7
Med 2012, 2(3), 93-118.
8. Research Frontier:
Cognitive Performance Genomics
Connecting personal genomics to cognition enhancement
Eras of Application in Cognitive Performance Genomics
Personal Genomics
Thinking Fast and Slow:
cognitive bias in thinking
• Ancestry, Pre-natal (loss aversion and optimism bias)
Screening, Identity
• Medical Genomics,
Pharmaceutical
Response Creativity and Innovation:
• Social Intelligence, process and capacity
Athletic Performance
• Cognitive Performance
General Cognitive Abilities:
• Predictive Profiling: memory, attention, speed,
Wellness, Environment, flexibility, problem-solving
Product Response
8
9. DIYgenomics Study Methodology
Goal: biophysical performance optimization and pre-
clinical disease prevention
Generalized hypothesis: Genetic polymorphisms
may result in out-of-bounds phenotypic marker
levels which may be improved through intervention
Genotype + Phenotype + Intervention = Outcome
Cognitive Standardized Brain Improved
performance instrument fitness cognitive
SNPs response training performance
Source: Swan, M., Hathaway, K., Hogg, C., McCauley, R., Vollrath, A. Citizen science genomics as a model for crowdsourced
preventive medicine research. J Participat Med. 2010, Dec 23; 2:e20. 9
10. Genes Associated with
Cognitive Performance
• Neurotransmitter activation and Neuroplasticity
– COMT (catechol-O-methyltransferase ) protein encoding to
inactivate neurotransmitters and hormones
– BDNF (brain-derived neurotrophic factor) stimulates nerve
growth factor; neuroplasticity
– NRG (neuregulin) related to neuronal development
• Dopamine and serotonin receptors
– DRD2 (dopamine receptor 2) modulates locomotion,
reward, reinforcement, risk-taking, memory, and learning
– DRD2/ANKK1, DRD4 7+ repeat associated with risk-taking
– SLC6A3 (solute carrier family 6) encodes a dopamine
transporter; terminates the action of dopamine
– 5-HTT, 5-HTTLPR Dopamine and serotonin transport 10
12. Thinking Fast and Slow
• Daniel Kahneman, Nobel Laureate in
Economics, 2002
• Decision-making function: two thinking
systems are used to make choices
– Fast, intuitive thinking
– Slow, rational thinking
• Helps to explain bias and prejudice
– Why there more chance we'll believe something
if it's in a bold type face
– Why judges are more likely to deny parole before
lunch
– Why we assume a good-looking person will be
more competent
12
13. Study: Thinking Fast and Slow
A. Loss Aversion
• Loss Aversion: loss avoidance vastly
preferred to gains
• Neural Processes: reward processing,
reward anticipation, action-taking, risk-
taking and risk-avoidance, impulse control,
addiction, and propensity for gambling
• Genes: 5-HTTLPR, COMT Val(158)Met,
T102C, DRD2/ANKK1, PDYN
• Instruments (open-source PEBL software)
– Loss Aversion Task: prospect theory
– Iowa Gambling Task: real-life decision-making
13
14. Study: Thinking Fast and Slow
B. Optimism Bias
• Optimism Bias: overconfidence, being
inaccurately optimistic about outcomes
• Neural Processes: reward processing,
positive mindset, attitude towards new
experience
• Genes: 5-HTTLPR, COMT Val(158)Met,
T102C, DRD2/ANKK1, OXTR
• Instruments
– Schowmaker’s Confident Decision Making test
– Blavatskyy’s Experimental Test of Overconfidence
– Critch’s Credence Game
14
15. Study: Thinking Fast and Slow
C. Thinking Systems
• Thinking systems: Fast (immediate gut
response) and slow (relaxed and deliberative)
• Neural Processes: adrenergic regulation of the
hormone epinephrine and the
neurotransmitter norepinephrine related to
the “fight or flight” response, sympathetic
nervous system arousal
• Genes: ADRB1, ADRB2
• Instruments
– Fight-or-Flight Response Test
– Fight or Flight Questionnaire
15
16. Important Role of Creativity
• Growing field of multi-disciplinary study
– Biology: natural selection, genomics, neurology
– Psychology: how the imagination works,
cognitive processes employed in creativity
– Philosophy: Metaphysics (existence definitions,
role of consciousness and intentionality), Ethics
(Is creativity valuable for its own sake apart from
what it produces? Is creativity a virtue?),
Aesthetics
16
17. 5 Steps in the Creative Process
1. Preparation: Becoming
immersed in the area
2. Incubation: Allowing the ideas
to turn around unconsciously
3. Insight: the “Aha!” moment
when things start to make sense
4. Evaluation: Deciding whether to
pursue the insight
5. Elaboration: Translating the
insight into its final form
Source: Csikszentmihalyi , Creativity: Flow and the Psychology of Discovery and Invention, 1996 17
18. Study: Quantified Creativity
• Creativity: The ability to make or bring something new
into existence (Webster)
• Neural Processes: Neuroplasticity, dopamine and
serotonin transportation, neuregulin (neuronal
development), neurotrophic factor (neuron and
synapse growth), risk-taking, openness to experience
• Genes: BDNF, 5-HTT , COMT, NRG, DRD2/ANKK1, DRD2
• Instruments
– Kirton Adaptation Innovation Inventory
– Buffalo Creative Process Inventory
– Creativity journal
– Consumer EEG tracking of gamma spikes
18
20. Continuous Information Climate
• Immersed in infinite data flow: we give off bits of
information that are sent to the data flow and the
data flow responds by sending information to us
20
21. Personal Data Privacy Rights
• Drone-proof anti-surveillance
Burqas from Stealth Wear
– Response to surveillance
drones in domestic airspace
– Wearers invisible to infrared
surveillance cameras
• Neural Data Privacy Rights
– Personal Faraday cage
• Behavioral conventions
– ‘Off-Glass’ conversations
Burqa: http://www.salon.com/2013/03/07/drone_proof_burqas_the_latest_fashion_trend_partner/ 21
22. Concluding Vision
• Continuous information climate
– Humans as collective intelligence computers (2012)
• Individuals and groups create, process, analyze, and
upload data in a living computing organism comprised of
individual nodes and mass collaboration
– Humans as collective intelligence biosensors (2013)
• Individuals and the crowd sense, diagnose, and support
individuals and groups using objective metric data
broadcast
• Data-driven wellness enabled at multiple layers
– Individuals (physical and mental peak performance)
– Communities, groups, human systems
– Habitats, ecosystems, planets
22
23. Thank you!
Slides: http://slideshare.net/LaBlogga
Collaborators: International collaborations:
Lorenzo Albanello Marat Nepomnyashy
Janet Chang Ted Odet JST and Rikengenesis
Cindy Chen Roland Parnaso Takashi Kido
John Furber Thomas Pickard Minae Kawashima
Hong Guo William Reinhardt Jin Yamanaka
Kristina Hathaway Greg Smith
Laura Klemme Aaron Vollrath University Hospitals of Geneva
Priya Kshirsagar Lawrence S. Wong Chiara Liverani
Melanie Swan
Lucymarie Mantese Armin Schnider Founder
DIYgenomics
Raymond McCauley +1-650-681-9482
@DIYgenomics
www.DIYgenomics.org
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