Pub. annotated bibliography 3
•Download as DOC, PDF•
1 like•124 views
1. Korean researchers used rRT-PCR to test for Borna Disease Virus (BDV) antibodies and RNA in peripheral blood mononuclear cells of 60 healthy and 198 psychiatric patients, including 60 with schizophrenia and 138 with other conditions. 2. All patients tested negative for BDV. However, the results were inconclusive due to uncertainties in the methodology, such as success rate and the researchers' experience with the new rRT-PCR technique. 3. More research is needed using improved methods to track the virus in order to determine if BDV could be linked to schizophrenia or other psychiatric conditions.
Report
Share
Report
Share
![Fall Semester 2012-13
Annotated Bibliography 3
Roll Book.# 6 Name Juan Enrique Maldonado Weng
Date: November 2nd, 20012
Annotated Bibliography 3:
Na K, Tae S, Song J and Kim Y. 2009. Failure to Detect Borna Disease Virus Antibody and
RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients. Official Journal of Korean
Neuropsychiatric Association, [Internet]; [Cited 2012 November 22]. DOI 10.4306/pi. 2009:6:306-312
Available at: http://synapse.koreamed.org/Synapse/Data/PDFData/0162PI/pi-6-306.pdf
These Korean investigators attempt to find the relationship between Borna Disease Virus (BDV) and
schizophrenia. It is believed that BDV is a cause for the schizophrenic conditions. With the utilization
of a new technique that has not been previously used for this type of study, rRT-PCR (real-time
Reverse Transcriptase Polymerase Chain Reaction), the researchers look for answers. This process
tracks BDV antibodies or RNA in the peripheral blood mononuclear cells (PBMC) of the human body.
For the study, sixty healthy patients were recruited for the control and 198 psychiatric patients were
recruited for the experimental. The experimental group was composed of sixty patients with
schizophrenia and 138 with other major psychiatric conditions. Within the rRT-PCR method, all the
patients tested negative for BDV. These results are not conclusive due to many uncertainties in the
methodology such as the success rate, their handling of the procedure, and the researcher's
experience with the procedure. Even though this method is shown to have low possibilities of
contamination, this is the first known utilization of the procedure. The researchers might be
inexperienced with the resulting reactions of the virus. Another example of an uncertainty is the lack
of comparison and continuation of the experiment. The researchers did not validate the results from
other tests nor did they publish their results of their other tests. This experiment shows that to find
answers, it is necessary to require new and more adequate methods to trace the virus in patients.
When that can be accomplished, a new origin of the schizophrenic condition may be found.
Words 225](https://image.slidesharecdn.com/pub-annotatedbibliography3-121221180734-phpapp02/85/Pub-annotated-bibliography-3-1-320.jpg)
Recommended
Crime scene
Three key pieces of evidence place suspects at the simulated crime scene:
1) Bur Oak and Mum spores matched Van Selama's plant profile.
2) Brianna Evian's fingerprints were found on the incubator and Snickers wrapper.
3) Hailey Wescott's prints matched those on the medicine spoon containing Voriconazole, suggesting she treated the victim for a fungal infection caused by Aspergillus found at the scene.
Quadruple helix dna and epigenetics in rheumatism genes
Researchers at Cambridge discovered quadruple-stranded DNA structures in human cancer cells. They believe these quadruplexes may be targeted to halt cancer cell proliferation. Using antibodies, they identified these structures, especially during cell division. A gene with more quadruplex DNA was found to be more susceptible to external interference. Separately, scientists at Johns Hopkins and Karolinska Institutet identified DNA sequences and regulatory tags linked to rheumatoid arthritis by studying white blood cells. Tracking these tags may help improve arthritis treatment by directly targeting implicated genes and tags. Epigenetic studies can help explain links between genetics and diseases.
Historical and ethical aspects of personalized medicine
This document discusses the shift from traditional medicine to personalized/precision medicine. It outlines several key eras: from the period of incidental discoveries up to the 1960s where specific germs were discovered to cause diseases; the era of high throughput screening from the 1970s-2000s which yielded treatments like statins and Velcade; and now the era of personalized/precision "iMedicine" which aims to be predictive, preventive, participatory and personalized. The document provides examples of advances and challenges that have contributed to this shift.
A qualitative and quantitative study of the incidence, features and aetiology...
A qualitative and quantitative study of the incidence, features and aetiology...José Luis Moreno Garvayo
Resultados del estudio piloto de 2001 diseñado para evaluar la frecuencia en que se daban experiencias cercanas a la muerte en personas que habían sobrevivido a paros cardíacos, así como para determinar las características de estas experiencias. Para más detalles visitar: http://www.afanporsaber.es/2014/01/experiencias-cercanas-a-la-muerte-i/Evidence of the Afterlife (Science of Mediumship Event)
This is a presentation summarizing 150 years of afterlife experience presented at the Science of Mediumship Event at the Novotel Hotel in Toronto, Canada. This presentation includes survival of consciousness evidence pertaining to mental and physical mediumship, near death experiences, out of body experiences, electric voice phenomenon and past life regression therapy
Anderson2015
This study compared brain volumes between three groups of schizophrenia patients: those responsive to first-line antipsychotics (FLR), those resistant but responsive to clozapine (TR), and those resistant to clozapine (UTR). T1-weighted MRI scans were obtained for 52 schizophrenia patients and 20 controls. The TR and UTR groups had significantly reduced global gray matter volume compared to controls and FLRs. TR patients also showed regional gray matter reductions compared to FLRs in several temporal, frontal and parietal areas. UTR patients showed reductions in the right parietal operculum and left cerebellum compared to FLRs. No significant differences were found between the TR and UTR groups. The results suggest treatment
AllTrials AAAS 2015 - Closing the Loop: Towards Claim-Evidence Networks in C...
The document discusses improving connections between clinical claims and evidence. It presents examples where claims in guidelines or drug marketing are not well supported by available evidence from clinical trials. Better systems are needed to link claims directly to supporting evidence, such as those used by Cancer Commons and Cochrane Collaboration, which connect websites, case reports, and trials. Tools to identify the strength and source of claims in research papers can also help form more rigorous claim-evidence networks in clinical practice.
Get into the Research
The document discusses definitions of disease flares in systemic lupus erythematosus (SLE) and the relationship between changes in anti-double stranded DNA (anti-dsDNA) antibody titers and clinical flares. It describes a study that aims to assess the association between a "DNA flare", defined as a rapid and substantial increase in anti-dsDNA titers, and subsequent severe, renal, or mild-moderate clinical flares within 6 months. The study will analyze data from an SLE patient registry to compare outcomes between patients who experience a DNA flare and matched control patients.
Recommended
Crime scene
Three key pieces of evidence place suspects at the simulated crime scene:
1) Bur Oak and Mum spores matched Van Selama's plant profile.
2) Brianna Evian's fingerprints were found on the incubator and Snickers wrapper.
