Here is a group of proverbs about solitude and peace of mind. The joy of solitude is a privilagecomes with no price tag but with a state of mind to accept it. Find more meaningful proverbs at www.cuteproverbs.com
The document provides information about TOEFL vocabulary related to synonyms and reading comprehension. It contains examples of sentences with underlined words and four options to choose from that best match the meaning of the original word. The examples are used to demonstrate that the word "inhospitable" means "uninviting" as seen from a sentence describing a mountain climate that looks "cold, forbidding and inhospitable" and another directly stating the mountain climate was "very uninviting."
This document provides a summary of superlative adjectives through examples of comparing places around the world. It begins with a trivia quiz asking about the highest, tallest, longest, driest, most populated, happiest, and most mysterious places. It then explains the three forms for creating superlative adjectives and provides rules and exceptions. Examples are used to compare the Amazon River as the longest river, Mount Everest as the highest mountain, and Disneyland as the happiest place on earth. Readers are then asked to practice changing adjectives to their superlative form and to create their own sentences using the superlatives.
In the adventure novel Hatchet by Gary Paulsen, Brian, a teenage boy flying to meet his newly divorced father, must face the challenge of survival when the pilot has a heart attack and dies, leaving Brian to crash land the plane into a lake. As the story develops, Brian works to build shelter and learn hunting and fishing skills. The climax occurs when a tornado destroys everything Brian has created for survival. In the end, Brian is rescued after turning on a transmitter and returns home stronger both mentally and physically after adjusting to his parents' divorce.
In the adventure novel Hatchet by Gary Paulsen, Brian learns to persevere through survival when he crash lands a plane in the wilderness and must use his wits and skills to survive alone until he is rescued. The document provides a template and example for writing a one-paragraph summary of a novel by highlighting the exposition, conflict, rising action, climax, falling action, and resolution.
The document discusses the concept of parallelism in writing, which refers to maintaining a consistent grammatical structure between different elements in a sentence, such as phrases or clauses, to create a sense of balance. It provides examples to illustrate parallel and unparallel constructions, noting that parallelism can occur within single sentences or between full sentences in a paragraph. The purpose is to emphasize ideas and concepts through repetition of grammatical patterns.
The document discusses different types of prepositions and their uses. Prepositions describe relationships between nouns, verbs, or adjectives. There are several types of prepositional relationships including vertical, horizontal, facing, movement, point in time, duration, reason, inclusion/exclusion, and contrast. The document provides examples to illustrate the different uses of prepositions to indicate spatial, temporal, and other relational meanings.
This document contains notes from a grammar class about using the definite article "the". It discusses when the is used, such as with superlatives, places or areas, things already mentioned, musical instruments, systems and services, countries with certain prefixes, adjectives describing groups of people, geographical features, newspapers, famous buildings and art, and hotels/pubs/restaurants. Examples are provided for each case of using the definite article.
The document provides information about TOEFL vocabulary related to synonyms and reading comprehension. It contains examples of sentences with underlined words and four options to choose from that best match the meaning of the original word. The examples are used to demonstrate that the word "inhospitable" means "uninviting" as seen from a sentence describing a mountain climate that looks "cold, forbidding and inhospitable" and another directly stating the mountain climate was "very uninviting."
This document provides a summary of superlative adjectives through examples of comparing places around the world. It begins with a trivia quiz asking about the highest, tallest, longest, driest, most populated, happiest, and most mysterious places. It then explains the three forms for creating superlative adjectives and provides rules and exceptions. Examples are used to compare the Amazon River as the longest river, Mount Everest as the highest mountain, and Disneyland as the happiest place on earth. Readers are then asked to practice changing adjectives to their superlative form and to create their own sentences using the superlatives.
In the adventure novel Hatchet by Gary Paulsen, Brian, a teenage boy flying to meet his newly divorced father, must face the challenge of survival when the pilot has a heart attack and dies, leaving Brian to crash land the plane into a lake. As the story develops, Brian works to build shelter and learn hunting and fishing skills. The climax occurs when a tornado destroys everything Brian has created for survival. In the end, Brian is rescued after turning on a transmitter and returns home stronger both mentally and physically after adjusting to his parents' divorce.
