Digital Health is transforming healthcare by revolutionizing healthy consumer behavior through digital technologies. Chronic diseases account for the majority of healthcare spending in western countries. Digital health applications are enhancing insurances and corporations' ability to participate in digitizing healthcare across the traditional care continuum from wellness to treatment. However, collaborations between digital health startups and large insurers or corporations have been limited due to differences in decision-making speeds, lack of relevant expertise on both sides, and misaligned incentives regarding cost optimization versus quality of care. Successful partnerships require identifying the right stakeholders, clear strategic targeting of business lines, validating the product and business model, and acceptance as an equal partner.