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April 22, 2021
Presenters: Dr. Sarah Neil-Sztramko, PhD
Dr. Maureen Dobbins, RN, PhD
Facilitator: Emily Clark, MSc
Rapid Review Methods in a COVID-19 World
Housekeeping
• We are using a new webinar platform
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Connection
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please send a private message to admin
• Use chat to post questions and/or
comments throughout the webinar
• Post your questions in the public chat box
• Send questions about technical
difficulties in a private chat to admin
• Polling
After Today
After the webinar, access the recording (in English) at
www.youtube.com/nccmt and slides in English and French at
www.slideshare.net/NCCMT/presentations.
Poll Question 1
How many people are watching today’s session with you?
A) Just Me
B) 2-3
C) 4-5
D) 6-10
E) >10
Poll Question 2
Have you visited the National Collaborating Centre for Methods
and Tools’ website or used its resources before?
A) Yes
B) No
Poll Question 3
If you stated YES on the previous question, how many times have
you used the NCCMT’s resources?
A) Once
B) 2-3 times
C) 4-10 times
D) 10+ times
Rapid Review Methods in a COVID-19 World
NCCMT Products and Services
Registry of Methods and Tools
Online Learning
Opportunities
Workshops
Video Series
Public Health+
Networking and
Outreach
Presenters
Dr. Sarah Neil-Sztramko, PhD
National Collaborating Centre for Methods and Tools
Dr. Maureen Dobbins, RN, PhD
National Collaborating Centre for Methods and Tools
Evidence-Informed Decision Making (EIDM)
The process of distilling and disseminating the best available evidence
from research, context and experience, and using that evidence to
inform and improve public health practice, programs and policy.
EIDM during COVID-19
NEEDCAPACITY
Rapid Evidence Service
• Urgent and ongoing need for synthesized evidence; little to no
capacity among front line public health service delivery organizations
• Pivot from synthesis training and support to conducting evidence
syntheses
• Response to public health decision makers’ requests for evidence on
priority public health questions
Methods: Rapid Evidence Service
• NCCMT prioritizes questions from
received requests
• Modified steps from the NCCMT Rapid
Review Guidebook
• “Relay race”
• Reviews completed within 5-10+ days
1. Define the
question
2. Search for
research
evidence
3. Critically
appraise
4. Synthesize
the evidence
5. Identify
applicability
and
transferability
issues
RES Team
• NCCMT Scientific Director
• NCCMT Operational Lead
• RES Scientific Lead
• Rapid Review Leads (3-4)
• RES Coordinator
• Rapid Review Search Lead
• Rapid Review Search Staff (1-2)
• Rapid Review Support Staff (3-4)
Receive and prioritize questions
• Questions from federal, provincial/territorial, local organizations + international
• Weekly team meeting
• Assess progress on current reviews
• Assess capacity to start new reviews
• Prioritization
• Avoid duplication
• COVID-END
• Urgency/relevance of question to Canadian context
• Content expertise in house to address question
• Availability of useful evidence
Formulate Question
• PICO or PS (where possible)
• Collaboration with requestor
• Used to set
inclusion/exclusion criteria
Searching
• Search strategy outlined
• Predominantly COVID-19 databases (some exceptions)
• Search for:
• English language
• Peer-reviewed sources, and pre-prints
• Depending on question:
• Grey literature
• Jurisdictional data
• Try to prioritize syntheses before single studies
COVID-19 Specific Databases
• LitCovid: Pubmed’s curated COVID-19
literature hub
• WHO’s Global literature on coronavirus
disease
• COVID-19 Evidence Alerts from McMaster
PLUS™
• L·OVE: COVID-19 Living Overview of the
Evidence
• Cochrane Coronavirus (COVID-19) Special
Collections
General Databases
• Guidelines International Network (GIN)
• Trip Medical Database
• MedRxiv preprint server
• Prospero Registry of Systematic Reviews
Relevant websites/repositories
• NCCMT COVID-19 Rapid Evidence Reviews
• NCC websites
• Public Health Ontario
• Institute national d’excellence en santé et en
services sociaux (INESSS)
• BCCDC
• Alberta Health Services
• USHER Network for COVID-19 Evidence
Reviews
• Centers for Disease Control and Prevention’s
Morbidity and Mortality Weekly Report
• Oxford COVID-19 Evidence Service
• Public Health England
Databases searched
• Single reviewer title & abstract screening
• Export to Distiller SR
• New: Use of DAISY re-rank and AI function
• Manual screening of some sources
• Track in excel
• Single reviewer full text screening
• Double checked during summary writing
Screening
• Data extracted by one reviewer,
checked by RR lead
• Key information
• Study design
• Population
• Setting
• Summary of findings
• Quality rating
• Other info as needed
Data extraction
Critical appraisal = Critically important
• By the end of April 2020, preprints accounted for approximately 40%
of all English-language COVID-19 scientific work (Fraser, 2020)
• Few syntheses appraising evidence
• How to identify the most trustworthy findings?