In the adventure novel Hatchet by Gary Paulsen, Brian learns to persevere through survival when he crash lands a plane in the wilderness and must use his wits and skills to survive alone until he is rescued. The document provides a template and example for writing a one-paragraph summary of a novel by highlighting the exposition, conflict, rising action, climax, falling action, and resolution.
The document discusses the concept of parallelism in writing, which refers to maintaining a consistent grammatical structure between different elements in a sentence, such as phrases or clauses, to create a sense of balance. It provides examples to illustrate parallel and unparallel constructions, noting that parallelism can occur within single sentences or between full sentences in a paragraph. The purpose is to emphasize ideas and concepts through repetition of grammatical patterns.
The document discusses different types of prepositions and their uses. Prepositions describe relationships between nouns, verbs, or adjectives. There are several types of prepositional relationships including vertical, horizontal, facing, movement, point in time, duration, reason, inclusion/exclusion, and contrast. The document provides examples to illustrate the different uses of prepositions to indicate spatial, temporal, and other relational meanings.
This document contains notes from a grammar class about using the definite article "the". It discusses when the is used, such as with superlatives, places or areas, things already mentioned, musical instruments, systems and services, countries with certain prefixes, adjectives describing groups of people, geographical features, newspapers, famous buildings and art, and hotels/pubs/restaurants. Examples are provided for each case of using the definite article.
The document discusses five types of figurative language: simile, metaphor, idiom, personification, and hyperbole. Simile uses like or as to compare two things, metaphor compares one thing to another as if it were that thing, and idiom uses groups of words with special meanings. Personification gives human qualities to non-human things, and hyperbole greatly exaggerates for effect.
Theme 2 the fear place vocabulary flash cards mod2013PEDH
The document is a vocabulary exercise that provides sample sentences for key words and asks the reader to determine the definitions of those words based on context clues. It includes 14 vocabulary words - adventure, cautious, concentrate, discomfort, dismayed, excitement, immobile, stamina, terrified, unsure, and their definitions. The purpose is to help readers learn new words and their meanings in different contexts.
Here is a 5 sentence paragraph comparing classmates' habits of doing assignments using adverbs of manner and frequency:
Some classmates always do their assignments carefully and thoroughly. A few students seldom complete homework on time and often rush through it sloppily. One student occasionally finishes assignments early but rarely puts forth her best effort. Most of us do our work diligently and turn it in daily, though a classmate never seems motivated to put in the necessary effort. While habits vary, we can all benefit from striving to approach assignments wisely and positively.
The document discusses paraphrasing and provides guidance on how to properly paraphrase a passage. It emphasizes understanding the original work, restating the main ideas in your own words without plagiarizing, and giving credit to the original author. Examples are given paraphrasing passages from speeches by Franklin D. Roosevelt and a short story to demonstrate the technique.
The document contains a lesson about a Cherokee story explaining how the Milky Way got its name. According to the story, long ago villagers noticed cornmeal was missing from storage baskets and saw dog prints. That night a giant dog flew down and ate cornmeal. The villagers scared the dog, who ran into the sky spilling cornmeal that became stars. The stars were then called "where the dog ran" and are now known as the Milky Way.
The document discusses the differences between day and night and how things look and feel at different times of day. It notes that day is brighter, louder and busier while night is quieter and calmer. The author expresses their preference for nighttime.
The document contains excerpts from a lesson plan including stories, vocabulary words, grammar and spelling exercises. It discusses a Cherokee story about the Milky Way where villagers saw a giant dog stealing cornmeal at night. They scared the dog into the sky where the spilled cornmeal became stars, now known as the Milky Way.
The document defines and provides examples of several literary devices:
1. Alliteration is the repetition of initial consonant sounds in words. Examples include "A peck of pickled peppers" and "Dan's dog dove deep in the dam."
2. Anaphora is the repetition of words or phrases at the beginning of successive sentences for emphasis, as in a Winston Churchill speech.
