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Contents
• Introduction of Idarubicin
• Sources of Idarubicin
• Methods of extraction
• Conclusion
Introduction
• Idarubicin is a chemotherapeutic drug that belongs to the class of
anthracyclines
• Idarubicin is a synthetic analog of the natural anthracycline compound
daunorubicin More specifically, idarubicin is a 9-substituted anthracycline
• Structure:C26H27NO9
• Brand name:idamycin pfs
• Idarubicin in combination with
other approved antileukemic drugs
is indicated for the treatment of
acute myeloid leukemia (AML) in
adults.
Sources
• Bacterium Species:Streptomyces coeruleorubidus
• Family:Streptomyces genus
Method of extraction
• idarubicin itself is not obtained directly from the microorganism,
and it is instead produced through chemical synthesis.
• To obtain daunorubicin from Streptomyces coeruleorubidus, the
microorganism is grown in a culture medium, and the antibiotic
is extracted from the fermentation broth.
• Daunorubicin is then chemically modified to produce idarubicin
by attaching a 4-demethoxydaunorubicinone moiety to the
daunorubicin molecule at the 4-position. This modification
enhances the antitumor activity of the compound and reduces
its toxicity.

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Presentation 2.pptx

  • 1.
  • 2. Contents • Introduction of Idarubicin • Sources of Idarubicin • Methods of extraction • Conclusion
  • 3. Introduction • Idarubicin is a chemotherapeutic drug that belongs to the class of anthracyclines • Idarubicin is a synthetic analog of the natural anthracycline compound daunorubicin More specifically, idarubicin is a 9-substituted anthracycline • Structure:C26H27NO9
  • 4. • Brand name:idamycin pfs • Idarubicin in combination with other approved antileukemic drugs is indicated for the treatment of acute myeloid leukemia (AML) in adults.
  • 5. Sources • Bacterium Species:Streptomyces coeruleorubidus • Family:Streptomyces genus
  • 6. Method of extraction • idarubicin itself is not obtained directly from the microorganism, and it is instead produced through chemical synthesis. • To obtain daunorubicin from Streptomyces coeruleorubidus, the microorganism is grown in a culture medium, and the antibiotic is extracted from the fermentation broth. • Daunorubicin is then chemically modified to produce idarubicin by attaching a 4-demethoxydaunorubicinone moiety to the daunorubicin molecule at the 4-position. This modification enhances the antitumor activity of the compound and reduces its toxicity.