This document discusses drugs that affect gastrointestinal motility, including laxatives, gastrointestinal stimulants, and antidiarrheal drugs. It describes the types and mechanisms of action of various laxatives including chemical stimulants, bulk stimulants, and lubricants. It also discusses gastrointestinal stimulants that increase motility and antidiarrheal drugs that decrease motility. Nursing considerations are provided for the administration and evaluation of these drug types. Laxatives should only be used short-term to prevent patients from developing cathartic dependence.