An STM works by using a sharp metallic probe tip placed very close to a sample surface. Electrons can quantum tunnel between the tip and surface. The STM maintains a constant tunneling current by precisely adjusting the tip's height as it scans the surface. This vertical movement is used to construct a topographical image of the surface with atomic resolution, revealing details of the atomic and molecular structure. STMs are powerful tools for nanoscale imaging crucial to fields like nanotechnology and materials science.
Neutron star ,an interesting part of astronomy. sobur hossain
A small work about neutron star which will make you interest in astrophysics ,a fascinating things on this earth.Moreover you will learn some facts about astronomy.
Atomic Structure, Sub atomic particles named as electrons, protons and neutronsNaveedAhmad717735
Atom is composed of Sub atomic particles named as electrons, protons and neutrons. For further details https://chem.libretexts.org/Bookshelves/General_Chemistry/Map%3A_A_Molecular_Approach_(Tro)/02%3A_Atoms_and_Elements/2.04%3A_The_Discovery_of_the_Electron
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
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Neutron star ,an interesting part of astronomy. sobur hossain
A small work about neutron star which will make you interest in astrophysics ,a fascinating things on this earth.Moreover you will learn some facts about astronomy.
Atomic Structure, Sub atomic particles named as electrons, protons and neutronsNaveedAhmad717735
Atom is composed of Sub atomic particles named as electrons, protons and neutrons. For further details https://chem.libretexts.org/Bookshelves/General_Chemistry/Map%3A_A_Molecular_Approach_(Tro)/02%3A_Atoms_and_Elements/2.04%3A_The_Discovery_of_the_Electron
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Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
2. 1.Neutron Basics
Start with the fundamental properties of neutrons. Neutrons are
subatomic particles found in the nucleus of an atom. They have no
electrical charge and contribute to the atomic mass. Learn about their
mass, spin, and other basic characteristics.
NUCLEUS
Neutrons
Did you know that neutron
have no electrical charge?
3. 2.Discovery of the Neutron
The history of the neutron’s discovery is fascinating. It was first
theorized by Ernest Rutherford in 1920 and later discovered by James
Chadwick in 1932. Explore the experiments and scientific
advancements that led to its identification.
4. 3.Neutron in Nuclear Physics
Neutrons are also essential in particle physics. Understanding their
interactions with other particles and their role in the structure of
atomic nuclei is a fascinating area of study.
5. 4.Neutron Stars and Beyond.
Study the role of neutrons in extreme astrophysical environments, such
as neutron stars. Neutron stars are incredibly dense and exhibit unique
properties due to the behavior of neutrons under extreme conditions.
6. 5.Nuclear Reactors and Energy Production
Explore how neutrons are used in nuclear reactors for electricity
generation. Learn about the concept of criticality, control of nuclear
reactions, and the safety aspects.
7. 6.Applications and Research
Neutrons are used in various research fields, including materials
science and biology. Neutron scattering techniques provide valuable
insights into the structure and properties of materials. Explore these
applications.
8. The formation of atomic nuclei, including the
creation of neutrons and protons
9. The formation of atomic nuclei, including the creation of neutrons and protons, occurred during the early stages of the universe
in a process known as nucleosynthesis. There are two main phases of nucleosynthesis:
1. **Primordial Nucleosynthesis:** This occurred during the first few minutes after the Big Bang. At this incredibly hot and dense
stage, only the lightest elements, such as hydrogen and helium, were formed. The universe was too hot for stable atomic nuclei
to exist, so only free protons and neutrons were present.
2. **Stellar Nucleosynthesis:** The formation of heavier elements, including stable nuclei containing protons and neutrons (such
as carbon, oxygen, iron, and beyond), occurs in the cores of stars. Stars are like nuclear reactors where nuclear fusion takes place.
High temperatures and pressures in a star’s core cause protons to combine and form helium through nuclear fusion. Later in a
star’s life, depending on its mass, heavier elements are also formed through successive fusion reactions.
Neutrons themselves are not “made” independently; they are a fundamental subatomic particle that exists in nature. They are
stable when bound within atomic nuclei but can undergo various interactions and reactions outside of nuclei.
To summarize, neutrons and protons were formed during the early moments of the universe, and they combine within atomic
nuclei during stellar nucleosynthesis, leading to the creation of all the elements we find in the universe. The detailed processes of
nucleosynthesis are studied in astrophysics and nuclear physics
10. Neutrons are one of the two types of nucleons (the other being protons) that make up the nucleus of an atom. They are
fundamental particles, meaning they are not composed of smaller particles. Neutrons are stable within the nucleus, and they are
formed during processes such as nucleosynthesis.
The formation of neutrons can occur in a few ways:
1. **Beta Decay:** Neutrons can be produced in certain types of radioactive decay, particularly in beta decay. In beta-minus
decay, a proton in the nucleus is transformed into a neutron by emitting a beta particle (an electron) and an antineutrino.
2. **Nuclear Reactions:** In nuclear reactions, such as those occurring in stars, protons can be converted into neutrons through
processes like proton-proton fusion. High temperatures and pressures in stars can facilitate these conversions.
Neutrons, once formed, are held within the nucleus by the strong nuclear force. This is one of the four fundamental forces in the
universe and is responsible for binding protons and neutrons together in the nucleus. The strong nuclear force is incredibly
powerful and acts over very short distances, effectively “gluing” the nucleons together.
The behavior of neutrons within the nucleus is governed by the laws of quantum mechanics. They do not “orbit” like electrons,
and they are subject to confinement within the nucleus due to the strong nuclear force. There isn’t an external force that keeps
them in place; it’s the inherent attraction between protons and neutrons in the nucleus that maintains their stability.
12. A Scanning Tunneling Microscope (STM) is a powerful instrument used to study surfaces at the atomic and molecular scale. It
operates based on the principles of quantum tunneling. Here’s how it works:
1. **Probe Tip:** The STM consists of a sharp metallic probe tip that is very close to the surface being studied. The probe tip is so
close that it’s almost touching the surface.
2. **Quantum Tunneling:** When the probe tip is brought very close to the surface, the electrons in the atoms of the tip and the
surface interact. Due to quantum mechanics, there’s a phenomenon known as tunneling. Electrons can “tunnel” through the small
gap between the probe tip and the surface.
3. **Feedback Mechanism:** The STM maintains a constant tunneling current by adjusting the distance between the probe tip and
the surface. As the tip scans over the surface, the height of the tip is adjusted to keep the current constant. The vertical movement
of the tip is precisely controlled, and this movement is used to create an image of the surface.
4. **Surface Imaging:** The tip moves horizontally across the surface in a systematic manner. As it follows the contours of the
surface, the height changes required to maintain a constant tunneling current are recorded. These height changes are then used to
generate a topographical map of the surface.
5. **Image Formation:** The data collected from the tip’s movement is processed to create a detailed image of the surface. The
resulting image reveals the arrangement of atoms and molecules on the surface with atomic resolution.
STMs are exceptionally powerful tools for studying nanoscale structures and have been instrumental in various scientific fields,
including nanotechnology and materials science. They can provide insights into the arrangement of atoms on surfaces and are vital
for understanding and manipulating materials at the atomic level.