3) Hailey Wescott's prints matched those on the medicine spoon containing Voriconazole, suggesting she treated the victim for a fungal infection caused by Aspergillus found at the scene.
Quadruple helix dna and epigenetics in rheumatism genes
Researchers at Cambridge discovered quadruple-stranded DNA structures in human cancer cells. They believe these quadruplexes may be targeted to halt cancer cell proliferation. Using antibodies, they identified these structures, especially during cell division. A gene with more quadruplex DNA was found to be more susceptible to external interference. Separately, scientists at Johns Hopkins and Karolinska Institutet identified DNA sequences and regulatory tags linked to rheumatoid arthritis by studying white blood cells. Tracking these tags may help improve arthritis treatment by directly targeting implicated genes and tags. Epigenetic studies can help explain links between genetics and diseases.
Historical and ethical aspects of personalized medicine
This document discusses the shift from traditional medicine to personalized/precision medicine. It outlines several key eras: from the period of incidental discoveries up to the 1960s where specific germs were discovered to cause diseases; the era of high throughput screening from the 1970s-2000s which yielded treatments like statins and Velcade; and now the era of personalized/precision "iMedicine" which aims to be predictive, preventive, participatory and personalized. The document provides examples of advances and challenges that have contributed to this shift.
A qualitative and quantitative study of the incidence, features and aetiology...
A qualitative and quantitative study of the incidence, features and aetiology...José Luis Moreno Garvayo
Resultados del estudio piloto de 2001 diseñado para evaluar la frecuencia en que se daban experiencias cercanas a la muerte en personas que habían sobrevivido a paros cardíacos, así como para determinar las características de estas experiencias. Para más detalles visitar: http://www.afanporsaber.es/2014/01/experiencias-cercanas-a-la-muerte-i/Evidence of the Afterlife (Science of Mediumship Event)
This is a presentation summarizing 150 years of afterlife experience presented at the Science of Mediumship Event at the Novotel Hotel in Toronto, Canada. This presentation includes survival of consciousness evidence pertaining to mental and physical mediumship, near death experiences, out of body experiences, electric voice phenomenon and past life regression therapy
Anderson2015
This study compared brain volumes between three groups of schizophrenia patients: those responsive to first-line antipsychotics (FLR), those resistant but responsive to clozapine (TR), and those resistant to clozapine (UTR). T1-weighted MRI scans were obtained for 52 schizophrenia patients and 20 controls. The TR and UTR groups had significantly reduced global gray matter volume compared to controls and FLRs. TR patients also showed regional gray matter reductions compared to FLRs in several temporal, frontal and parietal areas. UTR patients showed reductions in the right parietal operculum and left cerebellum compared to FLRs. No significant differences were found between the TR and UTR groups. The results suggest treatment
AllTrials AAAS 2015 - Closing the Loop: Towards Claim-Evidence Networks in C...
The document discusses improving connections between clinical claims and evidence. It presents examples where claims in guidelines or drug marketing are not well supported by available evidence from clinical trials. Better systems are needed to link claims directly to supporting evidence, such as those used by Cancer Commons and Cochrane Collaboration, which connect websites, case reports, and trials. Tools to identify the strength and source of claims in research papers can also help form more rigorous claim-evidence networks in clinical practice.
Get into the Research
The document discusses definitions of disease flares in systemic lupus erythematosus (SLE) and the relationship between changes in anti-double stranded DNA (anti-dsDNA) antibody titers and clinical flares. It describes a study that aims to assess the association between a "DNA flare", defined as a rapid and substantial increase in anti-dsDNA titers, and subsequent severe, renal, or mild-moderate clinical flares within 6 months. The study will analyze data from an SLE patient registry to compare outcomes between patients who experience a DNA flare and matched control patients.
Deletion 17q12 recurrent copy number variant ashadeep chandrareddy daniel d...
This document summarizes a study that found a recurrent 1.4 Mb deletion at chromosome 17q12 in patients with autism spectrum disorder (ASD) or schizophrenia, but not in controls. The deletion removes the HNF1B gene. In a follow up sample of over 8,000 patients and nearly 48,000 controls, the deletion was identified in patients with ASD/neurocognitive impairment and schizophrenia, but not controls. Clinical assessment of nine patients found features including macrocephaly, characteristic facial features, renal anomalies, and neurocognitive impairments. This provides further evidence that rare copy number variants can contribute to both ASD and schizophrenia, and that one or more genes in the 17q12 region are important
Annotated bibliography iii
Researchers studied 650 patients between ages 63-91, including 200 healthy patients and 450 with Parkinson's disease. They analyzed DNA markers for three polymorphisms of nitric oxide (NO) synthase enzymes (eNOS, nNOS, iNOS) that some research linked to loss of dopaminergic neurons in the substantia nigra pars compacta. The researchers found no association between these NO polymorphisms and Parkinson's disease.
Diagnostic Approach of Encephalitis
Acute encephalitis is a neurological emergency that can cause severe disability or death if not diagnosed promptly. It is most commonly caused by viral or autoimmune etiologies. Diagnosis requires evidence of central nervous system inflammation demonstrated by at least two of the following: fever, seizures, CSF pleocytosis, EEG findings, or neuroimaging findings suggestive of encephalitis. A lumbar puncture is vital to distinguish encephalitis from encephalopathy and guide management. Imaging is not required before lumbar puncture unless contraindicated. For suspected HSV encephalitis, aciclovir treatment should be started immediately to save lives as it is time-critical.
Hearing Loss in Wegener’s Granulomatosis
To describe the frequency, type, and clinical course
of hearing loss in Wegener’s granulomatosis and assess hearing
loss as an indicator of disease activity.
Eko med 23-ispr.
Dr. Adriana Bora is submitting a research proposal to the Society for Neuroscience for the Peter and Patricia Gruber International Research Award, supported by the Gruber Foundation. Her proposal focuses on developing novel clinical assays using functional peptidomics/metabolomics to better understand and monitor the different stages of HIV-associated neurological disorders in patients, even those receiving antiretroviral therapy. She has previously identified important glycoproteins and biomakers in cerebral spinal fluid that are involved in various pathways impacted by HIV in the brain. Her future research aims to identify alternative pathways and routes used by HIV to alter brain metabolism and cause impairment, which could lead to more personalized treatment approaches for HAND patients.
Tubercular Brain Abscess: Diagnostic Dilemma-A Case Report
Tubercular Brain Abscess: Diagnostic Dilemma-A Case ReportSSR Institute of International Journal of Life Sciences
Isolated central nervous system tuberculosis is uncommon in immunocompetent patients. It resembles a pyogenic brain abscess
clinically and radiologically and poses a problem in diagnosis and treatment. Here we described a case of recurrent frontal lobe
abscess, which was diagnosed as a tubercular abscess. There was no clinical or radiological evidence of active tuberculosis
elsewhere in the body. The diagnosis of tubercular abscess was confirmed by Mycobacterium tuberculosis by Polymerase Chain
Reaction (TB-PCR) in the abscess material aspirated via a burr hole.B26007011
The document discusses the potential future effects of nanomedicine on human generations. It describes how nanomedicine uses engineered nanodevices and knowledge of the human body to diagnose, treat, and prevent disease. Specifically, it outlines how nanodiamonds coated with drugs and proteins can target and destroy cancer cells without harming normal cells. The document also discusses how nanotubes may be used to deliver cancer drugs directly to diseased cells. While nanomedicine holds promise to revolutionize disease treatment, the document notes potential health risks from nanoparticle exposure that require further study.