Critical appraisal
• Completed by one reviewer, verified by a second
• Conflicts resolved through discussion, input from review lead as needed
• A variety of appraisal tools are used depending on design
• AMSTAR 1 (Systematic Reviews)
• AGREE II (Guidelines)
• Joanna Briggs Institute Checklists for all other designs
• Each study rated as strong, moderate, low quality
GRADE
• Grading of Recommendations, Assessment, Development, and Evaluation
• How likely are the findings to change with more evidence?
• Used to assess certainty of findings based on eight domains
• Risk of bias (quality assessment)
• Inconsistency of effects
• Indirectness of interventions/outcomes
• Imprecision in effect estimate
• Publication bias
• Magnitude of effect
• Dose-response relationship
• Accounting for confounding
• Certainty of findings rated as: very low, low, moderate, strong
Final Product
• Question
• Executive Summary
• Key findings and certainty
• What has changed (update)
• Overview of evidence and knowledge gaps
• Methods
• Results
• Tables
• COVID-19 Rapid Evidence Service:
nccmt.ca/res
• 28 reviews & 25 updates (April 2021)
• Posted to the NCCMT’s website
• E-mail notifications – subscription and
targeted
• Social media
• Monthly newsletter
• McMaster communications
Dissemination: Rapid Evidence Service
• > 25 000 page views, June 2020 – April 2021
• Priority questions from various organizations
(e.g. WHO, Public Health Ontario, public
health units)
• Collaborated with Public Health England on
an update
• Email subscribers in nearly all provinces and
territories
• Reviews indexed in various databases and
updates
• Media coverage in over 30 outlets
Accessed in >69 countries
Impact
• Balancing rigour with feasibility
• Minimizing duplication
• Getting the info into the right
hands at the right time for
decision making
• Proactive vs. reactive
• When to consider evidence “out
of date”?
• How useful is evidence from
other jurisdictions to Canada?
• Signal to noise ratio, low quality
evidence
Continuous challenges
Conclusion & Implications
• Implementation of a strategy that resulted in rapidly coordinated
efforts on a national scale
• Reduce duplication and disseminate quality evidence into the hands
of decisions makers
• Continuous evolution of methods as COVID evidence changes
• Transitioning to collaboration and supporting other organizations to
conduct high quality rapid reviews
RES Team
Maureen Dobbins, RN, PhD
Sarah Neil-Sztramko, PhD
Susan Snelling, PhD
Emily Belita, RN, PhD
Emily Clark, MSc
Robyn Trainor, MSc
Leah Hagerman, MPH
Izabelle Siqueira, MPH
Taylor Colangeli
Questions?
Webinar Feedback
Your responses will be kept anonymous.
1. Have you or your organization used one of the NCCMT’s rapid
reviews to inform decision-making?
A) Yes
B) No
Webinar Feedback
Your responses will be kept anonymous.
2. If you said yes, how? If you said no, why not? (Enter answer)
Webinar Feedback
Your responses will be kept anonymous.
Please indicate your level of agreement with the following
3. Participating in the webinar increased my knowledge and
understanding of evidence-informed decision making.
Strongly agree Agree Undecided Disagree Strongly Disagree
Webinar Feedback
Your responses will be kept anonymous.
Please indicate your level of agreement with the following:
4. I will use the information from today’s webinar in my own practice.
Strongly agree Agree Undecided Disagree Strongly Disagree
Webinar Feedback
Your responses will be kept anonymous.
