enzymes are biological molecules.it is protein produces by living cells.which help a chemical changes to happen more quickly,without being changed itself.more knowledge about enzymes in therapy in this slide.

1. Enzymes in therapy
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2. Introduction
Enzymes are proteins produced by the living
cells.
They catalyze several biochemical reaction.some
substances act with specific enzymes and are
called coenzymes.

3.  Enzymes used in therapeutics are:-
Mammalian enzymes – Hyaluronidase,trypsin,
chymotrypsin , alpha chymotrypsin, pancreatic dornase.
Bacterial enzymes – streptokinase,
streptodornase,collagenase,serratiopeptidase,L-
asparaginase.
Plant enzymes – papain (papase)

4.  Mammalian enzymes
1. TRYPSIN
It is obtained from pancreas .it is a proteolytic enzymes which
directly hydrolase natural proteins .it digests dead tissues ,
bacteria and debris .
Trypsin may be used topically ,sublingually or intramuscularly.
•Adverse effects :-allergic reaction can occur.

5. Uses
Trypsin solution used topically for debridement
of necrotic tissues.
Used topically for liquefaction of coagulated
blood and exudates.
Trypsin containing gelatin capsules are inserted
into sinuses and fistulae that can not be
adequately irrigated.
It can also be used for irrigation of nasal cavities.

6. 2. Hyaluronidase
Hyaluronidase is obtained from mammalian testes.
It increase the tissue permeability and enhances the
rate of absorption of subcutaneously, administered fluids
and drugs.
Hyaluronidase can produce allergic reaction .
It should not be injected around an infected an infected
site to avoid the spread of infection.
It is available as dry powder.

7. uses
To hasten resorption of fluids and blood in
hematoma.
Along with local anesthetics – to increase the
effectiveness of local anesthesia.
Radiography – hyaluronidase enhances
absorption of the radiopaque substances.

8.  Bacterial enzymes
1. streptodornase – it is liquify viscous and purulent material.
• they have no effect on living cells.they are active in presence
of magnesium ions.
• Adverse effects- allergic reaction may occur.it is contraindicated
in the presence of bleeding .They should not be used around a
local infected area.

9. Uses
•They are used topically to liquify clotted blood, pus and
to clear the debris in chronic ulcers and other wounds.
Plant enzymes
Papain is obtained from the unripe fruit of carica
papaya.it is a proteolytic enzymes used topically for
debriding wound surfaces.

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