Pub. annotated bibliography 3
1. Korean researchers used a new technique called rRT-PCR to test for the presence of Borna Disease Virus (BDV) antibodies or RNA in the blood cells of 198 psychiatric patients and 60 healthy controls.
2. The study found that none of the patients tested positive for BDV using this method.
3. However, the results were inconclusive due to uncertainties in the methodology, such as the researchers' experience with the new technique and a lack of validation or follow up testing. More research is still needed to fully understand the potential relationship between BDV and schizophrenia.
Pub. annotated bibliography 2
This study tested 619 patients in Germany for antibodies and RNA of the Borna Disease Virus (BDV) to examine the link between mental disorders and BDV infection. 416 psychiatric patients and 203 healthy controls were tested using reverse transcription polymerase chain reaction (RT-PCR) and serum testing. The results found that 40 of the psychiatric patients tested seropositive for BDV antibodies compared to only 3 of the controls. Of those psychiatric patients, 11 had schizophrenia and 7 of those 11 schizophrenic patients tested positive for BDV RNA strands. This provides evidence of a link between BDV infection and schizophrenia, as most BDV cases appeared in patients with schizophrenia.
Juan lab summary 3
This laboratory workshop focused on bacteriophages and proteomics. Bacteriophages are viruses that infect bacteria and each one is unique. The workshop involved testing a soil sample to see if it contained any bacteriophages, which could be revealed as clear spots on a plate with bacteria and broth. The goal was to isolate and purify a single bacteriophage from the sample in order to analyze and reveal its protein strands. The workshop provided a valuable learning experience about bacteriophages despite some challenges with the purification process.
7. juan reflex fall courserevised
The document summarizes a student's experience taking an Introduction to Scientific Literature course. The student initially thought it would take a PhD to understand research articles but learned to read and summarize five articles to write a research paper. The course required attending seminars to learn how to focus on main ideas and terms. It also allowed students to interact with guest speakers and get a better understanding of their work. While challenging, working on an annotated bibliography and review paper throughout the semester helped the student learn an efficient system to complete the difficult final project. Overall, the student felt the course was a great test of endurance that provided necessary skills and preparation for future studies.
Pub. review paper
The document discusses investigations into the relationship between the Borna Disease Virus (BDV) and schizophrenia. It summarizes findings from multiple studies that tested schizophrenic patients and controls for antibodies and RNA from BDV. Most investigations found higher percentages of BDV antibodies in schizophrenic patients compared to controls. However, one study from Korea found no evidence of BDV. Factors like geography and variations in testing procedures could account for differences in results. Overall, the evidence suggests BDV may play a role in the pathogenesis of schizophrenia for some infected individuals. More research is still needed to fully understand the virus and its relationship to mental illness.
7. juan. lab summary 1 revised 27.5 (1)
This document contains summaries from three laboratory workshops:
1) The first workshop focused on pipetting skills and transferring colored liquids accurately in small quantities.
2) The second workshop involved using microscopes to examine yeast cells and teach a lab mate how to use microscopy equipment.
3) The third workshop over the course of a weekend covered DNA and protein techniques like PCR and electrophoresis to test for genetic conditions like diabetes and lysosomal storage disease.
In sillico pub
1) The document discusses using in silico research to inhibit the methyltransferase enzyme of dengue virus, which is essential for viral replication.
2) Through virtual screening of chemical databases, the researchers identified 25 compounds predicted to bind tightly to the enzyme's GTP binding site with higher affinity than GTP.
3) The top 3 compounds were selected for testing, with DENV-M2_1 showing the highest binding affinity and occupying the active site similarly to how GTP binds. This supports inhibiting the enzyme's function through competitive binding, validating the hypothesis.
6. juan maldonado bdv REVIEW
The document discusses the role of Borna Disease Virus (BDV) in schizophrenia. BDV is a "mood virus" that can alter host behavior and cause disorders like depression. Several studies have found evidence of BDV infection in schizophrenia patients. One study found BDV RNA in the blood of 7 out of 11 schizophrenia patients. Another found BDV antibodies in 54% of schizophrenia patients. However, more research is still needed to definitively link BDV to schizophrenia, as findings have been mixed. The virus may play a role in neuropsychiatric illnesses and interact with intracellular signaling pathways in the brain.
Juan Lab Summary 2
This document contains summaries of three laboratory assignments from a biomedical techniques course at the University of Puerto Rico - Cayey. The first summary describes learning about nanotechnology and observing nano fibers using an electron microscope. The second discusses using nanoparticles and affinity chromatography to isolate specific proteins, then using SDS-Page gel electrophoresis to measure the results. The third summary explains how computer programs help researchers visualize proteins and compare them to databases to understand protein-protein interactions and design new drugs.
Juan biomedical course
1) The student took a biomedical techniques course through the RISE program which allowed them to meet professors and students from other universities and establish relationships.
2) They attended interesting seminars and workshops on topics like DNA, proteins, neuroscience, and computer simulations of viruses.
3) The student had a great mentorship experience working with Dr. Maldonado on computer simulations of inhibiting viruses using molecular compounds.
Juan Primary Article pub
1) The study aimed to identify a drug that could inhibit the Dengue virus methyltransferase enzyme from binding to GTP, disrupting the virus. 2) Using computer modeling, researchers identified the binding pocket of the methyltransferase and placed benzene rings there to define the pharmacophore. 3) Over 60,000 potential compounds were identified from a database that fit this pharmacophore. The top 25 compounds with highest affinity were selected, with DENV-M2_1 having the highest affinity of -10.4.
Biotechnology new directions_in_medicine
This document discusses the history and development of biotechnology. It explains that biotechnology has been practiced for thousands of years through processes like brewing beer and baking bread, but it emerged as a modern science and industry more recently. Key developments included the discovery of DNA's structure in the 1950s, which allowed for genetic engineering and the production of medicines like human insulin in bacteria in the 1970s. This laid the foundation for a new biotech industry and rapid expansion in the late 20th century as companies utilized these new techniques for medical research and development.
Pub. annotated bibliography 4
Sandra Odebrechet and her team investigated the potential pathogenesis of schizophrenia through the Borna Disease Virus. They tested 27 schizophrenic and schizoaffective patients, as well as 27 healthy volunteer controls and family members with and without mood disorders, for traces of Borna Disease Virus RNA. Their methodology followed international safety guidelines to prevent contamination. They found BDV RNA in 44% of schizophrenic subjects, 50% of relatives without mental disorders, and 37.5% of relatives with mood disorders. This study provided more geographical variation than others by being conducted in Brazil.
