This study compared outcomes for 44 young children with autism who received either home-based early intensive behavioral intervention (EIBI) or autism-specific nursery provision over 2 years. Measures of IQ, language, play, adaptive behavior, and autism severity showed small to moderate improvements for most children in both groups, with no statistically significant differences between groups. The results did not support claims that EIBI leads to nearly half of children achieving normal functioning, and instead highlighted the heterogeneous nature and individual variability in outcomes for children with autism.
Dogs can make a difference: Research overview and results by Professor Daniel...Dogs for the Disabled
This talk was presented at the conference "Autism in the Family: Can Dogs Help" held in London on the 22nd June 2013. Professor Daniel Mills is the UK's first Professor of Veterinary Behavioural Medicine and is based in the School of Life Sciences at the University of Lincoln. His research has focused on human –animal interactions, the assessment of emotion in companion animals and the use of semiochemicals to manage pet behavioural problems. He is a member of the Companion Animal Welfare Society. He has been the lead researcher on the ‘Pet Dogs for Children with Autism’ research project for the past 3 years.
Parental stress, affective symptoms and marital satisfaction in parents of ch...James Cook University
Lovisotto, R., Caltabiano, N., & Hajhashemi, K. (2015). International Journal of Humanities and Social Science, 5(10), 30-38.
Abstract: Parents of children with Autism Spectrum Disorder (ASD), a life-long developmental disorder, responded to an online survey considering their stress experience, affective symptoms and marital satisfaction. As these parents sourced different programs for their children, type of program was used to assign parents to different groups in order to consider their stress, affective symptoms and marital satisfaction. The type of programs parents used included the Applied Behaviour Analysis (n=15); Early Intervention Centre (n=13) and no formal program (n=16). Parents of children with ASD in the ABA group reported significantly lower parental stress scores, lower affective symptoms scores and higher marital satisfaction scores compared to the other two groups. These results are suggestive of the beneficial effect that an ABA program can have on the family unit.
Dogs can make a difference: Research overview and results by Professor Daniel...Dogs for the Disabled
This talk was presented at the conference "Autism in the Family: Can Dogs Help" held in London on the 22nd June 2013. Professor Daniel Mills is the UK's first Professor of Veterinary Behavioural Medicine and is based in the School of Life Sciences at the University of Lincoln. His research has focused on human –animal interactions, the assessment of emotion in companion animals and the use of semiochemicals to manage pet behavioural problems. He is a member of the Companion Animal Welfare Society. He has been the lead researcher on the ‘Pet Dogs for Children with Autism’ research project for the past 3 years.
Parental stress, affective symptoms and marital satisfaction in parents of ch...James Cook University
Lovisotto, R., Caltabiano, N., & Hajhashemi, K. (2015). International Journal of Humanities and Social Science, 5(10), 30-38.
Abstract: Parents of children with Autism Spectrum Disorder (ASD), a life-long developmental disorder, responded to an online survey considering their stress experience, affective symptoms and marital satisfaction. As these parents sourced different programs for their children, type of program was used to assign parents to different groups in order to consider their stress, affective symptoms and marital satisfaction. The type of programs parents used included the Applied Behaviour Analysis (n=15); Early Intervention Centre (n=13) and no formal program (n=16). Parents of children with ASD in the ABA group reported significantly lower parental stress scores, lower affective symptoms scores and higher marital satisfaction scores compared to the other two groups. These results are suggestive of the beneficial effect that an ABA program can have on the family unit.
How to Prevent Autism by Teaching At-Risk Infants and Toddlers to Talk
Presented at: Florida Association for Behavior Analysis Convention
September 2006
Authors: Philip W. Drash, Ph.D., BCBA,
Autism Early Intervention & Prevention Center, Tampa, FL
and
Roger M. Tudor, Ph.D.
Westfield State College, Westfield, MA
ARTICLEInfant Media Exposure and Toddler DevelopmentSuzy.docxfestockton
ARTICLE
Infant Media Exposure and Toddler Development
Suzy Tomopoulos, MD; Benard P. Dreyer, MD; Samantha Berkule, PhD;
Arthur H. Fierman, MD; Carolyn Brockmeyer, PhD; Alan L. Mendelsohn, MD
Objective: To determine whether duration and con-
tent of media exposure in 6-month-old infants are asso-
ciated with development at age 14 months.