3. Antithesis contrasts opposing ideas for effect.
4. Oxymorons place contradictory terms together, like "awfully good" or "found missing."
5. Rhetorical questions do not require answers but encourage thought or create humor.
This document provides information and instructions for an English class. It includes:
- Directions to complete an assignment in DLR (Daily Language Review) and reminds students to include their name.
- An essential understanding question about prepositions and the student's Cornell notes response.
- Examples and explanations of prepositional phrases.
- Recognition of students who did well on vocabulary.
- Five vocabulary words to study for an upcoming test along with sample sentences.
- A request to work with a partner to write sentences using the vocabulary words.
- A preview of the next class which will involve clarifying essays with help from named students.
The document provides rules and examples for using semicolons to join independent clauses and items in a series. It states that semicolons should be used sparingly, with no more than 1-2 in a 2,000 word essay. Semicolons can join two independent clauses that are closely related, or an independent clause and an introductory phrase. They can also be used to separate items in a series when the items contain commas. Quotation marks always take precedence over colons and semicolons.
This document presents a teaching/learning package about Asiatic lions that includes pre-viewing and post-viewing tasks. The pre-viewing tasks ask students to name wild animals, identify the king of the jungle, and think about living with lions. The document then provides a transcript about Girnar Mountain and the ancient Gir forest that is home to over 400 Asiatic lions. Post-viewing tasks include vocabulary exercises, a grammar task, role-playing, and sentence formation around words from the transcript.
Regular plural nouns are typically formed by adding "s" or "es" to the singular form, with exceptions for words ending in certain letters like "ch", "sh", "x". Irregular plural nouns do not follow this pattern and instead may change their spelling, vowel, or ending to become plural, such as changing "f" to "ves" or staying the same. Examples are given of both regular and irregular plural nouns.
This document outlines 15 basic spelling rules in English. It defines key terms like vowels, consonants, syllables, stress, prefixes, and suffixes. It then provides rules and examples for using "ch" or "tch", dropping final "e", spelling "ie" or "ei", using "j", "k" or "ck", "l" or "ll", "le", "t" or "tt", "r" or "rr", plural nouns, words ending in "ve", changing "y" to "i", suffixes like "able/ible", adding suffixes, dropping letters, and silent letters. Exceptions are noted for some rules.
1) The "i before e except after c" spelling rule has many exceptions, such as in words like "neighbor" and "weigh" where the pronunciation is different.
2) When adding suffixes to words, there are rules for changing "y" to "ies", adding "-es" to words ending in certain letters, and doubling consonants with one-syllable words stressed on the last syllable.
3) The "drop the 'e' rule" applies when adding suffixes to words, except when the root word ends in "-ce" or "-ge" to maintain a soft sound.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
The document discusses five types of figurative language: simile, metaphor, idiom, personification, and hyperbole. Simile uses like or as to compare two things, metaphor compares one thing to another as if it were that thing, and idiom uses groups of words with special meanings. Personification gives human qualities to non-human things, and hyperbole greatly exaggerates for effect.
Theme 2 the fear place vocabulary flash cards mod2013PEDH
The document is a vocabulary exercise that provides sample sentences for key words and asks the reader to determine the definitions of those words based on context clues. It includes 14 vocabulary words - adventure, cautious, concentrate, discomfort, dismayed, excitement, immobile, stamina, terrified, unsure, and their definitions. The purpose is to help readers learn new words and their meanings in different contexts.
Here is a 5 sentence paragraph comparing classmates' habits of doing assignments using adverbs of manner and frequency:
Some classmates always do their assignments carefully and thoroughly. A few students seldom complete homework on time and often rush through it sloppily. One student occasionally finishes assignments early but rarely puts forth her best effort. Most of us do our work diligently and turn it in daily, though a classmate never seems motivated to put in the necessary effort. While habits vary, we can all benefit from striving to approach assignments wisely and positively.
The document discusses paraphrasing and provides guidance on how to properly paraphrase a passage. It emphasizes understanding the original work, restating the main ideas in your own words without plagiarizing, and giving credit to the original author. Examples are given paraphrasing passages from speeches by Franklin D. Roosevelt and a short story to demonstrate the technique.