5. Which of the following statements apply to your experience with the
webinar today (check all that apply):
□ The webinar was relevant to me and my public health practice
□ The webinar was effectively facilitated
□ The webinar had opportunities to participate
□ The webinar was easy to follow along
□ The webinar met my expectations
Webinars from the NCCMT
Learn more about our webinars:
http://www.nccmt.ca/capacity-development/webinars
37
For more information:
NCCMT website: www.nccmt.ca
Contact: nccmt@mcmaster.ca

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Rapid Review Methods in a COVID-19 World

  • 1. April 22, 2021 Presenters: Dr. Sarah Neil-Sztramko, PhD Dr. Maureen Dobbins, RN, PhD Facilitator: Emily Clark, MSc Rapid Review Methods in a COVID-19 World
  • 2. Housekeeping • We are using a new webinar platform • Connection issues • We recommend using a wired Internet Connection • If you are experiencing technical issues please send a private message to admin • Use chat to post questions and/or comments throughout the webinar • Post your questions in the public chat box • Send questions about technical difficulties in a private chat to admin • Polling
  • 3. After Today After the webinar, access the recording (in English) at www.youtube.com/nccmt and slides in English and French at www.slideshare.net/NCCMT/presentations.
  • 4. Poll Question 1 How many people are watching today’s session with you? A) Just Me B) 2-3 C) 4-5 D) 6-10 E) >10
  • 5. Poll Question 2 Have you visited the National Collaborating Centre for Methods and Tools’ website or used its resources before? A) Yes B) No
  • 6. Poll Question 3 If you stated YES on the previous question, how many times have you used the NCCMT’s resources? A) Once B) 2-3 times C) 4-10 times D) 10+ times
  • 8. NCCMT Products and Services Registry of Methods and Tools Online Learning Opportunities Workshops Video Series Public Health+ Networking and Outreach
  • 9. Presenters Dr. Sarah Neil-Sztramko, PhD National Collaborating Centre for Methods and Tools Dr. Maureen Dobbins, RN, PhD National Collaborating Centre for Methods and Tools
  • 10. Evidence-Informed Decision Making (EIDM) The process of distilling and disseminating the best available evidence from research, context and experience, and using that evidence to inform and improve public health practice, programs and policy.
  • 12. Rapid Evidence Service • Urgent and ongoing need for synthesized evidence; little to no capacity among front line public health service delivery organizations • Pivot from synthesis training and support to conducting evidence syntheses • Response to public health decision makers’ requests for evidence on priority public health questions
  • 13. Methods: Rapid Evidence Service • NCCMT prioritizes questions from received requests • Modified steps from the NCCMT Rapid Review Guidebook • “Relay race” • Reviews completed within 5-10+ days 1. Define the question 2. Search for research evidence 3. Critically appraise 4. Synthesize the evidence 5. Identify applicability and transferability issues
  • 14. RES Team • NCCMT Scientific Director • NCCMT Operational Lead • RES Scientific Lead • Rapid Review Leads (3-4) • RES Coordinator • Rapid Review Search Lead • Rapid Review Search Staff (1-2) • Rapid Review Support Staff (3-4)
  • 15. Receive and prioritize questions • Questions from federal, provincial/territorial, local organizations + international • Weekly team meeting • Assess progress on current reviews • Assess capacity to start new reviews • Prioritization • Avoid duplication • COVID-END • Urgency/relevance of question to Canadian context • Content expertise in house to address question • Availability of useful evidence
  • 16. Formulate Question • PICO or PS (where possible) • Collaboration with requestor • Used to set inclusion/exclusion criteria
  • 17. Searching • Search strategy outlined • Predominantly COVID-19 databases (some exceptions) • Search for: • English language • Peer-reviewed sources, and pre-prints • Depending on question: • Grey literature • Jurisdictional data • Try to prioritize syntheses before single studies
  • 18. COVID-19 Specific Databases • LitCovid: Pubmed’s curated COVID-19 literature hub • WHO’s Global literature on coronavirus disease • COVID-19 Evidence Alerts from McMaster PLUS™ • L·OVE: COVID-19 Living Overview of the Evidence • Cochrane Coronavirus (COVID-19) Special Collections General Databases • Guidelines International Network (GIN) • Trip Medical Database • MedRxiv preprint server • Prospero Registry of Systematic Reviews Relevant websites/repositories • NCCMT COVID-19 Rapid Evidence Reviews • NCC websites • Public Health Ontario • Institute national d’excellence en santé et en services sociaux (INESSS) • BCCDC • Alberta Health Services • USHER Network for COVID-19 Evidence Reviews • Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report • Oxford COVID-19 Evidence Service • Public Health England Databases searched
  • 19. • Single reviewer title & abstract screening • Export to Distiller SR • New: Use of DAISY re-rank and AI function • Manual screening of some sources • Track in excel • Single reviewer full text screening • Double checked during summary writing Screening
  • 20. • Data extracted by one reviewer, checked by RR lead • Key information • Study design • Population • Setting • Summary of findings • Quality rating • Other info as needed Data extraction
  • 21. Critical appraisal = Critically important • By the end of April 2020, preprints accounted for approximately 40% of all English-language COVID-19 scientific work (Fraser, 2020) • Few syntheses appraising evidence • How to identify the most trustworthy findings?