Design: Longitudinal analysis of 259 mother-infant dy-
ads participating in a long-term study related to early child
development, from November 23, 2005, through January
14, 2008.
Setting: An urban public hospital.
Participants: Mothers with low socioeconomic status
and their infants.
Main Exposure: Duration and content of media expo-
sure at age 6 months.
Main Outcome Measures: Cognitive and language de-
velopment at age 14 months.
Results: Of 259 infants, 249 (96.1%) were exposed to me-
dia at age 6 months, with mean (SD) total exposure of 152.7
(124.5) min/d. In unadjusted and adjusted analyses, du-
ration of media exposure at age 6 months was associated
with lower cognitive development at age 14 months (un-
adjusted: r = −0.17, P � .01; adjusted: � = −0.15, P = .02) and
lower language development (r = −0.16, P � .01; � = −0.16,
P � .01). Of 3 types of content assessed, only 1 (older child/
adult–oriented) was associated with lower cognitive and
language development at age 14 months. No significant as-
sociations were seen with exposure to young child–
oriented educational or noneducational content.
Conclusions: This study is the first, to our knowledge,
to have longitudinally assessed associations between me-
dia exposure in infancy and subsequent developmental
outcomes in children from families with low socioeco-
nomic status in the United States. Findings provide strong
evidence in support of the American Academy of Pedi-
atrics recommendations of no media exposure prior to
age 2 years, although further research is needed.
Arch Pediatr Adolesc Med. 2010;164(12):1105-1111
M
EDIA EXPOSURE PLAYS
an increasing role in
the lives of infants and
toddlers,1-3 despite the
American Academy of
Pediatrics recommendation that children
younger than 2 years should have no me-
dia exposure.4,5 In part, the increasing ex-
posure of infants and toddlers to various
types of media has resulted from the emer-
gence of media content specifically geared
toward infants and toddlers and mar-
keted as educational.6,7 Children from fami-
lies with low socioeconomic status (SES)
are likely to be most vulnerable to any ad-
verse effects of media exposure on early
child development because they have been
documented to have the greatest expo-
sure to media8-10 and are at increased risk
in general for disparities in early develop-
ment, school readiness, and educational
achievement.11
A substantial body of literature12-14 has
documented adverse effects of noneduca-
tional media in preschool and school-
aged children on later outcomes, includ-
ing cognition, achievement, and behavior.
Emerging research strongly suggests ...
1
4
Discrete Trial Training (DTT) effect on children with ASD
Introduction
Autism Spectrum Disorder (ASD) is a condition that affects the development of an individual affecting their behaviour and the ability to communicate (Autism Spectrum Disorder, 2021). In most cases, this disorder exhibits its symptoms within the initial two years of an individual, despite its diagnosis being plausible for individuals of all ages. Persons diagnosed with this disorder often have repetitive behaviours and restricted interests, find it difficult to partake in social interactions and communication with others, and show other symptoms that may impede the individual's ability to perform well in school, work and several other aspects of life ("Autism Spectrum Disorder, 2021). The individuals diagnosed with the disorder will, in some cases, be reliant on their families and individuals close to them for help and support. Despite the disorder's potency as a life-long condition, some services and treatments are provided, helping an individual diagnosed with the condition improve the quality of their life. It is also important to note that the disorder has several different variations; hence, the spectrum of different characteristics, unique to every diagnosed individual.
According to studies conducted, one in fifty-four children is diagnosed with the disorder in the United States, occurring in children of all racial backgrounds and socioeconomic groups ("Data and Statistics on Autism Spectrum Disorder | CDC," 2021). According to the same report, the disease is four times more likely to occur in boys than in girls. Between 2009 to 2017, the number of children aged between 3-17 years diagnosed with development disorders, inclusive of ASD, increased from 16.2% to 17.8%. (Ünlü et al., 2018). In the use of discrete trial training (DTT), children are taught a plethora of skills, which include academic, language, and social skills, necessary to facilitate their development. In the treatment of ASD, options are limited. However, early diagnosis, coupled with behaviour interventions, is considered to have the best outcomes in managing the disorder's symptoms (Masi et al., 2017).
