This document summarizes a presentation given by Wayne Powell at an ISPC meeting on September 15th 2014. The presentation discussed changes in the expectations of science and research, including developments in genome editing, synthetic biology, and integrative approaches. It provided analyses of CGIAR's publication output, impact, research programs, collaboration networks, and strategic fit. It also summarized CGIAR's current portfolio and proposed a new framework oriented around challenges rather than individual commodities. Key messages included the need for strategic focus, innovation, excellence, impact, partnerships, and clear criteria for assessing success.