  • 22. Critical appraisal • Completed by one reviewer, verified by a second • Conflicts resolved through discussion, input from review lead as needed • A variety of appraisal tools are used depending on design • AMSTAR 1 (Systematic Reviews) • AGREE II (Guidelines) • Joanna Briggs Institute Checklists for all other designs • Each study rated as strong, moderate, low quality
  • 23. GRADE • Grading of Recommendations, Assessment, Development, and Evaluation • How likely are the findings to change with more evidence? • Used to assess certainty of findings based on eight domains • Risk of bias (quality assessment) • Inconsistency of effects • Indirectness of interventions/outcomes • Imprecision in effect estimate • Publication bias • Magnitude of effect • Dose-response relationship • Accounting for confounding • Certainty of findings rated as: very low, low, moderate, strong
  • 24. Final Product • Question • Executive Summary • Key findings and certainty • What has changed (update) • Overview of evidence and knowledge gaps • Methods • Results • Tables
  • 25. • COVID-19 Rapid Evidence Service: nccmt.ca/res • 28 reviews & 25 updates (April 2021) • Posted to the NCCMT’s website • E-mail notifications – subscription and targeted • Social media • Monthly newsletter • McMaster communications Dissemination: Rapid Evidence Service
  • 26. • > 25 000 page views, June 2020 – April 2021 • Priority questions from various organizations (e.g. WHO, Public Health Ontario, public health units) • Collaborated with Public Health England on an update • Email subscribers in nearly all provinces and territories • Reviews indexed in various databases and updates • Media coverage in over 30 outlets Accessed in >69 countries Impact
  • 27. • Balancing rigour with feasibility • Minimizing duplication • Getting the info into the right hands at the right time for decision making • Proactive vs. reactive • When to consider evidence “out of date”? • How useful is evidence from other jurisdictions to Canada? • Signal to noise ratio, low quality evidence Continuous challenges
  • 28. Conclusion & Implications • Implementation of a strategy that resulted in rapidly coordinated efforts on a national scale • Reduce duplication and disseminate quality evidence into the hands of decisions makers • Continuous evolution of methods as COVID evidence changes • Transitioning to collaboration and supporting other organizations to conduct high quality rapid reviews
  • 29. RES Team Maureen Dobbins, RN, PhD Sarah Neil-Sztramko, PhD Susan Snelling, PhD Emily Belita, RN, PhD Emily Clark, MSc Robyn Trainor, MSc Leah Hagerman, MPH Izabelle Siqueira, MPH Taylor Colangeli
  • 31. Webinar Feedback Your responses will be kept anonymous. 1. Have you or your organization used one of the NCCMT’s rapid reviews to inform decision-making? A) Yes B) No
  • 32. Webinar Feedback Your responses will be kept anonymous. 2. If you said yes, how? If you said no, why not? (Enter answer)
  • 33. Webinar Feedback Your responses will be kept anonymous. Please indicate your level of agreement with the following 3. Participating in the webinar increased my knowledge and understanding of evidence-informed decision making. Strongly agree Agree Undecided Disagree Strongly Disagree
  • 34. Webinar Feedback Your responses will be kept anonymous. Please indicate your level of agreement with the following: 4. I will use the information from today’s webinar in my own practice. Strongly agree Agree Undecided Disagree Strongly Disagree
  • 35. Webinar Feedback Your responses will be kept anonymous. 5. Which of the following statements apply to your experience with the webinar today (check all that apply): □ The webinar was relevant to me and my public health practice □ The webinar was effectively facilitated □ The webinar had opportunities to participate □ The webinar was easy to follow along □ The webinar met my expectations
  • 36. Webinars from the NCCMT Learn more about our webinars: http://www.nccmt.ca/capacity-development/webinars 37
  • 37. For more information: NCCMT website: www.nccmt.ca Contact: nccmt@mcmaster.ca