Sandra Odebrechet and her team investigated the potential pathogenesis of schizophrenia through the Borna Disease Virus. They tested 27 schizophrenic and schizoaffective patients, as well as 27 healthy volunteer controls and family members with and without mood disorders, for traces of Borna Disease Virus RNA. Their methodology followed international safety guidelines to prevent contamination. They found BDV RNA in 44% of schizophrenic subjects, 50% of relatives without mental disorders, and 37.5% of relatives with mood disorders. This study provided more geographical variation than others by being conducted in Brazil.