Genetic polymorphisms
This document discusses genetic polymorphisms and summarizes several research studies. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes three key points:
1) A study that used a cross-species strategy to identify 6 causal genes for Alzheimer's disease by studying interactions between human genes and neurotoxicity in the fly model.
2) Research confirming the association between a genetic variant in the PLA2R gene and membranous nephropathy through genome-wide association studies and previous Asian studies.
3) The potential medical benefits of these discoveries such as earlier diagnosis, improved treatment, and further genetic research.
More Related Content
What's hot
Deletion 17q12 recurrent copy number variant ashadeep chandrareddy daniel d...
This document summarizes a study that found a recurrent 1.4 Mb deletion at chromosome 17q12 in patients with autism spectrum disorder (ASD) or schizophrenia, but not in controls. The deletion removes the HNF1B gene. In a follow up sample of over 8,000 patients and nearly 48,000 controls, the deletion was identified in patients with ASD/neurocognitive impairment and schizophrenia, but not controls. Clinical assessment of nine patients found features including macrocephaly, characteristic facial features, renal anomalies, and neurocognitive impairments. This provides further evidence that rare copy number variants can contribute to both ASD and schizophrenia, and that one or more genes in the 17q12 region are important
Annotated bibliography iii
Researchers studied 650 patients between ages 63-91, including 200 healthy patients and 450 with Parkinson's disease. They analyzed DNA markers for three polymorphisms of nitric oxide (NO) synthase enzymes (eNOS, nNOS, iNOS) that some research linked to loss of dopaminergic neurons in the substantia nigra pars compacta. The researchers found no association between these NO polymorphisms and Parkinson's disease.
Diagnostic Approach of Encephalitis
Acute encephalitis is a neurological emergency that can cause severe disability or death if not diagnosed promptly. It is most commonly caused by viral or autoimmune etiologies. Diagnosis requires evidence of central nervous system inflammation demonstrated by at least two of the following: fever, seizures, CSF pleocytosis, EEG findings, or neuroimaging findings suggestive of encephalitis. A lumbar puncture is vital to distinguish encephalitis from encephalopathy and guide management. Imaging is not required before lumbar puncture unless contraindicated. For suspected HSV encephalitis, aciclovir treatment should be started immediately to save lives as it is time-critical.
Hearing Loss in Wegener’s Granulomatosis
To describe the frequency, type, and clinical course
of hearing loss in Wegener’s granulomatosis and assess hearing
loss as an indicator of disease activity.
Eko med 23-ispr.
Dr. Adriana Bora is submitting a research proposal to the Society for Neuroscience for the Peter and Patricia Gruber International Research Award, supported by the Gruber Foundation. Her proposal focuses on developing novel clinical assays using functional peptidomics/metabolomics to better understand and monitor the different stages of HIV-associated neurological disorders in patients, even those receiving antiretroviral therapy. She has previously identified important glycoproteins and biomakers in cerebral spinal fluid that are involved in various pathways impacted by HIV in the brain. Her future research aims to identify alternative pathways and routes used by HIV to alter brain metabolism and cause impairment, which could lead to more personalized treatment approaches for HAND patients.
Tubercular Brain Abscess: Diagnostic Dilemma-A Case Report
Tubercular Brain Abscess: Diagnostic Dilemma-A Case ReportSSR Institute of International Journal of Life Sciences
Isolated central nervous system tuberculosis is uncommon in immunocompetent patients. It resembles a pyogenic brain abscess
clinically and radiologically and poses a problem in diagnosis and treatment. Here we described a case of recurrent frontal lobe
abscess, which was diagnosed as a tubercular abscess. There was no clinical or radiological evidence of active tuberculosis
elsewhere in the body. The diagnosis of tubercular abscess was confirmed by Mycobacterium tuberculosis by Polymerase Chain
Reaction (TB-PCR) in the abscess material aspirated via a burr hole.What's hot (7)
Deletion 17q12 recurrent copy number variant ashadeep chandrareddy daniel d...
Deletion 17q12 recurrent copy number variant ashadeep chandrareddy daniel d...
Tubercular Brain Abscess: Diagnostic Dilemma-A Case Report
Tubercular Brain Abscess: Diagnostic Dilemma-A Case Report
Viewers also liked
B26007011
The document discusses the potential future effects of nanomedicine on human generations. It describes how nanomedicine uses engineered nanodevices and knowledge of the human body to diagnose, treat, and prevent disease. Specifically, it outlines how nanodiamonds coated with drugs and proteins can target and destroy cancer cells without harming normal cells. The document also discusses how nanotubes may be used to deliver cancer drugs directly to diseased cells. While nanomedicine holds promise to revolutionize disease treatment, the document notes potential health risks from nanoparticle exposure that require further study.
Pub. annotated bibliography 3
1. Korean researchers used a new technique called rRT-PCR to test for the presence of Borna Disease Virus (BDV) antibodies or RNA in the blood cells of 198 psychiatric patients and 60 healthy controls.
2. The study found that none of the patients tested positive for BDV using this method.
3. However, the results were inconclusive due to uncertainties in the methodology, such as the researchers' experience with the new technique and a lack of validation or follow up testing. More research is still needed to fully understand the potential relationship between BDV and schizophrenia.
Pub. annotated bibliography 2
This study tested 619 patients in Germany for antibodies and RNA of the Borna Disease Virus (BDV) to examine the link between mental disorders and BDV infection. 416 psychiatric patients and 203 healthy controls were tested using reverse transcription polymerase chain reaction (RT-PCR) and serum testing. The results found that 40 of the psychiatric patients tested seropositive for BDV antibodies compared to only 3 of the controls. Of those psychiatric patients, 11 had schizophrenia and 7 of those 11 schizophrenic patients tested positive for BDV RNA strands. This provides evidence of a link between BDV infection and schizophrenia, as most BDV cases appeared in patients with schizophrenia.
Juan lab summary 3
This laboratory workshop focused on bacteriophages and proteomics. Bacteriophages are viruses that infect bacteria and each one is unique. The workshop involved testing a soil sample to see if it contained any bacteriophages, which could be revealed as clear spots on a plate with bacteria and broth. The goal was to isolate and purify a single bacteriophage from the sample in order to analyze and reveal its protein strands. The workshop provided a valuable learning experience about bacteriophages despite some challenges with the purification process.
7. juan reflex fall courserevised
The document summarizes a student's experience taking an Introduction to Scientific Literature course. The student initially thought it would take a PhD to understand research articles but learned to read and summarize five articles to write a research paper. The course required attending seminars to learn how to focus on main ideas and terms. It also allowed students to interact with guest speakers and get a better understanding of their work. While challenging, working on an annotated bibliography and review paper throughout the semester helped the student learn an efficient system to complete the difficult final project. Overall, the student felt the course was a great test of endurance that provided necessary skills and preparation for future studies.