The prevalence of ASD in children has been noted to rise significantly in the population (Masi et al., 2017; "Data and Statistics on Autism Spectrum Disorder | CDC," 2021), affecting a larger portion of the population. This number of affected individuals is projected to rise even higher in the coming years, a problem in society that needs to be addressed. In the treatment of the disorder, drug interventions, while widely used, have failed to prove their efficiency in improving or managing symptoms in most cases (Masi et al., 2017). The treatment options for the disorder are also very limited. The use of drug interventions, early diagnosis, and early behavioural interventions is very expensive and inaccessible to many individuals affected by the condition. Identifying the disorder i ...
JOURNAL OF APPLIED BEHAVIOR ANALYSISIMPROVING SOCIAL SKILL.docxcroysierkathey
JOURNAL OF APPLIED BEHAVIOR ANALYSIS
IMPROVING SOCIAL SKILLS AND DISRUPTIVE BEHAVIOR IN
CHILDREN WITH AUTISM THROUGH SELF-MANAGEMENT
LYiNN KERN Koiwom, ROBERT L. KoEGia, CsmI HuRuLy, AND
WIn"IAM D. F"A
UNIVERSITY OF CAORNIA AT SANTA BARBARA
The literature suggests that children with autism typically are unresponsive to verbal initiations
from others in community settings, and that such unresponsiveness can lead to problematic social
interactions and severely disruptive behavior. The present study assessed whether self-management
could be used as a technique to produce extended improvements in responsiveness to verbal initiations
from others in community, home, and school settings without the presence of a treatment provider.
The results showed that children with autism who displayed severe deficits in social skills could
learn to self-manage responsivity to others in multiple community settings, and that such improve-
ments were associated with concomitant reductions in disruptive behavior without the need for
special intervention. The results are discussed in terms of their significance for improved development
of social skills in children with autism.
DESCRIPTORS: autism, self-management, social skills, language, disruptive behavior
Although language researchers traditionally have
been concerned with syntax (i.e., structure) and
semantics (i.e., referential meaning), a shift in the
field has gradually emerged that emphasizes a func-
tional approach to understanding communicative
competence and stresses a social perspective of lan-
guage use (Kaiser & Warren, 1985). With the
shift toward pragmatics, a greater emphasis is now
being placed on the social interaction of commu-
nicators within a given context, thus resulting in
the study of larger units of conversation. Some
questions of prime concern for pragmatic assess-
Funding for this research was provided in part by Cali-
fornia State Department of Education Special Study Grant
No. 42-03651-N27 1-00-33 that funded pilot work (USPHS
MH28210 and MH39434 from the National Institutes of
Mental Health) and by NIDRR Cooperative Agreement
G0087CO234 from the U.S. Department of Education. The
authors thank Alfred Bimbela, Yong Cho, Amanda Damron,
Diane De la Riva, Sherri Goldstein, Trina Gravelle, Julie
Jacobson, Kimberly Mullen, Teresa Paslawski, Deborah Ru-
more Parks, Annette Smith, Jodi Smith, Kimi Stahler, Shel-
ley Weichman, Laura Wilde, school personnel, and parents
for their assistance throughout the study. In addition, we
thank Rob Homer, Ted Canf, Wayne Sailor, and Glen Dun-
lap for their feedback on earlier drafts of this study.
Requests for reprints should be addressed to Lynn Kern
Koegel, Autism Research Center, Counseling/Clinical/
School/Psychology Program, Graduate School of Education,
University of California, Santa Barbara, California 93106-
9490.
ment are: (a) Does the child relay a message ac-
curately? (b) Can the child adhere to a topic without
abrupt transitions to ne ...
JOURNAL OF APPLIED BEHAVIOR ANALYSISIMPROVING SOCIAL SKILLkarenahmanny4c
JOURNAL OF APPLIED BEHAVIOR ANALYSIS
IMPROVING SOCIAL SKILLS AND DISRUPTIVE BEHAVIOR IN
CHILDREN WITH AUTISM THROUGH SELF-MANAGEMENT
LYiNN KERN Koiwom, ROBERT L. KoEGia, CsmI HuRuLy, AND
WIn"IAM D. F"A
UNIVERSITY OF CAORNIA AT SANTA BARBARA
The literature suggests that children with autism typically are unresponsive to verbal initiations
from others in community settings, and that such unresponsiveness can lead to problematic social
interactions and severely disruptive behavior. The present study assessed whether self-management
could be used as a technique to produce extended improvements in responsiveness to verbal initiations
from others in community, home, and school settings without the presence of a treatment provider.
