1. A Informative Slides On HERB + DRUG Interaction VANDANA JANGHEL Assistant Professor (M. Pharma, Pharmacognosy) (Siddhi Vinayaka Institute of Technology & Sciences, Bilaspur, C.G.) What comes from Nature + What we change in nature + What we don’t want 2. 1. What are Herb-drug interactions? 2. How herbs interact with other co administered drug ? 3. Whether they are diagnoised? 4. Are they neglected? 5. Any reports available ? 6. What is the significance of the study ? 7. Need for the study We will discuss on following points HERB + DRUG Interaction 3. Herb drugs + Allopathic drug = Some Reactions HERB + DRUG Interaction 1. When herbal medicinal products and western drugs administered together may interact each other in body leading to kinetic and dynamic alterations. 2. Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. 3. Herbs or Herbal drugs often taken with the Allopathic drugs with belief that it will have some Beneficial effect. 4. Most of the herbal drugs are taken because of- Availability, Economic consideration and its safety 4. PharmacodynamicPharmacokinetics Herb may causes Additive Synergistic Antagonistic Unidentified Response activity in relation to conventional drug Change the Absorption Distribution Metabolism Protein binding Excretion of the drug thus changing blood level of drug HERB + DRUG Interaction 5. Diagnosis Evidence of Interaction Preclinical Trials Clinical Trials Case studies from pharmacovigilance 1 2 3 6. 1. Drug interaction is the 4th to 6th cause of death in the world. 2. About 70-80 herbs may increase the risk of bleeding. 3. Aristolochic acid from Kidamari (Aristolochia Bracteolata) is toxic. 4. Ephedra (Somlata) caused more than 54 deaths and 1600 cases of adverse reaction. Facts about Herbal Drug Interactions 7. 1. Clinician lack of adequate knowledge about Drug-herb Interaction 2. No quality control and assurance for the purity and safety. 3. No advance research in this field. 4. Blind believe or over believe in Ayurverdic medicine 5. Avoidance of patient history about drug sensitivity 6. Adulteration in herbal drug Reason for Herb-Drug Interaction Less Knowledge No Quality Control No Documentation Mythological Believe Herbal-Drug Interaction 8. PHARMACOKINETIC INTERACTION Parameter Increases Decreases Absorption Ginger Fibers Green tea Mucilage containing herb Black pepper Mucilage containing herb Metabolism Guggul Grape juice Elimination Laxative (Aloe) Liquorices Diuretics herbs 9. ALOE VERA Interferes with drug absorption through Laxative action (Aloe latex) Decrease transit time Decrease Intestinal Fluids GINGKO BILOBA Decrease effectiveness of Alprazolam by decreasing its absorption. Ginkgo decreases absorption of Alprazolam rather than inducing hepatic metabolism of alprazolam. GINGER Enhance the absorption of sulfaguanidine and decreases blood sugar PHARMACOKINETIC INTERACTION Herbal drugs which shows Interaction related to Absorption 1

1. PRODUCT- MIX

2. What is product-mix ?
• Set of all product offered for sale by a
company.
• It consist of various product line.
• Any company’s product mix has four
dimension :
1. Width
2. Length
3. Depth
4. Consistency

3. • Width : Number of different product lines
carries by the company.
• Length : Total number of items in the
product mix of the company.
• Depth : Assortment of size, colour and
models offered in each item of a
product line.
• Consistency : It refers to the relationship of
various product line either in their
end use, production
requirement, distribution
channel or other way.

4. Product Mix of Hindustan
Unilever Limited
Home & Personal
Care
Beverages
Personal
Wash
Laundry Skin Care
Hair
Care
Oral Care Tea Coffee
Deodorants
Lux
Lifebuoy
Liril
Hamam
Breeze
Dove
Pears
Rexona
Surf excel
Rin
Wheel
Fair &
Lovely
Ponds
Vaseline
Sunsilk
Clinic +
Pepsodent
Close-up
Axe
Rexona Lipton
Brooke
Bond
Bru

5. PRODUCT-MIX DECISION
A. PRODUCT LINE ANALYSIS
Taking decision regarding whether adding
new product line or not, lengthen the existing
product line or not, analysis of product line is
useful.

6. 0
5
10
15
20
25
30
35
40
45
50
1 2 3 4 5
sales
profit
Product item
%
contribution
to sales
and profit

7. B. MARKET PROFILE
Product line manager must review the
position of its company’s product line
against competitors lines. Product map
is used to show the position of their items
against competitors items.

8. D B C
C B
D
X X A
D C
B
X A
B
LOW(90) MEDUM
(120)
HIGH
(150)
EXTRA
HIGH(180)
LOW
MED
HIGH

9. Methods of Extending Product-Line
• Line stretching : every company’s product
line covers a certain part of the total
possible range, when company lengthen
its product line beyond current range
known as line stretching.
1. Down-Market Stretch
2. Up-Market Stretch
3. Two-way Stretch

10. • Line Filling : A firm can lengthen its
product line by adding more items with in
the present range.

11. LINE MODERNIZING,
FEATURING AND PRUNING
• Product line need to be modernized. In
rapidly changing product markets,
modernization is continuous.
• The product line manager typically select
one or few items in the line to feature.
• Product line manager periodically review
the line for deadwood that is depressing
profit.