Pub. review paper
The document discusses investigations into the relationship between the Borna Disease Virus (BDV) and schizophrenia. It summarizes findings from multiple studies that tested schizophrenic patients and controls for antibodies and RNA from BDV. Most investigations found higher percentages of BDV antibodies in schizophrenic patients compared to controls. However, one study from Korea found no evidence of BDV. Factors like geography and variations in testing procedures could account for differences in results. Overall, the evidence suggests BDV may play a role in the pathogenesis of schizophrenia for some infected individuals. More research is still needed to fully understand the virus and its relationship to mental illness.
7. juan. lab summary 1 revised 27.5 (1)
This document contains summaries from three laboratory workshops:
1) The first workshop focused on pipetting skills and transferring colored liquids accurately in small quantities.
2) The second workshop involved using microscopes to examine yeast cells and teach a lab mate how to use microscopy equipment.
3) The third workshop over the course of a weekend covered DNA and protein techniques like PCR and electrophoresis to test for genetic conditions like diabetes and lysosomal storage disease.
In sillico pub
1) The document discusses using in silico research to inhibit the methyltransferase enzyme of dengue virus, which is essential for viral replication.
2) Through virtual screening of chemical databases, the researchers identified 25 compounds predicted to bind tightly to the enzyme's GTP binding site with higher affinity than GTP.
3) The top 3 compounds were selected for testing, with DENV-M2_1 showing the highest binding affinity and occupying the active site similarly to how GTP binds. This supports inhibiting the enzyme's function through competitive binding, validating the hypothesis.
6. juan maldonado bdv REVIEW
The document discusses the role of Borna Disease Virus (BDV) in schizophrenia. BDV is a "mood virus" that can alter host behavior and cause disorders like depression. Several studies have found evidence of BDV infection in schizophrenia patients. One study found BDV RNA in the blood of 7 out of 11 schizophrenia patients. Another found BDV antibodies in 54% of schizophrenia patients. However, more research is still needed to definitively link BDV to schizophrenia, as findings have been mixed. The virus may play a role in neuropsychiatric illnesses and interact with intracellular signaling pathways in the brain.
Juan Lab Summary 2
This document contains summaries of three laboratory assignments from a biomedical techniques course at the University of Puerto Rico - Cayey. The first summary describes learning about nanotechnology and observing nano fibers using an electron microscope. The second discusses using nanoparticles and affinity chromatography to isolate specific proteins, then using SDS-Page gel electrophoresis to measure the results. The third summary explains how computer programs help researchers visualize proteins and compare them to databases to understand protein-protein interactions and design new drugs.
Juan biomedical course
1) The student took a biomedical techniques course through the RISE program which allowed them to meet professors and students from other universities and establish relationships.
2) They attended interesting seminars and workshops on topics like DNA, proteins, neuroscience, and computer simulations of viruses.
3) The student had a great mentorship experience working with Dr. Maldonado on computer simulations of inhibiting viruses using molecular compounds.
Juan Primary Article pub
1) The study aimed to identify a drug that could inhibit the Dengue virus methyltransferase enzyme from binding to GTP, disrupting the virus. 2) Using computer modeling, researchers identified the binding pocket of the methyltransferase and placed benzene rings there to define the pharmacophore. 3) Over 60,000 potential compounds were identified from a database that fit this pharmacophore. The top 25 compounds with highest affinity were selected, with DENV-M2_1 having the highest affinity of -10.4.
Biotechnology new directions_in_medicine
This document discusses the history and development of biotechnology. It explains that biotechnology has been practiced for thousands of years through processes like brewing beer and baking bread, but it emerged as a modern science and industry more recently. Key developments included the discovery of DNA's structure in the 1950s, which allowed for genetic engineering and the production of medicines like human insulin in bacteria in the 1970s. This laid the foundation for a new biotech industry and rapid expansion in the late 20th century as companies utilized these new techniques for medical research and development.
Viewers also liked (13)
Similar to Pub. annotated bibliography 3
Pub. annotated bibliography 4
Sandra Odebrechet and her team investigated the potential pathogenesis of schizophrenia through the Borna Disease Virus. They tested 27 schizophrenic and schizoaffective patients, as well as 27 healthy volunteer controls and family members with and without mood disorders, for traces of Borna Disease Virus RNA. Their methodology followed international safety guidelines to prevent contamination. They found BDV RNA in 44% of schizophrenic subjects, 50% of relatives without mental disorders, and 37.5% of relatives with mood disorders. This study provided more geographical variation than others by being conducted in Brazil.
Genetic polymorphisms
This document discusses genetic polymorphisms and summarizes several research studies. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes three key points:
1) A study that used a cross-species strategy to identify 6 causal genes for Alzheimer's disease by studying interactions between human genes and neurotoxicity in the fly model.
2) Research confirming the association between a genetic variant in the PLA2R gene and membranous nephropathy through genome-wide association studies and previous Asian studies.
3) The potential medical benefits of these discoveries such as earlier diagnosis, improved treatment, and further genetic research.
Genetic polymorphisms pptx
This document discusses genetic polymorphisms and summarizes several articles on related topics. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes findings from articles on using cross-species strategies to study human disease like Alzheimer's, identifying genes linked to membranous nephritis and autoantibodies, and discusses the medical utility of early diagnosis and improved treatment from genetic studies.
Genetic polymorphisms
This document discusses genetic polymorphisms and summarizes several research articles. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes a study that used a cross-species strategy to identify genes involved in Alzheimer's disease by comparing human and fly genomes. Another section summarizes findings from a study linking certain genes to membranous nephritis. Specifically, it discusses the association between this disease and the PLA2R receptor gene. The document concludes by discussing the medical utility of these findings, such as enabling early diagnosis and treatment.
Essay 5- Mental
1) Schizophrenia is a mental disorder characterized by auditory hallucinations, delusional thoughts, and emotional changes. A major identifiable cause is a heritable genetic component.
2) Research has found links between specific genes and schizophrenia, as well as higher likelihood of developing the disorder in closer relatives.
3) Studying endophenotypes, or heritable biomarkers related to but not specific to the illness, may help identify genetic causes and allow research on a smaller scale prior to full diagnosis. This could help advance understanding and potential prevention of schizophrenia.
Pub. annotated bibliography 1
This summary provides the key details from the annotated bibliography in 3 sentences:
The annotated bibliography describes a longitudinal study that explored the role of the Borna Disease Virus in psychiatric patients over 21 years by measuring antibodies against the virus in patient samples. The study found that patients with advanced schizophrenia had higher levels of antibodies than those with early-stage schizophrenia, providing evidence that the virus may contribute to or support the development of schizophrenia. However, the study only used one testing method to detect the virus and could have benefited from additional varied testing to strengthen its findings.