The results showed that children with autism who displayed severe deficits in social skills could
learn to self-manage responsivity to others in multiple community settings, and that such improve-
ments were associated with concomitant reductions in disruptive behavior without the need for
special intervention. The results are discussed in terms of their significance for improved development
of social skills in children with autism.
DESCRIPTORS: autism, self-management, social skills, language, disruptive behavior
Although language researchers traditionally have
been concerned with syntax (i.e., structure) and
semantics (i.e., referential meaning), a shift in the
field has gradually emerged that emphasizes a func-
tional approach to understanding communicative
competence and stresses a social perspective of lan-
guage use (Kaiser & Warren, 1985). With the
shift toward pragmatics, a greater emphasis is now
being placed on the social interaction of commu-
nicators within a given context, thus resulting in
the study of larger units of conversation. Some
questions of prime concern for pragmatic assess-
Funding for this research was provided in part by Cali-
fornia State Department of Education Special Study Grant
No. 42-03651-N27 1-00-33 that funded pilot work (USPHS
MH28210 and MH39434 from the National Institutes of
Mental Health) and by NIDRR Cooperative Agreement
G0087CO234 from the U.S. Department of Education. The
authors thank Alfred Bimbela, Yong Cho, Amanda Damron,
Diane De la Riva, Sherri Goldstein, Trina Gravelle, Julie
Jacobson, Kimberly Mullen, Teresa Paslawski, Deborah Ru-
more Parks, Annette Smith, Jodi Smith, Kimi Stahler, Shel-
ley Weichman, Laura Wilde, school personnel, and parents
for their assistance throughout the study. In addition, we
thank Rob Homer, Ted Canf, Wayne Sailor, and Glen Dun-
lap for their feedback on earlier drafts of this study.
Requests for reprints should be addressed to Lynn Kern
Koegel, Autism Research Center, Counseling/Clinical/
School/Psychology Program, Graduate School of Education,
University of California, Santa Barbara, California 93106-
9490.
ment are: (a) Does the child relay a message ac-
curately? (b) Can the child adhere to a topic without
abrupt transitions to ne ...
Cross Sectional Study on Language Assessment of Speech Delay in Children 0 to...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Annotated bibliography prespared for a special education class. Ten papers presented. This bibliography involves hearing loss, with which I have some prior employment experience.
Parents perceptions of autism and theirhealth-seeking behavemelyvalg9
Parents' perceptions of autism and their
health-seeking behaviors
Maria Isabel O. Quilendrino a,*, Mary Anne R. Castor a,
Nenacia Ranali Nirena P. Mendoza b, Jacqueline R. Vea c,
Nina T. Castillo-Carandang c
a Department of Clinical Epidemiology and Department of Pediatrics, College of Medicine, University of the Philippines,
Manila, Philippines
b Department of Clinical Epidemiology and Department of Family and Community Medicine, College of Medicine,
University of the Philippines, Manila, Philippines
c Department of Clinical Epidemiology, College of Medicine, University of the Philippines, Manila, Philippines
c l i n i c a l e p i d e m i o l o g y a n d g l o b a l h e a l t h 3 ( 2 0 1 5 ) s 1 0 – s 1 5
a r t i c l e i n f o
Article history:
Received 15 September 2015
Accepted 13 November 2015
Available online 7 December 2015
Keywords:
Autism
Autistic disorder
Behavior
Perception
a b s t r a c t
Background: Parents' health-seeking behaviors, which in turn may be related to their per-
ceptions, are hypothesized to be the major determinant of the timing of diagnosis and
subsequent intervention for children with autism.
Objective: The primary objective of this study was to describe parental perceptions of autism
and health-seeking behaviors for urban Filipino children aged 2–6 years.
