Investors should ask their investment managers three key questions to determine if their portfolio is on track for long-term performance and properly aligned with the investor's interests. The questions are: 1) What is my asset allocation strategy? Asset allocation is the most important factor in long-term returns. 2) What is my total cost of ownership? High fees can significantly reduce long-term returns. 3) Are you a fiduciary? Investments should not be influenced by compensation incentives that are not in the investor's best interests. Periodically asking these questions can help investors assess if their portfolio and advisor are suitable for their long-term financial goals.