A Clinical Case Report Schizophrenia
This case report describes a 35-year-old female patient who was diagnosed with schizophrenia. She presented with symptoms of sleep disturbances, loss of appetite, hallucinations, and hearing voices. Her symptoms had gradually worsened over the past 1.5 years. After examination, she was diagnosed with schizophrenia and admitted to the hospital for treatment. Her treatment included antipsychotic medications, antidepressants, family therapy, yoga, and cognitive behavioral therapy. With this comprehensive treatment, her symptoms minimized and she was eventually discharged from the hospital with ongoing monitoring. The case report aims to demonstrate the identification and treatment of schizophrenia symptoms.
Validation of rare Variants in the Schizophrenia-linked gene DPYSL2 - Fatuma ...
Validation of rare Variants in the Schizophrenia-linked gene DPYSL2 - Fatuma ...Fatuma-Ayaan Rinderknecht
This document summarizes a study that aimed to validate rare variants in the schizophrenia-linked gene DPYSL2. DNA samples from 384 affected and unaffected Ashkenazi Jewish individuals were sequenced using Next Generation Sequencing. Four rare variants were chosen for validation with Sanger Sequencing. One variant, located in exon 4 and predicted to affect splicing, was successfully validated. Future work will focus on further validating variants and investigating the functional effects of the confirmed variant.Biomarcadores en epilepsia
This document discusses biomarkers for epileptogenesis and the challenges in developing clinically useful biomarkers to predict epilepsy risk, progression, and treatment response. It notes that while many potential biomarkers have been identified in preclinical studies, none have translated to clinical use. Some key challenges include the long timescales between injury and seizures, heterogeneity of epilepsy types and patients, and a focus on retrospective studies in refractory epilepsy patients rather than prospective validation. The document argues that combinatorial biomarkers analyzing multiple mechanisms may be more promising than single biomarkers, and that biomarkers should be validated as direct measures of patient outcomes rather than relying solely on seizure occurrence.
Declan Bennett 4th Year Project
This document is a research project report on analyzing genes involved in both memory formation and schizophrenia risk. The student examined the overlap between differentially expressed genes in memory formation in mice and genes located in schizophrenia risk loci. Regression analysis was performed on genotype and cognitive test scores in a large Irish dataset to analyze the effect of schizophrenia risk SNPs on cognition. Two genes showed association with memory tasks and three genes showed association with wider cognitive functions like social cognition and attention. The findings indicate these genes may have implications for the pathology of schizophrenia upon replication.
Esquizo toc 2009 diciembre
This document discusses the management of schizophrenia with obsessive-compulsive features. It provides an overview of the epidemiology and pathogenesis of obsessive-compulsive symptoms in schizophrenia. Obsessive-compulsive phenomena are commonly observed in patients with schizophrenia and can manifest in various ways, including as a prodrome, coexisting independent disorder, part of active psychosis, or emerging due to atypical antipsychotic treatment. Neurobiological studies have found similarities and differences in the brain circuitry and structures involved in schizophrenia and obsessive-compulsive disorder. Effective management of obsessive-compulsive symptoms in schizophrenia requires consideration of their various pathogenesis and treatment with antipsychotics or adjunctive antidepressants in some cases.
A guideline for discontinuing antiepileptic drugs in seizure-free patients – ...
The document discusses guidelines for discontinuing antiepileptic drug (AED) treatment in patients who have been seizure-free. It summarizes studies that identified factors associated with risk of seizure recurrence after stopping AEDs. For patients who are seizure-free for 2-5 years, have had only partial or generalized seizures, have a normal neurological exam and IQ, and a normalized EEG with treatment, the risk of recurrence is about 69% for children and 61% for adults. The guidelines recommend considering discontinuing AEDs for patients meeting these criteria. Future research is still needed to better predict individual patient risks.
Presentación plegable1
The document discusses two scientific investigations:
1) A study that deciphered a key step in the molecular process of DNA duplication, which could lead to new ways to stop rapid cell proliferation in cancer.
2) Research revealing how a protein called RBFOX1 controls expression of brain genes and stabilizes RNA, suggesting potential for autism therapy. Exploring RNA control codes could also provide insights into other diseases. Further research is still needed, but these studies increase understanding of molecular processes involved in health and disease.
Pandas- Pediatric Pediatric Autoimmune Neuropsychiatric Disorders Associated ...
PANDAS is an acronym for Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infection, which describes an acute onset of OCD and/or motor tics in children following a streptococcal throat infection. The symptoms are thought to be caused by an autoimmune response where antibodies cross-react with basal ganglia neurons. Treatment includes antibiotics to treat the infection as well as IVIG and plasma exchange to target the autoantibodies. A broader classification of CANS/PANS has been proposed to include more infectious agents and neuropsychiatric symptoms beyond OCD and tics.
Presentación plegable1
The document discusses two scientific investigations:
1) A study that deciphered a key step in the molecular process of DNA duplication, which could lead to new ways to stop uncontrolled cell proliferation in cancer.
2) Research revealing how a protein called RBFOX1 controls expression of brain genes and stabilizes RNA, suggesting a potential new treatment for autism and applications to other diseases. Further exploration of RNA and protein mechanisms was recommended to advance medical understanding and therapies.
Presentación plegable 1
The document discusses two scientific investigations:
1) A study that deciphered a key step in the molecular process of DNA duplication, which could lead to new ways to stop rapid cell proliferation in cancer.
2) Research revealing how a protein called RBFOX1 controls brain gene expression via RNA stabilization, suggesting a potential new therapy for autism. Continued exploration of RNA and unknown proteins may yield insights into other diseases.
Identification of potent inhibitors against potential
Schizophrenia is related with physiological condition. It affects brain sections including the prefrontal cortex, the basal ganglia as well as limbic system. There are certain neurotransmitters present in the brain such as dopamine. When level of dopamine is disturbed it causes schizophrenia. Environmental factors like stress, depression and anxiety also contribute to schizophrenia. Several drugs including first and second generation are available to provide treatment against schizophrenia. Second generation drugs have better results and fewer side effects than first generation. Clozapine is second generation drug which was recommended as best drug for schizophrenia. It rebalances dopamine and helps to treat the patients of schizophrenia as well as diminishing of suicidal thoughts. Therapies and counseling also help to overcome this disorder. Dopamine Beta Hydroxylase catalyzes the synthesis of norepinephrine. Dopamine beta hydroxylase activity was suggested as a biological marker for schizophrenia alongside other psychiatric disorders.
The diagnosis of dementia due to Alzheimer’s disease
The document presents revised criteria for diagnosing Alzheimer's disease (AD) dementia put forth by a workgroup convened by the National Institute on Aging and the Alzheimer's Association. The summary is:
1. The workgroup updated the 1984 NINCDS-ADRDA criteria for AD dementia to incorporate advances in understanding of AD pathology and clinical presentation, as well as biomarkers.
2. The revised criteria distinguish between all-cause dementia, probable AD dementia based on clinical criteria alone, and probable or possible AD dementia when biomarkers are also considered.
3. Probable AD dementia requires a gradual onset of cognitive decline in one of several domains including memory, language, visuospatial skills or executive function.