Methods: This was a cross-sectional study conducted in several phases. The first phase
involved collection of qualitative data from key informant interviews and small group
discussions. The second phase involved the development of a validated and reliable ques-
tionnaire, which was administered to 41 parents of children with autism, aged 2–6 years.
Results: Parents had varying perceptions of autism. They were generally undecided with
regard to the etiology of autism, but were in agreement that psychosocial factors, such as
parental sins and curses, were unlikely to be associated with autism. The most common
presenting symptom noted by parents was a qualitative impairment in social interaction.
There was a noted trend towards earlier age of symptom recognition (mean of 24 months)
and diagnosis of autism (mean of 39 months) among parents with younger children.
Conclusion: The results of this study showed some trends: There is improved awareness
regarding autism and the needs of children with autism. Parents tend to disagree with
previous myths about autism. There was an observable trend toward earlier diagnosis for
this group.
# 2015 INDIACLEN. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All
rights reserved.
* Corresponding author. Tel.: +63 9178033888; fax: +63 27311631.
E-mail address: [email protected] (M.I.O. Quilendrino).
Available online at www.sciencedirect.com
ScienceDirect
journal homepage: www.elsevier.com/locate/cegh
http://dx.doi.org/10.1016/j.cegh.2015.11.003
2213-3984/# 2015 INDIACLEN. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd. All rights reserved.
http://crossmar ...
The School Success Program ImprovingMaltreated Childrens A.docxjoshua2345678
The School Success Program: Improving
Maltreated Children's Academic and
School-related Outcomes
Christopher A. Mallett
Many victims of chudhood maltreatment expedence difficulties in school and with aca-
demic performance. This article reviews the evidence on the connection between child-
hood maltreatment and school performance and presents an evaluation of a unique
program established by Children's Services in Lorain County, Ohio. Since 2001, the
School Success Program, in collaboration with 18 Ohio public school distdcts, has pro-
vided individual tutodng and mentodng by certified teachers to 615 maltreated children
and youths, working closely with the whole family in an in-home setting. Most children
and youths in the program have progressed to their appropdate grade level whue improv-
ing overall grade point averages from 1.74 to 2.56 in core academic subjects. Program par-
ticipants have shown one-year improvements that are significant when compared with
those of their nonmaltreated peers: Basic reading and comprehension skills improved 58
percent; math reasoning and comprehension skills improved 50 percent; basic wddng
skills improved 48 percent; and overall academic skills improved 51 percent. These
improvements were seen across both gender and race, with almost equal gains made by
minodty and nonminodty children and youths, but particularly by boys. Implications for
school social work practice are set forth in light of these promising results.
KEY WORDS; children; maltreatment; mentor; school; tutor
A
cademic success is vital for children and
youths to transition without difficulty to
adolescence and young adulthood
(Buehler, Orme, Post, & Pattenon, 2000). This
transition is markedly more difficult for many
children w h o have been vicdms of maltreatment.
Abuse and neglect may affect children's abüities to
learn, decrease cognitive and language capacities
(SmithgaU, Gladden, Howard, Goerge, &
Courtney, 2004), increase dsk for special educa-
tion disabüities, decrease standardized tesdng out-
comes (Egeland, 1997), and decrease overall
academic performance (Leiter, 2007). It is import-
ant to develop interventions and programs tar-
geted specifically to this population that has
expedenced abuse, neglect, or both to provide
these children and youths the opportunity to
achieve school-related success. These interventive
efforts may have long-lasting and important future
impacts (Veltman &L Browne, 2001).
This investigation provides descdptive and lon-
gitudinal findings for a program initiated in 2001
in one Ohio county's children's services agency
that is trying to address and improve the academic
and school-related outcomes for maltreated children
and youths. Finding evidence of what may work
to address this child welfare, school social work,
and public educadon situadon is important not
only because academic difficuldes are a common
problem for maltreatment victims, but also because
few programs have been designed specifically.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Psy651 presentation
1. A two-year prospective follow-up study of community-based early
intensive behavioral intervention and specialist nursery provision for
children with autism spectrum disorders
Iliana Magiati, Tony Charman, and Patricia Howlin
Presented by: Candice Harley
2. Many studies report positive outcomes for young children with autism
spectrum disorders (ASD) receiving early intervention.
