Regression analysis is a statistical method used to determine the relationships between a dependent variable and one or more independent variables, often expressed as a linear equation. Multiple regression allows for multiple factors to influence the dependent variable, and the model's effectiveness is measured by metrics such as R-squared and p-values for individual variables and the model as a whole. Key potential issues in regression include multicollinearity, omitted variables, and endogeneity, which can affect the accuracy and interpretability of the results.