A molecular signature in blood identifies early parkinson’s disease
This document summarizes a research paper that identifies a molecular signature in blood that can identify early Parkinson's disease. The study examined the transcriptional expression of seven genes in blood samples from 62 early-stage Parkinson's patients and 64 healthy controls. Through regression analysis, they identified five genes (SKP1, HIP2, ALDH1A1, PSMC4, and HSP8) that optimally predicted Parkinson's risk. This five-gene signature classified all 30 advanced Parkinson's patients and differentiated Parkinson's from Alzheimer's disease with 100% accuracy, supporting its potential as an early diagnostic biomarker for Parkinson's disease.
The near death experience scale. Construction, reliability, and validity
En este artículo se expone un criterio de demarcación para las experiencias cercanas a la muerte conocido como “escala de Greyson”: se trata de un cuestionario formado por 16 preguntas agrupadas en cuatro bloques (componentes cognitivo, afectivo, paranormal y trascendental) en las que el entrevistado debe marcar la respuesta que más se acerque a la experiencia vivida (con un 0 si no la ha experimentado, un 1 si lo ha hecho de forma poco intensa, o un 2 si ha sido muy intensa). El análisis de los resultados sirve para evaluar si el sujeto vivió una ECM (alcanzado una puntuación mínima de 7 según los postulados de Greyson), permitiendo descartar un síndrome orgánico del cerebro o una respuesta no específica al estrés sufrido por el “miedo a morir”. Para más detalles visitar: http://www.afanporsaber.es/2014/01/experiencias-cercanas-a-la-muerte-i/
Similar to Pub. annotated bibliography 3 (20)
Validation of rare Variants in the Schizophrenia-linked gene DPYSL2 - Fatuma ...
Validation of rare Variants in the Schizophrenia-linked gene DPYSL2 - Fatuma ...
A guideline for discontinuing antiepileptic drugs in seizure-free patients – ...
A guideline for discontinuing antiepileptic drugs in seizure-free patients – ...
Pandas- Pediatric Pediatric Autoimmune Neuropsychiatric Disorders Associated ...
Pandas- Pediatric Pediatric Autoimmune Neuropsychiatric Disorders Associated ...
Identification of potent inhibitors against potential
Identification of potent inhibitors against potential
The diagnosis of dementia due to Alzheimer’s disease
The diagnosis of dementia due to Alzheimer’s disease
A molecular signature in blood identifies early parkinson’s disease
A molecular signature in blood identifies early parkinson’s disease
The near death experience scale. Construction, reliability, and validity
The near death experience scale. Construction, reliability, and validity
More from maldjuan
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors...
This document summarizes research aiming to discover novel inhibitors of the metabotropic glutamate receptor 3 (mGluR3) using an in silico drug discovery strategy. A pharmacophore model was generated based on a known inhibitor and used to screen a drug-like compound database. Compounds with high predicted binding energies were identified as potential leads. The top hits will be validated experimentally. If successful, this in silico approach could facilitate the development of new therapeutics targeting mGluR3-associated disorders.
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors...
This document discusses an in silico discovery approach to identify selective and high affinity inhibitors of the metabotropic glutamate receptor 3 (mGluR3). The researchers created a pharmacophore model of mGluR3 and used it to screen over 18 million drug-like compounds from the ZINC database. Compounds matching the model were docked into the receptor using Autodock Vina software. Over 3 million compounds were tested, with more than 130 having a predicted binding energy below -9.6 kcal/mol. The top 18 compounds below -10 kcal/mol were selected for further analysis in a bioassay to determine potency and selectivity for mGluR3. Preliminary results suggest this in silico
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors
This study developed an in silico drug discovery strategy to identify selective inhibitors of the metabotropic glutamate receptor 3 (mGluR3). The researchers created three pharmacophore models of mGluR3 based on known inhibitors and docking simulations. They screened over 18 million drug-like compounds from the ZINC database using the models, identifying over 130 compounds with predicted binding energies below -9.6 kcal/mol. The top 18 compounds below -10.0 kcal/mol were selected for further analysis in a bioassay to determine potency and selectivity for mGluR3. This in silico approach successfully identified several candidate mGluR3 inhibitor compounds for future experimental testing.
The expression of ITPK in normal colon and colorectal cancer cells - Paper
This document summarizes research into the expression of inositol 1,4,5-trisphosphate kinase (ITPK) isoforms in normal colon cells and colorectal cancer cells. The researchers hypothesize that ITPK isoform C (ITPKC) is downregulated in colorectal carcinoma cells compared to normal colon cells. They extracted RNA from normal colon and colorectal cancer cell lines and found the RNA to be intact. Quantitative PCR will be used to analyze expression levels of the three ITPK isoforms in the cell lines. Western blot analysis validated antibodies for detecting ITPK isoforms A and B. Preliminary results showed ITPK isoform A expression varied across colorectal cancer
The expression of ITPK in normal colon and colorectal cancer cells - Poster
This document summarizes a student's summer research project investigating expression levels of inositol trisphosphate kinase (ITPK) isoforms in normal colon cells and colorectal cancer cells. Preliminary studies found ITPKC overexpression inhibits cancer cell binding to liver cells, suggesting it is anti-metastatic. The student aimed to measure ITPK mRNA and protein levels to test if ITPKC is downregulated in cancer versus normal cells. Initial results showed ITPKA protein levels varied between cancer cell lines, and an additional higher molecular weight protein was lower in cancer cells. RNA extraction was initially unsuccessful but a second attempt yielded intact RNA for further analysis.
The expression of ITPK in normal colon and colorectal cancer cells - Presenta...
The document discusses research into the expression of the inositol 1,4,5-trisphosphate 3'-kinase (ITPK) enzyme in normal colon cells and colorectal cancer cells. The researchers aim to determine mRNA and protein levels of the three ITPK isoforms in colorectal cancer cell lines compared to normal colon epithelial cells. Preliminary results show they successfully extracted RNA from both normal and cancer cells. Western blot analysis detected ITPK isoform A protein levels across several colon cancer cell lines with varying metastatic potential. Future work will measure RNA expression levels and further characterize antibodies to study all three ITPK isoforms. The researchers hypothesize that ITPK levels may be downregulated in colon
Resume (Updated Nov 2015)
Juan Enrique Maldonado Weng is a biology major pursuing a PhD in Neuroscience. He has experience with cell cultures, biological assays, and virtual drug discovery from his undergraduate research. This includes work with an in silico drug discovery team and conducting cell culture work and assays as an intern. He has presented a poster on his research at the Annual Biomedical Research Conference for Minority Students.
Pub. annotated bibliography 3
1) Korean researchers used rRT-PCR to test for Borna Disease Virus (BDV) antibodies and RNA in peripheral blood mononuclear cells of 60 healthy and 198 psychiatric patients, including 60 with schizophrenia and 138 with other conditions.
2) All patients tested negative for BDV. However, the results were inconclusive due to uncertainties in the methodology, such as success rate and the researchers' experience with the new technique.