Particularly impressive results were reported for Early Intensive
Behavioral Intervention (EIBI), beginning around 2-3 years of age, with
claims that up to 47% of participants attain normal intellectual
functioning.
Duration/intensity of intervention, age, IQ, language level and autism
severity have all been reported as predictive variables of response to
intervention.
Very few studies have compared home-based EIBI programs with
autism-specific school-based provision.
3. This study provides independent outcome data on pre-school
children with ASD after 2 years of either home-based EIBI in a
community setting or autism-specific nursery provision.
Children in the two groups were closely matched at intake
The following questions were addressed:
At follow-up, were EIBI children functioning at a significantly
higher level than nursery children in the areas of IQ, language,
play, adaptive behavior, and severity of autism?
What specific child, family, or treatment characteristics were
related to outcome?
4. Participants
44 children between the ages of 22-54 months with a
professional diagnosis of autism/ASD
None of the participants have additional major
medical diagnoses
28 children in the EIBI group (27 boys; 1 girl)
16 children in the nursery group (12 boys; 4 girls)
5. Measures
The same tests were used at T1 and T2 (23-27 months after initial assessment)
IQ was measured using the Merrill-Palmer Scale of Mental Tests (MPS; Stutsman, 1948), the Bayley Scales
of Infant Development (BSID; Bayley, 1993), and the Weschler Pre-school and Primary School Intelligence
scales-Revised (WPPSI-R; Weschler, 1990).
Adaptive behavior was measured using Vineland Adaptive Behavior Scales (VABS; Sparrow, Balla, &
Cicchetti, 1984).
Receptive and expressive language was assessed on the British Picture Vocabulary Scale-II (Dunn, Dunn,
Whetton, & Burley, 1997) and the Expressive One- Word Picture Vocabulary Test-Revised (Gardner, 1990).
Play was assessed using the Symbolic Play Test- Second Edition (SPT-II; Lowe & Costello, 1988).
The Autism Diagnostic Interview-Revised (Lord et al., 1994) was used to confirm diagnosis and assess
autism severity.
A non-standardized questionnaire was designed to obtain information on family characteristics, and type,
intensity and duration of interventions from parents.
6. Interventions
EIBI Programs
All EIBI children received 1:1 home teaching. All families used discrete trial teaching
techniques, and most families attended an initial workshop of 1– 3 days. All families
employed a consultant and a supervisor. Consultants visited monthly; supervisors
visited weekly. Twenty families received supervision/consultancy from recognized ABA
organizations in the UK, Norway or USA; the remaining EIBI families were supervised
by independent supervisors.
School Provisions
Schooling emphasized structure, visual cues, individualized teaching and close liaison
with parents. The most common named practices were: TEACCH- based approaches;
PECS; Makaton and SPELL. Other developmental and behavioral teaching methods
were also used (unspecified). The average amount of 1:1 teaching was 6 hours per
week.
7. This figure illustrates the percentage of children
in each change category for IQ, language, play,
adaptive behavior and severity of autism
scores. The degree of change was generally
small to moderate from T1 to T2 for most
children in both groups; few made major
improvements.
At T2, no child was in a mainstream school
without 1:1 support.
There were no statistically significant
correlations between family
socioeconomic/educational status or intensity of
intervention and any T2 measures.
8. The wide variation in progress found in this study is consistent with the
heterogeneous nature of ASD and accords with other recent early
intervention studies, both home- and school-based.
Although conclusions from EIBI research have varied, due to
differences in intake criteria, length, intensity and type of intervention,
and outcome measures, the results of recent EIBI studies do not
support claims that almost 50% of participants achieve normal
educational and intellectual functioning’ (Lovaas, 1987).
Instead, it is important that factors affecting individual children’s
progress are routinely investigated and identified. Group analyses are
important but should not exclude careful study of the variability
of change among individuals.
9. Data from this study supports the growing
consensus that no one intervention for children
with ASD is universally superior to all others.
Successful interventions may share several
common elements that can help improve the skills
and lives of young children with ASD.
Identification of these key elements is the next
challenge for research in this area.
10. –Mary Anne Radmacher
“Courage does not always roar.
Sometimes courage is the quiet
voice at the end of the day saying ‘I
will try again tomorrow’”