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psoriasis 2
- 1. Patients with Severe Psoriasis are at Increased Risk of Cardiovascular Mortality By: Nehal Mehta
- 2. Psoriasis • Chronic auto-immune imflammatory skin disease • Who is at risk • Causes
- 5. Psoriasis to CV Disease • Hypothesis: Severe psoriasis patients have an increased risk of cardiovascular (CV) mortality • CV includes atherosclerosis, myocardial infarction (MI), and stroke
- 6. The Study • Significant values • Sex • Age • Diabetes • Hypertension • Former smokers • BMI >30 • Reason for end of study
- 7. Results
- 8. Conclusion
- 9. References • M e ht a , Ne ha l, Rahat S. Azfar, Dan iel B. Shin, Andrea L. N e i m a nn, an d Joel M. Gelfand. "Pat ients with severe psoriasis a re a t in cre as ed risk of cardiov ascu lar mor tality: cohor t st u dy usi ng th e General Practi ce Research Database ." Oxford J ou r n a l s : Eu rop ea n Hear t Journal . 31.8 (2009): 1000-1006. Print. • N e i m a nn, A n d rea L., Joel M. Gelfand , Daniel B. Shin, Xingmei Wa n g , an d Dav id J. Margolis. "Risk of Myocardial Infarction in Pa t i e n ts W ith Psoriasis." Jour nal o f the Amer ican Medical A s so ci a tion . (2 0 06): Print.
Editor's Notes
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- chronic=longterm ; auto-immune your immune system is the main cause because psoriasis is what is known as a t-cell mediated disease ... t cells are used to help your body fight disease keep your body balanced which includes maintaining your skin cell growth... with little to none of these your bodies process of remaking skin cells is rapidly increased and you get psoriasis\npsoriasis is not contagious; however is thought to be genetically transmitted..triggers of psoriasis include stressful events; medications; bacterial or viral infections that effect immune system; little to no sun; obesity\n
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- people of all ages can be affected anywhere from 3 to 95... its common in 20-30 then 50-60 \ncommon locations are soft tissue places;; elbows; under arms; knees; lower back; \nsymptoms include skin rashes either large or small; dry skin; sometimes joint paints; bad nail discoloration and disfiguration\n
- ather- fatty materials collecting around arteries;; causing clots\nmyocardial infarct- lack of oxygen to heart because of blocked arteries\nstroke- interuption of blood supply to brain or heart\n\n\n\nimflammation is said to have effects on blood vessels psoriasis is thought to increase the risk of getting CV disease.\nhowever exact schematics of psoriasis is still a mystery to most doctors; so this study works to explore the correlation of patients with both diseases...\n
- the control was larger than experimental group?\nnonpsoriasis patient control has larger age range from 33-65 vs 49-66\nmany of the psoriasis patients were former smokers \nmore psoriasis patients were significantly overweight with BMI numbers\npercents are slanted because controll is larger than experimental psoriasis group\n
- \nThe results of this study demonstrate that patients with severe psoriasis have a clinically significant 57% increased risk of CV death beyond the risk of death associated with traditional CV risk factors. On the basis of our data, a patient with severe psoriasis has an excess risk of CV death attributable to psoriasis of 1 in 283 patients per year\n\n\nThe frequency of deaths due to CVD was higher in patients with severe psoriasis.\n\n\nIt is also thought that medications prescribed for psoriasis have a major role in risk for CVD .... The results also persisted when examining the risk based on different treatments that theoretically could increase or decrease the risk of CVD.\n\n21\n\n,\n22\n T\n\nhu\n\ns, these findings suggest that the increased CV mortality is not due to treatment effect.\n\n
- with severe MI has a greater chance especially peaking at younger ages\nin mild psoriasis there is a less great risk however this is no significant peak from a younger age to an older age... the risk is still there.\nQuestions: would have like to see more comparison and tables of psoriasis and CV disease... also if you dont have knowledge of the two disease you would not be able to connect them... the paper fails to fill the reader in on how the immune system can be related to the cardiovascular system.\n
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