The document contains a lesson about a Cherokee story explaining how the Milky Way got its name. According to the story, long ago villagers noticed cornmeal was missing from storage baskets and saw dog prints. That night a giant dog flew down and ate cornmeal. The villagers scared the dog, who ran into the sky spilling cornmeal that became stars. The stars were then called "where the dog ran" and are now known as the Milky Way.
The document discusses the differences between day and night and how things look and feel at different times of day. It notes that day is brighter, louder and busier while night is quieter and calmer. The author expresses their preference for nighttime.
The document contains excerpts from a lesson plan including stories, vocabulary words, grammar and spelling exercises. It discusses a Cherokee story about the Milky Way where villagers saw a giant dog stealing cornmeal at night. They scared the dog into the sky where the spilled cornmeal became stars, now known as the Milky Way.
The document defines and provides examples of several literary devices:
1. Alliteration is the repetition of initial consonant sounds in words. Examples include "A peck of pickled peppers" and "Dan's dog dove deep in the dam."
2. Anaphora is the repetition of words or phrases at the beginning of successive sentences for emphasis, as in a Winston Churchill speech.
3. Antithesis contrasts opposing ideas for effect.
4. Oxymorons place contradictory terms together, like "awfully good" or "found missing."
5. Rhetorical questions do not require answers but encourage thought or create humor.
This document provides information and instructions for an English class. It includes:
- Directions to complete an assignment in DLR (Daily Language Review) and reminds students to include their name.
- An essential understanding question about prepositions and the student's Cornell notes response.
- Examples and explanations of prepositional phrases.
- Recognition of students who did well on vocabulary.
- Five vocabulary words to study for an upcoming test along with sample sentences.
- A request to work with a partner to write sentences using the vocabulary words.
- A preview of the next class which will involve clarifying essays with help from named students.
The document provides rules and examples for using semicolons to join independent clauses and items in a series. It states that semicolons should be used sparingly, with no more than 1-2 in a 2,000 word essay. Semicolons can join two independent clauses that are closely related, or an independent clause and an introductory phrase. They can also be used to separate items in a series when the items contain commas. Quotation marks always take precedence over colons and semicolons.
This document presents a teaching/learning package about Asiatic lions that includes pre-viewing and post-viewing tasks. The pre-viewing tasks ask students to name wild animals, identify the king of the jungle, and think about living with lions. The document then provides a transcript about Girnar Mountain and the ancient Gir forest that is home to over 400 Asiatic lions. Post-viewing tasks include vocabulary exercises, a grammar task, role-playing, and sentence formation around words from the transcript.
Regular plural nouns are typically formed by adding "s" or "es" to the singular form, with exceptions for words ending in certain letters like "ch", "sh", "x". Irregular plural nouns do not follow this pattern and instead may change their spelling, vowel, or ending to become plural, such as changing "f" to "ves" or staying the same. Examples are given of both regular and irregular plural nouns.
This document outlines 15 basic spelling rules in English. It defines key terms like vowels, consonants, syllables, stress, prefixes, and suffixes. It then provides rules and examples for using "ch" or "tch", dropping final "e", spelling "ie" or "ei", using "j", "k" or "ck", "l" or "ll", "le", "t" or "tt", "r" or "rr", plural nouns, words ending in "ve", changing "y" to "i", suffixes like "able/ible", adding suffixes, dropping letters, and silent letters. Exceptions are noted for some rules.
1) The "i before e except after c" spelling rule has many exceptions, such as in words like "neighbor" and "weigh" where the pronunciation is different.
2) When adding suffixes to words, there are rules for changing "y" to "ies", adding "-es" to words ending in certain letters, and doubling consonants with one-syllable words stressed on the last syllable.
3) The "drop the 'e' rule" applies when adding suffixes to words, except when the root word ends in "-ce" or "-ge" to maintain a soft sound.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
22. Find more interesting proverbs here:
www.cuteproverbs.com
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