Saint Luke's Hospital and Missouri Enterprise are collaborating to improve processes at Saint Luke's using Lean Six Sigma methods. Saint Luke's is a large non-profit hospital that has participated in over 10 Lean Six Sigma projects through a partnership with Missouri Enterprise, a consulting firm specialized in process improvement. The presentation introduces Lean and Six Sigma concepts and waste, and provides an example of how blood management was improved at Saint Luke's using these methods. It also reviews process mapping and customer requirements analysis tools.