3) More research is needed using improved methods to trace the virus in patients in order to determine if BDV could be linked to schizophrenia or other psychiatric conditions.
Portfolio
Juan Enrique Maldonado Weng participated in the Research Initiative for Scientific Enhancement (RISE) program over the summer. Through this program, he was able to take a General Biology course and improve his scientific skills and study habits. Although it was challenging, the experience allowed him to expand his interests in scientific research and learn how organisms interact with their environments. It also improved his research abilities and gave him a sense of curiosity to further scientific discovery. Overall, despite the difficult work, Weng believes the experience was worthwhile and transformed him into a new, young scientist committed to using research to find meaning and benefit the world.
Tabla temasunificantes
This document provides a summary of the eight unifying themes of biology according to a biology class at Universidad de Puerto Rico-Cayey. It lists each theme and provides a brief example of how that theme applies to living organisms. The themes discussed are: 1) New properties emerge at each level of the biology hierarchy. 2) Organisms interact with their environment and each other. 3) Life requires energy transfer and transformation. 4) Structure and function are correlated at all levels of biological organization. 5) The cell is the basic unit of structure and function of organisms. 6) Continuity of life is based on heritable information in DNA. 7) Feedback mechanisms regulate biological systems. 8)
Personal opinion
1) The author reflects on trips through two Puerto Rican forests, the Luquillo Mountains and Guánica State Forest, with their biology class.
2) They learned from their professors about the diversity and adaptations of the local flora, such as how leaves and thorns help plants survive the heat, humidity, and predators.
3) Notable stops included views from a mountain tower overlooking the whole island in Luquillo, and relaxing on a beautiful sunny beach in Guánica, where the class bonded like a family enjoying the sun.
Ecosistemas
This document summarizes and compares two ecosystems in Puerto Rico: Bosque Seco de Guánica and El Yunque National Forest. It describes the differences between their dry forest and rain forest areas in terms of rainfall, tree size, leaf size, canopy layering, and flora and fauna. It also notes that both ecosystems face threats from problems like overpopulation, pollution, invasive species, and climate change.
Proposal lucid dreams
This document summarizes a study on the effects of lucid dreaming on patients with Major Depressive Disorder. The study had four groups - those diagnosed with MDD who received lucidity training and did or did not maintain medication, and a control group without MDD but received lucidity training. Techniques like mnemonic induction and morning naps were used to induce lucid dreams. The conclusion was that lucid dreaming may be an effective way to treat depression but that more research is needed to find better treatment methods.
Lucidity in dreams proposal 3
The study aims to examine whether lucid dreaming can help treat depression. Subjects with depression will be divided into four groups. Two groups will receive lucid dreaming training while the other two will not. One group receiving training will also take antidepressants. Subjects will keep dream logs and be evaluated after three months to see if lucid dreaming improved their mood, behavior, and depression symptoms. The researchers hypothesize that by gaining control over dreams through lucidity, subjects can alter nightmares and improve sleep, which may help treat their depression.
Tabla temasunificantes
This document provides a summary of the eight unifying themes of biology according to a biology class at Universidad de Puerto Rico-Cayey. It lists each theme and provides a brief example of how that theme applies to living organisms. The themes discussed are: 1) New properties emerge at each level of the biology hierarchy. 2) Organisms interact with their environment and each other. 3) Life requires energy transfer and transformation. 4) Structure and function are correlated at all levels of biological organization. 5) The cell is the basic unit of structure and function of organisms. 6) Continuity of life is based on heritable information in DNA. 7) Feedback mechanisms regulate biological systems. 8)
Unifying themes of Biology
This document contains a summary of the key unifying themes of biology according to a class on the subject taught by Dr. Eneida Díaz. It lists 8 unifying themes: 1) New properties emerge at each level of the biology hierarchy, 2) Organisms interact with each other and their environment, 3) Life requires energy transfer and transformation, 4) Structure and function are correlated at all levels of biological organization, 5) The cell is the basic unit of structure and function of organisms, 6) Continuity of life is based on heritable information in DNA, 7) Feedback mechanisms regulate biological systems, and 8) Evolution accounts for the unity and diversity of life. For each theme,
Ecosystems PowerPoint Presentation
The document summarizes and compares two ecosystems in Puerto Rico: Bosque Seco de Guánica and El Yunque National Forest. It describes the different forest areas within each ecosystem, including the types of trees and canopy layers. It also discusses the differences in rainfall, soil composition, and how each ecosystem has adapted. Finally, it provides details on some of the unique flora and fauna found in each forest and some environmental problems currently facing them.
More from maldjuan (17)
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors...
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors...
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors...
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors...
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors
In Silico discovery of Metabotropic Glutamate Receptor-3 (mGluR-3) inhibitors
The expression of ITPK in normal colon and colorectal cancer cells - Paper
The expression of ITPK in normal colon and colorectal cancer cells - Paper
The expression of ITPK in normal colon and colorectal cancer cells - Poster
The expression of ITPK in normal colon and colorectal cancer cells - Poster
The expression of ITPK in normal colon and colorectal cancer cells - Presenta...
The expression of ITPK in normal colon and colorectal cancer cells - Presenta...
Pub. annotated bibliography 3
- 1. Fall Semester 2012-13 Annotated Bibliography 3 Roll Book.# 6 Name Juan Enrique Maldonado Weng Date: November 2nd, 20012 Annotated Bibliography 3: Na K, Tae S, Song J and Kim Y. 2009. Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients. Official Journal of Korean Neuropsychiatric Association, [Internet]; [Cited 2012 November 22]. DOI 10.4306/pi. 2009:6:306-312 Available at: http://synapse.koreamed.org/Synapse/Data/PDFData/0162PI/pi-6-306.pdf These Korean investigators attempt to find the relationship between Borna Disease Virus (BDV) and schizophrenia. It is believed that BDV is a cause for the schizophrenic conditions. With the utilization of a new technique that has not been previously used for this type of study, rRT-PCR (real-time Reverse Transcriptase Polymerase Chain Reaction), the researchers look for answers. This process tracks BDV antibodies or RNA in the peripheral blood mononuclear cells (PBMC) of the human body. For the study, sixty healthy patients were recruited for the control and 198 psychiatric patients were recruited for the experimental. The experimental group was composed of sixty patients with schizophrenia and 138 with other major psychiatric conditions. Within the rRT-PCR method, all the patients tested negative for BDV. These results are not conclusive due to many uncertainties in the methodology such as the success rate, their handling of the procedure, and the researcher's experience with the procedure. Even though this method is shown to have low possibilities of contamination, this is the first known utilization of the procedure. The researchers might be inexperienced with the resulting reactions of the virus. Another example of an uncertainty is the lack of comparison and continuation of the experiment. The researchers did not validate the results from other tests nor did they publish their results of their other tests. This experiment shows that to find answers, it is necessary to require new and more adequate methods to trace the virus in patients. When that can be accomplished, a new origin of the schizophrenic condition may be found. Words 225